1,106 Matching Annotations
  1. Jan 2021
  2. www.sciencedirect.com www.sciencedirect.com
    The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway
    1
    1. scibot 20 Jan 2021
      Rabbit anti-AKT S473

      DOI: 10.1016/j.celrep.2020.108659

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    sciencedirect.com/science/article/pii/S221112472031648X
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    ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
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    1. scibot 07 Jan 2021
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108572

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    sciencedirect.com/science/article/pii/S2211124720315618
  4. elifesciences.org elifesciences.org
    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1
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    1. scibot 06 Jan 2021
      RRID:AB_2315049

      DOI: 10.7554/eLife.58037

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    elifesciences.org/articles/58037
  5. Dec 2020
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer
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    1. scibot 13 Dec 2020
      RRID:AB_2315049

      DOI: 10.21037/atm-20-3731

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    ncbi.nlm.nih.gov/pmc/articles/PMC7723610/
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions
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    1. scibot 09 Dec 2020
      RRID:AB_2315049

      DOI: 10.1093/hmg/ddaa209

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    ncbi.nlm.nih.gov/pmc/articles/PMC7689298/
  8. elifesciences.org elifesciences.org
    BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages
    1
    1. scibot 09 Dec 2020
      RRID:AB_2315049

      DOI: 10.7554/eLife.56309

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    elifesciences.org/articles/56309
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    ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
    1
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      RRID:AB_2315049

      DOI: 10.1016/j.stem.2020.10.019

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    sciencedirect.com/science/article/pii/S1934590920305385
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    BPS Publications
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      DOI: 10.1111/bph.15169

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15169
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    Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease
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    1. scibot 07 Dec 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108420

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    sciencedirect.com/science/article/pii/S2211124720314091
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    miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling
    1
    1. scibot 07 Dec 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108436

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    sciencedirect.com/science/article/pii/S221112472031425X
  13. Nov 2020
  14. www.sciencedirect.com www.sciencedirect.com
    Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
    1
    1. scibot 24 Nov 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108403

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    sciencedirect.com/science/article/pii/S2211124720313929
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser
    1
    1. scibot 21 Nov 2020
      RRID:AB_2315049

      DOI: 10.7554/eLife.55994

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    ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
  16. www.sciencedirect.com www.sciencedirect.com
    ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
    1
    1. scibot 14 Nov 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108366

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    sciencedirect.com/science/article/pii/S2211124720313553
  17. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation
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    1. scibot 14 Nov 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108374

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    pubmed.ncbi.nlm.nih.gov/33176143/
  18. www.jneurosci.org www.jneurosci.org
    The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death
    1
    1. scibot 13 Nov 2020
      RRID:AB_2315049

      DOI: 10.1523/JNEUROSCI.1636-20.2020

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    jneurosci.org/content/40/45/8652
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cdc42 is involved in NC1 peptide–regulated BTB dynamics through actin and microtubule cytoskeletal reorganization
    1
    1. scibot 05 Nov 2020
      AB_2315049

      DOI: 10.1096/fj.201900991R

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    ncbi.nlm.nih.gov/pmc/articles/PMC6894087/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis
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    1. scibot 05 Nov 2020
      RRID:AB_2315049

      DOI: 10.7554/eLife.60445

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    ncbi.nlm.nih.gov/pmc/articles/PMC7599067/
  21. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel guanidine compounds inhibit platelet‐derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation
    1
    1. scibot 03 Nov 2020
      RRID:AB_2315049

      DOI: 10.1002/glia.23930

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    onlinelibrary.wiley.com/doi/full/10.1002/glia.23930
  22. Oct 2020
  23. www.sciencedirect.com www.sciencedirect.com
    TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity
    1
    1. scibot 31 Oct 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108326

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    sciencedirect.com/science/article/pii/S2211124720313152
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle
    1
    1. scibot 31 Oct 2020
      RRID:AB_2315049

      DOI: 10.3390/ijms21197062

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    ncbi.nlm.nih.gov/pmc/articles/PMC7583908/
  25. www.sciencedirect.com www.sciencedirect.com
    A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
    1
    1. scibot 27 Oct 2020
      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108284

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    sciencedirect.com/science/article/pii/S2211124720312730
  26. elifesciences.org elifesciences.org
    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
    1
    1. scibot 24 Oct 2020
      RRID:AB_2315049

      DOI: 10.7554/eLife.57395

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    elifesciences.org/articles/57395
  27. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Increased dopamine and its receptor dopamine receptor D1 promote tumor growth in human hepatocellular carcinoma
    1
    1. scibot 10 Oct 2020
      p‐AKT

      DOI: 10.1002/cac2.12103

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    onlinelibrary.wiley.com/doi/full/10.1002/cac2.12103
  28. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    A Marine Alkaloid, Ascomylactam A, Suppresses Lung Tumorigenesis via Inducing Cell Cycle G1/S Arrest through ROS/Akt/Rb Pathway
    1
    1. scibot 03 Oct 2020
      RRID:AB_2315049

      DOI: 10.3390/md18100494

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    pubmed.ncbi.nlm.nih.gov/32992455/
  29. Sep 2020
  30. www.sciencedirect.com www.sciencedirect.com
    Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats
    1
    1. scibot 30 Sep 2020
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      DOI: 10.1016/j.celrep.2020.108207

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    sciencedirect.com/science/article/pii/S2211124720311967
  31. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas
    1
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      RRID:AB_2315049

