2,154 Matching Annotations
  1. Jul 2023
  2. www.sciencedirect.com www.sciencedirect.com
    Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation
    1
    1. scibot 27 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.devcel.2023.07.001

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    sciencedirect.com/science/article/pii/S1534580723003313
  3. 52.53.155.43 52.53.155.43
    rational-design-and-development-of-selective-brd7-bromodomain-inhibitors-and-their-activity-in-prostate-cancer-html.html
    1
    1. scibot 26 Jul 2023
      plasmid_12259

      DOI: 10.26434/chemrxiv-2023-phgwf

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    52.53.155.43/4e60af0f68b5fa24838946fe9ae1c8a74f7bd52b/rational-design-and-development-of-selective-brd7-bromodomain-inhibitors-and-their-activity-in-prostate-cancer-html.html
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi’s sarcoma-associated herpesvirus
    1
    1. scibot 25 Jul 2023
      plasmid_12259

      DOI: 10.1101/2023.07.08.548212

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    ncbi.nlm.nih.gov/pmc/articles/PMC10350069/
  5. www.sciencedirect.com www.sciencedirect.com
    A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling
    1
    1. scibot 21 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2023.112819

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    sciencedirect.com/science/article/pii/S2211124723008306
  6. www.sciencedirect.com www.sciencedirect.com
    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
    1
    1. scibot 21 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2023.112794

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    sciencedirect.com/science/article/pii/S2211124723008057
  7. 52.53.155.43 52.53.155.43
    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
    1
    1. scibot 16 Jul 2023
      Plasmid_12259

      DOI: 10.1101/2023.05.10.540298

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    52.53.155.43/bc0eed2683790c341dcd40acf534b132d1de8ed2/2023.05.10.540298.full-html.html
  8. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer
    1
    1. scibot 13 Jul 2023
      RRID:Addgene_12 259

      DOI: 10.1002/advs.202301088

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    onlinelibrary.wiley.com/doi/10.1002/advs.202301088
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Actin nucleators safeguard replication forks by limiting nascent strand degradation
    1
    1. scibot 12 Jul 2023
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      DOI: 10.1093/nar/gkad369

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    ncbi.nlm.nih.gov/pmc/articles/PMC10325910/
  10. pubs.acs.org pubs.acs.org
    SIRIUS, Ultra-Scintillating Upconversion Breast Implant for Remote Orthotopic Photodynamic Therapy
    1
    1. scibot 11 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1021/acsnano.3c01916

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    pubs.acs.org/doi/10.1021/acsnano.3c01916
  11. www.sciencedirect.com www.sciencedirect.com
    Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
    1
    1. scibot 11 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.isci.2023.107044

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    sciencedirect.com/science/article/pii/S2589004223011215
  12. www.nature.com www.nature.com
    Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma
    1
    1. scibot 08 Jul 2023
      RRID: Addgene_12259

      DOI: 10.1038/s41420-023-01526-7

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    nature.com/articles/s41420-023-01526-7
  13. 52.53.155.43 52.53.155.43
    can-23-0269-html.html
    1
    1. scibot 08 Jul 2023
      12259

      DOI: 10.1158/0008-5472.can-23-0269

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    52.53.155.43/54e62d316063b1626eedcc4063c6657fd4e230c9/can-23-0269-html.html
  14. www.sciencedirect.com www.sciencedirect.com
    TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
    1
    1. scibot 08 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.cell.2023.06.005

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    sciencedirect.com/science/article/pii/S0092867423006451
  15. www.biorxiv.org www.biorxiv.org
    Cell-based assay to determine Type 3 Secretion System translocon assembly in Pseudomonas aeruginosa using split luciferase
    1
    1. scibot 07 Jul 2023
      plasmid_12259

