608 Matching Annotations
  1. Jun 2023
  2. www.sciencedirect.com www.sciencedirect.com
    Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma
    1
    1. scibot 03 Jun 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2023.112581

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    sciencedirect.com/science/article/pii/S2211124723005922
  3. www.biorxiv.org www.biorxiv.org
    Real Time In vivo Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune Diabetes
    1
    1. scibot 01 Jun 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1101/2023.05.23.541935

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    biorxiv.org/content/10.1101/2023.05.23.541935v1
  4. 52.53.155.43 52.53.155.43
    mct-23-0039-html.html
    1
    1. scibot 01 Jun 2023
      JAX:005557

      DOI: 10.1158/1535-7163.MCT-23-0039

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    52.53.155.43/2e399e27445b3309b8dca3d6b15c5701e7dc6c5e/mct-23-0039-html.html
  5. www.sciencedirect.com www.sciencedirect.com
    Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer
    1
    1. scibot 01 Jun 2023
      RRID:IMSR_JAX:005557Info

      DOI: 10.1016/j.celrep.2023.112533

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    sciencedirect.com/science/article/pii/S2211124723005442
  6. May 2023
  7. www.sciencedirect.com www.sciencedirect.com
    CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis
    1
    1. scibot 26 May 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2023.05.001

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    sciencedirect.com/science/article/pii/S153561082300168X
  8. www.sciencedirect.com www.sciencedirect.com
    Enhanced mitochondrial fission inhibits triple-negative breast cancer cell migration through a ROS-dependent mechanism
    1
    1. scibot 26 May 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.isci.2023.106788

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    sciencedirect.com/science/article/pii/S2589004223008659
  9. 52.53.155.43 52.53.155.43
    Intrinsic tumor resistance to CAR T cells is a dynamic transcriptional state that is exploitable with low-dose radiation
    1
    1. scibot 19 May 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1182/bloodadvances.2022009543

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    52.53.155.43/c3edf1bcbe114757202a2e57dfb535e151ecf522/RRID8-html.html
  10. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
    1
    1. scibot 13 May 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1096/fj.202300223R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300223R
  11. www.sciencedirect.com www.sciencedirect.com
    A chimeric antigen receptor uniquely recognizing MICA/B stress proteins provides an effective approach to target solid tumors
    1
    1. scibot 12 May 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.medj.2023.04.004

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    sciencedirect.com/science/article/pii/S2666634023001368
  12. www.embopress.org www.embopress.org
    Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC-driven lymphoma
    1
    1. scibot 10 May 2023
      JAX:005557

      DOI: 10.15252/emmm.202216910

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    embopress.org/doi/10.15252/emmm.202216910
  13. www.sciencedirect.com www.sciencedirect.com
    Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal
    1
    1. scibot 05 May 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2023.04.005

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    sciencedirect.com/science/article/pii/S1934590923001236
  14. www.sciencedirect.com www.sciencedirect.com
    Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblasts
    1
    1. scibot 04 May 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2023.112453

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    sciencedirect.com/science/article/pii/S2211124723004643
  15. Apr 2023
  16. www.sciencedirect.com www.sciencedirect.com
    A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
    1
    1. scibot 29 Apr 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2023.04.002

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    sciencedirect.com/science/article/pii/S1535610823001289
  17. aacrjournals.org aacrjournals.org
    Dual mTORC1/2 inhibition synergistically enhances AML cell death in combination with the BCL2 antagonist venetoclax
    1
    1. scibot 21 Apr 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1078-0432.CCR-22-2729

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    aacrjournals.org/clincancerres/article/29/7/1332/718764/Dual-mTORC1-2-Inhibition-Synergistically-Enhances
  18. www.sciencedirect.com www.sciencedirect.com
    A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer
    1
    1. scibot 19 Apr 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.101015

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    sciencedirect.com/science/article/pii/S2666379123001258
  19. www.sciencedirect.com www.sciencedirect.com
    Deficiency of the CD155-CD96 immune checkpoint controls IL-9 production in giant cell arteritis
    1
    1. scibot 19 Apr 2023
      JAX:005557

      DOI: 10.1016/j.xcrm.2023.101012

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    sciencedirect.com/science/article/pii/S2666379123001222
  20. www.sciencedirect.com www.sciencedirect.com
    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
    1
    1. scibot 19 Apr 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2023.03.002

