255 Matching Annotations
  1. Nov 2024
  2. www.biorxiv.org www.biorxiv.org
    Endocrine persistence in ER+ breast cancer is accompanied by metabolic vulnerability in oxidative phosphorylation
    1
    1. scibot 20 Nov 2024
      Addgene_52962

      DOI: 10.1101/2024.09.26.615177

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    biorxiv.org/content/10.1101/2024.09.26.615177v1
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial elongation impairs breast cancer metastasis
    1
    1. scibot 10 Nov 2024
      RRID:Addgene_52962

      DOI: 10.1126/sciadv.adm8212

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    pmc.ncbi.nlm.nih.gov/articles/PMC11540020/
  4. Sep 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1126/sciadv.adl5638

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    ncbi.nlm.nih.gov/pmc/articles/PMC466957/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screenings identified SMCHD1 as a host-restricting factor for AAV transduction
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1371/journal.ppat.1012344

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    ncbi.nlm.nih.gov/pmc/articles/PMC11257396/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1038/s41467-024-50298-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC11255242/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Aryl Hydrocarbon Receptor Controls IFNγ-Induced Immune Checkpoints PD-L1 and IDO via the JAK/STAT Pathway in Lung Adenocarcinoma
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1101/2024.08.12.607602

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    ncbi.nlm.nih.gov/pmc/articles/PMC11343147/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1038/s41419-024-06995-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11350041/
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1038/s41467-024-50498-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC11358161/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanism for controlled assembly of transcriptional condensates by Aire
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1038/s41590-024-01922-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC11362013/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1101/2024.09.09.612085

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    ncbi.nlm.nih.gov/pmc/articles/PMC11419122/
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming
    1
    1. scibot 29 Sep 2024
      52962

      DOI: 10.1158/1541-7786.MCR-23-0454

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    ncbi.nlm.nih.gov/pmc/articles/PMC11372370/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation
    1
    1. scibot 29 Sep 2024
      plasmid_52962

      DOI: 10.1038/s41467-024-52049-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11374810/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC35A2 modulates paramyxovirus fusion events during infection
    1
    1. scibot 28 Sep 2024
      52962

      DOI: 10.1101/2024.08.27.609835

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    ncbi.nlm.nih.gov/pmc/articles/PMC11382999/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A
    1
    1. scibot 28 Sep 2024
      Addgene_52962

      DOI: 10.1093/nar/gkae605

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    ncbi.nlm.nih.gov/pmc/articles/PMC11381347/
  17. www.sciencedirect.com www.sciencedirect.com
    Saturation mutagenesis-reinforced functional assays for disease-related genes
    1
    1. scibot 27 Sep 2024
      Plasmid_52962

      DOI: 10.1016/j.cell.2024.08.047

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    sciencedirect.com/science/article/pii/S0092867424009760
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability
    1
    1. scibot 26 Sep 2024
      52962

      DOI: 10.1016/j.molcel.2024.07.018

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    ncbi.nlm.nih.gov/pmc/articles/PMC11366124/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding RNA Metabolism by RNA-linked CRISPR Screening in Human Cells
    1
    1. scibot 26 Sep 2024
      52962

      DOI: 10.1101/2024.07.25.605204

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    ncbi.nlm.nih.gov/pmc/articles/PMC11291135/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT1 inhibition perturbs RNA metabolism and induces DNA damage in clear cell renal cell carcinoma
    1
    1. scibot 26 Sep 2024
      Plasmid_52962

      DOI: 10.1038/s41467-024-52507-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11413393/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Proteasome and Cul3-Dependent Protein Ubiquitination Is Required for Gli Protein-Mediated Activation of Gene Expression in the Hedgehog Pathway
    1
    1. scibot 25 Sep 2024
      lentiCas9-Blast

      DOI: 10.3390/cells13171496

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    ncbi.nlm.nih.gov/pmc/articles/PMC11394618/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
    1
    1. scibot 25 Sep 2024
      52962

