1,434 Matching Annotations
  1. May 2021
  2. www.sciencedirect.com www.sciencedirect.com
    CRISPR screens in physiologic medium reveal conditionally essential genes in human cells
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    1. scibot 01 May 2021
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      DOI: 10.1016/j.cmet.2021.02.005

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    sciencedirect.com/science/article/pii/S1550413121000619
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    Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification
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    1. scibot 01 May 2021
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      DOI: 10.1016/j.chembiol.2021.03.016

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    sciencedirect.com/science/article/pii/S2451945621001550
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    LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome
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    1. scibot 01 May 2021
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      DOI: 10.1016/j.cell.2021.04.001

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    cell.com/cell/fulltext/S0092-8674(21)00436-0
  5. Apr 2021
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    Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism
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    1. scibot 30 Apr 2021
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      DOI: 10.1016/j.cmet.2020.11.017

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    sciencedirect.com/science/article/pii/S1550413120306525
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    The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
    1
    1. scibot 30 Apr 2021
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      DOI: 10.1016/j.cmet.2020.11.011

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    sciencedirect.com/science/article/pii/S1550413120306069
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    High‐risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levels
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    1. scibot 30 Apr 2021
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      DOI: 10.1002/cncr.33567

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    acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33567
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    Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3
    1
    1. scibot 29 Apr 2021
      anti-mouse IgG, Horseradish peroxidase-conjugated

      DOI: 10.1016/j.cmet.2020.08.016

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    sciencedirect.com/science/article/pii/S1550413120304769
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    Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1550413120305519
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    Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.cmet.2020.10.002

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    sciencedirect.com/science/article/pii/S1550413120305350
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.medj.2021.04.009

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    ncbi.nlm.nih.gov/pmc/articles/PMC8043616/
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    Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction
    1
    1. scibot 29 Apr 2021
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      DOI: 10.1016/j.cmet.2020.05.012

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    sciencedirect.com/science/article/pii/S1550413120302515
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    Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer
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    1. scibot 28 Apr 2021
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      DOI: 10.1016/j.chembiol.2021.02.014

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    sciencedirect.com/science/article/pii/S2451945621000994
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    A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex
    1
    1. scibot 28 Apr 2021
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      DOI: 10.1016/j.chembiol.2021.02.007

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    sciencedirect.com/science/article/pii/S2451945621000921
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    Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine
    1
    1. scibot 28 Apr 2021
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      DOI: 10.1016/j.molcel.2021.03.020

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    ncbi.nlm.nih.gov/pmc/articles/PMC8122138/
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
    1
    1. scibot 28 Apr 2021
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      DOI: 10.1016/j.celrep.2021.109013

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    sciencedirect.com/science/article/pii/S2211124721003272
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    Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
    1
    1. scibot 27 Apr 2021
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      DOI: 10.1016/j.chembiol.2020.10.003

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    sciencedirect.com/science/article/pii/S2451945620303822
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    A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form
    1
    1. scibot 27 Apr 2021
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      DOI: 10.1016/j.chembiol.2020.09.004

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    sciencedirect.com/science/article/pii/S2451945620303767
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    A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome
    1
    1. scibot 27 Apr 2021
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      DOI: 10.1016/j.chembiol.2020.05.010

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    sciencedirect.com/science/article/pii/S2451945620301872
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    LncRNA CALB2 sponges miR-30b-3p to promote odontoblast differentiation of human dental pulp stem cells via up-regulating RUNX2
    1
    1. scibot 27 Apr 2021
      RRID:AB_330924

      DOI: 10.1016/j.cellsig.2020.109695

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    sciencedirect.com/science/article/pii/S0898656820301728
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    Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output
    1
    1. scibot 24 Apr 2021
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      DOI: 10.1016/j.cell.2020.08.009

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    sciencedirect.com/science/article/pii/S009286742031000X
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
    1
    1. scibot 24 Apr 2021
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      DOI: 10.1016/j.cell.2020.07.001

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    sciencedirect.com/science/article/pii/S0092867420308230
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    ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome
    1
    1. scibot 24 Apr 2021
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      DOI: 10.1016/j.cell.2020.07.008

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    sciencedirect.com/science/article/pii/S0092867420308734
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    iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia
    1
    1. scibot 24 Apr 2021
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      DOI: 10.1016/j.stem.2021.03.023

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    sciencedirect.com/science/article/pii/S1934590921001569
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    Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics
    1
    1. scibot 23 Apr 2021
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      DOI: 10.1016/j.cell.2020.05.028

