1,170 Matching Annotations
  1. Apr 2025
  2. www.sciencedirect.com www.sciencedirect.com
    The imidazoline I2 receptor agonist 2-BFI enhances cytotoxic activity of hydroxychloroquine by modulating oxidative stress , energy-related metabolism and autophagic influx in human colorectal adenocarcinoma cell lines
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    sciencedirect.com/science/article/pii/S0014299925003449
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11962599/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-invasive multi-cancer detection using DNA hypomethylation of LINE-1 retrotransposons
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    pmc.ncbi.nlm.nih.gov/articles/PMC11959274/
  5. 52.53.155.43 52.53.155.43
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    Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage
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    nature.com/articles/s41420-025-02441-9
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    Unveiling transcriptional mechanisms of B7-H3 in breast cancer stem cells through proteomic approaches
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    sciencedirect.com/science/article/pii/S2589004225004791
  8. Mar 2025
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    Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib
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    sciencedirect.com/science/article/pii/S2211124725002372
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    Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers
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    DAP12-associated synthetic antigen receptors enable multi-targeting of T cells with independent chimeric receptors in a small genetic payload
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  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanism Study of Bufalin Reversal of Drug Resistance by Inhibiting Hypoxic Colon Cancer Cell-Induced Polarization of M2 Macrophages
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    pmc.ncbi.nlm.nih.gov/articles/PMC11898227/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11900258/
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    The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis
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    sciencedirect.com/science/article/pii/S2211124725001743
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    Hypoxia inducible factor-1α drives cancer resistance to cuproptosis
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    sciencedirect.com/science/article/pii/S1535610825000674
  18. www.science.org www.science.org
    TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network
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  19. www.cell.com www.cell.com
    IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
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  20. link.springer.com link.springer.com
    Roux-en-Y gastric bypass-associated fecal tyramine promotes colon cancer risk via increased DNA damage, cell proliferation, and inflammation
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70006
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The CD64/CD28/CD3ζ chimeric receptor reprograms T-cell metabolism and promotes T-cell persistence and immune functions while triggering antibody-independent and antibody-dependent cytotoxicity
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  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer
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  24. Feb 2025
  25. www.mdpi.com www.mdpi.com
    Peptide Fractions Extracted from the Hemolymph of Hermetia illucens Inhibit Growth and Motility and Enhance the Effects of Traditional Chemotherapeutics in Human Colorectal Cancer Cells
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    Salicylate-Elicited Activation of AMP-Activated Protein Kinase Directly Triggers Degradation of C-Myc in Colorectal Cancer Cells
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    An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding
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    Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens
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    Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer
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  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
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  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of Lipid Species Signatures in FOLFOXIRI-Resistant Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11818583/
  34. aacrjournals.org aacrjournals.org
    Systematic characterization of p53-regulated long non-coding RNAs across human cancers reveals remarkable heterogeneity among different tumor types
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    Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis mediated epithelial-mesenchymal transition
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    CD24-Targeted NIR-II Fluorescence Imaging Enables Early Detection of Colorectal Neoplasia
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    E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence
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  40. www.cell.com www.cell.com
    Rhodoquinone carries electrons in the mammalian electron transport chain
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    cell.com/cell/fulltext/S0092-8674(24)01420-X
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    The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability
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    sciencedirect.com/science/article/pii/S2211124725000300
  42. Jan 2025
  43. academic.oup.com academic.oup.com
    HuR/miR-124-3p/VDR complex bridges lipid metabolism and tumor development in colorectal cancer
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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgae061/7747601
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination
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    pmc.ncbi.nlm.nih.gov/articles/PMC11763143/
  45. www.sciencedirect.com www.sciencedirect.com
    Mina53 catalyzes arginine demethylation of p53 to promote tumor growth
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  46. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17374
  47. rupress.org rupress.org
    TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells
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    rupress.org/jcb/article/224/3/e202109010/277212/TanGIBLE-A-selective-probe-for-evaluating
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    A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
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  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695814/
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    TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress
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  51. www.science.org www.science.org
    Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system
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    mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase
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  53. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    A non-canonical role for the tyrosyl tRNA synthetase: YARS regulates senescence induction and escape and controls the transcription of LIN9
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17381
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    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    Unraveling the mechanism of microRNA-134 in colon cancer progression: targeting KRAS and PIK3CA for cell cycle control and histone deacetylase regulation.
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    The human zinc-binding cysteine proteome
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    Anticancer effect of a single-chain variable fragment against pro-matrix metalloproteinase-7 in colon cancer
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    IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth
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  60. Dec 2024
  61. www.cell.com www.cell.com
    The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis
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    cell.com/current-biology/abstract/S0960-9822(24)01575-6
  62. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202414437
  63. www.researchsquare.com www.researchsquare.com
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    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance
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    TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
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    RPF2 and CARM1 cooperate to enhance colorectal cancer metastasis via the AKT/GSK-3β signaling pathway.
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    Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy
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    Molecular tag for promoting N-glycan maturation in the cargo receptor-mediated secretion pathway
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  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins
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  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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  74. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epigenetic Suppression of miR-137 Induces RNF4 Expression, Facilitating Wnt Signaling in Colorectal Cancer
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23859
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    CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
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    LncRNA DANCR-V1 is a novel regulator of Wnt/β-catenin and TGF-β1/SMAD signaling pathways in colorectal cancer: an in vitro and in silico study
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    Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer
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    Circular RNAs trigger nonsense-mediated mRNA decay
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    Glucocorticoid promotes metastasis of colorectal cancer via co-regulation of glucocorticoid receptor and TET2
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35285
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimized reporters for multiplexed detection of transcription factor activity
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    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    Biglycan promotes tumour proliferation and invasion in human colon cancers
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  85. www.nature.com www.nature.com
    The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression
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    Activity-dependent COX-2 proteolysis modulates aerobic respiration and proliferation in a prostaglandin-independent manner
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  87. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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  88. Nov 2024
  89. pubs.acs.org pubs.acs.org
    Evaluation of the Combinatory Anticancer Effect of Chemotherapeutic Compounds and Prodigiosin against HCT-116, LoVo, and A549 Cell lines
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    pubs.acs.org/doi/10.1021/acsomega.4c04760
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histone-acetyl epigenome regulates TGF-β pathway-associated chemoresistance in colorectal cancer
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  190. Apr 2024
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