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Jul 2025
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Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites

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1. scibot 17 Jul 2025
  
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  Addgene_122600
  
  DOI: 10.1038/s41467-025-57405-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11876333/
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1-s2.0-S2589004225013732-main-html.html

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1. scibot 16 Jul 2025
  
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  Addgene 12260
  
  DOI: 10.1016
  
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52.53.155.43/73ec1f388f41da4ad69bbc809bebcfccf70e9065/1-s2.0-S2589004225013732-main-html.html
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A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy

1
1. scibot 16 Jul 2025
  
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  Addgene_12260
  
  DOI: 10.1016/j.crmeth.2025.101106
  
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sciencedirect.com/science/article/pii/S2667237525001420
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The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint

1
1. scibot 15 Jul 2025
  
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  Addgene plasmid # 12260
  
  DOI: 10.1016/j.celrep.2025.115966
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12330366/
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Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity

1
1. scibot 15 Jul 2025
  
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  AddgenePlasmid# 12260
  
  DOI: 10.1016/j.cell.2025.06.004
  
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sciencedirect.com/science/article/pii/S0092867425006385
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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

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1. scibot 15 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.ccell.2025.06.011
  
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sciencedirect.com/science/article/pii/S1535610825002612
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Neuro-mesenchymal interaction mediated by a β2 adrenergic-nerve growth factor feedforward loop promotes colorectal cancer progression

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1. scibot 15 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/2159-8290.CD-24-0287
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11729495/
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EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation

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1. scibot 15 Jul 2025
  
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  Addgene_12260
  
  DOI: 10.1101/2025.07.07.663486
  
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biorxiv.org/content/10.1101/2025.07.07.663486v1
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PINK1 Loss of Function Selectively Alters the Mitochondrial‐Derived Vesicle Pathway

1
1. scibot 15 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1096/fba.2024-00200
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12242855/
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A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma

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1. scibot 15 Jul 2025
  
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  Addgene_12260
  
  DOI: 10.1016/j.cell.2025.06.019
  
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cell.com/cell/abstract/S0092-8674(25)00685-3
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SPOP-dependent destabilization of SYT12 in a GSK-3β-dependent manner in papillary thyroid cancer cells

1
1. scibot 13 Jul 2025
  
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  psPAX2
  
  DOI: 10.1007/s10238-025-01791-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12245953/
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SNORA74A Drives Self‐Renewal of Liver Cancer Stem Cells and Hepatocarcinogenesis Through Activation of Notch3 Signaling

1
1. scibot 13 Jul 2025
  
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  12260
  
  DOI: 10.1002/advs.202504054
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12245033/
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MYC Regulates a DNA Repair Gene Expression Program in Small Cell Carcinoma of the Ovary, Hypercalcemic Type

1
1. scibot 13 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.3390/cancers17132255
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12248706/
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Active Merlin Binds RalB to Regulate Exocytosis

1
1. scibot 12 Jul 2025
  
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  #12260
  
  DOI: 10.1101/2025.06.13.659557
  
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biorxiv.org/content/10.1101/2025.06.13.659557v1
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Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of Mycobacterium tuberculosis antigens

1
1. scibot 11 Jul 2025
  
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  addgene 12260
  
  DOI: 10.1101/2025.06.23.660389
  
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biorxiv.org/content/10.1101/2025.06.23.660389v1
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The GATE glycoprotein complex enhances human cytomegalovirus entry in endothelial cells

1
1. scibot 11 Jul 2025
  
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  Addgene plasmid no. 12260
  
  DOI: 10.1038/s41564-025-02025-4
  
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nature.com/articles/s41564-025-02025-4
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Uncovering novel lncRNAs linked to melanoma growth and migration with CRISPR-inhibition screening

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1. scibot 11 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/2767-9764.CRC-24-0416
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12238846/
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KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2-targeted immunotherapy in neuroblastoma

1
1. scibot 10 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1101/2025.07.01.662644
  
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biorxiv.org/content/10.1101/2025.07.01.662644v1
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A lentiviral fluorescent reporter to study circadian rhythms in single cells

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1. scibot 10 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1101/2025.06.30.661926
  
