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Mar 2026
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TIPE2 knockdown enhances the anti-tumor efficacy of NKG2D CAR-T cells against pancreatic cancer via activating NF-κb signaling pathway

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  plasmid_12
  
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Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1

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Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis

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Development and validation of a PSMA-positive triple-negative breast cancer mouse model for preclinical targeted radionuclide therapies

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New selective and allosteric FLT3 inhibitors show efficacy against resistant acute myeloid leukemia cells

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Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity

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Functional chromatin signatures premark future lineage-specific enhancers

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HE4 drives PD-L1 expression in myeloid cells via IFN-γR-JAK-STAT3 signaling to promote tumor immune evasion

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A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer

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Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia

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Species-specific chromatin architecture and neurogenesis mediated by a human enhancer

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1-s2.0-S2589004226007479-main-html.html

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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

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ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

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  Addgene_12260
  
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A single-cell CRISPR screen defines a gene regulatory network governing human pluripotency in primed and naive cells

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  plasmid_12260
  
  DOI: 10.1016/j.celrep.2026.117124
  
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sciencedirect.com/science/article/pii/S2211124726002020
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Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects

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  RRID:Addgene_12260
  
  DOI: 10.64898/2026.03.06.710116
  
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biorxiv.org/content/10.64898/2026.03.06.710116v1
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NIPAL1 Drives a Metabolic-Epigenetic Feedback Loop to Promote Lactate-Mediated Immune Evasion in Esophageal Cancer

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  RRID:Addgene_12260
  
  DOI: 10.1002/advs.202520055
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520055
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FEBS Press

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febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.70226
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Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC12934820/
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A developmentally regulated long-range enhancer-promoter contact mediates human neural development

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pmc.ncbi.nlm.nih.gov/articles/PMC12822576/
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aGPCR-HEK: A Stable High-Expression Inducible Mammalian Cell Expression System for Adhesion GPCR Structural Biology Applications

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  DOI: 10.21769/BioProtoc.5621
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12971277/
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Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects

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  12,260
  
  DOI: 10.1186/s13059-026-03967-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12924462/
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ATP release mediated by TRPM3 enhances invasion in glioblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12912218/
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Development and characterization of immortalized mouse intestinal epithelial cell lines

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pmc.ncbi.nlm.nih.gov/articles/PMC12966478/
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CRISPR screens identify PRMT7 as a therapeutic target to enhance T cell-mediated killing in breast cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12891518/
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Enhancing KLF15 activity in cardiomyocytes: a novel approach to prevent pathological reprogramming and fibrosis via nuclease-deficient dCas9VPR

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pmc.ncbi.nlm.nih.gov/articles/PMC12953643/
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Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration

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  DOI: 10.1016/j.stem.2025.12.019
  
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1-s2.0-S2589004226004827-main-html.html

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pmc.ncbi.nlm.nih.gov/articles/PMC12972699/
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MRCKα represses GEF-H1 mediated RhoA activation to promote ovarian cancer spheroid growth and invasion

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pmc.ncbi.nlm.nih.gov/articles/PMC12918926/
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Stress-specific NONO interactomes reveal a key role of Hsp70 chaperone activity in regulation of paraspeckle formation

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pmc.ncbi.nlm.nih.gov/articles/PMC12863303/
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Recurrent Immunogenic Neoantigens and Their Cognate T-cell Receptors in Treatment-Resistant Metastatic Prostate Cancer

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  DOI: 10.1158/2159-8290.CD-24-1213
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12749549/
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Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities

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pmc.ncbi.nlm.nih.gov/articles/PMC12905196/
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Pooled single-cell screen in colorectal cancer defines transcriptional modules linked to oncogenes

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pmc.ncbi.nlm.nih.gov/articles/PMC12954089/
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A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines

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pmc.ncbi.nlm.nih.gov/articles/PMC12903452/
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Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock

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sciencedirect.com/science/article/pii/S2451945626000620
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Loss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and histone modifications in Treg cells

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sciencedirect.com/science/article/pii/S2211124726001622
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Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks

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  DOI: 10.1016/j.molcel.2026.02.016
  
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Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells

1
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  RRID:Addgene_12260
  
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Molecular mechanism underlying the specific RNA recognition of mitochondrial helicase DDX28 and its critical role in mitoribosomal biogenesis

1
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  AddgeneCat# 12260
  
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Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment

1
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Targeting PGAM5-driven mitochondrial integrated stress response slows ALS progression across subtypes

1
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  plasmid_12260
  
  DOI: 10.1016/j.neuron.2026.02.003
  
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Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates

1
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Sec23b regulates cell migration by orchestrating collagen I secretion and processing

1
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Membrane Curvature Activates Src kinase and Promotes Metastatic Cancer Cell Survival

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A comprehensive functional atlas of ALK kinase domain variants reveals resistance landscape to ALK inhibitors

1
1. scibot 11 Mar 2026
  
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  Addgene_12
  
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Toxoplasma gondii effector MAF1 blocks mouse AIM2 inflammasome activation by inhibiting mtDNA release

1
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  Addgene no. 12260
  
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miR-181d coordinates homologous recombination and anti-tumor immune responses in glioblastoma

1
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  Addgene12260
  
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ZNF423 depletion induces the integrated stress response and represents a potential vulnerability in NF1-associated MPNST

1
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  RRID:Addgene_12260
  
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Optogenetic manipulation of estrogen receptor signaling to improve estrogen deficiency

1
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  Addgene_12260
  
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PEX5 integrates the p38 MAPK signaling pathway and taurine metabolism to regulate senescence in lung fibroblasts

1
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  RRID: Addgene_12260
  
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Modeling human prenatal adrenocortical functional zonation dynamics from pluripotent stem cells

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  RRID:Addgene_12260
  
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APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

1
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  Addgene_12260
  
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High-throughput ligand diversification to discover chemical inducers of proximity

1
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Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes

2
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  AddgeneCat# 12260
  
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54.241.53.176 54.241.53.176

1-s2.0-S2589004226005778-main-html.html

1
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  RRID: Addgene_12260
  
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Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs

1
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GPX4 Inhibitor Resistance and Metastatic Features in Triple-Negative Breast Cancer

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  DOI: 10.1002/advs.202523198
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202523198
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Aspartate availability drives differential engagement of the malate-aspartate shuttle

1
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  Addgene Plasmid #12260
  
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Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

1
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  Addgene_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12936425/
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The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors

1
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  plasmid_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11790392/
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Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis

1
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  addgene_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12946193/
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Valrubicin-loaded immunoliposomes targeting antigens on immunosuppressive cells to circumvent resistance to cancer immunotherapy

1
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.xcrm.2026.102632
  
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54.241.53.176 54.241.53.176

1-s2.0-S2589004226005705-main-html.html

1
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  RRID:Addgene_12260
  
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Lipocalin 2 orchestrates resistance to ferroptosis via AXL

1
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  RRID:Addgene_12260
  
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Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

1
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  Plasmid_12260
  
  DOI: 10.1016/j.cell.2026.01.028
  
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Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

1
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  plasmid_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12936417/
Feb 2026
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ASCL1 promotes nuclear shrinkage in transdifferentiation by suppressing NUP37

1
1. scibot 27 Feb 2026
  
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  12260
  
  DOI: 10.1016/j.stemcr.2026.102823
  
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Modulating Galectin-1 in human osteoblast-like cells alters mineralisation and influences the expression of genes associated with osteoblasts and osteocytes

1
1. scibot 26 Feb 2026
  
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  12260
  
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Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction

1
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Neuronal Cell-Cycle Re-entry Defines Divergent Outcomes Through Replication-Dependent DNA Damage in ALS

1
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  RRID:Addgene_12260
  
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Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

1
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  DOI: 10.1002/1878-0261.70128
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618758/
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Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay

2
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  Addgene #12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12905269/
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BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes

1
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  AddgenePlasmid #12260
  
  DOI: 10.1016/j.molcel.2026.01.012
  
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A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity

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ACSL4-associated lipid metabolism is a distinct therapeutic vulnerability in KMT2A-rearranged acute myeloid leukemia

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Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux

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TRPV1 Downregulation Impairs Prostate Cancer Growth: Functional and Translational Insights from Cellular and In Vivo Models

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HP1α depletion and TGFβ activation exert antagonistic effects on 3D genome organization

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Integrative CRISPR Screening and RNA Analyses Discover an Essential Role for PUF60 Interactions with 3' Splice Sites in Cancer Progression

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Bacterial vesicles from intratumoral L. salivarius enhance PD-1 blockade via FPR1-mediated macrophage polarization in gastric cancer

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Syndecan-1-targeted therapeutic antibody impairs macropinocytosis and elicits antitumor immunity in pancreatic cancer

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Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice

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Glomerular basement membrane structural integrity dictates trans-tissue deposition of laminin in the kidney

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Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature

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Effects of N361 Glycosylation on Epidermal Growth Factor Receptor Biological Function

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The mTORC2 component SIN1 post-transcriptionally regulates TYMS levels and modulates P53 activity in response to 5-FU chemotherapy

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Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition

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Ablation of Tumor-Derived IGFBP-3 Attenuates Cancer-Associated Skeletal Muscle Wasting in Murine Pancreatic Cancer

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Genome-wide screens identify core regulators of cell surface prion protein expression

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Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis

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SNAP25 undergoes phase separation to facilitate the assembly of the synaptic vesicle fusion machinery

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2026.01.31.703051.full-html.html

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IGF2BP3/m6A-mediated intron retention isoform of DUSP6 promotes cisplatin resistance in nasopharyngeal carcinoma by inhibiting pyroptosis

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Adgrg6/Gpr126 is required for compact wall integrity and establishing trabecular identity during cardiac trabeculation

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Cellular Mg2+ decrease causes a distinctive NF-κB-dependent form of cell death

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Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo

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HSPA1A and DNAJB1 regulate NELF condensate dynamics to safeguard transcriptional recovery under heat stress

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Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

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Mutations in VPS18 lead to a neutrophil maturation defect associated with disturbed vesicle homeostasis

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The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells

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Programmable iPSC-derived CAR-NK vesicles remodel the immune microenvironment and eradicate tumors

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The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancer

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Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability

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C9orf72 hexanucleotide repeat RNA drives transcriptional dysregulation through genome-wide DNA:RNA hybrid G-quadruplexes

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Integrating natural and engineered genetic variations to decode regulatory influence on blood traits

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The Lysine Demethylase KDM4C is an Oncogenic Driver and Regulates ERK Activity in KRAS Mutant Pancreatic Ductal Adenocarcinoma

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SF3B1K700E neoantigen is a CD8+ T-cell target shared across human myeloid neoplasms

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α-Synuclein expression is required for somatodendritic dopamine release and immediate early gene induction

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Repression of RIPK1 kinase by INPP5D inhibits expression of diverse proinflammatory mediators and late-onset Alzheimer’s disease risk factors

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Pharmacological Targeting of NR4A1 Restrains Lipid Metabolism–Ferroptosis Axis in UVR-Induced Skin Aging

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A neuron subtype-specific role of MEK-ERK signaling in axon survival via transcriptional regulation of Nmnat2

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NAD+ sensing by PARP7 regulates the C/EBPβ-dependent transcription program during adipogenesis

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Interferon dependent immune memory during HSV-1 neuronal latency via increased H3K9me3 and restriction by ATRX

1
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  plasmid_s12260
  
  DOI: 10.1038/s41467-025-66477-2
  
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Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy

1
1. scibot 01 Feb 2026
  
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  12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12665105/
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The castration-resistant prostate cancer-associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer-mediated chromatin interaction with SRRM4

1
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pmc.ncbi.nlm.nih.gov/articles/PMC12837743/
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Pancreatic Cancer Stem Cells Co-Expressing SOX2, OCT4, and TERThigh Represent an Aggressive Subpopulation

1
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  psPAX_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12839176/
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Bromhexine inhibits SARS-CoV-2 Omicron and variant pseudovirus infection via ACE2-targeted mechanisms

