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Feb 2024
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Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

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1. scibot 15 Feb 2024
  
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  plasmid_52962
  
  DOI: 10.1126/sciadv.adj4767
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
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Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1

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1. scibot 13 Feb 2024
  
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  lentiCas9-Blast
  
  DOI: 10.1038/s41467-023-44466-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10761827/
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Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing

1
1. scibot 09 Feb 2024
  
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  Addgene_52962
  
  DOI: 10.1101/2023.12.03.569825
  
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biorxiv.org/content/10.1101/2023.12.03.569825v1
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Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy

1
1. scibot 08 Feb 2024
  
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  Plasmid_52962
  
  DOI: 10.1101/2024.01.14.575614
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10827061/
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Alternative polyadenylation determines the functional landscape of inverted Alu repeats

1
1. scibot 06 Feb 2024
  
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  AddgeneCat# 52962
  
  DOI: 10.1016/j.molcel.2024.01.008
  
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sciencedirect.com/science/article/pii/S1097276524000091
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RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9

1
1. scibot 06 Feb 2024
  
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  52,962
  
  DOI: 10.1186/s13059-023-03149-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10785552/
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Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

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1. scibot 06 Feb 2024
  
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  Addgene_52962
  
  DOI: 10.1158/2159-8290.CD-22-0982
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10524862/
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Multiplexed screening reveals how cancer-specific alternative polyadenylation shapes tumor growth in vivo

1
1. scibot 04 Feb 2024
  
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  52962
  
  DOI: 10.1038/s41467-024-44931-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10834521/
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METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation

1
1. scibot 04 Feb 2024
  
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  52962
  
  DOI: 10.1186/s13045-024-01526-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10835888/
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Two-step evolution of HIV-1 budding system leading to pandemic in the human population

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1. scibot 02 Feb 2024
  
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  Addgene_52962
  
  DOI: 10.1016/j.celrep.2024.113697
  
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sciencedirect.com/science/article/pii/S2211124724000251
Jan 2024
www-sciencedirect-com.proxy.uchicago.edu www-sciencedirect-com.proxy.uchicago.edu

Cell surface RNAs control neutrophil recruitment

1
1. scibot 23 Jan 2024
  
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  AddgeneCat# 52962
  
  DOI: 10.1016/j.cell.2023.12.033
  
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www-sciencedirect-com.proxy.uchicago.edu/science/article/pii/S0092867423014435
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Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia

1
1. scibot 18 Jan 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.1038/s41598-024-52020-8
  
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nature.com/articles/s41598-024-52020-8
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Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors

1
1. scibot 11 Jan 2024
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2023.113629
  
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sciencedirect.com/science/article/pii/S2211124723016406
Dec 2023
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EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

1
1. scibot 29 Dec 2023
  
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  Cat# 52962, Addgene
  
  DOI: 10.1016/j.ccell.2023.12.002
  
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sciencedirect.com/science/article/pii/S1535610823004300
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality

1
1. scibot 20 Dec 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1158/0008-5472.CAN-22-2948
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10722143/
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Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers

1
1. scibot 17 Dec 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.immuni.2023.11.008
  
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sciencedirect.com/science/article/pii/S1074761323004909
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Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

1
1. scibot 15 Dec 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.7554/eLife.87098
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
Nov 2023
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Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma

1
1. scibot 28 Nov 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.xcrm.2023.101264
  
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sciencedirect.com/science/article/pii/S266637912300441X
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HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

1
1. scibot 17 Nov 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2023.113352
  
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sciencedirect.com/science/article/pii/S2211124723013645
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The promiscuous development of an unconventional Qa1b-restricted T cell population

1
1. scibot 16 Nov 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.3389/fimmu.2023.1250316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10644506/
Oct 2023
www.biorxiv.org www.biorxiv.org

Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level

1
1. scibot 27 Oct 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1101/2023.10.16.562592
  
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biorxiv.org/content/10.1101/2023.10.16.562592v1
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Genome-wide CRISPR/Cas9 screen identifies MAT2A as a critical host factor for BK Polyomavirus

1
1. scibot 27 Oct 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1101/2023.10.20.563362
  
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biorxiv.org/content/10.1101/2023.10.20.563362v1
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ADAR1 Biology Can Hinder Effective Antiviral RNA Interference