      DOI: 10.1101/2023.06.22.546099

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    biorxiv.org/content/10.1101/2023.06.22.546099v1
  16. www.sciencedirect.com www.sciencedirect.com
    Oncogenic K-Ras suppresses global miRNA function
    1
    1. scibot 06 Jul 2023
      Addgene_12259

      DOI: 10.1016/j.molcel.2023.06.008

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    sciencedirect.com/science/article/pii/S109727652300429X
  17. www.sciencedirect.com www.sciencedirect.com
    Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
    1
    1. scibot 05 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2023.112725

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    sciencedirect.com/science/article/pii/S2211124723007362
  18. www.sciencedirect.com www.sciencedirect.com
    Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
    1
    1. scibot 04 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2023.112705

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    sciencedirect.com/science/article/pii/S2211124723007167
  19. 52.53.155.43 52.53.155.43
    cd-22-0411-html.html
    1
    1. scibot 01 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1158/2159-8290.cd-22-0411

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    52.53.155.43/453457acda6208aed297e8061921a5c2d2ddddf2/cd-22-0411-html.html
  20. 52.53.155.43 52.53.155.43
    cir-22-0815-html.html
    1
    1. scibot 01 Jul 2023
      RRID:Addgene_12259

      DOI: 10.1158/2326-6066.CIR-22-0815

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    52.53.155.43/0c7b493d1804c631a7718bd69d23acbb033c9efb/cir-22-0815-html.html
  21. Jun 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Identification of XAF1 as an endogenous AKT inhibitor
    1
    1. scibot 29 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2023.112690

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    sciencedirect.com/science/article/pii/S2211124723007015
  23. www.sciencedirect.com www.sciencedirect.com
    Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth
    1
    1. scibot 29 Jun 2023
      Plasmid_12259

      DOI: 10.1016/j.celrep.2023.112680

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    sciencedirect.com/science/article/pii/S2211124723006915
  24. www.sciencedirect.com www.sciencedirect.com
    QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
    1
    1. scibot 28 Jun 2023
      RRID: Addgene_12259

      DOI: 10.1016/j.cell.2023.05.047

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    sciencedirect.com/science/article/pii/S0092867423005986
  25. www.sciencedirect.com www.sciencedirect.com
    An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer
    1
    1. scibot 27 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.isci.2023.107115

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    sciencedirect.com/science/article/pii/S2589004223011926
  26. www.nature.com www.nature.com
    Extracellular vesicle-associated IGF2BP3 tunes Ewing sarcoma cell migration and affects PI3K/Akt pathway in neighboring cells
    1
    1. scibot 27 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1038/s41417-023-00637-8

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    nature.com/articles/s41417-023-00637-8
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes
    1
    1. scibot 24 Jun 2023
      Addgene_12259

      DOI: 10.1101/2023.06.07.544100

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    ncbi.nlm.nih.gov/pmc/articles/PMC10274806/
  28. link.springer.com link.springer.com
    Development of a Series of Neutralizing Nanobodies against SARS-CoV-2 Spike Protein
    1
    1. scibot 24 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1134/S0026893323030196

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    link.springer.com/article/10.1134/S0026893323030196
  29. www.biorxiv.org www.biorxiv.org
    A functional single nucleotide polymorphism upstream of the collagen type III gene may contribute to catastrophic fracture risk in Thoroughbred horses
    1
    1. scibot 23 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1101/2023.06.16.545331

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    biorxiv.org/content/10.1101/2023.06.16.545331v1
  30. www.mdpi.com www.mdpi.com
    Effects of the Co-Overexpression of the BCL and BDNF Genes on the Gamma-Aminobutyric Acid-Ergic Differentiation of Wharton’s-Jelly-Derived Mesenchymal Stem Cells
    1
    1. scibot 23 Jun 2023
      RRID:Addgene_12259

      DOI: 10.3390/biomedicines11061751

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    mdpi.com/2227-9059/11/6/1751
  31. www.embopress.org www.embopress.org
    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
    1
    1. scibot 23 Jun 2023
      RRID:Addgene_12259