1
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  psPAX2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12832721/
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Menin-driven mTOR signaling sustains taxane resistance in CRPC and reveals a targetable vulnerability for combination therapy

1
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  DOI: 10.1186/s12964-025-02594-1
  
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BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans

1
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  12260
  
  DOI: 10.1186/s12943-025-02510-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12777463/
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Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation

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  12260
  
  DOI: 10.1126/sciadv.ady2539
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12757029/
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The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition

1
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  12260
  
  DOI: 10.1101/2025.11.04.686150
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12637489/
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Genome-scale CRISPR screen identifies host factors associated with bovine parainfluenza virus 3 infection

1
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  12,260
  
  DOI: 10.1080/21505594.2025.2589554
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12674325/
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ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer

1
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  DOI: 10.1038/s44318-025-00657-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12811383/
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ASS1 facilitates T-ALL progression via the arginine-mediated mTORC1/c-Myc signaling pathway

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  DOI: 10.1038/s41598-025-27576-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12706054/
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Mapping cis- and trans-regulatory target genes of human-specific deletions

1
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  12260
  
  DOI: 10.1038/s41467-025-67424-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12727812/
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DDX6 undergoes phase separation to modulate metabolic plasticity and chemoresistance

1
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  12260
  
  DOI: 10.1038/s41467-025-66966-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12783633/
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SNORA49 negatively regulates self-renewal of liver cancer stem cells and hepatocarcinogenesis via suppressing SOX9 transcription

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  12260
  
  DOI: 10.1038/s41467-025-66486-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12824223/
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Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation

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  Addgene_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12710741/
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Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression

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  RRID:Addgene_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12744402/
Jan 2026
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ATAD2 drives melanoma growth and progression and inhibits ferroptosis

1
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  RRID:Addgene_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12852765/
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Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML

1
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  Addgene_12260
  
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CRISPR activation screens map the genomic landscape of cancer glycome remodeling

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  Addgene12260
  
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54.241.53.176 54.241.53.176

1-s2.0-S2589004226001665-main-html.html

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  RRID: Addgene_12260
  
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Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo

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pmc.ncbi.nlm.nih.gov/articles/PMC12885239/
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Cholesterol-DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

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  plasmid_12260
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/admi.202500806
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FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion

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  RRID:Addgene_12260
  
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54.241.53.176 54.241.53.176

2026.01.19.700398v1.full-html.html

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54.241.53.176/920dac77fb602c31bea028e2a56d4a986d400748/2026.01.19.700398v1.full-html.html
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Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression

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  addgeneCat# 12260
  
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e013832.full-html.html

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54.241.53.176/ca60c4c2a1e906c1762fed2c822dc77ccf0438f0/e013832.full-html.html
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Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target

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  RRID:Addgene_12260
  
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SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity

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  RRID:Addgene_12260
  
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Dual targeting of AMRC12 and Malassezia globosa disrupts MYC liquid condensates-driven nuclear pore complex biogenesis in neuroblastoma

1
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  psPAX2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12775802/
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Genome-wide CRISPR screening identifies CLDN1 as a central node in the anticancer mechanisms of berberine and as a therapeutic target in lung cancer

1
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  12260
  
  DOI: 10.3892/ol.2025.15415
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12690534/
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MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

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  12260
  
  DOI: 10.1242/jcs.264444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12813672/
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Non-canonical EGFR signaling promotes MAPK-dependent extrusion of epithelial cells

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  12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12752489/
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Ribosome-binding protein 1 maintains peroxisome biogenesis

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  12260
  
  DOI: 10.1242/jcs.264075
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12752496/
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NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress

1
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EMT activates ER-to-Golgi trafficking through upregulation of REEP2 to promote lung cancer progression

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Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells

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Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma

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Discovering the complete enhancer map of human herpesviruses using a natural language processing model

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Myomaker and ether lipids cooperate to promote fusion-competent membrane states

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Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018–2020 epidemic

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The hemopexin domain of matrix metalloproteinase-9 attenuates lipopolysaccharide-induced interleukin-6 secretion in liver

1
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Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

1
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Context-specific Angiogenin-mediated tRNA fragments (tDRs) biogenesis shapes the mitochondrial stress response.

