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  1. Last 7 days
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    A p85 isoform switch enhances PI3K activation on endosomes by a MAP4- and PI3P-dependent mechanism
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    RAD51 restricts DNA over-replication from re-activated origins
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    Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2
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      DOI: 10.7554/eLife.91678

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    Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties
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  6. Apr 2024
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    FEBS Press
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    SRRM2 phase separation drives assembly of nuclear speckle subcompartments
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    Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator
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    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
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    p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response
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  12. Mar 2024
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    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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    Eosinophils exhibit a unique transcriptional signature and increased sensitivity to IL-3-induced activation in response to colorectal cancer cells
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    Reduced chemokine C‐C motif ligand 1 expression may negatively regulate colorectal cancer progression at liver metastatic sites
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    Shaping immune landscape of colorectal cancer by cholesterol metabolites
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    A gut-derived hormone regulates cholesterol metabolism
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    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
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    RAD51 restricts DNA over-replication from re-activated origins
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    RAD51 restricts DNA over-replication from re-activated origins
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    KRAS silencing impacts chromatin organization and transcriptional activity in colorectal cancer cells
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
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  24. Feb 2024
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    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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    Specialized replication mechanisms maintain genome stability at human centromeres
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    GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines
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    RNF4 prevents genomic instability caused by chronic DNA under-replication
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
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    Stratification of Colorectal Patients Based on Survival Analysis Shows the Value of Consensus Molecular Subtypes and Reveals the CBLL1 Gene as a Biomarker of CMS2 Tumours
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    Mieap forms membrane-less organelles involved in cardiolipin metabolism
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    Functionalized tetrahedral DNA frameworks for the capture of circulating tumor cells
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    Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites
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    Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor
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    Locked Nucleic Acid Oligonucleotides Facilitate RNA•LNA-RNA Triple-Helix Formation and Reduce MALAT1 Levels
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    Autophagy-dependent alternative splicing of ribosomal protein S24 produces a more stable isoform that aids in hypoxic cell survival
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  40. Jan 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells
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    Non-alcoholic fatty liver disease promotes liver metastasis of colorectal cancer via fatty acid synthase dependent EGFR palmitoylation
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      DOI: 10.1038/s41420-023-01770-x

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  43. www.cell.com www.cell.com
    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning
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  45. www.sciencedirect.com www.sciencedirect.com
    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effector program of human CD8 T cells supports tissue remodeling
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    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
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    A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer
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  52. Dec 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1
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  55. www.sciencedirect.com www.sciencedirect.com
    Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells
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    Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies
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  57. www.tandfonline.com www.tandfonline.com
    Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RPF2 mediates the CARM1‑MYCN axis to promote chemotherapy resistance in colorectal cancer cells
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  59. pubs.acs.org pubs.acs.org
    Selective Tumor Hypoxia Targeting Using M75 Antibody Conjugated Photothermally Active MoOx Nanoparticles
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      CCL-247, ATCC

      DOI: 10.1021/acsomega.3c01934

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  60. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transcript CD81-215 may be a long noncoding RNA of stromal origin with tumor-promoting role in colon cancer
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
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  62. link.springer.com link.springer.com
    Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
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  63. www.biorxiv.org www.biorxiv.org
    A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation
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      DOI: 10.1101/2023.11.15.567291