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biorxiv.org/content/10.1101/2025.06.30.661926v1
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Anthrax toxin receptor 2 is the Receptor for Clostridium perfringens NetF: Structural Insights into Toxin Binding and Pore Formation

1
1. scibot 10 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1101/2025.07.02.662835
  
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biorxiv.org/content/10.1101/2025.07.02.662835v1
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Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

1
1. scibot 10 Jul 2025
  
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  Addgene_12260
  
  DOI: 10.1002/ijc.35490
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12232590/
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TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer

1
1. scibot 08 Jul 2025
  
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  no. 12260
  
  DOI: 10.1126/sciadv.adu2339
  
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science.org/doi/10.1126/sciadv.adu2339
academic.oup.com academic.oup.com

Toward optimizing diversifying base editors for high-throughput mutational scanning studies

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1. scibot 08 Jul 2025
  
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  Addgene, #12260
  
  DOI: 10.1093/nar/gkaf620
  
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academic.oup.com/nar/article/53/12/gkaf620/8185969
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Oncogenic YAP sensitizes cells to CHK1 inhibition via CDK4/6 driven G1 acceleration | EMBO reports

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1. scibot 08 Jul 2025
  
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  12260
  
  DOI: 10.1038/s44319-025-00514-5
  
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embopress.org/doi/full/10.1038/s44319-025-00514-5
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Requirement for Cyclin D1 Underlies Cell-Autonomous HIF2 Dependence in Kidney Cancer

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1. scibot 08 Jul 2025
  
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  Addgene_12260
  
  DOI: 10.1158/2159-8290.CD-24-1378
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12223508/
52.53.155.43 52.53.155.43

1-s2.0-S0016508525057324-main-html.html

1
1. scibot 08 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1053/j.gastro.2025.07.003
  
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52.53.155.43/a363e4ae90be5a0c17cae72bbc9ca19379f34011/1-s2.0-S0016508525057324-main-html.html
link.springer.com link.springer.com

HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability

1
1. scibot 08 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1038/s41564-025-02054-z
  
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link.springer.com/article/10.1038/s41564-025-02054-z
52.53.155.43 52.53.155.43

1-s2.0-S2589004225013203-main-html.html

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1. scibot 08 Jul 2025
  
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  Addgene_12260
  
  DOI: 10.1016/j.isci.2025.113059
  
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52.53.155.43/cf5e79d9430fe2c0516d8255d5ed63fff73c6faf/1-s2.0-S2589004225013203-main-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

B-cell Receptor Silencing Reveals the Origin and Dependencies of High-Grade B-cell Lymphomas with MYC and BCL2 Rearrangements

1
1. scibot 04 Jul 2025
  
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  plasmid_12260
  
  DOI: 10.1158/2643-3230.BCD-25-0099
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12209767/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin

1
1. scibot 04 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/0008-5472.CAN-24-0749
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12214879/
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Dissecting FAP+ Cell Diversity in Pancreatic Cancer Uncovers an Interferon-Response Subtype of Cancer-Associated Fibroblasts with Tumor-Restraining Properties

1
1. scibot 04 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/0008-5472.CAN-23-3252
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12214878/
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Chromosomal tethering and mitotic transcription promote ecDNA nuclear inheritance

1
1. scibot 03 Jul 2025
  
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  Addgene_12260
  
  DOI: 10.1016/j.molcel.2025.06.013
  
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sciencedirect.com/science/article/pii/S1097276525005428
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TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling

1
1. scibot 03 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.molcel.2025.06.009
  
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sciencedirect.com/science/article/pii/S109727652500509X
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MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

1
1. scibot 03 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.molcel.2025.06.005
  
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sciencedirect.com/science/article/pii/S1097276525005052
cancerci.biomedcentral.com cancerci.biomedcentral.com

The GD3 ganglioside promotes cell growth, plasticity and chemotherapy resistance of human glioblastoma cancer stem cells

1
1. scibot 03 Jul 2025
  
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  Addgene_12260
  
  DOI: 10.1186/s12935-025-03790-2
  
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cancerci.biomedcentral.com/articles/10.1186/s12935-025-03790-2
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

