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Sep 2023
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Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling

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1. scibot 08 Sep 2023
  
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  DOI: 10.1016/j.molcel.2023.08.005
  
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Oligodendrocyte precursor cells stop sensory axons regenerating into the spinal cord

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1. scibot 01 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113068
  
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sciencedirect.com/science/article/pii/S2211124723010793
Aug 2023
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Ets1 facilitates EMT/invasion through Drp1-mediated mitochondrial fragmentation in ovarian cancer

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1. scibot 23 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107537
  
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Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia

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1. scibot 17 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112982
  
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Human iPSC-derived neural stem cells display a radial glia-like signature in vitro and favorable long-term safety in transplanted mice

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1. scibot 12 Aug 2023
  
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  DOI: 10.1101/2023.08.04.551937
  
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biorxiv.org/content/10.1101/2023.08.04.551937v1
Jul 2023
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Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.immuni.2023.06.020
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10433941/
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Low-level repressive histone marks fine-tune gene transcription in neural stem cells

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1. scibot 15 Jul 2023
  
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  DOI: 10.7554/eLife.86127
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10344426/
Jun 2023
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Apolipoprotein E intersects with amyloid-β within neurons

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1. scibot 24 Jun 2023
  
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  DOI: 10.26508/lsa.202201887
  
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2. scibot 12 Jun 2023
  
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  DOI: 10.26508/lsa.202201887
  
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52.53.155.43/d79c74abbe0299455dfcf8568ff6bf527c1e5b68/e202201887.full-html.html
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Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107070
  
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sciencedirect.com/science/article/pii/S2589004223011471
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Transcriptomic landscape of early hair follicle and epidermal development

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112643
  
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sciencedirect.com/science/article/pii/S221112472300654X
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Astrocytes Differentiated from LRRK2-I1371V Parkinson’s-Disease-Induced Pluripotent Stem Cells Exhibit Similar Yield but Cell-Intrinsic Dysfunction in Glutamate Uptake and Metabolism, ATP Generation, and Nrf2-Mediated Glutathione Machinery

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1. scibot 16 Jun 2023
  
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  DOI: 10.3390/cells12121592
  
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mdpi.com/2073-4409/12/12/1592
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Neural crest-related NXPH1/α-NRXN signaling opposes neuroblastoma malignancy by inhibiting organotropic metastasis

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1. scibot 13 Jun 2023
  
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  DOI: 10.1038/s41388-023-02742-2
  
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nature.com/articles/s41388-023-02742-2
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Presence of Extracellular Alpha-Synuclein Aggregates Trigger Astrocytic Degeneration Through Enhanced Membrane Rigidity and Deregulation of Store-Operated Calcium Entry (SOCE) into the Endoplasmic Reticulum

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1. scibot 10 Jun 2023
  
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  DOI: 10.1007/s12035-023-03400-0
  
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link.springer.com/article/10.1007/s12035-023-03400-0
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A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia

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1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.106997
  
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Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice

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1. scibot 08 Jun 2023
  
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  DOI: 10.1016/j.devcel.2023.05.004
  
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Developmental expression of Neuregulin-3 in the rat central nervous system

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1. scibot 02 Jun 2023
  
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  DOI: 10.1002/cne.24559
  
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onlinelibrary.wiley.com/doi/10.1002/cne.24559
May 2023
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Antagonistic interactions among structured domains in the multivalent Bicc1-ANKS3-ANKS6 protein network govern phase transitioning of target mRNAs

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1. scibot 26 May 2023
  
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  DOI: 10.1016/j.isci.2023.106855
  
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sciencedirect.com/science/article/pii/S258900422300932X
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Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast

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1. scibot 25 May 2023
  
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  DOI: 10.1098/rsob.220366
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10205182/
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Unconventional initiation of PINK1/Parkin mitophagy by Optineurin

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1. scibot 19 May 2023
  
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  DOI: 10.1016/j.molcel.2023.04.021
  