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    sciencedirect.com/science/article/pii/S1535610823000508
  21. www.sciencedirect.com www.sciencedirect.com
    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
    1
    1. scibot 06 Apr 2023
      JAX:005557

      DOI: 10.1016/j.celrep.2023.112324

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    sciencedirect.com/science/article/pii/S2211124723003352
  22. Mar 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
    1
    1. scibot 28 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2023.112296

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    sciencedirect.com/science/article/pii/S2211124723003078
  24. www.embopress.org www.embopress.org
    RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer
    1
    1. scibot 18 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.15252/emmm.202216715

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    embopress.org/doi/10.15252/emmm.202216715
  25. www.sciencedirect.com www.sciencedirect.com
    Purification and characterization of human neural stem and progenitor cells
    1
    1. scibot 17 Mar 2023
      JAX:005557

      DOI: 10.1016/j.cell.2023.02.017

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    sciencedirect.com/science/article/pii/S0092867423001605
  26. www.science.org www.science.org
    Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancer
    1
    1. scibot 16 Mar 2023
      JAX:005557

      DOI: 10.1126/sciimmunol.ade4656

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    science.org/doi/10.1126/sciimmunol.ade4656
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A tri-specific killer engager against mesothelin targets NK cells towards lung cancer
    1
    1. scibot 16 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.3389/fimmu.2023.1060905

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    ncbi.nlm.nih.gov/pmc/articles/PMC9992642/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S100A8/S100A9 promote progression of multiple myeloma via expansion of megakaryocytes
    1
    1. scibot 16 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-22-0368

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    ncbi.nlm.nih.gov/pmc/articles/PMC10010194/
  29. www.sciencedirect.com www.sciencedirect.com
    Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans
    1
    1. scibot 11 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2023.112218

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    sciencedirect.com/science/article/pii/S2211124723002292
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Humanized Patient-derived Xenograft Models of Disseminated Ovarian Cancer Recapitulate Key Aspects of the Tumor Immune Environment within the Peritoneal Cavity
    1
    1. scibot 04 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-22-0300

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    ncbi.nlm.nih.gov/pmc/articles/PMC9973420/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intertumoral Differences Dictate the Outcome of TGF-β Blockade on the Efficacy of Viro-Immunotherapy
    1
    1. scibot 04 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2767-9764.CRC-23-0019

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    ncbi.nlm.nih.gov/pmc/articles/PMC9973387/
  32. www.sciencedirect.com www.sciencedirect.com
    A bispecific T cell engager recruits both type 1 NKT and Vγ9Vδ2-T cells for the treatment of CD1d-expressing hematological malignancies
    1
    1. scibot 03 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2023.100961

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    sciencedirect.com/science/article/pii/S2666379123000538
  33. www.sciencedirect.com www.sciencedirect.com
    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
    1
    1. scibot 03 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2023.02.004

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    sciencedirect.com/science/article/pii/S1535610823000326
  34. www.sciencedirect.com www.sciencedirect.com
    Multiomics reveals glutathione metabolism as a driver of bimodality during stem cell aging
    1
    1. scibot 02 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cmet.2023.02.001

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    sciencedirect.com/science/article/pii/S1550413123000372
  35. www.cell.com www.cell.com
    Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy
    1
    1. scibot 02 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.chembiol.2023.02.005

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    cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00054-5
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of CD70-specific CAR T cells targeting acute myeloid leukemia
    1
    1. scibot 02 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.3389/fimmu.2023.1093750

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    ncbi.nlm.nih.gov/pmc/articles/PMC9950117/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Wide Analysis of lncRNA-mRNA Co-Expression Networks in CD133+/CD44+ Stem-like PDAC Cells
    1
    1. scibot 02 Mar 2023
      RRID:IMSR_JAX:005557

      DOI: 10.3390/cancers15041053

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    ncbi.nlm.nih.gov/pmc/articles/PMC9954787/
  38. Feb 2023
  39. www.sciencedirect.com www.sciencedirect.com
    CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR mutated and overexpressed oral cancer
    1
    1. scibot 25 Feb 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.isci.2023.106089

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    sciencedirect.com/science/article/pii/S2589004223001669
  40. www.sciencedirect.com www.sciencedirect.com
    An adverse tumor-protective effect of IDO1 inhibition
    1
    1. scibot 23 Feb 2023
      RRID:IMSR_JAX:005

