1,170 Matching Annotations
  1. Mar 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A gut-derived hormone regulates cholesterol metabolism
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    sciencedirect.com/science/article/pii/S0092867424002265
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10933359/
  4. www.embopress.org www.embopress.org
    RAD51 restricts DNA over-replication from re-activated origins
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    embopress.org/doi/full/10.1038/s44318-024-00038-z
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    RAD51 restricts DNA over-replication from re-activated origins
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    embopress.org/doi/10.1038/s44318-024-00038-z
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KRAS silencing impacts chromatin organization and transcriptional activity in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10896403/
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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    sciencedirect.com/science/article/pii/S1097276524001291
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    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
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    sciencedirect.com/science/article/pii/S2589004224004097
  9. Feb 2024
  10. 52.53.155.43 52.53.155.43
    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    52.53.155.43/4a182fdd92d1ce35b13f136f7657c6c9ec6a6224/2023.10.02.560521v1.full-html.html
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    sciencedirect.com/science/article/pii/S2666379124000570
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10866396/
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    Specialized replication mechanisms maintain genome stability at human centromeres
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    sciencedirect.com/science/article/pii/S1097276524000546
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    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/full/10.1111/febs.17080
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    GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines
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    onlinelibrary.wiley.com/doi/10.1002/ijc.34865
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    RNF4 prevents genomic instability caused by chronic DNA under-replication
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    sciencedirect.com/science/article/pii/S1568786424000223
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
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    sciencedirect.com/science/article/pii/S2211124724001062
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    Stratification of Colorectal Patients Based on Survival Analysis Shows the Value of Consensus Molecular Subtypes and Reveals the CBLL1 Gene as a Biomarker of CMS2 Tumours
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    mdpi.com/1422-0067/25/3/1919
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mieap forms membrane-less organelles involved in cardiolipin metabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC10845071/
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    Functionalized tetrahedral DNA frameworks for the capture of circulating tumor cells
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    link.springer.com/article/10.1038/s41596-023-00943-3
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    Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites
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    sciencedirect.com/science/article/pii/S2666979X24000259
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    Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor
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    sciencedirect.com/science/article/pii/S2451945624000382
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    Locked Nucleic Acid Oligonucleotides Facilitate RNA•LNA-RNA Triple-Helix Formation and Reduce MALAT1 Levels
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    mdpi.com/1422-0067/25/3/1630
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    Autophagy-dependent alternative splicing of ribosomal protein S24 produces a more stable isoform that aids in hypoxic cell survival
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14804
  25. Jan 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10805602/
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    Non-alcoholic fatty liver disease promotes liver metastasis of colorectal cancer via fatty acid synthase dependent EGFR palmitoylation
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    nature.com/articles/s41420-023-01770-x
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    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
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    cell.com/cell-reports/abstract/S2211-1247(23)01438-9
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    MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning
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    ncbi.nlm.nih.gov/pmc/articles/PMC10800076/
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    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    sciencedirect.com/science/article/pii/S2211124724000160
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    sciencedirect.com/science/article/pii/S2666379123006031
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effector program of human CD8 T cells supports tissue remodeling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10791561/
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    Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S2666379123006055
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    A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
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    sciencedirect.com/science/article/pii/S1535610823004440
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 NSP14 MTase activity is critical for inducing canonical NF-κB activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10776897/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The feedback loop of EFTUD2/c-MYC impedes chemotherapeutic efficacy by enhancing EFTUD2 transcription and stabilizing c-MYC protein in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10759692/
  37. Dec 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulation of homologous recombination repair by MRE11 lactylation
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    sciencedirect.com/science/article/pii/S009286742301276X
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10723637/
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    Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells
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    sciencedirect.com/science/article/pii/S2451945623004233
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    Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies
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    sciencedirect.com/science/article/pii/S2666379123005050
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    Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation
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    tandfonline.com/doi/abs/10.1080/14756366.2023.2290458
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RPF2 mediates the CARM1‑MYCN axis to promote chemotherapy resistance in colorectal cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10696550/
  44. pubs.acs.org pubs.acs.org
    Selective Tumor Hypoxia Targeting Using M75 Antibody Conjugated Photothermally Active MoOx Nanoparticles
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    pubs.acs.org/doi/full/10.1021/acsomega.3c01934
  45. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transcript CD81-215 may be a long noncoding RNA of stromal origin with tumor-promoting role in colon cancer
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    onlinelibrary.wiley.com/doi/full/10.1002/cbf.3890
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metastatic or xenograft colorectal cancer induce divergent anabolic deficits and pro-inflammatory effectors of muscle wasting in a tumor-type dependent manner
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    ncbi.nlm.nih.gov/pmc/articles/PMC9678410/
  47. www.nature.com www.nature.com
    Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho
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    nature.com/articles/s41388-023-02904-2
  48. www.biorxiv.org www.biorxiv.org