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Synaptic oligomeric tau in Alzheimer’s disease — A potential culprit in the spread of tau pathology through the brain

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1. scibot 17 May 2023
  
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  DOI: 10.1016/j.neuron.2023.04.020
  
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A phospho-switch constrains BTL2-mediated phytocytokine signaling in plant immunity

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  DOI: 10.1016/j.cell.2023.04.027
  
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sciencedirect.com/science/article/pii/S0092867423004233
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Ventrolateral periaqueductal gray astrocytes regulate nociceptive sensation and emotional motivation in diabetic neuropathic pain

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1. scibot 06 May 2023
  
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  DOI: 10.1523/JNEUROSCI.0920-22.2022
  
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jneurosci.org/content/42/43/8184
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Immune mechanisms shape the clonal landscape during early progression of prostate cancer

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1. scibot 06 May 2023
  
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  DOI: 10.1016/j.devcel.2023.04.010
  
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Lipid-induced alteration in retinoic acid signaling leads to mitochondrial dysfunction in HepG2 and Huh7 cells

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1. scibot 04 May 2023
  
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  DOI: 10.1139/bcb-2022-0266
  
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cdnsciencepub.com/doi/10.1139/bcb-2022-0266
Apr 2023
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Blastopore gating mechanism to regulate extracellular fluid excretion

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1. scibot 26 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106585
  
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APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells

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  DOI: 10.1016/j.isci.2023.106583
  
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Oncogene-mediated nuclear accumulation of lactate promotes epigenetic alterations to induce cancer cell proliferation

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1. scibot 05 Apr 2023
  
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  DOI: 10.1002/jcb.30381
  
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onlinelibrary.wiley.com/doi/10.1002/jcb.30381
Mar 2023
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NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes

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1. scibot 26 Mar 2023
  
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  DOI: 10.1016/j.isci.2023.106313
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10034470/
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A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors

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1. scibot 11 Mar 2023
  
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  DOI: 10.1016/j.devcel.2023.02.017
  
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A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses

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1. scibot 02 Mar 2023
  
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  DOI: 10.1016/j.neuron.2023.02.004
  
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sciencedirect.com/science/article/pii/S089662732300082X
Feb 2023
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Physcomitrium patens PpRIC, an ancestral CRIB-domain ROP effector, inhibits auxin-induced differentiation of apical initial cells

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1. scibot 16 Feb 2023
  
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  DOI: 10.1016/j.celrep.2023.112130
  
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sciencedirect.com/science/article/pii/S2211124723001419
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Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome

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1. scibot 10 Feb 2023
  
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  DOI: 10.7554/eLife.81892
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9904759/
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Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins

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1. scibot 02 Feb 2023
  
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  DOI: 10.1016/j.celrep.2023.112065
  
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sciencedirect.com/science/article/pii/S2211124723000761
Jan 2023
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Behavioral state-dependent modulation of insulin-producing cells in Drosophila

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1. scibot 28 Jan 2023
  
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  DOI: 10.1016/j.cub.2022.12.005
  
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Aedes aegypti exhibits a distinctive mode of late ovarian development

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EGFR-dependent suppression of synaptic autophagy is required for neuronal circuit development

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Generation of two mother-child pairs of iPSCs from maternally inherited Leigh syndrome patients with m.8993T > G and m.9176T > G MT-ATP6 mutations

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Brain-derived neurotrophic factor (BDNF) induces antagonistic action to Nogo signaling by the upregulation of lateral olfactory tract usher substance (LOTUS) expression

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Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer

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Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice

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A synthetic human 3D in vitro lymphoid model enhancing B-cell survival and functional differentiation

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The ultrastructural organization of endoplasmic reticulum-plasma membrane contacts is conserved in epithelial cells

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T follicular helper cells and the germinal centre are required for memory B cell formation and humoral immunity after ChAdOx1 nCoV-19 vaccination.