Blood group O expression in normal tissues and tumors

1
1. scibot 03 Jul 2025
  
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  plasmid_12260
  
  DOI: 10.1111/febs.70172
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70172
www.nature.com www.nature.com

Molecular docking and biological evaluation of a novel IWS1 inhibitor for the treatment of human retroperitoneal liposarcoma

1
1. scibot 03 Jul 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1038/s41598-025-07215-y
  
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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The quantitative impact of 3′UTRs on gene expression

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  plasmid_12
  
  DOI: 10.1093/nar/gkaf568
  
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IRF6 controls Epstein-Barr virus (EBV) lytic reactivation and differentiation in EBV-infected epithelial cells

1
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  DOI: 10.1371/journal.ppat.1013236
  
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Nerve-to-cancer transfer of mitochondria during cancer metastasis

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A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancer

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  plasmid_12260
  
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Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity

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  Plasmid_12260
  
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Functional assessment of all ATM SNVs using prime editing and deep learning

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  Addgene_12260
  
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RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation

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  AddgeneCat#12260
  
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Systematic profiling reveals betaine as an exercise mimetic for geroprotection

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  plasmid_12260
  
  DOI: 10.1016/j.cell.2025.06.001
  
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High-content image-based pooled screens reveal regulators of synaptogenesis

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  Addgene #12260
  
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De novo assembly of RNA m6A modification factors into viral genome-associated nuclear bodies drives HCMV RNA accumulation

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  Addgene#12260
  
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Rear cortex contraction aids in nuclear transit during confined migration by increasing pressure in the cell posterior

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  Addgene_12260
  
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ChemPerturb-seq screen identifies a small molecule cocktail enhancing human beta cell survival after subcutaneous transplantation

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  RRID:Addgene_12260
  
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Protocol for establishing genetically engineered murine lung organoids mimicking cell plasticity and regeneration

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PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer

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  plasmid_12260
  
  DOI: 10.1038/s41586-025-09017-8
  
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52.53.155.43 52.53.155.43

Deletion of Ascl1 in pancreatic β-cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress

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52.53.155.43/b1a8b4466726dfc851796ffaf4a6ed2d264a732e/Online_Supplemental_Materials_5-html.html
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Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale

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  Plasmid_12260
  
  DOI: 10.1016/j.crmeth.2025.101084
  
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cell.com/cell-reports-methods/fulltext/S2667-2375(25)00120-1
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Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation

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  AddgeneCat#: 12260
  
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Hub genes and key pathways of traumatic brain injury:... : Neural Regeneration Research

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journals.lww.com/nrronline/fulltext/2022/06000/guardians_of_the_eye__new_tales_about_retinal.24.aspx
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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation

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  Addgene, cat. no. 12260
  
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Blocking the functional domain of cancer cell surface TIP1 upregulates Midkine via the β-catenin/Wnt signaling pathway

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A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12167931/
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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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  RRID:Addgene_12260
  
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52.53.155.43 52.53.155.43

PDF-html.html

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PDF-html.html

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Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing

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  RRID:Addgene_12260
  
  DOI: 10.1038/s41593-025-01971-w
  
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DEPP1: A prognostic biomarker linked to stroma-rich and immunosuppressive microenvironment, promoting oxaliplatin resistance in gastric cancer

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Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression

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  psPAX2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12099056/
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CD44 Marks Dormant Tumor Cells After HER2 Inhibition in Breast Cancer Cells

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  12260
  
  DOI: 10.3390/ijms26104907
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12112730/
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Metabolic profiling of glioblastoma and identification of G0S2 as a metabolic target

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  12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12162274/
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Pan-cancer analysis of TMED2: unraveling potential immune characteristics and prognostic value in cancer therapy

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  12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12162309/
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Spatially Resolved Panoramic in vivo CRISPR Screen via Perturb-DBiT

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  12260
  
  DOI: 10.21203/rs.3.rs-6481967/v1
  
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STAT3, MYC, and EBNA1 cooperate through a ZC3H18 transcriptional network to regulate survival and proliferation of EBV-positive lymphomas

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  DOI: 10.1371/journal.ppat.1013166
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12091888/
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绒毛样蛋白VILL通过与LMO7蛋白相互作用抑制鼻咽癌细胞的增殖

