1,315 Matching Annotations
  1. Nov 2021
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    Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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  6. Oct 2021
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2
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    Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth
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    Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity
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    Glycogen accumulation and phase separation drives liver tumor initiation
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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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    RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    Overexpression of FGF2 delays the progression of osteonecrosis of the femoral head activating the PI3K/Akt signaling pathway
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    A role for AKT1 in nonsense-mediated mRNA decay
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    Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome
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    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    Wnt5a Regulates Junctional Function of Sertoli cells Through PCP-Mediated Effects on mTORC1 and mTORC2
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    Preclinical and Clinical Characterization of Fibroblast-derived Neuregulin-1 on Trastuzumab and Pertuzumab Activity in HER2-positive Breast Cancer
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    Involvement of multiple scavenger receptors in advanced glycation end product-induced vessel tube formation in endothelial cells
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  24. Sep 2021
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    Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
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    Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
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    SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages
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    Treatment of acromegaly by rosiglitazone via upregulating 15-PGDH in both pituitary adenoma and liver
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    UV-induced reduction in Polycomb repression promotes epidermal pigmentation
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  33. Aug 2021
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    BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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    Coordination of tumor growth and host wasting by tumor-derived Upd3
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    NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms
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    Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects
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    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
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    Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis
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    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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    Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines
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    Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
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    A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes
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    Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC
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    Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6
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    Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease
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    T-cell–derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2
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  78. Jul 2021
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    Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice
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    The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3
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    Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication
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