1,106 Matching Annotations
  1. Oct 2021
  2. www.sciencedirect.com www.sciencedirect.com
    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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      DOI: 10.1016/j.celrep.2021.109804

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    sciencedirect.com/science/article/pii/S221112472101264X
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    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109854

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    sciencedirect.com/science/article/pii/S2211124721013218
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    1. scibot 21 Oct 2021
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      DOI: 10.1016/j.celrep.2021.109870

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    sciencedirect.com/science/article/pii/S2211124721013371
  5. josr-online.biomedcentral.com josr-online.biomedcentral.com
    Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway
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    1. scibot 19 Oct 2021
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      DOI: 10.1186/s13018-021-02715-9

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    josr-online.biomedcentral.com/articles/10.1186/s13018-021-02715-9
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    A role for AKT1 in nonsense-mediated mRNA decay
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    1. scibot 15 Oct 2021
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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab882/6389627
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bioenergetic Requirements and Spatiotemporal Profile of Nerve Growth Factor Induced PI3K-Akt Signaling Along Sensory Axons
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      DOI: 10.3389/fnmol.2021.726331

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    ncbi.nlm.nih.gov/pmc/articles/PMC8497901/
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    Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome
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    sciencedirect.com/science/article/pii/S2211124721012663
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    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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    sciencedirect.com/science/article/pii/S2211124721012444
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    1. scibot 05 Oct 2021
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    sciencedirect.com/science/article/pii/S1534580721007267
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    Wnt5a Regulates Junctional Function of Sertoli cells Through PCP-Mediated Effects on mTORC1 and mTORC2
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    1. scibot 01 Oct 2021
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      DOI: 10.1210/endocr/bqab149

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    academic.oup.com/endo/article/162/10/bqab149/6334711
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    Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer
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    1. scibot 01 Oct 2021
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    clincancerres.aacrjournals.org/content/27/18/5096
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    Involvement of multiple scavenger receptors in advanced glycation end product-induced vessel tube formation in endothelial cells
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    1. scibot 01 Oct 2021
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      DOI: 10.1016/j.yexcr.2021.112857

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    sciencedirect.com/science/article/pii/S0014482721004110
  14. Sep 2021
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice
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    1. scibot 28 Sep 2021
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      DOI: 10.1016/j.isci.2021.103089

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    ncbi.nlm.nih.gov/pmc/articles/PMC8449244/
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
    1
    1. scibot 28 Sep 2021
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    sciencedirect.com/science/article/pii/S1534580721006821
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
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    1. scibot 22 Sep 2021
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      DOI: 10.7554/eLife.68843

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    ncbi.nlm.nih.gov/pmc/articles/PMC8445623/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production
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    ncbi.nlm.nih.gov/pmc/articles/PMC8426284/
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    Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
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    sciencedirect.com/science/article/pii/S2211124721011189
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    SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages
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      DOI: 10.1016/j.celrep.2021.109662

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    sciencedirect.com/science/article/pii/S2211124721011062
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
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    1. scibot 04 Sep 2021
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      DOI: 10.1016/j.isci.2021.102983

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    ncbi.nlm.nih.gov/pmc/articles/PMC8403734/
  22. www.sciencedirect.com www.sciencedirect.com
    UV-induced reduction in Polycomb repression promotes epidermal pigmentation
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    1. scibot 03 Sep 2021
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      DOI: 10.1016/j.devcel.2021.08.006

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    sciencedirect.com/science/article/pii/S1534580721006365
  23. Aug 2021
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
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    1. scibot 25 Aug 2021
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      DOI: 10.1016/j.isci.2021.102942

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    ncbi.nlm.nih.gov/pmc/articles/PMC8369003/
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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    sciencedirect.com/science/article/pii/S1534580721006341
  26. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.15442

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15442
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    Coordination of tumor growth and host wasting by tumor-derived Upd3
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    sciencedirect.com/science/article/pii/S2211124721009876
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    NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms
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      DOI: 10.1016/j.celrep.2021.109515