1
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  DOI: 10.12122/j.issn.1673-4254.2025.05.07
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12104744/
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Host susceptibilities and entry processes of SARS-CoV-2 Omicron variants using pseudotyped viruses carrying spike protein

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  12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12108000/
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CDK2 inhibition produces a persistent population of polyploid cancer cells

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  12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12128980/
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TIMP1 secretion induced by Toxoplasma effector GRA24 via p38 MAPK signaling promotes non-disruptive parasite translocation across polarized brain endothelial monolayers

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  12260
  
  DOI: 10.1128/msphere.00102-25
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12108053/
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The ELF3-TRIM22-MAVS signaling axis regulates type I interferon and antiviral responses

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pmc.ncbi.nlm.nih.gov/articles/PMC12090806/
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Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes

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pmc.ncbi.nlm.nih.gov/articles/PMC12090716/
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In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis

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science.org/doi/10.1126/scitranslmed.ado7225
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Gradual labeling with fluorogenic probes: A general method for MINFLUX imaging and tracking

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  DOI: 10.1126/sciadv.adv5971
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12094232/
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Snora54 negatively regulates self-renewal of intestinal stem cells and gut regeneration via suppression of Notch2 signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC12101510/
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Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12118637/
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Immune cell infiltration into brain tumor microenvironment is mediated by Rab27-regulated vascular wall integrity

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pmc.ncbi.nlm.nih.gov/articles/PMC12101492/
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FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia

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pmc.ncbi.nlm.nih.gov/articles/PMC12118595/
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HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A

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pmc.ncbi.nlm.nih.gov/articles/PMC12132197/
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Orthogonal resistance mechanisms of classical- and induced-proximity inhibitors

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pmc.ncbi.nlm.nih.gov/articles/PMC12132341/
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Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers

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pmc.ncbi.nlm.nih.gov/articles/PMC12082454/
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Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways

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pmc.ncbi.nlm.nih.gov/articles/PMC12101352/
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Calpains orchestrate secretion of annexin-containing microvesicles during membrane repair

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pmc.ncbi.nlm.nih.gov/articles/PMC12083247/
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Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system

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pmc.ncbi.nlm.nih.gov/articles/PMC12084362/
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Luteolin targets MKK4 to attenuate particulate matter-induced MMP-1 and inflammation in human keratinocytes

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pmc.ncbi.nlm.nih.gov/articles/PMC12081746/
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Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex

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  DOI: 10.1038/s41593-025-01933-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12081304/
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Bat organoids reveal antiviral responses at epithelial surfaces

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  DOI: 10.1038/s41590-025-02155-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12133567/
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EndoMAP.v1 charts the structural landscape of human early endosome complexes

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pmc.ncbi.nlm.nih.gov/articles/PMC12222028/
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CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly

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pmc.ncbi.nlm.nih.gov/articles/PMC12125367/
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Efficient generation of germline chimeras in a non-rodent species using rabbit induced pluripotent stem cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12134177/
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Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia

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  DOI: 10.1038/s41467-025-60304-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12130354/
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De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS

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pmc.ncbi.nlm.nih.gov/articles/PMC12134298/
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Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC12134272/
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Clustering of NLRP3 induced by membrane or protein scaffolds promotes inflammasome assembly

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pmc.ncbi.nlm.nih.gov/articles/PMC12117088/
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CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12120064/
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FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction

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FOXA2 promotes metastatic competence in small cell lung cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12106783/
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RNA-binding proteins DND1 and NANOS3 cooperatively suppress the entry of germ cell lineage

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pmc.ncbi.nlm.nih.gov/articles/PMC12102168/
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Protocol for in vivo CRISPR knockout screening of autophagy genes to identify breast cancer metastasis suppressors

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pmc.ncbi.nlm.nih.gov/articles/PMC12084073/
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Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases

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pmc.ncbi.nlm.nih.gov/articles/PMC12086040/
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Newcastle disease virus induces degradation of folliculin to regulate host cell energy metabolism and facilitate viral replication