      DOI: 10.15252/embr.202256399

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    embopress.org/doi/full/10.15252/embr.202256399
  32. www.sciencedirect.com www.sciencedirect.com
    Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression
    1
    1. scibot 23 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2023.112642

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    sciencedirect.com/science/article/pii/S2211124723006538
  33. www.sciencedirect.com www.sciencedirect.com
    Adhesion tunes speed and persistence by coordinating protrusions and extracellular matrix remodeling
    1
    1. scibot 22 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.devcel.2023.05.013

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    sciencedirect.com/science/article/pii/S1534580723002460
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micronutrient optimization for tissue engineered articular cartilage production of type II collagen
    1
    1. scibot 22 Jun 2023
      RRID:Addgene_12259

      DOI: 10.3389/fbioe.2023.1179332

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    ncbi.nlm.nih.gov/pmc/articles/PMC10280293/
  35. www.biorxiv.org www.biorxiv.org
    Transcriptional landscape of DTP-DTEP transition reveals DUSP6 as a driver of HER2 inhibitor tolerance via Neuregulin/HER3 axis
    1
    1. scibot 22 Jun 2023
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      DOI: 10.1101/2023.06.14.544493

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    biorxiv.org/content/10.1101/2023.06.14.544493v1
  36. www.biorxiv.org www.biorxiv.org
    Host ZCCHC3 blocks HIV-1 infection and production by a dual mechanism
    1
    1. scibot 22 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1101/2023.06.14.544911

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    biorxiv.org/content/10.1101/2023.06.14.544911v2
  37. www.biorxiv.org www.biorxiv.org
    VAMP2 regulates phase separation of alpha-synuclein
    1
    1. scibot 22 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1101/2023.06.16.545277

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    biorxiv.org/content/10.1101/2023.06.16.545277v1
  38. www.sciencedirect.com www.sciencedirect.com
    Acetate controls endothelial-to-mesenchymal transition
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    1. scibot 21 Jun 2023
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    sciencedirect.com/science/article/pii/S1550413123002036
  39. www.sciencedirect.com www.sciencedirect.com
    DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs
    2
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.cell.2023.05.028

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      RRID:Addgene_122

      DOI: 10.1016/j.cell.2023.05.028

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    sciencedirect.com/science/article/pii/S0092867423005809
  40. www.sciencedirect.com www.sciencedirect.com
    LRP12 is an endogenous transmembrane inactivator of α4 integrins
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112667

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    sciencedirect.com/science/article/pii/S2211124723006782
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing
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    1. scibot 17 Jun 2023
      RRID:Addgene_12259

      DOI: 10.26508/lsa.202301964

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    ncbi.nlm.nih.gov/pmc/articles/PMC10264968/
  42. www.sciencedirect.com www.sciencedirect.com
    Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination
    1
    1. scibot 16 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.molcel.2023.05.026

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    sciencedirect.com/science/article/pii/S1097276523003829
  43. aacrjournals.org aacrjournals.org
    MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
    1
    1. scibot 10 Jun 2023
      RRID:Addgene_12259