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T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus

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Dopaminergic Neurons Differentiated from LRRK2 I1371V-Induced Pluripotent Stem Cells Display a Lower Yield, α-Synuclein Pathology, and Functional Impairment

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Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

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Generation of cell-type-specific proteomes of neurodevelopment from human cerebral organoids

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The prominent role of the S100A8/S100A9-CD147 axis in the progression of penile cancer

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The ultrastructural organization of endoplasmic reticulum-plasma membrane contacts is conserved in epithelial cells

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Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation

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Development of a 3D-immunofluorescence analysis for sensory nerve endings in human ligaments

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Imaging and quantification of apical microvilli in the syncytial blastoderm of Drosophila embryos

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Calcium/calmodulin-dependent protein kinase II associates with the K+ channel isoform Kv4.3 in adult rat optic nerve

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Experimental Induction of Intracranial Aneurysms in Rats: A New Model Utilizing a Genetic Modification within the EDNRA Gene

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A natural transdifferentiation event involving mitosis is empowered by integrating signaling inputs with conserved plasticity factors

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Original research: Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression

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An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow

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Regional cytoarchitecture of the adult and developing mouse enteric nervous system

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AQP4-dependent glioma cell features affect the phenotype of surrounding cells via extracellular vesicles

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Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis

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Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes

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Constitutive expression of JASMONATE RESISTANT 1 induces molecular changes that prime the plants to better withstand drought

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Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

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Octopamine mediates sugar relief from a chronic-stress-induced depression-like state in Drosophila

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Ranolazine Counteracts Strength Impairment and Oxidative Stress in Aged Sarcopenic Mice

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BPS Publications

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The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression

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Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1

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Serotonergic regulation of bipolar cell survival in the developing cerebral cortex

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  DOI: 10.21203/rs.3.rs-658360/v1
  
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Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts

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Histological quantification of cerebral cavernous malformations in the murine brain

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Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment

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Acute (R,S)-Ketamine Administration Induces Sex-Specific Behavioral Effects in Adolescent but Not Aged Mice

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Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination

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Differential activation of pain circuitry neuron populations in a mouse model of spinal cord injury induced neuropathic pain

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Optogenetic activation of the inhibitory nigro-collicular circuit evokes contralateral orienting movements in mice

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Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques

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Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease

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Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

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Therapeutic advantages of combined gene/cell therapy strategies in a murine model of GM2 gangliosidosis

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An H2R-dependent medial septum histaminergic circuit mediates feeding behavior

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STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells

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Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury

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Laser microscopy acquisition and analysis of premotor synapses in the murine spinal cord

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Mapping Motor Neuron Vulnerability in the Neuraxis of Male SOD1G93A Mice Reveals Widespread Loss of Androgen Receptor Occurring Early in Spinal Motor Neurons

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Myelination synchronizes cortical oscillations by consolidating parvalbumin-mediated phasic inhibition

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Pathway-specific effects of ADSL deficiency on neurodevelopment

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Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability

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SoxD genes are required for adult neural stem cell activation

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Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses

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Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection

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Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells

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Myofibre injury induces capillary disruption and regeneration of disorganized microvascular networks

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Brain connectivity inversely scales with developmental temperature in Drosophila

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Analgesic α-conotoxins modulate native and recombinant GIRK1/2 channels via GABAB receptor activation and reduce neuroexcitability

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Impact of monomeric and aggregated wild-type and A30P/A53T double-mutant α-synuclein on antioxidant mechanism and glutamate metabolic profile of cultured astrocytes

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Distinct molecular pathways govern presynaptic homeostatic plasticity

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Live imaging Arabidopsis thaliana embryos under different hydration conditions

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REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion

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Coordinated repression of pro-differentiation genes via P-bodies and transcription maintains Drosophila intestinal stem cell identity

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Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load

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An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers

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A large panel of chicken cells are invaded in vivo by Salmonella Typhimurium even when depleted of all known invasion factors