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pmc.ncbi.nlm.nih.gov/articles/PMC12164175/
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Fighting RNA viruses with a gold nanoparticle Cas13d gene-editing armor

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pmc.ncbi.nlm.nih.gov/articles/PMC12088821/
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Gallium disrupts endoplasmic reticulum iron metabolism to induce lipid metabolic reprogramming in glioblastoma cells

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Differentiation of Brain Mural Cells from Human Pluripotent Stem Cell-Derived Neural Crest by Activation of Notch3 Signaling

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Disruption of ATR Signaling by Epstein–Barr Virus Latent Membrane Protein 1 Sensitizes Nasopharyngeal Carcinoma Cells to Cisplatin

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pmc.ncbi.nlm.nih.gov/articles/PMC12100692/
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The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

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pmc.ncbi.nlm.nih.gov/articles/PMC12089071/
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NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

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  DOI: 10.1002/advs.202413508
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12120717/
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Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

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  DOI: 10.1002/advs.202412953
  
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Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion

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Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

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Lentiviral CRISPRa/i in the adult prairie vole brain: modulating neuronal gene expression without DNA cleavage

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Xenoline-polarized macrophages as a physiologically relevant in vitro model of tumor-associated macrophages in glioblastoma

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A monomeric envelope glycoprotein cytoplasmic tail is sufficient for HIV-1 Gag lattice trapping and incorporation

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Tumor-derived erythropoietin acts as an immunosuppressive switch in cancer immunity

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Pancreatic cancer-restricted cryptic antigens are targets for T cell recognition

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Genetically encoded fluorescent reporter for polyamines

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pmc.ncbi.nlm.nih.gov/articles/PMC12117157/
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Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12

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Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer

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Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function

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Rational Design and Organoid‐Based Evaluation of a Cocktail CAR‐γδ T Cell Therapy for Heterogeneous Glioblastoma

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Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

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Lovastatin Targets the USP14–Survivin Axis to Suppress Triple-Negative Breast Cancer via Ubiquitin-Mediated Proteasomal Degradation

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pmc.ncbi.nlm.nih.gov/articles/PMC12154129/
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PELI2 inhibits colorectal cancer development through MAPK signaling pathway

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FEBS Press

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pmc.ncbi.nlm.nih.gov/articles/PMC12138165/
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Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

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pmc.ncbi.nlm.nih.gov/articles/PMC12147664/
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CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity

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Loss of LAPTM4A inhibits M2 polarization of tumor-associated macrophages in glioblastoma, promoting immune activation and enhancing anti-PD1 therapy

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pmc.ncbi.nlm.nih.gov/articles/PMC12159176/
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Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress

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Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

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pmc.ncbi.nlm.nih.gov/articles/PMC12158785/
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Control of epithelial tissue organization by mRNA localization

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SWI/SNF ATPase silenced HLF potentiates lung metastasis in solid cancers

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pmc.ncbi.nlm.nih.gov/articles/PMC12141477/
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Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteins

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Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer

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Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma

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GLI2-HRD1 axis facilitates 5-FU resistance in gastric cancer cells by regulating ubiquitination degradation of UCK2

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Hepatic ChREBP reciprocally modulates systemic insulin sensitivity in NAFLD

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NUDT16 enhances the resistance of cancer cells to DNA-damaging agents by regulating replication fork stability via reversing HMGA1 ADP-ribosylation

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Heat shock induces alternative polyadenylation through dynamic DNA methylation and chromatin looping

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SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases

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Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signal

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  plasmid_12260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12148026/
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Cell‐Type‐Specific Autophagy in Human Leukocytes

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Discovery of potential small molecule inhibitors against β-hCG: an in silico study with in vitro validation

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β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1

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CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9

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pmc.ncbi.nlm.nih.gov/articles/PMC12159223/
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CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

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RalGAP complexes control secretion and primary cilia in pancreatic disease

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Delta-catenin is required for cell proliferation in virus-positive Merkel cell carcinoma cell lines but not in human fibroblasts

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Protocol for genetic dissection of class switch recombination using genome-editing tools

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The immortality mechanism of TERT promoter mutant cancers is self-reinforcing and reversible

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The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury

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Vault RNAs aid RNA virus infection by facilitating cytoplasmic localization of hnRNP C and ELAVL1