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    sciencedirect.com/science/article/pii/S2211124721009451
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    Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
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      DOI: 10.1016/j.xcrm.2021.100373

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    sciencedirect.com/science/article/pii/S2666379121002275
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    sciencedirect.com/science/article/pii/S2211383521003051
  31. academic.oup.com academic.oup.com
    Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects
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      DOI: 10.1210/endocr/bqab142

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    academic.oup.com/endo/article/162/10/bqab142/6321973
  32. www.nature.com www.nature.com
    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
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      DOI: 10.1038/s41467-021-24821-2

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    nature.com/articles/s41467-021-24821-2
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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      DOI: 10.1016/j.immuni.2021.07.009

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    sciencedirect.com/science/article/pii/S1074761321002958
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    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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    sciencedirect.com/science/article/pii/S1097276521005906
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    Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
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    ncbi.nlm.nih.gov/pmc/articles/PMC8313754/
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    Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
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    sciencedirect.com/science/article/pii/S2211124721008639
  37. www.physiology.org www.physiology.org
    A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes
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      DOI: 10.1152/ajpcell.00504.2018

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    physiology.org/doi/abs/10.1152/ajpcell.00504.2018
  38. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2019.03.067

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    sciencedirect.com/science/article/pii/S2211124719303973
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    Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress
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    sciencedirect.com/science/article/pii/S0889159121002968
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      DOI: 10.1111/jnc.14081

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14081
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      DOI: 10.1111/bph.14553

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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.28527

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    ncbi.nlm.nih.gov/pmc/articles/PMC5553934/
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    ncbi.nlm.nih.gov/pmc/articles/PMC5761600/
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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    Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma
    1
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  87. www.sciencedirect.com www.sciencedirect.com
    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
    1
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      Phospho-Akt (Ser473) (D9E) XPu00a0Rabbit mAb

      DOI: 10.1016/j.immuni.2019.03.005

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    sciencedirect.com/science/article/pii/S1074761319300950
  88. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.immuni.2018.09.018

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    sciencedirect.com/science/article/pii/S1074761318304333
  89. www.sciencedirect.com www.sciencedirect.com
    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
    1
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      DOI: 10.1016/j.molcel.2017.09.024

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  90. www.sciencedirect.com www.sciencedirect.com
    Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling
    1
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      RRID:AB_2315049

      DOI: 10.1016/j.ccell.2018.11.016

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    sciencedirect.com/science/article/pii/S1535610818305373
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  93. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PTEN knockdown alters dendritic spine/protrusion morphology, not density
    1
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      Anti-pAKTMonoclonalRabbitEpitope surrounds serine 473 of AKT sequence1:200Cell Signaling4060AB_916027

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    onlinelibrary.wiley.com/doi/10.1002/cne.23488/full
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  95. www.cell.com www.cell.com
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    cell.com/developmental-cell/abstract/S1534-5807(17)30871-7
  96. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14311
  97. www.heliyon.com www.heliyon.com
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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  100. www.sciencedirect.com www.sciencedirect.com
    Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis
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      DOI: 10.1016/j.stem.2019.09.009

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    sciencedirect.com/science/article/pii/S1934590919304205
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    OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling
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      DOI: 10.1016/j.ebiom.2019.02.051

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    sciencedirect.com/science/article/pii/S2352396419301306
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      DOI: 10.1016/j.neuron.2018.10.051

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    Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance
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      DOI: 10.1016/j.celrep.2018.11.015

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    Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway
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      AB_916024

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    Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
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    Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms
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      DOI: 10.1210/jendso/bvab102

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    Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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      DOI: 10.1016/j.molcel.2021.06.017

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    Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability
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      DOI: 10.1016/j.celrep.2021.109327

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    IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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    Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
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    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
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  118. www.embopress.org www.embopress.org
    Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy
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    β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275
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    A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
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    Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library
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    TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease
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    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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    Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms
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    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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    NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407
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    Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM
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    Hdac9 inhibits medial artery calcification through down-regulation of Osterix
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells
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    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
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    A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
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    Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
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    An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping
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    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
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    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
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