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  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Revisiting the role of endogenous STAT3 in HPV-positive cervical cancer cells
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  65. Nov 2023
  66. www.sciencedirect.com www.sciencedirect.com
    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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  67. www.sciencedirect.com www.sciencedirect.com
    Targeted perturbation of signaling-driven condensates
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  68. link.springer.com link.springer.com
    Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability
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    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development
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    Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis
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  74. link.springer.com link.springer.com
    TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
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    In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Matrix stiffness triggers lipid metabolic crosstalk between tumor and stromal cells to mediate bevacizumab resistance in colorectal cancer liver metastases
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma
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  78. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  79. www.sciencedirect.com www.sciencedirect.com
    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
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  80. Oct 2023
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    The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation
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    BRD4-binding enhancer promotes CRC progression by interacting with YY1 to activate the Wnt pathway through upregulation of TCF7L2
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WIP1 is a novel specific target for growth hormone action
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  84. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7
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  85. www.mdpi.com www.mdpi.com
    Studying the Association of TKS4 and CD2AP Scaffold Proteins and Their Implications in the Partial Epithelial–Mesenchymal Transition (EMT) Process
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells
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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High-content microscopy reveals a morphological signature of bortezomib resistance
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  89. 52.53.155.43 52.53.155.43
    FEBS Press
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  90. 52.53.155.43 52.53.155.43
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1)
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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Solid Cancers with a Cancer-Specific Monoclonal Antibody to Surface Expressed Aberrantly O-glycosylated Proteins
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  93. Sep 2023
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence
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  95. www.sciencedirect.com www.sciencedirect.com
    Natural killer cell therapy targeting cancer stem cells: Old wine in a new bottle
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  96. 52.53.155.43 52.53.155.43
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenomic analysis reveals a unique DNA methylation program of metastasis-competent circulating tumor cells in colorectal cancer
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
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  99. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Kleszcz-html.html
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  100. Aug 2023
  101. www.sciencedirect.com www.sciencedirect.com
    exo-FISH: Protocol for detecting DNA breaks in repetitive regions of mammalian genomes
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  102. 52.53.155.43 52.53.155.43
    Nuclear transport surveillance of p53 by nuclear pores in glioblastoma
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  105. dx.doi.org dx.doi.org
    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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  106. elifesciences.org elifesciences.org
    Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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  108. Jul 2023
  109. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer
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  112. www.nature.com www.nature.com
    High-throughput Oligopaint screen identifies druggable 3D genome regulators
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  113. www.sciencedirect.com www.sciencedirect.com
    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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  114. www.nature.com www.nature.com
    E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
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  115. www.sciencedirect.com www.sciencedirect.com
    TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
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    Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER
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  117. 52.53.155.43 52.53.155.43
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  118. Jun 2023
  119. www.sciencedirect.com www.sciencedirect.com
    Protocol to analyze endogenous translesion DNA synthesis in single mammalian cells
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    The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3
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  121. www.embopress.org www.embopress.org
    DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres
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  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Released dsDNA‐triggered inflammasomes serve as intestinal radioprotective targets
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  123. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
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  124. 52.53.155.43 52.53.155.43
    The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence
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    A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
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    Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks
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    A novel EGFR Inhibitor, HNPMI regulates apoptosis and oncogenesis by modulating BCL-2/BAX and p53 in colon cancer
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  134. www.science.org www.science.org
    Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
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    The dicarbonyl electrophile scavenger 2-hydroxybenzylamine (2-HOBA) prevents colorectal carcinogenesis and reduces tumor growth
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  146. www.biorxiv.org www.biorxiv.org
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    Fanconi anemia-associated chromosomal radial formation is dependent on POLθ-mediated alternative end joining
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    Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models
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    Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950
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    An integrated multi-omics analysis of rectal cancer patients identified POU2F3 as a putative druggable target and entinostat as a cytotoxic enhancer of 5-Fluorouracil
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    Dual role of sprouty2 as an inhibitor of RAS/ERK-driven proliferation and a promoter of cancer invasion in KRAS wild-type colorectal cancer
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  163. www.nature.com www.nature.com
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
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    Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in the enteric nervous system
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    Optimized Antimicrobial Peptide Jelleine-I Derivative Br-J-I Inhibits Fusobacterium Nucleatum to Suppress Colorectal Cancer Progression
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    PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index
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    ANGPTL4-Mediated Promotion of Glycolysis Facilitates the Colonization of Fusobacterium nucleatum in Colorectal Cancer
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  190. Dec 2022
  191. link.springer.com link.springer.com
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    The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates
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  200. aacrjournals.org aacrjournals.org
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  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34289
  210. www.sciencedirect.com www.sciencedirect.com
    Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells
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    1. scibot 03 Nov 2022
      CCL-247

      DOI: 10.1016/j.molcel.2022.10.005

      Resource: (KCB Cat# KCB 200706YJ, RRID:CVCL_0291)

      Curator: @a5munoz

      SciCrunch record: RRID:CVCL_0291

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    sciencedirect.com/science/article/pii/S1097276522009625
  211. 52.53.155.43 52.53.155.43
    ABCC10-mediated Oxaliplatin resistance in colorectal cancer cells was alleviated by intense endoplasmic reticulum stress (ERS) / IRE1α
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    1. scibot 03 Nov 2022
      RRID:CVCL_0291

      DOI: 10.21203/rs.3.rs-1947659/v1

      Resource: (KCB Cat# KCB 200706YJ, RRID:CVCL_0291)

      Curator: @scibot

      SciCrunch record: RRID:CVCL_0291

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      RRID:CVCL_0291
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    52.53.155.43/ee9544f92d24a784e439b5f8ccd0815fd1dd27bc/f0a3133f-5e3c-40fc-b375-09b76f1fe1f4-html.html