Hypothesis

491 Matching Annotations

Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Translation in amino-acid-poor environments is limited by tRNAGln charging

1
1. scibot 27 Feb 2021
  
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  RRID:AB_477629
  
  DOI: 10.7554/eLife.62307
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model

1
1. scibot 27 Feb 2021
  
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  RRID:AB_477629
  
  DOI: 10.3389/fimmu.2020.566279
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7581917/
www.nature.com www.nature.com

Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins

1
1. scibot 24 Feb 2021
  
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  RRID:_AB:477629
  
  DOI: 10.1038/s41598-020-71550-5
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
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  RRIDCUR:Unresolved RRIDCUR:SyntaxError RRID:AB_477629
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nature.com/articles/s41598-020-71550-5
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Generation of stress fibers through myosin-driven reorganization of the actin cortex

1
1. scibot 24 Feb 2021
  
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  RRID:AB_477629
  
  DOI: 10.7554/eLife.60710
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
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  RRIDCUR:Validated RRID:AB_477629
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ncbi.nlm.nih.gov/pmc/articles/PMC7877910/
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Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

1
1. scibot 11 Feb 2021
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.cub.2021.01.007
  
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  RRIDCUR:Validated RRID:AB_477629
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sciencedirect.com/science/article/pii/S0960982221000403
Jan 2021
www.sciencedirect.com www.sciencedirect.com

The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

1
1. scibot 20 Jan 2021
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2020.108659
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
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  RRIDCUR:Validated RRID:AB_477629
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sciencedirect.com/science/article/pii/S221112472031648X
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Increased demand for NAD+ relative to ATP drives aerobic glycolysis

1
1. scibot 05 Jan 2021
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.molcel.2020.12.012
  
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  RRIDCUR:Validated RRID:AB_477629
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sciencedirect.com/science/article/pii/S1097276520309047
Dec 2020
www.sciencedirect.com www.sciencedirect.com

The ubiquitin ligase RFWD3 is required for translesion DNA synthesis

1
1. scibot 16 Dec 2020
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.molcel.2020.11.029
  
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  RRID:AB_477629 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276520308297
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

1
1. scibot 12 Dec 2020
  
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  RRID:AB_477629
  
  DOI: 10.7554/eLife.59258
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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ncbi.nlm.nih.gov/pmc/articles/PMC7723411/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MASTL promotes cell contractility and motility through kinase-independent signaling

1
1. scibot 07 Dec 2020
  
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  RRID:AB_477629
  
  DOI: 10.1083/jcb.201906204
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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ncbi.nlm.nih.gov/pmc/articles/PMC7265322/
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BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

1
1. scibot 07 Dec 2020
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.molcel.2020.10.040
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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sciencedirect.com/science/article/pii/S1097276520307747
Nov 2020
elifesciences.org elifesciences.org

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

1
1. scibot 21 Nov 2020
  
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  RRID:AB_477629
  
  DOI: 10.7554/eLife.62731
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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elifesciences.org/articles/62731
Oct 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

1
1. scibot 27 Oct 2020
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.xcrm.2020.100125
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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pubmed.ncbi.nlm.nih.gov/33205075/
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Gene therapy with secreted acid alpha-glucosidase rescues Pompe disease in a novel mouse model with early-onset spinal cord and respiratory defects

1
1. scibot 13 Oct 2020
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.ebiom.2020.103052
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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pubmed.ncbi.nlm.nih.gov/33039711/
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

1
1. scibot 30 Sep 2020
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2020.108196
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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pubmed.ncbi.nlm.nih.gov/32997991/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Telophase correction refines division orientation in stratified epithelia

1
1. scibot 23 Sep 2020
  
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  RRID:AB_477629
  
  DOI: 10.7554/eLife.49249
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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scibot

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ncbi.nlm.nih.gov/pmc/articles/PMC6959978/
www.sciencedirect.com www.sciencedirect.com

Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

1
1. scibot 23 Sep 2020
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2020.107731
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720307117
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Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons

1
1. scibot 23 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.molcel.2020.01.020
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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scibot

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sciencedirect.com/science/article/pii/S1097276520300411
www.sciencedirect.com www.sciencedirect.com