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The RNA-stability-independent role of the RNA m6A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance

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NDF/GLYR1 Promotes RNA Polymerase II Processivity via Pol II Binding and Nucleosome Destabilization

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Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

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Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain

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A Commander-independent function of COMMD3 in endosomal trafficking

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Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy

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The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect

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Phosphatase activity is dispensable for PRL-3-mediated oncogenesis and tumor progression

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Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells

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Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation

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Fitness and transcriptional plasticity of human breast cancer single-cell-derived clones

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Screening a living biobank identifies cabazitaxel as a strategy to combat acquired taxol resistance in high-grade serous ovarian cancer

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Targeting IDH2 promotes antitumor immunity through epigenetic activation of cGAS-STING pathway

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Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy

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Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity

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hnRNPL phase separation activates PIK3CB transcription and promotes glycolysis in ovarian cancer

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IGF2BP1 restricts the induction of human primordial germ cell fate in an m6A-dependent manner

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Machine-learning-assisted universal protein activation in living mice

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Delta-catenin is required for cell proliferation in virus-positive Merkel cell carcinoma cell lines but not in human fibroblasts

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Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D

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KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells

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Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

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HBV sequence integrated to enhancer acting as oncogenic driver epigenetically promotes hepatocellular carcinoma development

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IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

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CapdevilaCastillo_columbia_0054D_18600-html.html

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52.53.155.43/defa13d4e31bf105e951133a04f91af42d68a175/CapdevilaCastillo_columbia_0054D_18600-html.html
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SFSWAP is a negative regulator of OGT intron detention and global pre-mRNA splicing

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1. scibot 22 May 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.7554/eLife.104439
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12017769/
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Division of labor among H3K4 methyltransferases defines distinct facets of homeostatic plasticity

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115746
  
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sciencedirect.com/science/article/pii/S2211124725005170
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PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

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1. scibot 22 May 2025
  
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  Addgene_12260
  
  DOI: 10.1016/j.celrep.2025.115735
  
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sciencedirect.com/science/article/pii/S2211124725005066
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

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1. scibot 22 May 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1016/j.celrep.2025.115733
  
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sciencedirect.com/science/article/pii/S2211124725005042
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Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity

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1. scibot 21 May 2025
  
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  plasmid_12260
  
  DOI: 10.3390/v17040514
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12031279/
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Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis

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1. scibot 21 May 2025
  
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  plasmid_12260
  
  DOI: 10.3390/cells12010062
  
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pmc.ncbi.nlm.nih.gov/articles/PMC9818499/
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Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma

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1. scibot 21 May 2025
  
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  Addgene_12260
  
  DOI: 10.3389/fphar.2025.1575332
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12021886/
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CLEC12A-directed immunocytokine with target cell–restricted IL-15 activity for treatment of acute myeloid leukemia

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1. scibot 21 May 2025
  
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  Addgene_12260
  
  DOI: 10.3389/fimmu.2025.1561823
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11983603/
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RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer

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1. scibot 21 May 2025
  
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  Addgene_12260
  
  DOI: 10.3389/fimmu.2025.1515568
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12075365/
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SAMHD1 knockout hiPSC model enables high lentiviral transduction efficiency in myeloid cell types

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1. scibot 21 May 2025
  
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  Addgene_12260
  
  DOI: 10.3389/fgene.2025.1574545
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12009803/
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Incomplete paralog compensation generates selective dependency on TRA2A in cancer

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1. scibot 21 May 2025
  
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  DOI: 10.1371/journal.pgen.1011685
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12077678/
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Predicting adenine base editing efficiencies in different cellular contexts by deep learning

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1. scibot 21 May 2025
  
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  Addgene_12260
  
  DOI: 10.1186/s13059-025-03586-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12060317/
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The evolution of AKAPs and emergence of PKA isotype selective anchoring determinants

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1. scibot 20 May 2025
  
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  DOI: 10.1016/j.jbc.2025.108480
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12083921/
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Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1

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1. scibot 20 May 2025
  
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  RRID:Addgene_12260
  
  DOI: 10.1158/0008-5472.CAN-24-1388
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11534540/

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