      DOI: 10.1158/1541-7786.MCR-22-0554

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    aacrjournals.org/mcr/article/21/5/444/726027/MYC-Glutamine-Dependency-Is-a-Therapeutic
  44. aacrjournals.org aacrjournals.org
    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
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    aacrjournals.org/mcr/article/21/6/578/726510/USP10-Regulates-ZEB1-Ubiquitination-and-Protein
  45. aacrjournals.org aacrjournals.org
    Targeting RNA exonuclease XRN1 potentiates efficacy of cancer immunotherapy
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    aacrjournals.org/cancerres/article/83/6/922/718565/Targeting-RNA-Exonuclease-XRN1-Potentiates
  46. www.embopress.org www.embopress.org
    STAT1 is required to establish but not maintain interferon-γ-induced transcriptional memory
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  47. aacrjournals.org aacrjournals.org
    AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis
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    aacrjournals.org/cancerres/article/83/7/1062/718991/AMPK-Phosphorylates-ZDHHC13-to-Increase-MC1R
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multivesicular release favors short term synaptic depression in hippocampal autapses
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  49. aacrjournals.org aacrjournals.org
    ASPM activates Hedgehog and Wnt signaling to promote small cell lung cancer stemness and progression
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  50. aacrjournals.org aacrjournals.org
    Enhanced glutaminolysis drives hypoxia-induced chemoresistance in pancreatic cancer
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    aacrjournals.org/cancerres/article/83/5/735/716680/Enhanced-Glutaminolysis-Drives-Hypoxia-Induced
  51. www.sciencedirect.com www.sciencedirect.com
    KLHL7 promotes hepatocellular carcinoma progression and molecular therapy resistance by degrading RASA2
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  52. May 2023
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    Proteomics of immune cells from liver tumors reveals immunotherapy targets
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  54. www.embopress.org www.embopress.org
    Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy
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  57. www.biorxiv.org www.biorxiv.org
    Single-cycle SARS-CoV-2 vaccine elicits high protection and sterilizing immunity in hamsters
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    Unraveling human, rodent and snake Kolmioviridae replication to anticipate cross-species transmission
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  59. www.biorxiv.org www.biorxiv.org
    Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells
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    Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemia
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  61. www.sciencedirect.com www.sciencedirect.com
    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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  62. www.sciencedirect.com www.sciencedirect.com
    Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4+ T cells
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    Actuation of single downstream nodes in growth factor network steers immune cell migration
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  64. www.sciencedirect.com www.sciencedirect.com
    Modeling human ectopic pregnancies with trophoblast and vascular organoids
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  65. elifesciences.org elifesciences.org
    pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells
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    elifesciences.org/articles/82863
  66. elifesciences.org elifesciences.org
    Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction
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  67. www.sciencedirect.com www.sciencedirect.com
    Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21
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  68. www.nature.com www.nature.com
    A prime editor mouse to model a broad spectrum of somatic mutations in vivo
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  69. journals.plos.org journals.plos.org
    XRN2 suppresses aberrant entry of tRNA trailers into argonaute in humans and Arabidopsis
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  70. www.sciencedirect.com www.sciencedirect.com
    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized metrics for orthogonal combinatorial CRISPR screens
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A rabies virus–based toolkit for efficient retrograde... : Neural Regeneration Research
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  74. www.nature.com www.nature.com
    Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Syngeneic mouse model of human HER2+ metastatic breast cancer for the evaluation of trastuzumab emtansine combined with oncolytic rhabdovirus
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHD-associated enhancers shape human cardiomyocyte lineage commitment
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  77. www.sciencedirect.com www.sciencedirect.com
    Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
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  78. www.sciencedirect.com www.sciencedirect.com
    Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
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  79. www.sciencedirect.com www.sciencedirect.com
    Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer
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  81. www.biorxiv.org www.biorxiv.org
    L1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
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  82. www.biorxiv.org www.biorxiv.org
    Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly
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  83. www.nature.com www.nature.com
    KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress
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  84. www.sciencedirect.com www.sciencedirect.com
    TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation SIRT1/p53
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  85. Apr 2023
  86. www.sciencedirect.com www.sciencedirect.com
    Integrative dissection of gene regulatory elements at base resolution
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  87. academic.oup.com academic.oup.com
    Dynamics of Chromatin Accessibility during Hematopoietic Stem Cell Differentiation into Progressively Lineage-Committed Progeny
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    Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis
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    A tissue injury sensing and repair pathway distinct from host pathogen defense
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    C9ORF72 suppresses JAK-STAT mediated inflammation
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  91. aacrjournals.org aacrjournals.org
    Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity
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  92. aacrjournals.org aacrjournals.org
    Dual mTORC1/2 inhibition synergistically enhances AML cell death in combination with the BCL2 antagonist venetoclax
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells
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    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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    PHLPP1 regulates PINK1-parkin signalling and life span
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-suppressor scanning for systematic discovery of drug resistance mutations
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    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism
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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Asparagine starvation suppresses histone demethylation through iron depletion
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    Phosphorylation barcodes direct biased chemokine signaling at CXCR3
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    Systemwide disassembly and assembly of SCF ubiquitin ligase complexes