      DOI: 10.1016/j.celrep.2024.114606

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    ncbi.nlm.nih.gov/pmc/articles/PMC11407228/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting SNRNP200-induced splicing dysregulation offers an immunotherapy opportunity for glycolytic triple-negative breast cancer
    1
    1. scibot 25 Sep 2024
      52962

      DOI: 10.1038/s41421-024-00715-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC11405407/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes
    1
    1. scibot 25 Sep 2024
      Addgene_52962

      DOI: 10.1093/bib/bbae452

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    ncbi.nlm.nih.gov/pmc/articles/PMC11410378/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression
    1
    1. scibot 25 Sep 2024
      Addgene_52962

      DOI: 10.1038/s41698-024-00705-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11411125/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma
    1
    1. scibot 25 Sep 2024
      Addgene_52

      DOI: 10.1186/s40478-024-01831-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11304869/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines
    1
    1. scibot 25 Sep 2024
      Addgene_52

      DOI: 10.1186/s13073-024-01341-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC11181638/
  28. www.sciencedirect.com www.sciencedirect.com
    IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
    1
    1. scibot 25 Sep 2024
      RRID:Addgene_52

      DOI: 10.1016/j.cellsig.2023.110684

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    sciencedirect.com/science/article/pii/S0898656823000980
  29. www.sciencedirect.com www.sciencedirect.com
    Protocol to identify receptors of secreted proteins through CRISPR-Cas9 whole-genome screening technology
    1
    1. scibot 17 Sep 2024
      RRID:Addgene_52962

      DOI: 10.1016/j.xpro.2024.103315

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    sciencedirect.com/science/article/pii/S2666166724004805
  30. www.sciencedirect.com www.sciencedirect.com
    MIG6 loss increased RET inhibitor tolerant persister cells in RET-rearranged non-small cell lung cancer
    1
    1. scibot 06 Sep 2024
      #52962, Addgene

      DOI: 10.1016/j.canlet.2024.217220

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    sciencedirect.com/science/article/pii/S0304383524006153
  31. Aug 2024
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Shifts in receptors during submergence of an encephalitic arbovirus
    1
    1. scibot 26 Aug 2024
      52962

      DOI: 10.1038/s41586-024-07740-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11324528/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection
    1
    1. scibot 26 Aug 2024
      52962

      DOI: 10.1371/journal.ppat.1012444

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    ncbi.nlm.nih.gov/pmc/articles/PMC11341029/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Gsk3a reverses immune evasion to enhance immunotherapy in hepatocellular carcinoma
    1
    1. scibot 26 Aug 2024
      lentiCas9-Blast

      DOI: 10.1136/jitc-2024-009642

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    ncbi.nlm.nih.gov/pmc/articles/PMC11340705/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening develops an epigenetic and transcriptional gene signature for risk stratification and target prediction in neuroblastoma
    1
    1. scibot 26 Aug 2024
      52962

      DOI: 10.3389/fcell.2024.1433008

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    ncbi.nlm.nih.gov/pmc/articles/PMC11338898/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Specific multivalent molecules boost CRISPR-mediated transcriptional activation
    1
    1. scibot 26 Aug 2024
      52962

      DOI: 10.1038/s41467-024-51694-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11341856/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates
    1
    1. scibot 26 Aug 2024
      plasmid_52962

      DOI: 10.1101/2024.05.09.593370

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    ncbi.nlm.nih.gov/pmc/articles/PMC11326134/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INAUGURAL ARTICLE by a Recently Elected Academy Member:Small-molecule inhibition of MAP2K4 is synergistic with RAS inhibitors in KRAS-mutant cancers
    1
    1. scibot 26 Aug 2024
      Addgene_52962

      DOI: 10.1073/pnas.2319492121

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    ncbi.nlm.nih.gov/pmc/articles/PMC10907260/
  39. www.sciencedirect.com www.sciencedirect.com
    CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism
    1
    1. scibot 23 Aug 2024
      Addgene Cat#52962