      DOI: 10.1016/j.xcrm.2023.100941

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    sciencedirect.com/science/article/pii/S2666379123000332
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer
    1
    1. scibot 17 Feb 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-22-2245

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    ncbi.nlm.nih.gov/pmc/articles/PMC9929516/
  42. www.sciencedirect.com www.sciencedirect.com
    Post-transplant cyclophosphamide prevents xenogeneic graft-versus-host disease while depleting proliferating regulatory T cells
    1
    1. scibot 17 Feb 2023
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.isci.2023.106085

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    sciencedirect.com/science/article/pii/S2589004223001621
  43. 52.53.155.43 52.53.155.43
    91-html.html
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      RRID:IMSR_JAX:005557

      DOI: 10.1158/1541-7786.MCR-22-0594

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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysregulated lipid synthesis by oncogenic IDH1 mutation is a targetable synthetic lethal vulnerability
    1
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      DOI: 10.1158/2159-8290.CD-21-0218

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  45. www.nature.com www.nature.com
    Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy
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      DOI: 10.1038/s41467-022-35583-w

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  46. Jan 2023
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors
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      RRID:IMSR_JAX:005557

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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells
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      DOI: 10.1126/sciadv.ade9120

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  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis
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      DOI: 10.1126/sciadv.abq3951

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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma
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  52. www.science.org www.science.org
    ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis
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      DOI: 10.1126/sciadv.abq3951

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  53. www.science.org www.science.org
    Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells
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      DOI: 10.1126/sciadv.ade9120

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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical Development of [211At]meta- astatobenzylguanidine ([211At]MABG) as an Alpha Particle Radiopharmaceutical Therapy for Neuroblastoma
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel B7-H6–Targeted IgG-Like T Cell–Engaging Antibody for the Treatment of Gastrointestinal Tumors
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  58. www.sciencedirect.com www.sciencedirect.com
    Microbiota-dependent and -independent postnatal development of salivary immunity
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    Human cortical interneurons optimized for grafting specifically integrate, abort seizures, and display prolonged efficacy without over-inhibition
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      DOI: 10.1016/j.neuron.2022.12.014

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  61. www.sciencedirect.com www.sciencedirect.com
    A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endometriosis-associated mesenchymal stem cells support ovarian clear cell carcinoma through iron regulation
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  64. 52.53.155.43 52.53.155.43
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      DOI: 10.1182/blood.2022016943

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  65. www.mdpi.com www.mdpi.com
    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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      DOI: 10.3390/cancers15010241

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  66. Dec 2022
  67. 52.53.155.43 52.53.155.43
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  68. www.sciencedirect.com www.sciencedirect.com
    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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      The Jackson LaboratoryCat#005557

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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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    Expression of inducible factors reprograms CAR-T cells for enhanced function and safety
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    Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells
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  72. aacrjournals.org aacrjournals.org
    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
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  73. Nov 2022
  74. www.sciencedirect.com www.sciencedirect.com
    Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis
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    Estrone, the major postmenopausal estrogen, binds ERa to induce SNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancer metastasis
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    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
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  77. www.science.org www.science.org
    Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
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      DOI: 10.1126/scitranslmed.abm1463

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    Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma
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    Protocol for evaluating antitumor activity of KIR3DL3 blockade in an NK cell-based xenogeneic lung tumor model
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    Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy
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  81. Oct 2022
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier
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    Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation
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    PARP-inhibition reprograms macrophages toward an anti-tumor phenotype
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.111462

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    Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.molcel.2022.09.007

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    Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
    1
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      JAX:005557

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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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      RRID:IMSR_JAX

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  88. Sep 2022
  89. www.sciencedirect.com www.sciencedirect.com
    Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I−/− iPSCs for β cell replacement
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      JAX:005557

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    The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.111428

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    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
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      005557

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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acute Myeloid Leukemia Alters Group 1 Innate Lymphoid Cell Differentiation from a Common Precursor
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      RRID:IMSR_JAX:005557

      DOI: 10.4049/jimmunol.2100023

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    In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy
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    Targeting histone methylation to reprogram the transcriptional state that drives survival of drug-tolerant myeloid leukemia persisters
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    ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes
    1
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      Mouse: NSG NOD/ShiLtJ