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  102. 52.53.155.43 52.53.155.43
    A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma
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  103. www.sciencedirect.com www.sciencedirect.com
    ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas
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    Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars
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    Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome
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    Novel role of pre-replication complex component cell division cycle 6 in retinal neovascularization
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    A micropattern-based assay to study contact inhibition of locomotion and entosis of adherent human and canine cells in vitro
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    Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells
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    Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development
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    Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals
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    Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
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    m6A-driven SF3B1 translation control steers splicing to direct genome integrity and leukemogenesis
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    FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
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  117. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout
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  118. 52.53.155.43 52.53.155.43
    Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
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  119. www.biorxiv.org www.biorxiv.org
    Disease Modifying Osteoarthritis Drug Discovery Using A Temporal Phenotypic Reporter In Primary Human Chondrocytes
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    Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4+ T cells
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    FAM193A is a positive regulator of p53 activity
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    Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
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    Inhibition of RNA Polymerase III Augments the Anti-Cancer Properties of TNFα
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  124. www.biorxiv.org www.biorxiv.org
    LCP1 Regulates Cell Motility in Chondrosarcoma and Correlates with Metastatic Potential and Poor Patient Outcomes
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    The tyrosine phosphatase LAR acts as a receptor of the nidogen-tetanus toxin complex
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    The effect of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly
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    SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo
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    Inactivation of SARS-CoV-2 on Surfaces by Cold-Plasma-Generated Reactive Species
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    A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses
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  130. www.biorxiv.org www.biorxiv.org
    Mapping the dynamic cell surface interactome of high-density lipoprotein reveals Aminopeptidase N as modulator of its endothelial uptake
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  131. rupress.org rupress.org
    EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons
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  132. Feb 2023
  133. www.sciencedirect.com www.sciencedirect.com
    Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HER2-driven breast cancer suppression by the JNK signaling pathway
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  135. www.sciencedirect.com www.sciencedirect.com
    An adverse tumor-protective effect of IDO1 inhibition
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  136. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer
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  139. www.sciencedirect.com www.sciencedirect.com
    Archaic humans have contributed to large-scale variation in modern human T cell receptor genes
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs
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  141. www.sciencedirect.com www.sciencedirect.com
    CRISPR-based large-scale modeling of loss-of-function mutations to investigate mechanisms of stress resistance in cancer
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  142. www.nature.com www.nature.com
    ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
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  144. aacrjournals.org aacrjournals.org
    PINK1-mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells
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    aacrjournals.org/cancerres/article/83/3/398/716188/PINK1-Mediated-Mitophagy-Promotes-Oxidative
  145. www.sciencedirect.com www.sciencedirect.com
    Monitoring cell fate in 3D organotypic human squamous epithelial cultures
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  146. www.sciencedirect.com www.sciencedirect.com
    Piperlongumine conjugates induce targeted protein degradation
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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  149. www.sciencedirect.com www.sciencedirect.com
    Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
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  150. www.sciencedirect.com www.sciencedirect.com
    A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
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  153. Jan 2023
  154. www.sciencedirect.com www.sciencedirect.com
    Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies
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  156. www.mdpi.com www.mdpi.com
    Comparison of a Genotype 1 and a Genotype 2 Macaque Foamy Virus env Gene Indicates Distinct Infectivity and Cell-Cell Fusion but Similar Tropism and Restriction of Cell Entry by Interferon-Induced Transmembrane Proteins
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression
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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Attenuating iPSC reprogramming stress with dominant-negative BET peptides
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  159. www.sciencedirect.com www.sciencedirect.com
    Optimized protocols for chromatin immunoprecipitation of exogenously expressed epitope-tagged proteins
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    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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    Protocol to study presynaptic protein synthesis in ex vivo mouse hippocampal slices using HaloTag technology
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  163. www.biorxiv.org www.biorxiv.org
    Actin nucleators safeguard replication forks by limiting nascent strand degradation
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    Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    Controlling organoid symmetry breaking uncovers an excitable system underlying human axial elongation
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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  170. journals.lww.com journals.lww.com
    Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research
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  171. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Acute COG inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles
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  172. link.springer.com link.springer.com
    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
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    link.springer.com/article/10.1007/s00125-022-05856-6
  173. rupress.org rupress.org
    Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II–dependent fashion
    1
    1. scibot 12 Jan 2023
      plasmid_12259