      DOI: 10.1016/j.celrep.2024.114662

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    sciencedirect.com/science/article/pii/S2211124724010131
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    YTHDC1 m6A-dependent and m6A-independent functions converge to preserve the DNA damage response
    1
    1. scibot 21 Aug 2024
      lentiCas9-Blast

      DOI: 10.1038/s44318-024-00153-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC11329685/
  41. www.sciencedirect.com www.sciencedirect.com
    The SW480 cell line as a model of resident and migrating colon cancer stem cells
    1
    1. scibot 21 Aug 2024
      Addgene_52962

      DOI: 10.1016/j.isci.2024.110658

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    sciencedirect.com/science/article/pii/S2589004224018832
  42. www.cell.com www.cell.com
    SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
    1
    1. scibot 18 Aug 2024
      RRID:Addgene_52962

      DOI: 10.1016/j.celrep.2024.114536

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    cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMYD5 is a regulator of the mild hypothermia response
    1
    1. scibot 18 Aug 2024
      Addgene_52962

      DOI: 10.1016/j.celrep.2024.114554

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    ncbi.nlm.nih.gov/pmc/articles/PMC11401508/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs
    1
    1. scibot 17 Aug 2024
      52962

      DOI: 10.1038/s41551-024-01204-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC11310080/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Library‐Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity
    1
    1. scibot 17 Aug 2024
      52962

      DOI: 10.1002/advs.202309004

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    ncbi.nlm.nih.gov/pmc/articles/PMC11321652/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors
    1
    1. scibot 13 Aug 2024
      52962

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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    2024.04.26.591029v1.full-html.html
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription
    1
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  49. www.cell.com www.cell.com
    PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C
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  50. Jul 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiency
    1
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Hippo pathway kinases LATS1 and 2 attenuate cellular responses to heavy metals through phosphorylating MTF1
    1
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      plasmid_52962

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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Netrin signaling mediates survival of dormant epithelial ovarian cancer cells
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  55. www.sciencedirect.com www.sciencedirect.com
    The extracellular matrix integrates mitochondrial homeostasis
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  56. www.embopress.org www.embopress.org
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
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  58. www.biorxiv.org www.biorxiv.org
    Acute BRCAness Induction and AR Signaling Blockage through CDK12/7/9 Degradation Enhances PARP Inhibitor Sensitivity in Prostate Cancer
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  59. www.sciencedirect.com www.sciencedirect.com
    Synthetic lethal CRISPR screen identifies a cancer cell-intrinsic role of PD-L1 in regulation of vulnerability to ferroptosis
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  60. www.biorxiv.org www.biorxiv.org
    Homologous recombination promotes mitotic death to suppress the innate immune response
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: IFNγ mediates the resistance of tumor cells to distinct NK cell subsets
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  62. Jun 2024
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E
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  64. www.cell.com www.cell.com
    An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential
    1
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  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation
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  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The integrin CD11b inhibits MSU-induced NLRP3 inflammasome activation in macrophages and protects mice against MSU-induced joint inflammation
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells
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  71. www.sciencedirect.com www.sciencedirect.com
    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Selective regulation of chemosensitivity in glioblastoma by phosphatidylinositol 3-kinase beta
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  73. May 2024
  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes
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  75. www.sciencedirect.com www.sciencedirect.com
    Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma
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  76. www.nature.com www.nature.com
    De novo generation of multi-target compounds using deep generative chemistry
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition
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  78. elifesciences.org elifesciences.org
    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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  79. www.nature.com www.nature.com
    Pooled multicolour tagging for visualizing subcellular protein dynamics
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Clinical Correlates of Venetoclax-Based Combination Sensitivities to Augment Acute Myeloid Leukemia Therapy
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      Addgene, #52962

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  81. Apr 2024
  82. www.sciencedirect.com www.sciencedirect.com
    GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYADM binds human parechovirus 1 and is essential for viral entry
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency
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  85. www.sciencedirect.com www.sciencedirect.com
    IGSF8 is an innate immune checkpoint and cancer immunotherapy target
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10944492/
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens
    1
    1. scibot 15 Apr 2024
      52962