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    Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
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  97. Aug 2022
  98. www.sciencedirect.com www.sciencedirect.com
    Vitamin D receptor activation is a feasible therapeutic target to impair adrenocortical tumorigenesis
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      JAX_005557

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    ARID1A-deficient bladder cancer is dependent on PI3K signaling and sensitive to EZH2 and PI3K inhibitors
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      RRID:IMSR_JAX:005557

      DOI: 10.1172/jci.insight.155899

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    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
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      RRID:IMSR_JAX:005557

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    Off-The-Shelf Third-Party HSC-Engineered iNKT Cells for Ameliorating GvHD While Preserving GvL Effect in the Treatment of Blood Cancers
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      The Jackson LaboratoryStock #: 005557

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    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
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      Jackson LaboratoryCat #005557

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    BCL10 mutations define distinct dependencies guiding precision therapy for DLBCL
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      RRID:IMSR_JAX

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    EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity
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      Jackson LaboratoriesCat# 005557

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    Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells
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      RRID:IMSR_JAX:005557

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    Co-targeting of specific epigenetic regulators in combination with CDC7 potently inhibit melanoma growth
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      Jackson LaboratoryStock No. 005557

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  107. Jul 2022
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
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      The Jackson Laboratory005557

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    EGFR inhibition enhances the cellular uptake and antitumor-activity of the HER3 antibody drug conjugate HER3-DXd
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      RRID:IMSR_JAX:005557

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  110. Jun 2022
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      RRID:IMSR_JAX:005557

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    Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
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      JAX:005557

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    Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma
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      Jackson LaboratoryStock# 005557

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    Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas
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      JacksonCat#005557

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    Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
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      The Jackson LaboratoryStock No: 005557

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    Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
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      Jackson Laboratory005557

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  117. aacrjournals.org aacrjournals.org
    Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors
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      RRID:IMSR_JAX:005557

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    Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids
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      The Jackson LaboratoryStrain #005557

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    A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs
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      RRID:IMSR_JAX:005557

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  120. May 2022
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    Therapeutic development for Canavan disease using patient iPSCs introduced with the wild-type ASPA gene
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      Jackson Laboratory005557

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    Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors
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      The Jackson LaboratoryCat#005557

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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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      The Jackson Laboratory005557

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    c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity
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      Jackson Laboratory005557

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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    1. scibot 19 May 2022
      JACKSON LABORATORYStock #: 005557

      DOI: 10.1016/j.celrep.2022.110814

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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Matricellular protein WISP2 is an endogenous inhibitor of collagen linearization and cancer metastasis
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-20-3982

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    ncbi.nlm.nih.gov/pmc/articles/PMC8595651/
  127. www.sciencedirect.com www.sciencedirect.com
    Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cmet.2022.04.012

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    sciencedirect.com/science/article/pii/S1550413122001826
  128. www.sciencedirect.com www.sciencedirect.com
    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
    1
    1. scibot 12 May 2022
      Jackson Laboratories#005557

      DOI: 10.1016/j.cell.2022.04.019

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    sciencedirect.com/science/article/pii/S0092867422004664
  129. www.sciencedirect.com www.sciencedirect.com
    Antigen presentation safeguards the integrity of the hematopoietic stem cell pool
    1
    1. scibot 06 May 2022
      JAX:005557

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    sciencedirect.com/science/article/pii/S1934590922001606
  130. www.sciencedirect.com www.sciencedirect.com
    Patient-derived models of brain metastases recapitulate human disseminated disease
    1
    1. scibot 05 May 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.xcrm.2022.100623

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    sciencedirect.com/science/article/pii/S2666379122001409
  131. Apr 2022
  132. www.sciencedirect.com www.sciencedirect.com
    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
    1
    1. scibot 29 Apr 2022
      The Jackson LaboratoryStrain: 005557

      DOI: 10.1016/j.devcel.2022.04.010

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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SynNotch CAR Circuits Enhance Solid Tumor Recognition and Promote Persistent Anti-tumor Activity in Mouse Models
    1
    1. scibot 29 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abd8836

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  134. www.sciencedirect.com www.sciencedirect.com
    The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma
    1
    1. scibot 28 Apr 2022
      Jackson Laboratoriesstrain 005557

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    sciencedirect.com/science/article/pii/S153458072200243X
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    Enhanced safety and efficacy of protease-regulated CAR-T cell receptors
    1
    1. scibot 28 Apr 2022
      Jackson Laboratory005557