      DOI: 10.1083/jcb.202204100

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    rupress.org/jcb/article/222/2/e202204100/213712/Fibroblasts-secrete-fibronectin-under-lamellipodia
  174. www.sciencedirect.com www.sciencedirect.com
    DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling
    1
    1. scibot 12 Jan 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2022.111986

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    sciencedirect.com/science/article/pii/S2211124722018903
  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A whole genome CRISPR screen identifies AHR loss as a mechanism of PARP7 inhibitor resistancePARP7 inhibitor CRISPR screen
    1
    1. scibot 12 Jan 2023
      RRID:Addgene_12259

      DOI: 10.1158/1535-7163.MCT-21-0841

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    ncbi.nlm.nih.gov/pmc/articles/PMC9769698/
  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nonstructural protein 1 widespread RNA decay phenotype varies among coronaviruses
    1
    1. scibot 11 Jan 2023
      Plasmid #12259 (Addgene)

      DOI: 10.1016/j.isci.2022.105887

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    ncbi.nlm.nih.gov/pmc/articles/PMC9794394/
  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells
    1
    1. scibot 11 Jan 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.xpro.2022.101992

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    ncbi.nlm.nih.gov/pmc/articles/PMC9826815/
  178. www.sciencedirect.com www.sciencedirect.com
    Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin
    1
    1. scibot 11 Jan 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.cell.2022.12.016

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    sciencedirect.com/science/article/pii/S009286742201529X
  179. www.sciencedirect.com www.sciencedirect.com
    Resurrection of endogenous retroviruses during aging reinforces senescence
    1
    1. scibot 07 Jan 2023
      plasmid_12259

      DOI: 10.1016/j.cell.2022.12.017

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    sciencedirect.com/science/article/pii/S0092867422015306
  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor
    1
    1. scibot 07 Jan 2023
      Addgene_12259

      DOI: 10.1158/2159-8290.CD-21-0646

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    ncbi.nlm.nih.gov/pmc/articles/PMC9453853/
  181. www.sciencedirect.com www.sciencedirect.com
    Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis
    1
    1. scibot 06 Jan 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.joca.2022.12.010

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    sciencedirect.com/science/article/pii/S1063458423000018
  182. www.sciencedirect.com www.sciencedirect.com
    METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
    1
    1. scibot 06 Jan 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.stem.2022.12.006

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    sciencedirect.com/science/article/pii/S1934590922004908
  183. www.cell.com www.cell.com
    Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
    1
    1. scibot 02 Jan 2023
      RRID:Addgene_12259

      DOI: 10.1016/j.ccell.2022.12.003

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    cell.com/cancer-cell/fulltext/S1535-6108(22)00589-X
  184. Dec 2022
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection
    1
    1. scibot 31 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1128/mbio.02446-22

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    ncbi.nlm.nih.gov/pmc/articles/PMC9765453/
  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis
    1
    1. scibot 31 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1158/2767-9764.crc-22-0262