      DOI: 10.1038/s41594-024-01211-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10948361/
  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14
    1
    1. scibot 15 Apr 2024
      Addgene_52962

      DOI: 10.1101/2024.03.07.583953

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    ncbi.nlm.nih.gov/pmc/articles/PMC10942435/
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A fast-acting lipid checkpoint in G1 prevents mitotic defects
    1
    1. scibot 15 Apr 2024
      plasmid_52962

      DOI: 10.1038/s41467-024-46696-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10948896/
  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of the insulin receptor by insulin-like growth factor 2
    1
    1. scibot 15 Apr 2024
      Addgene_52962

      DOI: 10.1038/s41467-024-46990-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10960814/
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype
    1
    1. scibot 14 Apr 2024
      52962

      DOI: 10.1038/s41467-024-47190-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC10981749/
  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma
    1
    1. scibot 05 Apr 2024
      RRID:Addgene_52962

      DOI: 10.1002/jcb.30542

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    onlinelibrary.wiley.com/doi/10.1002/jcb.30542
  98. www.sciencedirect.com www.sciencedirect.com
    Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer
    1
    1. scibot 04 Apr 2024
      RRID:Addgene_52962

      DOI: 10.1016/j.celrep.2024.114041

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    sciencedirect.com/science/article/pii/S2211124724003693
  99. Mar 2024
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 targeting of passenger single nucleotide variants in haploinsufficient or essential genes expands cancer therapy prospects
    1
    1. scibot 31 Mar 2024
      52,962

      DOI: 10.1038/s41598-024-58094-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10978915/
  101. www.sciencedirect.com www.sciencedirect.com
    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
    1
    1. scibot 29 Mar 2024
      Addgene52962

      DOI: 10.1016/j.crmeth.2024.100737

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    sciencedirect.com/science/article/pii/S2667237524000626
  102. www.sciencedirect.com www.sciencedirect.com
    A gut-derived hormone regulates cholesterol metabolism
    2
    1. scibot 19 Mar 2024
      RRID:Addgene_52962

      DOI: 10.1016/j.cell.2024.02.024

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      RRID:Addgene_52962

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    sciencedirect.com/science/article/pii/S0092867424002265
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic determinants of micronucleus formation in vivo
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    1. scibot 17 Mar 2024
      52962

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    ncbi.nlm.nih.gov/pmc/articles/PMC10917660/
  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells
    1
    1. scibot 17 Mar 2024
      52962

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920982/
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in pancreatic cancer cells
    1
    1. scibot 17 Mar 2024
      Addgene_52962

      DOI: 10.1101/2024.02.15.580539

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    ncbi.nlm.nih.gov/pmc/articles/PMC10896345/
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer
    1
    1. scibot 16 Mar 2024
      Addgene_52962

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    ncbi.nlm.nih.gov/pmc/articles/PMC10528687/
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functionally-instructed modifiers of response to ATR inhibition in experimental glioma
    1
    1. scibot 15 Mar 2024
      RRID:Addgene_52962

      DOI: 10.1186/s13046-024-02995-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10935927/
  108. www.sciencedirect.com www.sciencedirect.com
    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    1
    1. scibot 08 Mar 2024
      Plasmid #52962

      DOI: 10.1016/j.molcel.2024.02.010

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    sciencedirect.com/science/article/pii/S1097276524001291
  109. www.sciencedirect.com www.sciencedirect.com
    In vivo CRISPR screening directly targeting testicular cells
    1
    1. scibot 06 Mar 2024
      Addgene: #52962

      DOI: 10.1016/j.xgen.2024.100510

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    sciencedirect.com/science/article/pii/S2666979X24000375
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracting, filtering and simulating cellular barcodes using CellBarcode tools
    1
    1. scibot 01 Mar 2024
      52962

      DOI: 10.1038/s43588-024-00595-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10899113/
  111. Feb 2024
  112. www.sciencedirect.com www.sciencedirect.com
    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
    1
    1. scibot 29 Feb 2024
      AddgeneCat#52962

