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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation

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Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations

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Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin

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Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC

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Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6

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Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells

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Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

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Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease

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T-cell–derived extracellular vesicles regulate B-cell IgG production via pyruvate kinase muscle isozyme 2

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Jul 2021
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Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice

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  anti-Akt
  
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The Parkinson's gene PINK1 activates Akt via PINK1 kinase-dependent regulation of the phospholipid PI(3,4,5)P3

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Sex difference in corticosterone-induced insulin resistance in mice

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CDK12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS1‐ErbB‐PI3K signaling

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  p‐AKT
  
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Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication

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Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice

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Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer

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  p-AKT-S473
  
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TrkB‐mediated activation of the phosphatidylinositol‐3‐kinase/Akt cascade reduces the damage inflicted by oxygen‐glucose deprivation in area CA3 of the rat hippocampus

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Akt3-mTOR regulates hippocampal neurogenesis in adult mouse

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Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

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PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling

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  RRID:AB_2315049
  
  DOI: 10.7554/eLife.32021
  
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  RRID:AB_2315049
  
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Vascular Endothelial Growth Factor–D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity

1
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  AB_2315049
  
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Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

1
1. scibot 28 Jul 2021
  
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  Phospho-Akt (Ser473) (D9E) XPu00a0Rabbit mAb
  
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PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K

1
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  RRID:AB_2315049
  
  DOI: 10.1016/j.molcel.2017.09.024
  
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Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

1
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  DOI: 10.1016/j.cmet.2018.08.013
  
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PTEN knockdown alters dendritic spine/protrusion morphology, not density

1
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  Anti-pAKTMonoclonalRabbitEpitope surrounds serine 473 of AKT sequence1:200Cell Signaling4060AB_916027
  
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cell.com/developmental-cell/abstract/S1534-5807(17)30871-7
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  AB_2315049
  
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Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis

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  RRID:AB_10234665
  
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OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling

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  RRID:AB_2341228
  
  DOI: 10.1016/j.ebiom.2019.02.051
  
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  RRID:AB_10234665
  
  DOI: 10.1016/j.neuron.2018.10.051
  
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Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance

1
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  RRID:AB_2750995
  
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Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway

1
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  AB_916024
  
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Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats

1
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  AB_2315049
  
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Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells

1
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  RRID:AB_2315049
  
  DOI: 10.1111/jnc.15268
  
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Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms

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  AB_2315049
  
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Microscopic image-based covariation network analysis for actin scaffold-modified insulin signaling

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability

1
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  RRID:AB_10234665
  
  DOI: 10.1016/j.celrep.2021.109327
  
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IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3

1
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Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

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  4060
  
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Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression

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OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin

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Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

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Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

1
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  DOI: 10.7554/eLife.67315
  
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Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy

1
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  RRID:AB_2315049
  
  DOI: 10.15252/emmm.202114059
  
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β-elemene alleviates airway stenosis via the ILK/Akt pathway modulated by MIR143HG sponging miR-1275

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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

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NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

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FEBS Press

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Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling

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Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library

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TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease

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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia

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Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

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The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding

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Limited inhibition of multiple nodes in a driver network blocks metastasis

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A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non-small cell lung cancer

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UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

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Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms

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The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1

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NC1-peptide from collagen α3 (IV) chains in the basement membrane of testes regulates spermatogenesis via p-FAK-Y407

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SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem

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Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM

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Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice

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Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains

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BPS Publications

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Hdac9 inhibits medial artery calcification through down-regulation of Osterix

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Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

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Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

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Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model

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Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

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Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

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Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression

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Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases

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Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

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An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

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Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism

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The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

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An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells

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Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake

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Metabolic stress drives sympathetic neuropathy within the liver

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Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

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Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference

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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

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Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

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An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells

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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation

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Cell Lineage-Based Stratification for Glioblastoma

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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis

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Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor

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Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

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S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

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SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells

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Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis

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BPS Publications

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FSH Promotes Progesterone Synthesis by Enhancing Autophagy to Accelerate Lipid Droplet Degradation in Porcine Granulosa Cells

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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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Recombinant human growth hormone activates neuroprotective growth factors in hypoxic brain injury in neonatal mice

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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

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Maternal high fat diet multigenerationally impairs hippocampal synaptic plasticity and memory in male rat offspring

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Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma

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PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

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Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in male mice

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Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

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A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

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L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness

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Glucocorticoids attenuate interleukin‐6‐induced c‐Fos and Egr1 expression and impair neuritogenesis in PC12 cells

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The kinase PDK1 is critical for promoting T follicular helper cell differentiation

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Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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Comprehensive pharmacogenomic characterization of gastric cancer

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Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2

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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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(+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma

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Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish

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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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MiR-3121-3p promotes tumor invasion and metastasis by suppressing Rap1GAP in papillary thyroid cancer in vitro

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Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

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An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia

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Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

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Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders

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The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

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ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

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Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

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RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer

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Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

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BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages

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ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence

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BPS Publications

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Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease

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miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling

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Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

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Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation

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The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death

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Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization

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Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis

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Novel guanidine compounds inhibit platelet‐derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation

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TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity

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PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle

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  DOI: 10.3390/ijms21197062
  
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A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis

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Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila

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  DOI: 10.7554/eLife.57395
  
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Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma

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1. scibot 10 Oct 2020
  
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A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway

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Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats

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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

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BPS Publications

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  DOI: 10.1111/bph.14980
  
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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

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A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control

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Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT

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GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function

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An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

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11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

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The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance

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BPS Publications

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Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of MatriptaseThe double face of Matriptase

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  DOI: 10.1083/jcb.201905190
  
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Tau Reduction Prevents Key Features of Autism in Mouse Models

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Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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cell.com/cell-reports/abstract/S2211-1247(20)30021-8
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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

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Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

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