      DOI: 10.1016/j.celrep.2020.108196

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    pubmed.ncbi.nlm.nih.gov/32997991/
  32. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      RRID:AB_2315049

      DOI: 10.1111/bph.14980

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14980
  33. www.sciencedirect.com www.sciencedirect.com
    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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      DOI: 10.1016/j.celrep.2020.107571

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    sciencedirect.com/science/article/pii/S2211124720305209
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    A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control
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      RRID:AB_2315049

      DOI: 10.1016/j.cels.2020.02.005

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    sciencedirect.com/science/article/pii/S2405471220300752
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    Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT
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      DOI: 10.1016/j.celrep.2020.107579

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    sciencedirect.com/science/article/pii/S2211124720305283
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    GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
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      DOI: 10.1016/j.cmet.2020.05.001

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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance
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      DOI: 10.1016/j.cmet.2020.01.009

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    ncbi.nlm.nih.gov/pmc/articles/PMC7104778/
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    11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma
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      DOI: 10.1016/j.celrep.2020.108171

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    sciencedirect.com/science/article/pii/S2211124720311608
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    The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance
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      DOI: 10.1016/j.celrep.2020.107794

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    sciencedirect.com/science/article/pii/S2211124720307750
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      DOI: 10.1111/bph.15010

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15010
  41. rupress.org rupress.org
    Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of MatriptaseThe double face of Matriptase
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      RRID:AB_2315049

      DOI: 10.1083/jcb.201905190

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    rupress.org/jcb/article/219/2/e201905190/132730/Entosis-and-apical-cell-extrusion-constitute-a
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    Tau Reduction Prevents Key Features of Autism in Mouse Models
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      DOI: 10.1016/j.neuron.2020.01.038

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    sciencedirect.com/science/article/pii/S0896627320300659
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    Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
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      DOI: 10.1016/j.stem.2020.04.001

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    sciencedirect.com/science/article/pii/S1934590920301405
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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      DOI: 10.1016/j.celrep.2020.01.080

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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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    Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression
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    Disc1 Carrier Mice Exhibit Alterations in Neural pIGF-1Rβ and Related Kinase Expression
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  83. www.embopress.org www.embopress.org
    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
    1
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      phosphor‐Akt

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  84. www.mdpi.com www.mdpi.com
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  85. www.sciencedirect.com www.sciencedirect.com
    Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity
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      pAkt

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  86. www.sciencedirect.com www.sciencedirect.com
    Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia
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  87. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination
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  89. stke.sciencemag.org stke.sciencemag.org
    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
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      pS473-AKT

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  90. www.mdpi.com www.mdpi.com
    IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β–Nrf2–BNIP3 Pathway
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      rabbit anti-phospho-AKT

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  91. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
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      phosphorylated‐AKT (S473)

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  92. www.sciencedirect.com www.sciencedirect.com
    High expression of miR-135b predicts malignant transformation and poor prognosis of gastric cancer
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      anti-phospho-Akt (Ser473) (D9E) XP® rabbit mAb

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  93. mcr.aacrjournals.org mcr.aacrjournals.org
    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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  94. journals.physiology.org journals.physiology.org
    Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism
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      monoclonal rabbit phospho-Akt S473

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    Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
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  96. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK‐3β in 3xTg‐AD mice
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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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      DOI: 10.1523/JNEUROSCI.0642-19.2019

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  98. Mar 2020
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    Untitled document
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  100. Jan 2020
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    Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers
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  102. academic.oup.com academic.oup.com
    Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-expressing Neurons
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      DOI: 10.1210/en.2019-00341

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    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
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    An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
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    Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis
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  106. dev.biologists.org dev.biologists.org
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    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
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    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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    Upregulation of GLT-1 via PI3K/Akt Pathway Contributes to Neuroprotection Induced by Dexmedetomidine
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      DOI: 10.3389/fneur.2019.01041

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    Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling
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    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    Keratinocyte growth factor reduces injury and leads to early recovery from cyclophosphamide bladder injury
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    Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis
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    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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  115. elifesciences.org elifesciences.org
    Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA
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    Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors
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    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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    Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2
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    Synergistic Highly Potent Targeted Drug Combinations in different Pheochromocytoma Models including Human Tumor Cultures
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    Mechanical loading stimulates hypertrophy in tissue‐engineered skeletal muscle: Molecular and phenotypic responses
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    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
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    Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
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    Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer
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    A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas
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    Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D
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    The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
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    CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways
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    The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling
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    TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance
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    The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
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    Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway
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    Individual Cells Can Resolve Variations in Stimulus Intensity along the IGF-PI3K-AKT Signaling Axis
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    Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
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    Ghrelin-Induced Sodium Reabsorption is Mediated by PKA and Microtubule-Dependent αE Na C Translocation In Female Rats
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    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
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    MAPK Erk5 in leptin receptor-expressing neurons controls body weight and systemic energy homeostasis in female mice
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    PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1
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    A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
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    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
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    Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
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    Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection
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    Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages
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    Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity
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    A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism
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    sciencedirect.com/science/article/pii/S1535610818303763
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    Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs
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    sciencedirect.com/science/article/pii/S1534580718306981
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    Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM
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    sciencedirect.com/science/article/pii/S0896627318307839
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    ncbi.nlm.nih.gov/pmc/articles/PMC6113930/
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    ncbi.nlm.nih.gov/pmc/articles/PMC6134327/