742 Matching Annotations
  1. Jun 2022
  2. www.sciencedirect.com www.sciencedirect.com
    Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors
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    sciencedirect.com/science/article/pii/S2589004222007982
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    The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
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    link.springer.com/article/10.1186/s12964-022-00843-1
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    Itaconate is a lysosomal inducer that promotes antibacterial innate immunity
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    sciencedirect.com/science/article/pii/S1097276522004439
  5. academic.oup.com academic.oup.com
    Elevated levels of follicular fatty acids induce ovarian inflammation via ERK1/2 and inflammasome activation in PCOS
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac281/6581607
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    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
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    Phloretin Protects Bovine Rumen Epithelial Cells from LPS-Induced Injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC9147548/
  8. May 2022
  9. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
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    SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production
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    sciencedirect.com/science/article/pii/S2211124722005149
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    Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders
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    ncbi.nlm.nih.gov/pmc/articles/PMC9062031/
  12. Apr 2022
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    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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    sciencedirect.com/science/article/pii/S2589004222004813
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    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9007586/
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    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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    onlinelibrary.wiley.com/doi/10.1111/cns.13839
  16. Mar 2022
  17. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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    onlinelibrary.wiley.com/doi/10.1002/glia.23583
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    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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    sciencedirect.com/science/article/pii/S2211124722002893
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC8927994/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
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    ncbi.nlm.nih.gov/pmc/articles/PMC8901637/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC8419025/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combination of Resminostat with Ruxolitinib Exerts Antitumor Effects in the Chick Embryo Chorioallantoic Membrane Model for Cutaneous T Cell Lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC8870185/
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    Cancer-associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: potential role of ADAM9
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33947
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    Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
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    sciencedirect.com/science/article/pii/S1097276522001101
  25. Feb 2022
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin
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    ncbi.nlm.nih.gov/pmc/articles/PMC8840593/
  27. www.embopress.org www.embopress.org
    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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    embopress.org/doi/abs/10.15252/emmm.202114876
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    Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
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    sciencedirect.com/science/article/pii/S2352396422000317
  29. Jan 2022
  30. link.springer.com link.springer.com
    miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice
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    link.springer.com/article/10.1007/s13105-022-00871-y
  31. academic.oup.com academic.oup.com
    Regulation of mouse primordial follicle formation by signaling through the PI3K pathway
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    academic.oup.com/biolreprod/advance-article/doi/10.1093/biolre/ioab204/6414948
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    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    sciencedirect.com/science/article/pii/S1535610821006620
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Triple targeting of breast tumors driven by hormonal receptors and HER2
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    ncbi.nlm.nih.gov/pmc/articles/PMC8742793/
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    Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis
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    sciencedirect.com/science/article/pii/S1534580721010352
  36. Dec 2021
  37. link.springer.com link.springer.com
    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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    link.springer.com/article/10.1007/s10863-018-9750-3
  38. www.nature.com www.nature.com
    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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    nature.com/articles/s41419-021-04394-0
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    Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
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    sciencedirect.com/science/article/pii/S1534580721009448
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    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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    nature.com/articles/s42003-021-02842-3
  41. Nov 2021
  42. 52.53.155.43 52.53.155.43
    ajpheart.00125.2021-html.html
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    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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    sciencedirect.com/science/article/pii/S2211124721015424
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    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15695
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    Non-canonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish
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    sciencedirect.com/science/article/pii/S2589004221013572
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    Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment
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    sciencedirect.com/science/article/pii/S2211124721014534
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary nitrate supplementation prevents radiotherapy-induced xerostomia
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    ncbi.nlm.nih.gov/pmc/articles/PMC8563005/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts
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    ncbi.nlm.nih.gov/pmc/articles/PMC8568182/
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    Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors
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    link.springer.com/article/10.1007/s00018-021-04005-3
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    GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
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    sciencedirect.com/science/article/pii/S2589004221012803
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC8550759/
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    Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors
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    sciencedirect.com/science/article/pii/S2211124721014327
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    Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action
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    sciencedirect.com/science/article/pii/S2211124721013917
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    link.springer.com/article/10.1007/s00213-021-06015-2
  55. Oct 2021
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs
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    ncbi.nlm.nih.gov/pmc/articles/PMC8545060/
  57. www.sciencedirect.com www.sciencedirect.com
    Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease
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    sciencedirect.com/science/article/pii/S221112472101367X
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity
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    ncbi.nlm.nih.gov/pmc/articles/PMC8518616/
  59. www.sciencedirect.com www.sciencedirect.com
    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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    sciencedirect.com/science/article/pii/S221112472101264X
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    sciencedirect.com/science/article/pii/S2211124721012316
  61. www.sciencedirect.com www.sciencedirect.com
    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    sciencedirect.com/science/article/pii/S1534580721007267
  62. Sep 2021
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC8437974/
  64. www.sciencedirect.com www.sciencedirect.com
    NSD2 dimethylation at H3K36 promotes lung adenocarcinoma pathogenesis
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC8445623/
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    Diurnal regulation of oxidative phosphorylation restricts hepatocyte proliferation and inflammation
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    SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages
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  68. Aug 2021
  69. www.sciencedirect.com www.sciencedirect.com
    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124721010342
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    CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
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    Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord
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    sciencedirect.com/science/article/pii/S0969996121002151
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    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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    A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength
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    TSH activates macrophage inflammation by G13 and G15-dependent pathways
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    academic.oup.com/endo/article/162/8/bqab077/6225351
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    Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells
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    academic.oup.com/endo/article/160/11/2692/5551999
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    ncbi.nlm.nih.gov/pmc/articles/PMC5761600/
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    Mitogen‐activated protein kinase signaling mediates opioid‐induced presynaptic NMDA receptor activation and analgesic tolerance
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14628
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    TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
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    Stimulus evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization
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    sciencedirect.com/science/article/pii/S0306452217304967
  87. onlinelibrary.wiley.com onlinelibrary.wiley.com
    High‐intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23996/full
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  90. www.mdpi.com www.mdpi.com
    CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines
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    mdpi.com/1422-0067/20/22/5706
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  92. Jul 2021
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    An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma
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    sciencedirect.com/science/article/pii/S2211124719312987
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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  99. journals.sagepub.com journals.sagepub.com
    ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes - Mami Takano, Naoto Hirose, Chikako Sumi, Makoto Yanoshita, Sayuri Nishiyama, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto,
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