1,106 Matching Annotations
  1. Nov 2018
  2. www.sciencedirect.com www.sciencedirect.com
    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    sciencedirect.com/science/article/pii/S1097276518306853
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    PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism
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    sciencedirect.com/science/article/pii/S2352396418303712
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    sciencedirect.com/science/article/pii/S1550413118305229
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    Curcumin Attenuates gp120-Induced Microglial Inflammation by Inhibiting Autophagy via the PI3K Pathway
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    1. scibot 05 Nov 2018
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    link.springer.com/article/10.1007/s10571-018-0616-3
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    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    sciencedirect.com/science/article/pii/S1535610818303696
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    sciencedirect.com/science/article/pii/S2405844018331190
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6122955/
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    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
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    sciencedirect.com/science/article/pii/S155041311830514X
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    Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies
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    sciencedirect.com/science/article/pii/S1550413118305072
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    Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration
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    sciencedirect.com/science/article/pii/S2211124718312385
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    Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate
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    onlinelibrary.wiley.com/doi/full/10.1002/pros.23702
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    sciencedirect.com/science/article/pii/S2211124718311665
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    ncbi.nlm.nih.gov/pmc/articles/PMC6097439/
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0557-9
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    Circulating Adipose Fatty Acid Binding Protein Is a New Link Underlying Obesity-Associated Breast/Mammary Tumor Development
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    sciencedirect.com/science/article/pii/S1550413118304492
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    academic.oup.com/endo/article/159/8/2917/4995800
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    ncbi.nlm.nih.gov/pmc/articles/PMC6063731/
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    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    sciencedirect.com/science/article/pii/S1535610818302691
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    A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
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    sciencedirect.com/science/article/pii/S1550413118303954
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    onlinelibrary.wiley.com/doi/full/10.1111/ejn.13880
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    mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma
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    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1534580717308249
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    Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
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    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S0092867418300412
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    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
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    sciencedirect.com/science/article/pii/S1074761317304235
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    RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis
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    sciencedirect.com/science/article/pii/S1535610818300011
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    Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
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    sciencedirect.com/science/article/pii/S0028390818302429
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    Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases
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    sciencedirect.com/science/article/pii/S2405471218301923
  28. www.jneurosci.org www.jneurosci.org
    R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System
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    jneurosci.org/content/38/22/5096
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    mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
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    sciencedirect.com/science/article/pii/S1097276518303460
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    A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer
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    sciencedirect.com/science/article/pii/S155041311830305X
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    The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells
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    sciencedirect.com/science/article/pii/S1097276518301084
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    Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade
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    sciencedirect.com/science/article/pii/S1535610818301740
  33. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Exogenous H2S exerts biphasic effects on porcine mammary epithelial cells proliferation through PI3K/Akt‐mTOR signaling pathway
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    onlinelibrary.wiley.com/doi/full/10.1002/jcp.26630
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    Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1
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    sciencedirect.com/science/article/pii/S1931312818302038
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    B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells
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    sciencedirect.com/science/article/pii/S1074761318300293
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    Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress
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    sciencedirect.com/science/article/pii/S1934590918301644
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    Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment
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    sciencedirect.com/science/article/pii/S1550413118301177
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    Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation
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    sciencedirect.com/science/article/pii/S1934590918301085
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    EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation
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    sciencedirect.com/science/article/pii/S1097276518302211
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    c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling
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    sciencedirect.com/science/article/pii/S1535610817305664
  41. academic.oup.com academic.oup.com
    Catch-Up Growth in Zebrafish Embryo Requires Neural Crest Cells Sustained by Irs1 Signaling
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    academic.oup.com/endo/article-abstract/159/4/1547/4828198
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
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      rabbit anti-p-AKT (S473) (1:2000, Cell Signaling #4060)

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    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
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    Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
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    Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
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    Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis
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    IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure
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    KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS
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  49. europepmc.org europepmc.org
    Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins.
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    Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead
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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Method for the Acute and Rapid Degradation of Endogenous Proteins
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  52. academic.oup.com academic.oup.com
    The Response of Prostate Smooth Muscle Cells to Testosterone Is Determined by the Subcellular Distribution of the Androgen Receptor
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    Insulinlike Growth Factor–Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance
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    Direct Activation of Angiotensin II Type 2 Receptors Enhances Muscle Microvascular Perfusion, Oxygenation, and Insulin Delivery in Male Rats
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    Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells
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    Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes
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  59. europepmc.org europepmc.org
    MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma
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    Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer
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    Region-Specific Suppression of Hypothalamic Responses to Insulin To Adapt to Elevated Maternal Insulin Secretion During Pregnancy
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    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
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  63. Nov 2017
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    Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice
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    Divergent JNK Phosphorylation of HDAC3 in Triple-Negative Breast Cancer Cells Determines HDAC Inhibitor Binding and Selectivity
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    The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells
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    A Split-Abl Kinase for Direct Activation in Cells
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    PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network
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    YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis
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    Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity
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    Autophagy impairment by caspase‐1‐dependent inflammation mediates memory loss in response to β‐Amyloid peptide accumulation
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    Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye
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    Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor‐2 signaling impairment in the aged neurogenic niche
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  74. academic.oup.com academic.oup.com
    Effects of the Activation of Three Major Hepatic Akt Substrates on Glucose Metabolism in Male Mice
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  75. academic.oup.com academic.oup.com
    Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
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    A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding
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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
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    EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis
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    IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis
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    IGF1R Expression in Ovarian Granulosa Cells is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice
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    Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival
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  83. www.sciencedirect.com www.sciencedirect.com
    Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis
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  84. www.sciencedirect.com www.sciencedirect.com
    mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
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  85. www.sciencedirect.com www.sciencedirect.com
    Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS
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  86. elifesciences.org elifesciences.org
    The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca2+ signaling
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    elifesciences.org/articles/26362
  87. academic.oup.com academic.oup.com
    JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin–Estrogen Feedback Loop and Reproductive Function
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    academic.oup.com/endo/article/158/6/1798/3064423/JMJD3-Is-Crucial-for-the-Female-AVPV-RIP-Cre
  88. academic.oup.com academic.oup.com
    Hyperhomocysteinemia Promotes Insulin Resistance and Adipose Tissue Inflammation in PCOS Mice Through Modulating M2 Macrophage Polarization via Estrogen Suppression
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  89. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease
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    onlinelibrary.wiley.com/doi/10.1111/jnc.14033/full
  90. link.springer.com link.springer.com
    Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats
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    link.springer.com/article/10.1007/s12035-017-0538-y
  91. elifesciences.org elifesciences.org
    The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration
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    elifesciences.org/content/6/e22871
  92. www.sciencedirect.com www.sciencedirect.com
    The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover
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  93. elifesciences.org elifesciences.org
    SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
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    elifesciences.org/content/6/e25158
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    Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a
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    Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes
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  96. www.sciencedirect.com www.sciencedirect.com
    Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
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  97. www.jneurosci.org www.jneurosci.org
    Soluble cpg15 from Astrocytes Ameliorates Neurite Outgrowth Recovery of Hippocampal Neurons after Mouse Cerebral Ischemia
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    Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy
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    Multivalent Small-Molecule Pan-RAS Inhibitors
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  100. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
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    ncbi.nlm.nih.gov/pmc/articles/PMC4931344/
  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC5241115/
  103. elifesciences.org elifesciences.org
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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