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  136. www.science.org www.science.org
    SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models
    1
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      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abd8836

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  137. www.sciencedirect.com www.sciencedirect.com
    The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes
    1
    1. scibot 22 Apr 2022
      Jackson Laboratory005557

      DOI: 10.1016/j.stem.2022.03.015

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    sciencedirect.com/science/article/pii/S1934590922001503
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    The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function
    1
    1. scibot 22 Apr 2022
      Jackson LaboratoryJax: 005557

      DOI: 10.1016/j.cmet.2022.03.013

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    sciencedirect.com/science/article/pii/S1550413122001279
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    Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia
    1
    1. scibot 22 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2022.04.001

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    sciencedirect.com/science/article/pii/S153561082200157X
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    Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche
    1
    1. scibot 21 Apr 2022
      The Jackson LaboratoryStrain #:005557

      DOI: 10.1016/j.cell.2022.03.033

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    sciencedirect.com/science/article/pii/S0092867422003439
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    Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis
    1
    1. scibot 21 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.cell.2022.03.030

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    sciencedirect.com/science/article/pii/S0092867422003403
  142. www-sciencedirect-com.ezp-prod1.hul.harvard.edu www-sciencedirect-com.ezp-prod1.hul.harvard.edu
    Modular design of synthetic receptors for programmed gene regulation in cell therapies
    1
    1. scibot 20 Apr 2022
      Jackson LaboratoriesCat#005557

      DOI: 10.1016/j.cell.2022.03.023

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    www-sciencedirect-com.ezp-prod1.hul.harvard.edu/science/article/pii/S0092867422003336
  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multilayered control of splicing regulatory networks by DAP3 leads to widespread alternative splicing changes in cancer
    1
    1. scibot 09 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41467-022-29400-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC8980049/
  144. www.sciencedirect.com www.sciencedirect.com
    Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment
    1
    1. scibot 08 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2022.03.004

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    sciencedirect.com/science/article/pii/S1934590922001023
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    Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer
    1
    1. scibot 07 Apr 2022
      Jackson#005557

      DOI: 10.1016/j.celrep.2022.110641

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    sciencedirect.com/science/article/pii/S221112472200393X
  146. www.sciencedirect.com www.sciencedirect.com
    Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma
    1
    1. scibot 07 Apr 2022
      Jackson LaboratoriesCat# 005557

      DOI: 10.1016/j.celrep.2022.110637

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    sciencedirect.com/science/article/pii/S2211124722003898
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    Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors
    1
    1. scibot 07 Apr 2022
      The Jackson Laboratory; OCI colonyCat#005557

      DOI: 10.1016/j.celrep.2022.110621

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    sciencedirect.com/science/article/pii/S2211124722003692
  148. aacrjournals.org aacrjournals.org
    mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment
    1
    1. scibot 07 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1541-7786.MCR-20-0799

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    aacrjournals.org/mcr/article/19/4/717/672854/mDKN-01-a-Novel-Anti-DKK1-mAb-Enhances-Innate
  149. www.sciencedirect.com www.sciencedirect.com
    Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
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    1. scibot 07 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.110634

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      RRID:IMSR_JAX:005

      DOI: 10.1016/j.celrep.2022.110634

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    sciencedirect.com/science/article/pii/S2211124722003862
  150. aacrjournals.org aacrjournals.org
    Subversion of serotonin-receptor signaling in osteoblasts by kynurenine drives Acute Myeloid Leukemia
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    1. scibot 05 Apr 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-21-0692

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    aacrjournals.org/cancerdiscovery/article/12/4/1106/689604/Subversion-of-Serotonin-Receptor-Signaling-in
  151. Mar 2022
  152. www.nature.com www.nature.com
    ADARs act as potent regulators of circular transcriptome in cancer
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    1. scibot 26 Mar 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s41467-022-29138-2

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    nature.com/articles/s41467-022-29138-2
  153. www.sciencedirect.com www.sciencedirect.com
    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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    1. scibot 18 Mar 2022
      Jackson LaboratoryStock No: 005557

      DOI: 10.1016/j.cmet.2022.02.009

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    sciencedirect.com/science/article/pii/S1550413122000535
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    Lamin B1 deletion in myeloid neoplasms causes nuclear anomaly and altered hematopoietic stem cell function
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      Jackson labscat#: 005557