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    ncbi.nlm.nih.gov/pmc/articles/PMC9770512/
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Virus-like particle – mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection
    1
    1. scibot 30 Dec 2022
      plasmid_12259

      DOI: 10.3389/fcimb.2022.1079926

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    ncbi.nlm.nih.gov/pmc/articles/PMC9795031/
  188. link.springer.com link.springer.com
    The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities
    1
    1. scibot 29 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1007/s12035-022-03153-2

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    link.springer.com/article/10.1007/s12035-022-03153-2
  189. aacrjournals.org aacrjournals.org
    IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis
    1
    1. scibot 24 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1158/2767-9764.CRC-22-0262

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    aacrjournals.org/cancerrescommun/article/2/12/1545/711358/IL1-Expression-Driven-by-Androgen-Receptor-Absence
  190. aacrjournals.org aacrjournals.org
    Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
    1
    1. scibot 24 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1158/0008-5472.CAN-21-2519

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    aacrjournals.org/cancerres/article/82/17/3002/708290/Efficient-Correction-of-Oncogenic-KRAS-and-TP53
  191. www.sciencedirect.com www.sciencedirect.com
    IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury
    1
    1. scibot 24 Dec 2022
      Addgene_12259

      DOI: 10.1016/j.celrep.2022.111848

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    sciencedirect.com/science/article/pii/S2211124722017405
  192. www.sciencedirect.com www.sciencedirect.com
    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
    1
    1. scibot 20 Dec 2022
      Addgene_12259

      DOI: 10.1016/j.devcel.2022.11.015

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    sciencedirect.com/science/article/pii/S1534580722008152
  193. link.springer.com link.springer.com
    AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer
    1
    1. scibot 20 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1007/s00018-022-04638-y

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    link.springer.com/article/10.1007/s00018-022-04638-y
  194. www.sciencedirect.com www.sciencedirect.com
    The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
    1
    1. scibot 18 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2022.111819

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    sciencedirect.com/science/article/pii/S2211124722017119
  195. www.sciencedirect.com www.sciencedirect.com
    Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection
    1
    1. scibot 18 Dec 2022
      Addgene_12259

      DOI: 10.1016/j.celrep.2022.111817

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    sciencedirect.com/science/article/pii/S2211124722017090
  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines
    2
    1. scibot 17 Dec 2022
      plasmid_12259

      DOI: 10.1007/978-1-0716-2639-9_22

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      RRID:Addgene_12

      DOI: 10.1007/978-1-0716-2639-9_22

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    ncbi.nlm.nih.gov/pmc/articles/PMC10026839/
  197. link.springer.com link.springer.com
    Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System
    1
    1. scibot 17 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1007/978-1-0716-2639-9_23

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    link.springer.com/protocol/10.1007/978-1-0716-2639-9_23
  198. www.sciencedirect.com www.sciencedirect.com
    Engineered cell entry links receptor biology with single-cell genomics
    1
    1. scibot 17 Dec 2022
      addgene_12259

      DOI: 10.1016/j.cell.2022.11.016

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    sciencedirect.com/science/article/pii/S009286742201460X
  199. www.sciencedirect.com www.sciencedirect.com
    A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates
    1
    1. scibot 11 Dec 2022
      plasmid_12259

      DOI: 10.1016/j.cell.2022.11.005

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    sciencedirect.com/science/article/pii/S0092867422014155
  200. www.sciencedirect.com www.sciencedirect.com
    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
    1
    1. scibot 08 Dec 2022
      12259

      DOI: 10.1016/j.celrep.2022.111653

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    sciencedirect.com/science/article/pii/S2211124722015248
  201. www.sciencedirect.com www.sciencedirect.com
    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
    1
    1. scibot 08 Dec 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.molcel.2022.11.010

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    sciencedirect.com/science/article/pii/S1097276522010991