1
1. scibot 06 Oct 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1128/jvi.00245-23
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10134826/
Sep 2023
www.nature.com www.nature.com

Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia

1
1. scibot 20 Sep 2023
  
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  plasmid_52962
  
  DOI: 10.1038/s41375-022-01755-2
  
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nature.com/articles/s41375-022-01755-2
Aug 2023
www.biorxiv.org www.biorxiv.org

Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

1
1. scibot 16 Aug 2023
  
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  plasmid_52962
  
  DOI: 10.1101/2023.07.26.550648
  
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biorxiv.org/content/10.1101/2023.07.26.550648v2
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BET Inhibitors Target the SCLC-N subtype of Small Cell Lung Cancer by Blocking NEUROD1 Transactivation

1
1. scibot 02 Aug 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1158/1541-7786.MCR-22-0594
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9898120/
Jul 2023
www.nature.com www.nature.com

Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities

1
1. scibot 29 Jul 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1038/s41594-023-01041-4
  
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nature.com/articles/s41594-023-01041-4
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Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation

1
1. scibot 27 Jul 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.devcel.2023.07.001
  
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sciencedirect.com/science/article/pii/S1534580723003313
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi’s sarcoma-associated herpesvirus

1
1. scibot 25 Jul 2023
  
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  plasmid_52962
  
  DOI: 10.1101/2023.07.08.548212
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10350069/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

APOBEC3 activity promotes the survival and evolution of drug-tolerant persister cells during acquired resistance to EGFR inhibitors in lung cancer

1
1. scibot 25 Jul 2023
  
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  plasmid_52962
  
  DOI: 10.1101/2023.07.02.547443
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10350004/
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Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

1
1. scibot 21 Jul 2023
  
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  Plasmid_52962
  
  DOI: 10.1016/j.ccell.2023.06.010
  
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sciencedirect.com/science/article/pii/S1535610823002350
52.53.155.43 52.53.155.43

cir-22-0815-html.html

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1. scibot 01 Jul 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1158/2326-6066.CIR-22-0815
  
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52.53.155.43/0c7b493d1804c631a7718bd69d23acbb033c9efb/cir-22-0815-html.html
Jun 2023
www.sciencedirect.com www.sciencedirect.com

QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

1
1. scibot 28 Jun 2023
  
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  RRID: Addgene_52962
  
  DOI: 10.1016/j.cell.2023.05.047
  
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sciencedirect.com/science/article/pii/S0092867423005986
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An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

1
1. scibot 23 Jun 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.ccell.2023.06.001
  
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sciencedirect.com/science/article/pii/S1535610823002088
www.biorxiv.org www.biorxiv.org

Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis

1
1. scibot 22 Jun 2023
  
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  plasmid_52962
  
  DOI: 10.1101/2023.06.14.544493
  
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biorxiv.org/content/10.1101/2023.06.14.544493v1
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network

1
1. scibot 14 Jun 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.immuni.2022.10.021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7614333/
aacrjournals.org aacrjournals.org

(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

1
1. scibot 10 Jun 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1158/2159-8290.CD-22-0825
  
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aacrjournals.org/cancerdiscovery/article/13/6/1478/726967/R-2-Hydroxyglutarate-Inhibits-KDM5-Histone-Lysine
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RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition

1
1. scibot 03 Jun 2023
  
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  RRID: Addgene_52962
  
  DOI: 10.1158/0008-5472.CAN-22-1549
  
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aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

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May 2023
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Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia

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  DOI: 10.1101/2023.05.18.541265
  
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A genome-wide optical pooled screen reveals regulators of cellular antiviral responses

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Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition

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Apr 2023
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IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling

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  DOI: 10.1016/j.cellsig.2023.110684
  
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Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

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  DOI: 10.1158/2326-6066.CIR-22-0056
  
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aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
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Proteomic discovery of chemical probes that perturb protein complexes in human cells

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Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens

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Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome

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  RRID:Addgene_52962
  
  DOI: 10.1101/2023.02.13.528260
  
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biorxiv.org/content/10.1101/2023.02.13.528260v1
Mar 2023
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Rlf–Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer

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aacrjournals.org/cancerdiscovery/article/11/12/3214/674718/Rlf-Mycl-Gene-Fusion-Drives-Tumorigenesis-and
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FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation

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  plasmid_52962
  
  DOI: 10.1038/s41586-021-04144-4
  
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nature.com/articles/s41586-021-04144-4
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The protective role of conjunctival goblet cell mucin sialylation

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  DOI: 10.1038/s41467-023-37101-y
  
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In vivo interrogation of regulatory genomes reveals extensive quasi-insufficiency in cancer evolution

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Feb 2023
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An adverse tumor-protective effect of IDO1 inhibition

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91-html.html

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52.53.155.43/67ba005538cc0cc62d34c50598f914c3efc88864/91-html.html
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CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2023.112076
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
Jan 2023
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Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia

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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2023.112027
  
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Identification of β2 microglobulin, the product of B2M gene, as a Host Factor for Vaccinia Virus Infection by Genome-Wide CRISPR genetic screens

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ncbi.nlm.nih.gov/pmc/articles/PMC9829182/
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Deletion of Bak1 alleviates microglial necroptosis and neuroinflammation after experimental subarachnoid hemorrhage

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1. scibot 10 Jan 2023
  
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  RRID:Addgene_52962
  
  DOI: 10.1111/jnc.15751
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15751
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METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism

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  DOI: 10.1016/j.stem.2022.12.006
  
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sciencedirect.com/science/article/pii/S1934590922004908
Dec 2022
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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

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IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia

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embopress.org/doi/10.15252/emmm.202115631
Nov 2022
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Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins

1
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Tetraspanin-5–mediated MHC class I clustering is required for optimal CD8 T cell activation

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  RRID:Addgene_52962
  
  DOI: 10.1073/pnas.2122188119
  
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pnas.org/doi/abs/10.1073/pnas.2122188119
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Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

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Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling

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  DOI: 10.1016/j.celrep.2022.111581
  
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sciencedirect.com/science/article/pii/S2211124722014462
Sep 2022
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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

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  DOI: 10.1038/s41467-022-32758-3
  
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nature.com/articles/s41467-022-32758-3
Aug 2022
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ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain

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  DOI: 10.1016/j.celrep.2022.111268
  
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Cancer genes disfavoring T cell immunity identified via integrated systems approach

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  Addgene Cat# 52962
  
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sciencedirect.com/science/article/pii/S2211124722009627
Jul 2022
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Modulating the excitability of olfactory output neurons affects whole-body metabolism

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  DOI: 10.1523/JNEUROSCI.0190-22.2022
  
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jneurosci.org/content/42/30/5966
Jun 2022
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Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells

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  DOI: 10.15252/embr.202154133
  
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embopress.org/doi/10.15252/embr.202154133
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RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells

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  DOI: 10.1016/j.xcrm.2022.100655
  
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Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model

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  DOI: 10.1007/s10120-022-01307-8
  
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link.springer.com/article/10.1007/s10120-022-01307-8
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The SETDB1–TRIM28 complex suppresses antitumor immunity

1
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  DOI: 10.1158/2326-6066.CIR-21-0754
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8647838/
May 2022
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Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

1
1. scibot 18 May 2022
  
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  plasmid_52962
  
  DOI: 10.7554/eLife.76541
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9094746/
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Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

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  DOI: 10.1158/2159-8290.CD-21-1006
  
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aacrjournals.org/cancerdiscovery/article/12/5/1314/694563/Melanoma-Secreted-Amyloid-Beta-Suppresses
Apr 2022
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Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma

1
1. scibot 07 Apr 2022
  
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  AddgeneCat# 52962
  
  DOI: 10.1016/j.celrep.2022.110637
  
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sciencedirect.com/science/article/pii/S2211124722003898
Mar 2022
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Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection

1
1. scibot 30 Mar 2022
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2022.110559
  
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sciencedirect.com/science/article/pii/S2211124722003035
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

1
1. scibot 26 Mar 2022
  
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  plasmid_52962
  
  DOI: 10.7554/eLife.77444
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8942469/
link.springer.com link.springer.com

Partial p53 reactivation is sufficient to induce cancer regression

1
1. scibot 03 Mar 2022
  
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  RRID:Addgene_52962
  
  DOI: 10.1186/s13046-022-02269-6
  
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link.springer.com/article/10.1186/s13046-022-02269-6
Feb 2022
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ZEB1-regulated lnc-Nr2f1 promotes the migration and invasion of lung adenocarcinoma cells