      DOI: 10.1016/j.stem.2022.02.010

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    sciencedirect.com/science/article/pii/S1934590922000613
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    3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells
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    1. scibot 18 Mar 2022
      Jackson LaboratoryStrain #005557

      DOI: 10.1016/j.stem.2022.02.009

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    sciencedirect.com/science/article/pii/S1934590922000601
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    Identification of the global miR-130a targetome reveals a role for TBL1XR1 in hematopoietic stem cell self-renewal and t(8;21) AML
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    1. scibot 09 Mar 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.110481

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    sciencedirect.com/science/article/pii/S2211124722002145
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    Tumor-derived Jagged1 promotes cancer progression through immune evasion
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    1. scibot 09 Mar 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2022.110492

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    sciencedirect.com/science/article/pii/S221112472200225X
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    CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
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      JAX:005557

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  159. Feb 2022
  160. www.sciencedirect.com www.sciencedirect.com
    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
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    1. scibot 23 Feb 2022
      Jackson LaboratoryCat# 005557

      DOI: 10.1016/j.molcel.2022.01.022

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    sciencedirect.com/science/article/pii/S1097276522000879
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    Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination
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    1. scibot 16 Feb 2022
      The Jackson Laboratory005557

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    sciencedirect.com/science/article/pii/S2211124722001097
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    Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth
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      RRID:IMSR_JAX

      DOI: 10.1016/j.medj.2021.12.008

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    sciencedirect.com/science/article/pii/S2666634021004098
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    Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
    2
    1. scibot 11 Feb 2022
      005557

      DOI: 10.1016/j.celrep.2022.110322

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      005557

      DOI: 10.1016/j.celrep.2022.110322

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  164. link.springer.com link.springer.com
    When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer
    1
    1. scibot 08 Feb 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1186/s10020-022-00440-5

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    link.springer.com/article/10.1186/s10020-022-00440-5
  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.
    1
    1. scibot 02 Feb 2022
      RRID:IMSR_JAX:005557

      DOI: 10.1158/0008-5472.CAN-20-1200

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    ncbi.nlm.nih.gov/pmc/articles/PMC7854521/
  166. Jan 2022
  167. www.sciencedirect.com www.sciencedirect.com
    Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells
    1
    1. scibot 27 Jan 2022
      #005557

      DOI: 10.1016/j.devcel.2021.12.020

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    sciencedirect.com/science/article/pii/S1534580721010406
  168. www.sciencedirect.com www.sciencedirect.com
    Autologous humanized mouse models of iPSC-derived tumors enable characterization and modulation of cancer-immune cell interactions
    1
    1. scibot 16 Jan 2022
      The Jackson LaboratoryCat# 005557

      DOI: 10.1016/j.crmeth.2021.100153

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    sciencedirect.com/science/article/pii/S2667237521002307
  169. www.sciencedirect.com www.sciencedirect.com
    SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
    1
    1. scibot 12 Jan 2022
      The Jackson LaboratoryStock No: 005557

      DOI: 10.1016/j.celrep.2021.110233

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    sciencedirect.com/science/article/pii/S2211124721017423
  170. www.sciencedirect.com www.sciencedirect.com
    Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness
    1
    1. scibot 05 Jan 2022
      Cat#005557

      DOI: 10.1016/j.cmet.2021.12.001

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    sciencedirect.com/science/article/pii/S1550413121006203
  171. Dec 2021
  172. www.sciencedirect.com www.sciencedirect.com
    GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity
    1
    1. scibot 31 Dec 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2021.12.005

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    sciencedirect.com/science/article/pii/S1535610821006589
  173. www.sciencedirect.com www.sciencedirect.com
    EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion
    1
    1. scibot 28 Dec 2021
      Stock No. 005557

      DOI: 10.1016/j.cell.2021.12.005

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    sciencedirect.com/science/article/pii/S0092867421014276
  174. www.sciencedirect.com www.sciencedirect.com
    An NK-like CAR T cell transition in CAR T cell dysfunction
    1
    1. scibot 03 Dec 2021
      Cat# 5557

      DOI: 10.1016/j.cell.2021.11.016

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    sciencedirect.com/science/article/pii/S0092867421013313
  175. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
    1
    1. scibot 03 Dec 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1038/s42003-021-02842-3