    A novel antagonist of the CCL5/CCR5 axis suppresses the tumor growth and metastasis of triple-negative breast cancer by CCR5-YAP1 regulation
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    biorxiv.org/content/10.1101/2023.11.15.567291v1
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    Revisiting the role of endogenous STAT3 in HPV-positive cervical cancer cells
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    onlinelibrary.wiley.com/doi/10.1002/jmv.29230
  50. Nov 2023
  51. www.sciencedirect.com www.sciencedirect.com
    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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    sciencedirect.com/science/article/pii/S1097276523008493
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    Targeted perturbation of signaling-driven condensates
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    sciencedirect.com/science/article/pii/S1097276523008602
  53. link.springer.com link.springer.com
    Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak
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    link.springer.com/article/10.1007/s10495-023-01917-2
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability
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    ncbi.nlm.nih.gov/pmc/articles/PMC10651173/
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    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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    sciencedirect.com/science/article/pii/S2451945623003719
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
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    sciencedirect.com/science/article/pii/S2211124723013645
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    Deficiency of BCAT2-mediated branched-chain amino acid catabolism promotes colorectal cancer development
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    sciencedirect.com/science/article/pii/S0925443923003071
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    Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis
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    sciencedirect.com/science/article/pii/S1074761323004442
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    TCOF1 promotes the colorectal cancer progression by stabilizing β-catenin
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    link.springer.com/article/10.1007/s12032-023-02218-z
  60. www.sciencedirect.com www.sciencedirect.com
    In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin
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  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Matrix stiffness triggers lipid metabolic crosstalk between tumor and stromal cells to mediate bevacizumab resistance in colorectal cancer liver metastases
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618741/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618738/
  63. aacrjournals.org aacrjournals.org
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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    aacrjournals.org/cancerdiscovery/article/13/11/2412/729848/MRTX1719-Is-an-MTA-Cooperative-PRMT5-Inhibitor
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    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
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    sciencedirect.com/science/article/pii/S1074761323004181
  65. Oct 2023
  66. www.sciencedirect.com www.sciencedirect.com
    The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation
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    BRD4-binding enhancer promotes CRC progression by interacting with YY1 to activate the Wnt pathway through upregulation of TCF7L2
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    sciencedirect.com/science/article/pii/S0006295223004689
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WIP1 is a novel specific target for growth hormone action
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    ncbi.nlm.nih.gov/pmc/articles/PMC10590974/
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    Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7
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    febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13537
  70. www.mdpi.com www.mdpi.com
    Studying the Association of TKS4 and CD2AP Scaffold Proteins and Their Implications in the Partial Epithelial–Mesenchymal Transition (EMT) Process
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    mdpi.com/1422-0067/24/20/15136
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Complementary CRISPR screen highlights the contrasting role of membrane-bound and soluble ICAM-1 in regulating antigen-specific tumor cell killing by cytotoxic T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10586807/
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Spatial Profiling of Circular RNAs in Cancer Reveals High Expression in Muscle and Stromal Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10570686/
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    High-content microscopy reveals a morphological signature of bortezomib resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC10584373/
  74. 52.53.155.43 52.53.155.43
    FEBS Press
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    52.53.155.43/7b3101f3d01462bbcf14399b3becbcb8b341bb38/Molecular Oncology - 2023 - Hsieh - Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer-html.html
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    Piperlongumine is a ligand for the orphan nuclear receptor 4A1 (NR4A1)
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    ncbi.nlm.nih.gov/pmc/articles/PMC10551445/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Solid Cancers with a Cancer-Specific Monoclonal Antibody to Surface Expressed Aberrantly O-glycosylated Proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC10543972/
  78. Sep 2023
  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The identification of high-performing antibodies for Coiled-coil-helix-coiled-coil-helix domain containing protein 10 (CHCHD10) for use in Western Blot, immunoprecipitation and immunofluorescence
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    Natural killer cell therapy targeting cancer stem cells: Old wine in a new bottle
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    sciencedirect.com/science/article/pii/S0304383523002793
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    Epigenomic analysis reveals a unique DNA methylation program of metastasis-competent circulating tumor cells in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10505142/
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
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    ncbi.nlm.nih.gov/pmc/articles/PMC10472876/
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    British J Pharmacology - 2023 - Kleszcz-html.html
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  85. Aug 2023
  86. www.sciencedirect.com www.sciencedirect.com
    exo-FISH: Protocol for detecting DNA breaks in repetitive regions of mammalian genomes
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    sciencedirect.com/science/article/pii/S2666166723004549
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    Nuclear transport surveillance of p53 by nuclear pores in glioblastoma
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    52.53.155.43/64ae675a86b73874b1bb5c50aa8d9678e93e36d6/PIIS2211124723008938-html.html
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    MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids
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    ncbi.nlm.nih.gov/pmc/articles/PMC10411481/
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FEBS Press
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  90. aacrjournals.org aacrjournals.org
    Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer
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    aacrjournals.org/mct/article/22/8/962/727921/Vincristine-Enhances-the-Efficacy-of-MEK
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    Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer
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    elifesciences.org/articles/86913
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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    sciencedirect.com/science/article/pii/S2211124723009385
  93. Jul 2023
  94. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Cheng - Pharmacological targeting of Axin2 suppresses cell growth and metastasis in-html.html
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