1
1. scibot 16 Feb 2022
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.canlet.2022.215601
  
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sciencedirect.com/science/article/pii/S0304383522000763
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Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells

2
1. scibot 11 Feb 2022
  
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  Addgene 52962
  
  DOI: 10.1016/j.chembiol.2022.01.002
  
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2. scibot 11 Feb 2022
  
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  Addgene 52962
  
  DOI: 10.1016/j.chembiol.2022.01.002
  
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sciencedirect.com/science/article/pii/S2451945622000022
Jan 2022
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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

1
1. scibot 15 Jan 2022
  
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  RRID:Addgene_52962
  
  DOI: 10.1038/s42003-021-02953-x
  
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nature.com/articles/s42003-021-02953-x
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ACE2 can act as the secondary receptor in the FcγR-dependent ADE of SARS-CoV-2 infection

1
1. scibot 14 Jan 2022
  
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  AddgeneCAT#52962
  
  DOI: 10.1016/j.isci.2021.103720
  
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sciencedirect.com/science/article/pii/S2589004221016904
Sep 2021
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Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog—GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition

1
1. scibot 04 Sep 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.3390/cancers13164227
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8394935/
Aug 2021
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TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

1
1. scibot 14 Aug 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.molcel.2019.03.025
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6671628/
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Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance

1
1. scibot 11 Aug 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.ccell.2017.10.008
  
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sciencedirect.com/science/article/pii/S1535610817304610
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Untitled document

1
1. scibot 11 Aug 2021
  
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  plasmid_52962
  
  DOI: 10.1038/s41598-018-37940-6
  
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nature.com/articles/s41598-018-37940-6
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Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

2
1. scibot 05 Aug 2021
  
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  RRID:Addgene_529
  
  DOI: 10.1016/j.celrep.2021.109460
  
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  Curator: @Naa003
  
  SciCrunch record: RRID:Addgene_52962
  
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  RRIDCUR:Unresolved RRIDCUR:SyntaxError RRID:Addgene_52962
2. scibot 01 Aug 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.celrep.2021.109460
  
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The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

1
1. scibot 01 Aug 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.celrep.2019.12.014
  
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sciencedirect.com/science/article/pii/S221112471931664X
Jul 2021
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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis

1
1. scibot 29 Jul 2021
  
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  RRID: Addgene_52962
  
  DOI: 10.1016/j.cell.2019.10.034
  
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sciencedirect.com/science/article/pii/S0092867419312115
elifesciences.org elifesciences.org

CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

1
1. scibot 28 Jul 2021
  
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  RRID:Addgene_ 52962
  
  DOI: 10.7554/eLife.43653
  
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  RRID:Addgene_52962 RRIDCUR:Unrecognized
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elifesciences.org/articles/43653
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Untitled document

1
1. scibot 28 Jul 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.ccell.2017.10.008
  
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cell.com/cancer-cell/abstract/S1535-6108(17)30461-0
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

1
1. scibot 27 Jul 2021
  
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  RRID_Addgene_52962
  
  DOI: 10.1016/j.ccell.2019.12.007
  
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sciencedirect.com/science/article/pii/S153561081930577X
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HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV

1
1. scibot 14 Jul 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2021.109378
  
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sciencedirect.com/science/article/pii/S2211124721007762
Jun 2021
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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

1
1. scibot 30 Jun 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.molcel.2021.06.020
  
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sciencedirect.com/science/article/pii/S1097276521005001
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

1
1. scibot 25 Jun 2021
  
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  52962
  
  DOI: 10.1016/j.cell.2021.05.038
  
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sciencedirect.com/science/article/pii/S0092867421006905
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The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance

1
1. scibot 25 Jun 2021
  
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  Cat#52962
  
  DOI: 10.1016/j.ccell.2021.06.003
  
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sciencedirect.com/science/article/pii/S1535610821002865
May 2021
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Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway

1
1. scibot 14 May 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.cub.2021.04.075
  
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sciencedirect.com/science/article/pii/S0960982221006229
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Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation

1
1. scibot 09 May 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.stem.2020.12.005
  
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sciencedirect.com/science/article/pii/S1934590920305890
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RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins

1
1. scibot 07 May 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.molcel.2020.06.023
  
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sciencedirect.com/science/article/pii/S1097276520304251
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SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts

1
1. scibot 07 May 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.molcel.2020.05.011
  
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sciencedirect.com/science/article/pii/S1097276520303129
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A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability

1
1. scibot 05 May 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.devcel.2020.07.022
  
  Resource: RRID:Addgene_52962
  
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sciencedirect.com/science/article/pii/S1534580720305979
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Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

1
1. scibot 03 May 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.molcel.2021.02.025
  
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sciencedirect.com/science/article/pii/S1097276521001350
Apr 2021
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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

1
1. scibot 30 Apr 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.cmet.2020.12.003
  
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sciencedirect.com/science/article/pii/S1550413120306586
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Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors

1
1. scibot 28 Apr 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.chom.2020.05.012
  
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sciencedirect.com/science/article/pii/S1931312820302948
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Illuminating Host-Mycobacterial Interactions with Genome-wide CRISPR Knockout and CRISPRi Screens

1
1. scibot 27 Apr 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.cels.2020.08.010
  
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sciencedirect.com/science/article/pii/S2405471220302945
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Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

1
1. scibot 24 Apr 2021
  
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  addgene_52962
  
  DOI: 10.1016/j.cell.2020.06.006
  
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sciencedirect.com/science/article/pii/S0092867420306930
www.nature.com www.nature.com

CRL4 AMBRA1 is a master regulator of D-type cyclins

1
1. scibot 22 Apr 2021
  
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  plasmid_52962
  
  DOI: 10.1038/s41586-021-03445-y
  
  Resource: RRID:Addgene_52962
  
  Curator: @evieth
  
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  RRIDCUR:Validated RRID:Addgene_52962
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nature.com/articles/s41586-021-03445-y
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Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

1
1. scibot 20 Apr 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.ccell.2020.06.006
  
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  RRIDCUR:Validated RRID:Addgene_52962
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sciencedirect.com/science/article/pii/S153561082030310X
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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

1
1. scibot 17 Apr 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.ccell.2020.04.017
  
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  RRID:Addgene_52962 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1535610820302166
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The dystonia gene THAP1 controls DNA double-strand break repair choice

1
1. scibot 15 Apr 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.molcel.2021.03.034
  
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  RRID:Addgene_52962 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S109727652100229X
Mar 2021
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A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection

1
1. scibot 17 Mar 2021
  
  in Public
  
  Plasmid_52962
  
  DOI: 10.1016/j.celrep.2021.108859
  
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sciencedirect.com/science/article/pii/S221112472100173X
Feb 2021
elifesciences.org elifesciences.org

Diverse viral proteases activate the NLRP1 inflammasome

1
1. scibot 28 Feb 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.7554/eLife.60609
  
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elifesciences.org/articles/60609
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SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

1
1. scibot 26 Feb 2021
  
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  plasmid_52962
  
  DOI: 10.1016/j.cell.2020.09.033
  
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sciencedirect.com/science/article/pii/S0092867420312307
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Vitamin B6 Addiction in Acute Myeloid Leukemia

1
1. scibot 24 Feb 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.ccell.2019.12.002
  
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sciencedirect.com/science/article/pii/S1535610819305720
www.cell.com www.cell.com

TMEM41B IS A PAN-FLAVIVIRUS HOST FACTOR

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1. scibot 24 Feb 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.cell.2020.12.005
  
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cell.com/cell/abstract/S0092-8674(20)31627-5
journals.plos.org journals.plos.org

N-Glycans and sulfated glycosaminoglycans contribute to the action of diverse Tc toxins on mammalian cells

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1. scibot 24 Feb 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1371/journal.ppat.1009244
  
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

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1. scibot 23 Feb 2021
  
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  RRID:_Addgene_52962
  
  DOI: 10.1016/j.ccell.2019.12.007
  
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Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation

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1. scibot 11 Feb 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.ccell.2020.03.001
  
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sciencedirect.com/science/article/pii/S153561082030101X
Jan 2021
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Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

1
1. scibot 29 Jan 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.chom.2020.12.009
  
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sciencedirect.com/science/article/pii/S1931312820306715
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Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

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1. scibot 29 Jan 2021
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.cell.2020.12.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7796900/
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Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

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1. scibot 20 Jan 2021
  
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  Addgene_52962
  
  DOI: 10.1016/j.xcrm.2020.100188
  
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sciencedirect.com/science/article/pii/S2666379120302433
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The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules

1
1. scibot 15 Jan 2021
  
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  Plasmid_52962
  
  DOI: 10.1016/j.chom.2020.04.024
  
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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins

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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108532
  
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sciencedirect.com/science/article/pii/S2211124720315217
Dec 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin’s lymphoma and testicular cancer cells

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1. scibot 09 Dec 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1038/s41419-020-03231-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7705021/
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Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

1
1. scibot 07 Dec 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108444
  
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sciencedirect.com/science/article/pii/S2211124720314339
Nov 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells

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1. scibot 18 Nov 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.ccell.2020.09.014
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7737474/
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41

2
1. scibot 14 Nov 2020
  
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  Addgene #52962
  
  DOI: 10.1016/j.celrep.2020.108371
  
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2. scibot 14 Nov 2020
  
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  Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108371
  
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pubmed.ncbi.nlm.nih.gov/33176151/
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G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program

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1. scibot 12 Nov 2020
  
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  Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108341
  
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sciencedirect.com/science/article/pii/S2211124720313309
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Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection

1
1. scibot 05 Nov 2020
  
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  Lenti-Cas9-Blast
  
  DOI: 10.1016/j.cell.2020.10.028
  
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sciencedirect.com/science/article/pii/S0092867420313921
Oct 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TMEM41B is a pan-flavivirus host factor

1
1. scibot 24 Oct 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1101/2020.10.09.334128
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7553181/
Sep 2020
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Kinetic Heterogeneity of Cancer Cell Fractional Killing

1
1. scibot 26 Sep 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.107845
  
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sciencedirect.com/science/article/pii/S2211124720308263
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Identification of BLNK and BTK as mediators of rituximab‐induced programmed cell death by CRISPR screens in GCB‐subtype diffuse large B‐cell lymphoma

1
1. scibot 26 Sep 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1002/1878-0261.12753
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7463323/
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

1
1. scibot 16 Sep 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.ccell.2019.12.007
  
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sciencedirect.com/science/article/pii/S153561081930577X
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MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation

1
1. scibot 16 Sep 2020
  
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  Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.107860
  
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sciencedirect.com/science/article/pii/S221112472030841X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Locally acting transcription factors regulate p53-dependent cis-regulatory element activity

1
1. scibot 13 Sep 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1093/nar/gkaa147
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7192610/
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The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks

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1. scibot 05 Sep 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.celrep.2019.12.067
  
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sciencedirect.com/science/article/pii/S2211124719317243
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Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

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1. scibot 04 Sep 2020
  
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  Addgene_52962
  
  DOI: 10.1016/j.celrep.2020.108080
  
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sciencedirect.com/science/article/pii/S2211124720310652
Aug 2020
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Vitamin B6 Addiction in Acute Myeloid Leukemia

1
1. scibot 14 Aug 2020
  
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  Addgene Plasmid #52962
  
  DOI: 10.1016/j.ccell.2019.12.002
  
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sciencedirect.com/science/article/pii/S1535610819305720
Jan 2020
www.nature.com www.nature.com

α-Ketoglutarate links p53 to cell fate during tumour suppression

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1038/s41586-019-1577-5
  
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nature.com/articles/s41586-019-1577-5
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Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

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1. scibot 13 Jan 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.cell.2019.06.014
  
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sciencedirect.com/science/article/pii/S0092867419306774
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Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG

1
1. scibot 13 Jan 2020
  
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.ccell.2019.09.005
  
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sciencedirect.com/science/article/pii/S1535610819304258
www.embopress.org www.embopress.org

A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

1
1. scibot 13 Jan 2020
  
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  plasmid_52962
  
  DOI: 10.15252/embr.201948235
  
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embopress.org/doi/full/10.15252/embr.201948235
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Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

1
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  RRID:Addgene_52962
  
  DOI: 10.1016/j.ccell.2019.05.013
  
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sciencedirect.com/science/article/pii/S1535610819302557
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Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

1
1. scibot 13 Jan 2020
  
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  Plasmid_52962
  
  DOI: 10.1016/j.ccell.2018.01.012
  
  Resource: RRID:Addgene_52962
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1535610818300126
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

1
1. scibot 12 Jan 2020
  
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  plasmid_52962
  
  DOI: 10.1038/s41598-018-37940-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6362041/

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