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Sep 2021
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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

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Increased fidelity of protein synthesis extends lifespan

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Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

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Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species

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Chromatin-mediated alternative splicing regulates cocaine-reward behavior

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A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells

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Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice

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Aug 2021
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Effect of handling on ATP utilization of cerebral Na,K-ATPase in rats with trimethyltin-induced neurodegeneration

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Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration

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Serine/threonine ligation-assisted chemical synthesis of HMGA1a protein with site-specific post-translational modifications

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Activation of the iNOS/NO/cGMP pathway by Revactin® in human corporal smooth muscle cells

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Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria

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Skin exposure to UVB light induces a skin-brain-gonad axis and sexual behavior

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BPS Publications

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  DOI: 10.1111/bph.15442
  
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Cdc42 is required for male germline niche development in mice

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The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons

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NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells

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  DOI: 10.1016/j.isci.2021.102890
  
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A light-switching pyrene probe to detect phase separated biomolecules

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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

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Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

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Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

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Computation-guided optimization of split protein systems

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Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells

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Oestrogen signalling drives ciliogenesis in human endometrial organoids

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Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability

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  DOI: 10.1523/JNEUROSCI.2282-17.2018
  
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Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity

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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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Untitled document

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Untitled document

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Molecular analysis of cell survival and death pathways in the proteasome inhibitor bortezomib-resistant PC3 prostate cancer cell line

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  DOI: 10.1111/jnc.14591
  
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FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection

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  DOI: 10.1016/j.chom.2018.10.006
  
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Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams

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Sugar causes obesity and metabolic syndrome in mice independently of sweet taste

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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

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Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells

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SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover

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Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages

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CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain

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ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

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Cdc42 and its BORG2 and BORG3 effectors control the subcellular localization of septins between actin stress fibers and microtubules

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Counteracting the effect of leukemia exosomes by antiangiogenic gold nanoparticles

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Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/β‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide

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Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells

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TGF‐β1 activates RSC96 Schwann cells migration and invasion through MMP‐2 and MMP‐9 activities

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Combination of antioxidants and NFAT (nuclear factor of activated T cells) inhibitor protects auditory hair cells from ototoxic insult

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Sexually dimorphic responses of rats to fluoxetine in the forced swimming test are unrelated to the function of the serotonin transporter in the brain

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Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice

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Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing

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Role of GluN2A NMDA receptor in homocysteine‐induced prostaglandin E2 release from neurons

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Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction

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BPS Publications

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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

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Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

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CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

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MicroRNA501‐5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells

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Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS

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A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype

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Conformational Change in the Ligand-Binding Pocket via a KISS1R Mutation (P147L) Leads to Isolated Gonadotropin-Releasing Hormone Deficiency

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An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

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The Polyploid State Plays a Tumor-Suppressive Role in the Liver

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Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

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Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination

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An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells

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Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy

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Peroxisomes in the mouse parotid glands: An in-depth morphological and molecular analysis

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β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression

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KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis

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Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms

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Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis

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FANCI functions as a repair/apoptosis switch in response to DNA crosslinks

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Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

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Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy

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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

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Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.

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Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition

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LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes

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Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1

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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

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ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

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SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ

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Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors

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SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

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A systematic analysis of signaling reactivation and drug resistance

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Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions

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Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy

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Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

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β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

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Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway

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Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables DNA damage survival in non-replicating bacteria

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Invariant natural killer T cells coordinate removal of senescent cells

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Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity

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The β1 integrin plays a key role in lymphatic endothelial cell invasion in an optimized 3D Collagen matrix model

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Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

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Hdac9 inhibits medial artery calcification through down-regulation of Osterix

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Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes

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Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model

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G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD

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DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells

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TopBP1 assembles nuclear condensates to switch on ATR signaling

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Purkinje neurons with loss of STIM1 exhibit age-dependent changes in gene expression and synaptic components

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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

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ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

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Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

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Oxindole–curcumin hybrid compound enhances the transcription of γ-glutamylcysteine ligase

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In-gel proteasome assay to determine the activity, amount, and composition of proteasome complexes from mammalian cells or tissues

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Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

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Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

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The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

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Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

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Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

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CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

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Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification

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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

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Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism

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The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation

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High‐risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levels

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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

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Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

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Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

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SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system

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Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction

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Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer

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A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

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Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

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A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form

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A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome

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LncRNA CALB2 sponges miR-30b-3p to promote odontoblast differentiation of human dental pulp stem cells via up-regulating RUNX2

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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

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ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

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iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia

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Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics

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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis

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MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism

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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

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Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly

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A membrane arm of mitochondrial complex I sufficient to promote respirasome formation

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Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

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Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

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Capturing human trophoblast development with naive pluripotent stem cells in vitro

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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK

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Sarbecovirus ORF6 proteins hamper the induction of interferon signaling

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  DOI: 10.1016/j.celrep.2021.108916
  
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On the role of p53 in the cellular response to aneuploidy

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  DOI: 10.1016/j.celrep.2021.108892
  
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H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model

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Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins

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MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells

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DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells

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  DOI: 10.1007/s11064-021-03273-6
  
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Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold

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  DOI: 10.1186/s12915-021-00967-9
  
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Centromeric chromatin integrity is compromised by loss of Cdk5rap2, a transcriptional activator of CENP-A

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Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock

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Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

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Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics

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  DOI: 10.7554/eLife.64395
  
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Molecular forms of neurogranin in cerebrospinal fluid

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BPS Publications

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  DOI: 10.1111/bph.15281
  
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Neurosteroid allopregnanolone (3α,5α-THP) inhibits inflammatory signals induced by activated MyD88-dependent toll-like receptors

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  DOI: 10.1038/s41398-021-01266-1
  
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LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection

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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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  DOI: 10.1016/j.devcel.2020.12.016
  
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An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

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Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP

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Feb 2021
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BPS Publications

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  DOI: 10.1111/bph.15350
  
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Rho‐Kinase Inhibition by Fasudil Modulates Presynaptic Vesicle Dynamics

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  DOI: 10.1111/jnc.15274
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15274

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