1
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Reactive oligodendrocytes promote glioblastoma progression through CCL5/CCR5-mediated glioma stem cell maintenance

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CLN3 mediates chloride efflux from lysosomes

2
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Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity

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YAP/TAZ-VGLL3 governs adipocyte fate via epigenetic reprogramming of PPARγ and its target enhancers

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Loss of EHMT2 enhances NK cell-driven anti-tumor immunity through TGF-β1 suppression

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Regulation of stress tolerance by CREB1 sustains multiple myeloma cell survival

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CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance

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54.241.53.176 54.241.53.176

1-s2.0-S295032992600010X-main-html.html

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Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling

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Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1

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Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity

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cell.com/cancer-cell/fulltext/S1535-6108(25)00552-5
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sechrist-et-al-2026-ablation-of-tumor-derived-igfbp-3-attenuates-cancer-associated-skeletal-muscle-wasting-in-murine-html.html

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Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma

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Decreased Kinase Activity of the VEGFR3 Variant c.3175G>C Associated with Primary Lymphedema

1
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Inhibiting macrophage-derived lactate transport restores cGAS–STING signalling and enhances antitumour immunity in glioblastoma

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A combinatorial transcription factor screening platform for immune cell reprogramming

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  DOI: 10.1016/j.cels.2025.101457
  
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Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

1
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MYST acetyltransferases are a targetable therapeutic vulnerability in SETBP1-mutant leukemia

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2026.01.07.697614v1.full-html.html

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PRMT5 upregulates KCNMB4 expression via histone methylation to promote paclitaxel resistance in advanced nasopharyngeal carcinoma

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Protocols to evaluate mutant specificity of an oncogene-targeting siRNA using orthogonal in vitro and in vivo approaches

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2026.01.09.698661v1.full-html.html

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Polyclonal and single clonal patient-derived organoid models of Barrett oesophagus and oesophageal adenocarcinoma establish a platform for the analysis of heterogeneity in disease progression and therapy response

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Characterization of the p38α MAPK allosteric inhibition by a single chain Fv antibody

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Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

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sciencedirect.com/science/article/pii/S2451945625003952
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DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling

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  DOI: 10.1016/j.celrep.2025.116796
  
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Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer

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  AddgeneCat# 12260
  
  DOI: 10.1016/j.ccell.2025.12.014
  
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Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

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  AddgeneCat# 12260
  
  DOI: 10.1016/j.ccell.2025.12.013
  
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CDK4/6 inhibition overcomes venetoclax resistance mechanisms with enhanced combination activity in acute myeloid leukemia

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  DOI: 10.1016/j.xcrm.2025.102526
  
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SMC5/6-mediated plasmid silencing is directed by SIMC1–SLF2 and antagonized by the SV40 large T antigen

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  DOI: 10.7554/eLife.106815
  
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Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation

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  DOI: 10.1016/j.cmet.2025.11.016
  
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Affinity maturation and light-chain-mediated paratope diversification anticipates viral evolution

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  AddgeneCat#12260
  
  DOI: 10.1016/j.celrep.2025.116800
  
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analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com

A Chip-Based Surveillance Platform for Detecting Antibody-Based Immunity and Immune Escape Using SARS-CoV-2 Pseudovirus Surrogates

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  RRID:Addgene 12260
  
  DOI: 10.1002/bit.70143
  
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analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/bit.70143
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LncRNA DANCR Activates p38/mTOR‐Mediated Autophagy via ANXA2 to Exacerbate Oxygen‐Induced Retinal Neovascularization in Mice

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  RRID:Addgene_12260
  
  DOI: 10.1096/fj.202502408R
  
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RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria

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  DOI: 10.1016/j.molcel.2025.12.003
  
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ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer

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  RRID:Addgene_12260
  
  DOI: 10.1016/j.jbc.2025.111110
  
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