      DOI: 10.1016/j.molcel.2024.02.002

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    sciencedirect.com/science/article/pii/S1097276524000984
  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery
    1
    1. scibot 29 Feb 2024
      52962

      DOI: 10.1126/sciadv.adk3127

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    ncbi.nlm.nih.gov/pmc/articles/PMC10889360/
  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons
    1
    1. scibot 15 Feb 2024
      plasmid_52962

      DOI: 10.1126/sciadv.adj4767

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    ncbi.nlm.nih.gov/pmc/articles/PMC10857481/
  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1
    1
    1. scibot 13 Feb 2024
      lentiCas9-Blast

      DOI: 10.1038/s41467-023-44466-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10761827/
  116. www.biorxiv.org www.biorxiv.org
    Saturation resistance profiling of EGFR variants against tyrosine kinase inhibitors using prime editing
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      Addgene_52962

      DOI: 10.1101/2023.12.03.569825

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    biorxiv.org/content/10.1101/2023.12.03.569825v1
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy
    1
    1. scibot 08 Feb 2024
      Plasmid_52962

      DOI: 10.1101/2024.01.14.575614

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    ncbi.nlm.nih.gov/pmc/articles/PMC10827061/
  118. www.sciencedirect.com www.sciencedirect.com
    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
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    1. scibot 06 Feb 2024
      AddgeneCat# 52962

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    sciencedirect.com/science/article/pii/S1097276524000091
  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9
    1
    1. scibot 06 Feb 2024
      52,962

      DOI: 10.1186/s13059-023-03149-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10785552/
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid
    1
    1. scibot 06 Feb 2024
      Addgene_52962

      DOI: 10.1158/2159-8290.CD-22-0982

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524862/
  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiplexed screening reveals how cancer-specific alternative polyadenylation shapes tumor growth in vivo
    1
    1. scibot 04 Feb 2024
      52962

      DOI: 10.1038/s41467-024-44931-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10834521/
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation
    1
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      52962

      DOI: 10.1186/s13045-024-01526-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC10835888/
  123. www.sciencedirect.com www.sciencedirect.com
    Two-step evolution of HIV-1 budding system leading to pandemic in the human population
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    1. scibot 02 Feb 2024
      Addgene_52962

      DOI: 10.1016/j.celrep.2024.113697

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    sciencedirect.com/science/article/pii/S2211124724000251
  124. Jan 2024
  125. www-sciencedirect-com.proxy.uchicago.edu www-sciencedirect-com.proxy.uchicago.edu
    Cell surface RNAs control neutrophil recruitment
    1
    1. scibot 23 Jan 2024
      AddgeneCat# 52962

      DOI: 10.1016/j.cell.2023.12.033

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    www-sciencedirect-com.proxy.uchicago.edu/science/article/pii/S0092867423014435
  126. www.nature.com www.nature.com
    Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodia
    1
    1. scibot 18 Jan 2024
      RRID:Addgene_52962

      DOI: 10.1038/s41598-024-52020-8

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    nature.com/articles/s41598-024-52020-8
  127. www.sciencedirect.com www.sciencedirect.com
    Metabolic reprogramming by histone deacetylase inhibition preferentially targets NRF2-activated tumors
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    1. scibot 11 Jan 2024
      RRID:Addgene_52962

      DOI: 10.1016/j.celrep.2023.113629

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    sciencedirect.com/science/article/pii/S2211124723016406
  128. Dec 2023
  129. www.sciencedirect.com www.sciencedirect.com
    EGFR-activated myofibroblasts promote metastasis of pancreatic cancer
    1
    1. scibot 29 Dec 2023
      Cat# 52962, Addgene

      DOI: 10.1016/j.ccell.2023.12.002

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    sciencedirect.com/science/article/pii/S1535610823004300
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality
    1
    1. scibot 20 Dec 2023
      RRID:Addgene_52962

      DOI: 10.1158/0008-5472.CAN-22-2948

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