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

1
1. scibot 23 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.cell.2020.04.014
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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scibot

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sciencedirect.com/science/article/pii/S0092867420304761
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1038/s41467-019-14085-2
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC6965108/
www.sciencedirect.com www.sciencedirect.com

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

1
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2020.107764
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720307440
www.cell.com www.cell.com

PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

2
1. scibot 17 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2019.12.061
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
2. scibot 07 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2019.12.061
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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cell.com/cell-reports/abstract/S2211-1247(19)31718-8
www.sciencedirect.com www.sciencedirect.com

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

1
1. scibot 16 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.cell.2020.02.009
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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scibot

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sciencedirect.com/science/article/pii/S0092867420301537
www.sciencedirect.com www.sciencedirect.com

FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

1
1. scibot 14 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2020.108018
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720310032
www.jneurosci.org www.jneurosci.org

Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity

1
1. scibot 11 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1523/JNEUROSCI.1076-19.2019
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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jneurosci.org/content/40/2/459
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity

1
1. scibot 11 Sep 2020
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.neuron.2020.01.020
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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ncbi.nlm.nih.gov/pmc/articles/PMC7272217/
www.sciencedirect.com www.sciencedirect.com

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

1
1. scibot 09 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.molcel.2020.01.008
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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sciencedirect.com/science/article/pii/S1097276520300083
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Sensing Actin Dynamics through Adherens Junctions

1
1. scibot 05 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2020.01.106
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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sciencedirect.com/science/article/pii/S2211124720301509
onlinelibrary.wiley.com onlinelibrary.wiley.com

Next‐generation sequencing reveals a novel role of lysine‐specific demethylase 1 in adhesion of rhabdomyosarcoma cells

1
1. scibot 04 Sep 2020
  
  in Public
  
  mouse anti‐Vinculin
  
  DOI: 10.1002/ijc.32806
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_477629
  
  Curator comments: Monoclonal Anti-Vinculin antibody produced in mouse Sigma-Aldrich Cat# V9131
  
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  RRID:AB_477629 RRIDCUR:Missing
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onlinelibrary.wiley.com/doi/10.1002/ijc.32806
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

1
1. scibot 03 Sep 2020
  
  in Public
  
  vinculin
  
  DOI: 10.1158/1078-0432.CCR-19-2706
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @Naa003
  
  SciCrunch record: RRID:AB_477629
  
  Curator comments: Monoclonal Anti-Vinculin antibody produced in mouse Sigma-Aldrich Cat# V9131
  
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  RRID:AB_477629 RRIDCUR:Missing
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clincancerres.aacrjournals.org/content/26/12/2997
www.sciencedirect.com www.sciencedirect.com

The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks

1
1. scibot 03 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2019.12.067
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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sciencedirect.com/science/article/pii/S2211124719317243
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ATR expands embryonic stem cell fate potential in response to replication stress

1
1. scibot 03 Sep 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.7554/eLife.54756
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_477629
  
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  RRIDCUR:Validated RRID:AB_477629
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ncbi.nlm.nih.gov/pmc/articles/PMC7067586/
Jan 2020
www.sciencedirect.com www.sciencedirect.com

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

1
1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2019.07.084
  
  Resource: (Sigma-Aldrich Cat# V9131, RRID:AB_477629)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_477629
  
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  RRID:AB_477629 RRIDCUR:Validated
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Murine maternal dietary restriction affects neural Humanin expression and cellular profile

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Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling

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The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics

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Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

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PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells

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Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

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Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions

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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

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Circulating blood cellular glucose transporters – Surrogate biomarkers for neonatal hypoxic ischemic encephalopathy assessed by novel scoring systems

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The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

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Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity

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MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer

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Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness

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Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

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A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation

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An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

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Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns

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c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling

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Untitled document

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ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

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Untitled document

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Untitled document

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Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

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Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions

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mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis

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As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

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Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

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Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.

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Nov 2017
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Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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Calpain-Mediated Proteolysis of Talin and FAK Regulates Adhesion Dynamics Necessary for Axon Guidance

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The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

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Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules

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Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis

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Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores

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Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores

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Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model

1
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