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A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells

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Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors

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Global chromatin relabeling accompanies spatial inversion of chromatin in rod photoreceptors

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Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

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Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

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Differential synaptic remodeling by dopamine in direct and indirect striatal projection neurons in Pitx3-/- mice, a genetic model of Parkinson's disease

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Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in Drosophila

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Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

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SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water

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Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus

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Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

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Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

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Myc‐dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor‐2

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Proliferation of Inhibitory Input to the Substantia Nigra in Experimental Parkinsonism

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Syntaphilin-mediated docking of mitochondria at the growth cone is dispensable for axon elongation in vivo

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Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice

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PDMS-PMOXA-Nanoparticles Featuring a Cathepsin B-Triggered Release Mechanism

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Prostaglandin D2 synthase modulates macrophage activity and accumulation in injured peripheral nerves

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CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity

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Experimental Infection of Pregnant Female Sheep with Zika Virus During Early Gestation

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Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

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Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling

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Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns

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The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells

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Differentiation of adipose-derived stem cells to functional CD105<Superscript>neg</Superscript> CD73<Superscript>low</Superscript> melanocyte precursors guided by defined culture condition

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Endosome and Golgi‐associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism

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Degron-tagged reporters probe membrane topology and enable the specific labelling of membrane-wrapped structures

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Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis

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A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

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Optimization of immunolabeling and clearing techniques for indelibly labeled memory traces

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BPS Publications

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Shear stress and oxygen availability drive differential changes in opossum kidney proximal tubule cell metabolism and endocytosis

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Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate

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Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache

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Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

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Transcriptome profiling of the Olig2-expressing astrocyte subtype reveals their unique molecular signature

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Crash landing of Vibrio cholerae by MSHA pili-assisted braking and anchoring in a viscoelastic environment

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Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis

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A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation

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A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

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BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling

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Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development

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Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

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Cytokinins initiate secondary growth in the Arabidopsis root through a set of LBD genes

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Patient Derived Colonoids as Drug Testing Platforms–Critical Importance of Oxygen Concentration

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Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis

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GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration

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TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

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Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation

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Multimerization of Zika Virus-NS5 Causes Ciliopathy and Forces Premature Neurogenesis

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mTOR-driven neural circuit changes initiate an epileptogenic cascade

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ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

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Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy

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Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation

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Condensed Chromatin Behaves like a Solid on the Mesoscale In Vitro and in Living Cells

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells

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1. scibot 20 Apr 2021
  
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  DOI: 10.1016/j.devcel.2021.03.008
  
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Capturing human trophoblast development with naive pluripotent stem cells in vitro

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  DOI: 10.1016/j.stem.2021.03.013
  
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Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways

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Ground state depletion microscopy as a tool for studying microglia–synapse interactions

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  DOI: 10.1002/jnr.24819
  
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Microglial trogocytosis and the complement system regulate axonal pruning in vivo

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  DOI: 10.7554/eLife.62167
  
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Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

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Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ

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  DOI: 10.1038/s41598-021-83938-y
  
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Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

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  DOI: 10.1016/j.molcel.2020.12.042
  
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Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1

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Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice

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Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits

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Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium

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Nogo receptor antagonist LOTUS exerts suppression on axonal growth‐inhibiting receptor PIR‐B

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  DOI: 10.1111/jnc.15013
  
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Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes

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  DOI: 10.7554/eLife.53403
  
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Serotonin signaling by maternal neurons upon stress ensures progeny survival

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AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury

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  DOI: 10.1096/fj.201901730R
  
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TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression

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  DOI: 10.1016/j.cels.2021.01.002
  
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ATP activation of peritubular cells drives testicular sperm transport

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Acute post-injury blockade of α2δ-1 calcium channel subunits prevents pathological autonomic plasticity after spinal cord injury

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Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

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1. scibot 26 Jan 2021
  
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  DOI: 10.7554/eLife.62876
  
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