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    sciencedirect.com/science/article/pii/S0092867420306231
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    Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis
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    1. scibot 22 Apr 2021
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      DOI: 10.1016/j.ccell.2021.02.016

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    sciencedirect.com/science/article/pii/S1535610821001185
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    MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
    1
    1. scibot 22 Apr 2021
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      DOI: 10.1016/j.ccell.2021.02.006

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    sciencedirect.com/science/article/pii/S1535610821001082
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    Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer
    1
    1. scibot 22 Apr 2021
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      DOI: 10.1016/j.ccell.2020.08.015

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    sciencedirect.com/science/article/pii/S1535610820304268
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
    1
    1. scibot 22 Apr 2021
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      DOI: 10.1016/j.cmet.2021.03.025

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    sciencedirect.com/science/article/pii/S1550413121001662
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
    1
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      DOI: 10.1016/j.ccell.2020.04.014

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    sciencedirect.com/science/article/pii/S1535610820302130
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    Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly
    1
    1. scibot 16 Apr 2021
      HRP-conjugated anti-mouse IgG

      DOI: 10.1016/j.bcp.2020.114280

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    sciencedirect.com/science/article/pii/S0006295220305165
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    A membrane arm of mitochondrial complex I sufficient to promote respirasome formation
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      DOI: 10.1016/j.celrep.2021.108963

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    sciencedirect.com/science/article/pii/S2211124721002771
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    Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein
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      DOI: 10.7554/eLife.64393

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    elifesciences.org/articles/64393
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    Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
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      DOI: 10.1016/j.celrep.2021.108998

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    sciencedirect.com/science/article/pii/S2211124721003120
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    Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules
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    sciencedirect.com/science/article/pii/S0092867421003627
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    Capturing human trophoblast development with naive pluripotent stem cells in vitro
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      DOI: 10.1016/j.stem.2021.03.013

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    sciencedirect.com/science/article/pii/S1934590921001193
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
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      DOI: 10.7554/eLife.63326

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    ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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      DOI: 10.1016/j.molcel.2021.03.009

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    sciencedirect.com/science/article/pii/S1097276521001775
  40. Mar 2021
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK
    1
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      DOI: 10.1016/j.devcel.2020.11.017

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    ncbi.nlm.nih.gov/pmc/articles/PMC8005871/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sarbecovirus ORF6 proteins hamper the induction of interferon signaling
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      DOI: 10.1016/j.celrep.2021.108916

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    ncbi.nlm.nih.gov/pmc/articles/PMC7953434/
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    On the role of p53 in the cellular response to aneuploidy
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      DOI: 10.1016/j.celrep.2021.108892

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    H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model
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    Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins
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    DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells
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    Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold
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    Centromeric chromatin integrity is compromised by loss of Cdk5rap2, a transcriptional activator of CENP-A
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    Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock
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    Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer
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    LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection
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    Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
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    Ouabain-Induced Gene Expression Changes in Human iPSC-Derived Neuron Culture Expressing Dopamine and cAMP-Regulated Phosphoprotein 32 and GABA Receptors
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0
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    Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury
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    PDX1 LOW MAFA LOW β-cells contribute to islet function and insulin release
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    Development of a potent and selective chemical probe for the pleiotropic kinase CK2
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor
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    Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells
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    Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution
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    The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity
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    Microglial mTOR is neuronal protective and anti-epileptogenic in the pilocarpine model of temporal lobe epilepsy
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    Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
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  99. Dec 2020
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    FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells
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    Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease
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    Association of Hyperuricemia With Immune Disorders and Intestinal Barrier Dysfunction
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      DOI: 10.3389/fphys.2020.524236

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    Vagal afferent fibers contribute to the anti-inflammatory reactions by vagus nerve stimulation in concanavalin A model of hepatitis in rats
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      DOI: 10.1186/s10020-020-00247-2

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  104. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Intranasal deferoxamine can improve memory in healthy C57 mice, suggesting a partially non‐disease‐specific pathway of functional neurologic improvement
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      DOI: 10.1002/brb3.1536

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    Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis
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    A novel HDAC6 inhibitor improves myelination of Schwann cells in a model of Charcot‐Marie‐Tooth disease type 1A
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      DOI: 10.1111/bph.15231

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  107. Nov 2020
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    CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion
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    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    Impact of Wnt/β‐catenin signaling on ethanol‐induced changes in brain endothelial cell permeability
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    Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A
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    Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti
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    ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
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    ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription
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    Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons
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    Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2
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      Horse anti-mouse HRP

