1,143 Matching Annotations
  1. Feb 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens
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    sciencedirect.com/science/article/pii/S1097276525000565
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    Targeting both the enzymatic and non-enzymatic functions of DHODH as a therapeutic vulnerability in c-Myc-driven cancer
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    sciencedirect.com/science/article/pii/S2211124725000981
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair
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    pmc.ncbi.nlm.nih.gov/articles/PMC11831107/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of Lipid Species Signatures in FOLFOXIRI-Resistant Colorectal Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11818583/
  6. aacrjournals.org aacrjournals.org
    Systematic characterization of p53-regulated long non-coding RNAs across human cancers reveals remarkable heterogeneity among different tumor types
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    aacrjournals.org/mcr/article/22/6/555/745427/Systematic-Characterization-of-p53-Regulated-Long
  7. aacrjournals.org aacrjournals.org
    Serotonin receptor HTR2B facilitates colorectal cancer metastasis via CREB1-ZEB1 axis mediated epithelial-mesenchymal transition
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    aacrjournals.org/mcr/article/22/6/538/745428/Serotonin-Receptor-HTR2B-Facilitates-Colorectal
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    ccr-24-2669-html.html
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    CD24-Targeted NIR-II Fluorescence Imaging Enables Early Detection of Colorectal Neoplasia
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    aacrjournals.org/cancerres/article/84/23/4099/750177/CD24-Targeted-NIR-II-Fluorescence-Imaging-Enables
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    E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence
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    pmc.ncbi.nlm.nih.gov/articles/PMC11805377/
  12. www.cell.com www.cell.com
    Rhodoquinone carries electrons in the mammalian electron transport chain
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    cell.com/cell/fulltext/S0092-8674(24)01420-X
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    The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability
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    sciencedirect.com/science/article/pii/S2211124725000300
  14. Jan 2025
  15. academic.oup.com academic.oup.com
    HuR/miR-124-3p/VDR complex bridges lipid metabolism and tumor development in colorectal cancer
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    academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgae061/7747601
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination
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    pmc.ncbi.nlm.nih.gov/articles/PMC11763143/
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    Mina53 catalyzes arginine demethylation of p53 to promote tumor growth
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    sciencedirect.com/science/article/pii/S2211124725000130
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17374
  19. rupress.org rupress.org
    TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells
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    rupress.org/jcb/article/224/3/e202109010/277212/TanGIBLE-A-selective-probe-for-evaluating
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    A constitutive interferon-high immunophenotype defines response to immunotherapy in colorectal cancer
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    sciencedirect.com/science/article/pii/S1535610824004835
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11695814/
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    TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress
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    sciencedirect.com/science/article/pii/S2211124724015183
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    Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system
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    science.org/doi/10.1126/sciadv.adq6652
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    mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase
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    sciencedirect.com/science/article/pii/S2211124724015304
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    A non-canonical role for the tyrosyl tRNA synthetase: YARS regulates senescence induction and escape and controls the transcription of LIN9
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17381
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    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    sciencedirect.com/science/article/pii/S2451945624004896
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.17422
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    Unraveling the mechanism of microRNA-134 in colon cancer progression: targeting KRAS and PIK3CA for cell cycle control and histone deacetylase regulation.
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    sciencedirect.com/science/article/pii/S0014482724004762
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    The human zinc-binding cysteine proteome
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    Anticancer effect of a single-chain variable fragment against pro-matrix metalloproteinase-7 in colon cancer
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    sciencedirect.com/science/article/pii/S0945053X24001513
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    IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth
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  32. Dec 2024
  33. www.cell.com www.cell.com
    The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis
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    cell.com/current-biology/abstract/S0960-9822(24)01575-6
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    Nerve Growth Factor Signaling Promotes Nuclear Translocation of TRAF4 to Enhance Tumor Stemness and Metastatic Dormancy Via C-Jun-mediated IL-8 Autocrine
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    onlinelibrary.wiley.com/doi/full/10.1002/advs.202414437
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    Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
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    nature.com/articles/s41418-024-01439-7
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody-Drug Conjugates Targeting the EGFR Ligand Epiregulin Elicit Robust Anti-Tumor Activity in Colorectal Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11601497/
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    DDX39A resolves replication fork-associated RNA-DNA hybrids to balance fork protection and cleavage for genomic stability maintenance
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    TurboCas: A method for locus-specific labeling of genomic regions and isolating their associated protein interactome
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    RPF2 and CARM1 cooperate to enhance colorectal cancer metastasis via the AKT/GSK-3β signaling pathway.