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    nature.com/articles/s42003-021-02842-3
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer
    1
    1. scibot 01 Dec 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abb3738

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    ncbi.nlm.nih.gov/pmc/articles/PMC8627689/
  177. Nov 2021
  178. www.sciencedirect.com www.sciencedirect.com
    Immuno-transcriptomic profiling of extracranial pediatric solid malignancies
    1
    1. scibot 30 Nov 2021
      Stock No: 005557

      DOI: 10.1016/j.celrep.2021.110047

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    sciencedirect.com/science/article/pii/S2211124721015333
  179. www.sciencedirect.com www.sciencedirect.com
    Distinct contributions of partial and full EMT to breast cancer malignancy
    1
    1. scibot 30 Nov 2021
      JAX:005557

      DOI: 10.1016/j.devcel.2021.11.006

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    sciencedirect.com/science/article/pii/S1534580721008911
  180. www.sciencedirect.com www.sciencedirect.com
    Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
    1
    1. scibot 24 Nov 2021
      Stock# 005557

      DOI: 10.1016/j.celrep.2021.110054

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    sciencedirect.com/science/article/pii/S2211124721015400
  181. www.sciencedirect.com www.sciencedirect.com
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    1
    1. scibot 24 Nov 2021
      005557

      DOI: 10.1016/j.celrep.2021.110056

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    sciencedirect.com/science/article/pii/S2211124721015424
  182. www.sciencedirect.com www.sciencedirect.com
    Effective chimeric antigen receptor T-cells (CAR-Ts) against SARS-CoV-2
    1
    1. scibot 18 Nov 2021
      005557

      DOI: 10.1016/j.isci.2021.103295

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    sciencedirect.com/science/article/pii/S2589004221012645
  183. www.sciencedirect.com www.sciencedirect.com
    Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy
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    1. scibot 17 Nov 2021
      Stock #: 005557

      DOI: 10.1016/j.xcrm.2021.100449

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    sciencedirect.com/science/article/pii/S2666379121003177
  184. www.sciencedirect.com www.sciencedirect.com
    A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors
    1
    1. scibot 09 Nov 2021
      005557

      DOI: 10.1016/j.celrep.2021.109953

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    sciencedirect.com/science/article/pii/S2211124721014303
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells
    1
    1. scibot 05 Nov 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ebiom.2021.103646

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    ncbi.nlm.nih.gov/pmc/articles/PMC8546421/
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies
    1
    1. scibot 05 Nov 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-20-1243

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    ncbi.nlm.nih.gov/pmc/articles/PMC8406797/
  187. Oct 2021
  188. www.sciencedirect.com www.sciencedirect.com
    Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections
    1
    1. scibot 30 Oct 2021
      005557

      DOI: 10.1016/j.cell.2021.10.004

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    sciencedirect.com/science/article/pii/S0092867421011788
  189. www.sciencedirect.com www.sciencedirect.com
    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
    1
    1. scibot 21 Oct 2021
      005557

      DOI: 10.1016/j.celrep.2021.109870

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    sciencedirect.com/science/article/pii/S2211124721013371
  190. www.sciencedirect.com www.sciencedirect.com
    Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer
    1
    1. scibot 21 Oct 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2021.109852

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    sciencedirect.com/science/article/pii/S221112472101319X
  191. www.sciencedirect.com www.sciencedirect.com
    Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas
    1
    1. scibot 21 Oct 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2021.109873

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    sciencedirect.com/science/article/pii/S2211124721013401
  192. www.science.org www.science.org
    Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels
    1
    1. scibot 18 Oct 2021
      005557

      DOI: 10.1126/sciadv.abi7511

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    science.org/doi/abs/10.1126/sciadv.abi7511
  193. www.science.org www.science.org
    Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer
    1
    1. scibot 18 Oct 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1126/scitranslmed.abb3738

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    science.org/doi/abs/10.1126/scitranslmed.abb3738
  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels
    1
    1. scibot 15 Oct 2021
      JAX stock #005557

      DOI: 10.1126/sciadv.abi7511

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    ncbi.nlm.nih.gov/pmc/articles/PMC8494442/
  195. www.sciencedirect.com www.sciencedirect.com
    Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells
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    1. scibot 13 Oct 2021
      005557