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  117. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Unbiased Proteomic Screening Identifies a Novel Role for the E3 Ubiquitin Ligase Nedd4‐2 in Translational Suppression During ER Stress
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    (−)-Epicatechin reduces muscle waste after complete spinal cord transection in a murine model: role of ubiquitin–proteasome system
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    Two MicroRNAs Are Sufficient for Embryonic Patterning in C. elegans
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    Generating an MEIS1 homozygous knockout human embryonic stem cell line using the CRISPR/Cas9 system
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  121. Oct 2020
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    Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells
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    Phosphorylation of STAT3 by axonal Cdk5 promotes axonal regeneration by modulating mitochondrial activity
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    Non-Transcriptional and Translational Function of Canonical NF-κB Signaling in Activating ERK1/2 in IL-1β-Induced COX-2 Expression in Synovial Fibroblasts
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    Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
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    Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation
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    Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
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    MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia
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    Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
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    A novel HER2-targeting antibody 5G9 identified by large-scale trastuzumab-based screening exhibits potent synergistic antitumor activity
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    A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders
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    A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways
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    Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion
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    The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine Maturation
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    Quantitative immunoblotting analyses reveal that the abundance of actin, tubulin, synaptophysin and EEA1 proteins is altered in the brains of aged mice
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    Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly
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    The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis
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    PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
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    Differential Cellular Response to Translocated Toxic Effectors and Physical Penetration by the Type VI Secretion System
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    Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease
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    Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis
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    Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation
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    Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation
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    A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation
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    mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis
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    Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis
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    Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults
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    The endothelial barrier is not rate-limiting to insulin action in the myocardium of male mice
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    Ceramide analog SACLAC modulates sphingolipid levels and Mcl-1 splicing to induce apoptosis in acute myeloid leukemia
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    p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells
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    Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila
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    Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections
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    TMEM173 Drives Lethal Coagulation in Sepsis
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    Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells
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    Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy
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    BIS-INDOLE DERIVED NUCLEAR RECEPTOR 4A1 (NR4A1, Nur77) LIGANDS AS INHIBITORS OF ENDOMETRIOSIS
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    Replication Stress Induces ATR/CHK1-Dependent Nonrandom Segregation of Damaged Chromosomes
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    Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR)
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    Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in Dystonia musculorum mice
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    The role of Rif1 in telomere length regulation is separable from its role in origin firing
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    Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development
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    Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila
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    Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
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    Hypercapnia Exacerbates the Blood–Brain Barrier Disruption Via Promoting HIF-1a Nuclear Translocation in the Astrocytes of the Hippocampus: Implication in Further Cognitive Impairment in Hypoxemic Adult Rats
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    Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation
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    Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair
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    KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species‐mediated apoptosis
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    Hormonal Regulation of Autophagy in Thyroid PCCL3 Cells and the Thyroids of Male Mice
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    Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA
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    Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P
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    Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability
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    Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells
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    Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade
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    SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference
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    Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins
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    ncbi.nlm.nih.gov/pmc/articles/PMC7316060/
  203. www.sciencedirect.com www.sciencedirect.com
    An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates
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    1. scibot 06 Sep 2020
      RRID:AB_330924

      DOI: 10.1016/j.ccell.2019.12.001

      Resource: (Cell Signaling Technology Cat# 7076, RRID:AB_330924)

      Curator: @ethanbadger

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      RRIDCUR:Validated RRID:AB_330924
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    sciencedirect.com/science/article/pii/S1535610819305719
  204. www.sciencedirect.com www.sciencedirect.com
    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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    1. scibot 06 Sep 2020
      RRID:AB_330924

      DOI: 10.1016/j.ccell.2019.12.006

      Resource: (Cell Signaling Technology Cat# 7076, RRID:AB_330924)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_330924

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      RRIDCUR:Validated RRID:AB_330924
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    sciencedirect.com/science/article/pii/S1535610819305768
  205. www.sciencedirect.com www.sciencedirect.com
    Quantitative and Dynamic Catalogs of Proteins Released during Apoptotic and Necroptotic Cell Death
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    1. scibot 05 Sep 2020
      RRID:AB_330924

      DOI: 10.1016/j.celrep.2019.12.079

      Resource: (Cell Signaling Technology Cat# 7076, RRID:AB_330924)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_330924

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      RRIDCUR:Validated RRID:AB_330924
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    sciencedirect.com/science/article/pii/S2211124719317449