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    sciencedirect.com/science/article/pii/S0014482724004658
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    Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy
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    sciencedirect.com/science/article/pii/S0925443924006240
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    Molecular tag for promoting N-glycan maturation in the cargo receptor-mediated secretion pathway
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    sciencedirect.com/science/article/pii/S2589004224026841
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins
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    pmc.ncbi.nlm.nih.gov/articles/PMC11630818/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11632859/
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Epigenetic Suppression of miR-137 Induces RNF4 Expression, Facilitating Wnt Signaling in Colorectal Cancer
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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23859
  47. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    febs.onlinelibrary.wiley.com/doi/10.1111/febs.17350
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    CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
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    sciencedirect.com/science/article/pii/S1097276524009493
  49. link.springer.com link.springer.com
    LncRNA DANCR-V1 is a novel regulator of Wnt/β-catenin and TGF-β1/SMAD signaling pathways in colorectal cancer: an in vitro and in silico study
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    link.springer.com/article/10.1007/s11033-024-10128-0
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    Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer
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    sciencedirect.com/science/article/pii/S2213231724004361
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    Circular RNAs trigger nonsense-mediated mRNA decay
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  52. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Glucocorticoid promotes metastasis of colorectal cancer via co-regulation of glucocorticoid receptor and TET2
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35285
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimized reporters for multiplexed detection of transcription factor activity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11667439/
  54. www.sciencedirect.com www.sciencedirect.com
    DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states
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    sciencedirect.com/science/article/pii/S1097276524009146
  55. www.sciencedirect.com www.sciencedirect.com
    p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis
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    sciencedirect.com/science/article/pii/S1097276524009183
  56. journals.sagepub.com journals.sagepub.com
    Biglycan promotes tumour proliferation and invasion in human colon cancers
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    journals.sagepub.com/doi/full/10.1177/03000605241300067
  57. www.nature.com www.nature.com
    The dysadherin/MMP9 axis modifies the extracellular matrix to accelerate colorectal cancer progression
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    nature.com/articles/s41467-024-54920-9
  58. www.sciencedirect.com www.sciencedirect.com
    Activity-dependent COX-2 proteolysis modulates aerobic respiration and proliferation in a prostaglandin-independent manner
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    sciencedirect.com/science/article/pii/S2589004224026282
  59. www.sciencedirect.com www.sciencedirect.com
    B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies
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    sciencedirect.com/science/article/pii/S235239642400495X
  60. Nov 2024
  61. pubs.acs.org pubs.acs.org
    Evaluation of the Combinatory Anticancer Effect of Chemotherapeutic Compounds and Prodigiosin against HCT-116, LoVo, and A549 Cell lines
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    pubs.acs.org/doi/10.1021/acsomega.4c04760
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Histone-acetyl epigenome regulates TGF-β pathway-associated chemoresistance in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC11585898/
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    Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint
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    sciencedirect.com/science/article/pii/S107476132400493X
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inter-chromosomal contacts demarcate genome topology along a spatial gradient
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    pmc.ncbi.nlm.nih.gov/articles/PMC11557711/
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    Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress
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    sciencedirect.com/science/article/pii/S0092867424011887
  66. 52.53.155.43 52.53.155.43
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  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Replication stress induces POLQ-mediated structural variant formation throughout common fragile sites after entry into mitosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11541566/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance
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    pmc.ncbi.nlm.nih.gov/articles/PMC11539641/
  69. Oct 2024
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443776/
  71. www.biorxiv.org www.biorxiv.org
    Metabolic mapping of the human solute carrier superfamily
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    biorxiv.org/content/10.1101/2024.09.23.614124v1
  72. aacrjournals.org aacrjournals.org
    Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation
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    aacrjournals.org/cancerimmunolres/article/9/9/1008/666146/Overproduction-of-Gastrointestinal-5-HT-Promotes
  73. aacrjournals.org aacrjournals.org
    2-Hydroxylation of Fatty Acids Represses Colorectal Tumorigenesis and Metastasis via the YAP Transcriptional Axis
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    aacrjournals.org/cancerres/article/81/2/289/649623/2-Hydroxylation-of-Fatty-Acids-Represses
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    Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division
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  75. Sep 2024
  76. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    CASCADES, a novel SOX2 super-enhancer-associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13735
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13708
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia
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    ncbi.nlm.nih.gov/pmc/articles/PMC11424096/
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRAP1 modulates mitochondrial biogenesis via PGC-1α/TFAM signalling pathway in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11416412/
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    Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
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    sciencedirect.com/science/article/pii/S1535610824003180
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel immunotherapeutics against LGR5 to target multiple cancer types
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    ncbi.nlm.nih.gov/pmc/articles/PMC11393416/
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    Tumour-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signalling.
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    sciencedirect.com/science/article/pii/S2589004224019266
  83. www.biorxiv.org www.biorxiv.org
    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    biorxiv.org/content/10.1101/2024.09.05.611458v1
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    14-3-3σ restricts YY1 to the cytoplasm, promoting therapy resistance, and tumor progression in colorectal cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35176
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11372367/
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    TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
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    sciencedirect.com/science/article/pii/S0092867424009115
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Proteogenomic Profiling Reveals the Molecular Characteristics of Colorectal Cancer at Distinct Stages of Progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11372369/
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    IDO1 inhibitors are synergistic with CXCL10 agonists in inhibiting colon cancer growth
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    sciencedirect.com/science/article/pii/S0753332224012976
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    Synergistic Anti-tumorigenic Effect of Diosmetin in Combination with 5-Fluorouracil on Human Colon Cancer Xenografts in Nude Mice
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    sciencedirect.com/science/article/pii/S0006291X24012130
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    Five miRNAs identified in fucosylated extracellular vesicles as non-invasive diagnostic signatures for hepatocellular carcinoma
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