      DOI: 10.1016/j.celrep.2021.109812

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    sciencedirect.com/science/article/pii/S2211124721012766
  196. Sep 2021
  197. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
    1
    1. scibot 23 Sep 2021
      Strain# 005557

      DOI: 10.1016/j.molcel.2021.08.034

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    sciencedirect.com/science/article/pii/S1097276521007140
  198. www.sciencedirect.com www.sciencedirect.com
    Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
    1
    1. scibot 21 Sep 2021
      Stock# 005557

      DOI: 10.1016/j.celrep.2021.109689

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    sciencedirect.com/science/article/pii/S2211124721011360
  199. www.sciencedirect.com www.sciencedirect.com
    Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer
    1
    1. scibot 15 Sep 2021
      005,557

      DOI: 10.1016/j.chembiol.2021.08.011

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    sciencedirect.com/science/article/pii/S2451945621004001
  200. www.sciencedirect.com www.sciencedirect.com
    Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy
    1
    1. scibot 15 Sep 2021
      JAX:005557

      DOI: 10.1016/j.stem.2021.08.013

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    sciencedirect.com/science/article/pii/S1934590921003507
  201. www.sciencedirect.com www.sciencedirect.com
    Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor
    1
    1. scibot 14 Sep 2021
      005557

      DOI: 10.1016/j.ccell.2021.08.009

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    sciencedirect.com/science/article/pii/S1535610821004499
  202. Aug 2021
  203. www.sciencedirect.com www.sciencedirect.com
    Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors
    1
    1. scibot 25 Aug 2021
      JAX:005557

      DOI: 10.1016/j.celrep.2021.109568

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    sciencedirect.com/science/article/pii/S2211124721010020
  204. www.sciencedirect.com www.sciencedirect.com
    Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection
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    1. scibot 18 Aug 2021
      Stock No: 005557

      DOI: 10.1016/j.celrep.2021.109538

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    sciencedirect.com/science/article/pii/S2211124721009724
  205. www.sciencedirect.com www.sciencedirect.com
    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
    1
    1. scibot 16 Aug 2021
      JAX:005557

      DOI: 10.1016/j.ccell.2021.07.006

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    sciencedirect.com/science/article/pii/S1535610821003834
  206. www.sciencedirect.com www.sciencedirect.com
    Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
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    1. scibot 16 Aug 2021
      JAX:005557

      DOI: 10.1016/j.cell.2021.07.020

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    sciencedirect.com/science/article/pii/S0092867421008795
  207. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
    1
    1. scibot 15 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1158/2159-8290.CD-20-0331

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    ncbi.nlm.nih.gov/pmc/articles/PMC8110214/
  208. www.sciencedirect.com www.sciencedirect.com
    Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
    1
    1. scibot 14 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2019.06.003

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  209. www.sciencedirect.com www.sciencedirect.com
    Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression
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    1. scibot 11 Aug 2021
      JAX:005557

      DOI: 10.1016/j.stem.2016.12.001

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    sciencedirect.com/science/article/pii/S193459091630457X
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    ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
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    1. scibot 07 Aug 2021
      Stock No: 005557

      DOI: 10.1016/j.molcel.2021.07.018

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      RRID:IMSR_JAX:005557 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1097276521005876
  211. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer
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    1. scibot 06 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.7554/eLife.43024

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    ncbi.nlm.nih.gov/pmc/articles/PMC6597241/
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    Studying immunotherapy resistance in a melanoma autologous humanized mouse xenograft.
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    1. scibot 05 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1158/1541-7786.MCR-20-0686

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    ncbi.nlm.nih.gov/pmc/articles/PMC7864867/
  213. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53
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    1. scibot 05 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.7554/eLife.70429

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    ncbi.nlm.nih.gov/pmc/articles/PMC8321552/
  214. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2018.11.006

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    sciencedirect.com/science/article/pii/S1535610818305270
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    TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate
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    1. scibot 04 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.stem.2021.07.003

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    sciencedirect.com/science/article/pii/S1934590921002885
  216. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      JAX:005557

      DOI: 10.1016/j.stem.2016.12.001

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    The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.molcel.2017.11.025

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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.ccell.2018.06.012

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    The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma
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    1. scibot 01 Aug 2021
      RRID:IMSR_JAX:005557

      DOI: 10.1016/j.celrep.2019.05.069

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    sciencedirect.com/science/article/pii/S2211124719306989