2,113 Matching Annotations
  1. Oct 2022
  2. www.nature.com www.nature.com
    Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome
    1
    1. scibot 11 Oct 2022
      RRID:Addgene_12259

      DOI: 10.1038/s41587-022-01494-w

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    nature.com/articles/s41587-022-01494-w
  3. www.sciencedirect.com www.sciencedirect.com
    The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
    1
    1. scibot 09 Oct 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.cell.2022.09.020

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    sciencedirect.com/science/article/pii/S0092867422011928
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration
    1
    1. scibot 02 Oct 2022
      Addgene_12259

      DOI: 10.1016/j.isci.2022.105050

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    ncbi.nlm.nih.gov/pmc/articles/PMC9519511/
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfments
    1
    1. scibot 01 Oct 2022
      Addgene_12259

      DOI: 10.1016/j.isci.2022.105144

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    ncbi.nlm.nih.gov/pmc/articles/PMC9519618/
  6. Sep 2022
  7. www.sciencedirect.com www.sciencedirect.com
    Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors
    1
    1. scibot 30 Sep 2022
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      DOI: 10.1016/j.immuni.2022.09.001

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    sciencedirect.com/science/article/pii/S1074761322004149
  8. www.sciencedirect.com www.sciencedirect.com
    Opto-katanin, an optogenetic tool for localized, microtubule disassembly
    1
    1. scibot 29 Sep 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.cub.2022.09.010

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    sciencedirect.com/science/article/pii/S0960982222014543
  9. www.sciencedirect.com www.sciencedirect.com
    A screening-compatible live cell fluorescence resonance energy transfer-based assay for modulation of Rho GTPase activity
    1
    1. scibot 24 Sep 2022
      Addgene#12259

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    sciencedirect.com/science/article/pii/S2666166722005858
  10. www.sciencedirect.com www.sciencedirect.com
    Determining glioma cell invasion and proliferation in ex vivo organotypic mouse brain slices using whole-mount immunostaining and tissue clearing
    1
    1. scibot 22 Sep 2022
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    sciencedirect.com/science/article/pii/S2666166722005834
  11. journals.biologists.com journals.biologists.com
    TGFBR3 supports anoikis through suppressing ATF4 signaling
    1
    1. scibot 22 Sep 2022
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      DOI: 10.1242/jcs.258396

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    journals.biologists.com/jcs/article/135/17/jcs258396/276460/TGFBR3-supports-anoikis-through-suppressing-ATF4
  12. www.sciencedirect.com www.sciencedirect.com
    GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
    2
    1. scibot 22 Sep 2022
      Addgene_12259

      DOI: 10.1016/j.celrep.2022.111344

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    2. scibot 22 Sep 2022
      Addgene_12259

      DOI: 10.1016/j.celrep.2022.111344

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    sciencedirect.com/science/article/pii/S221112472201172X
  13. www.sciencedirect.com www.sciencedirect.com
    Meteorin links the bone marrow hypoxic state to hematopoietic stem/progenitor cell mobilization
    1
    1. scibot 22 Sep 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2022.111361

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    sciencedirect.com/science/article/pii/S2211124722011937
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation
    1
    1. scibot 22 Sep 2022
      RRID:Addgene_12259

      DOI: 10.3389/fendo.2022.932286

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    ncbi.nlm.nih.gov/pmc/articles/PMC9483015/
  15. www.sciencedirect.com www.sciencedirect.com
    Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin
    1
    1. scibot 21 Sep 2022
      Plasmid pMD2.G

      DOI: 10.1016/j.celrep.2022.111390

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    sciencedirect.com/science/article/pii/S221112472201227X
  16. www.sciencedirect.com www.sciencedirect.com
    CRISPR-Cas9 screen in human embryonic stem cells to identify genes required for neural differentiation
    1
    1. scibot 18 Sep 2022
      plasmid_12259

      DOI: 10.1016/j.xpro.2022.101682

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    sciencedirect.com/science/article/pii/S2666166722005627
  17. www.sciencedirect.com www.sciencedirect.com
    Scalable CRISPR-Cas9 chemical genetic screens in non-transformed human cells
    1
    1. scibot 15 Sep 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.xpro.2022.101675

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    sciencedirect.com/science/article/pii/S266616672200555X
  18. www.sciencedirect.com www.sciencedirect.com
    SerpinB3 drives cancer stem cell survival in glioblastoma
    1
    1. scibot 15 Sep 2022
      Addgene_12259

      DOI: 10.1016/j.celrep.2022.111348

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    sciencedirect.com/science/article/pii/S2211124722011767
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins
    1
    1. scibot 10 Sep 2022
      RRID:Addgene_12259

      DOI: 10.1158/2159-8290.CD-22-0043

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    ncbi.nlm.nih.gov/pmc/articles/PMC9437572/
  20. www.sciencedirect.com www.sciencedirect.com
    Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages
    1
    1. scibot 08 Sep 2022
      Plasmid_12259

      DOI: 10.1016/j.celrep.2022.111315

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    sciencedirect.com/science/article/pii/S2211124722011391
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human coronaviruses disassemble processing bodies
    1
    1. scibot 07 Sep 2022
      Addgene_12259

      DOI: 10.1371/journal.ppat.1010724

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    ncbi.nlm.nih.gov/pmc/articles/PMC9439236/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
    1
    1. scibot 02 Sep 2022
      RRID:Addgene_12259

      DOI: 10.1158/2159-8290.CD-21-1077

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    ncbi.nlm.nih.gov/pmc/articles/PMC8904298/
  23. www.sciencedirect.com www.sciencedirect.com
    Inhibition of HIV-1 replication using the CRISPR/cas9-no NLS system as a prophylactic strategy
    1
    1. scibot 01 Sep 2022
      plasmid_12259

      DOI: 10.1016/j.heliyon.2022.e10483

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    sciencedirect.com/science/article/pii/S2405844022017716
  24. Aug 2022
  25. www.sciencedirect.com www.sciencedirect.com
    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
    1
    1. scibot 31 Aug 2022
      Addgene #12259

      DOI: 10.1016/j.celrep.2022.111296

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    sciencedirect.com/science/article/pii/S2211124722011160
  26. www.sciencedirect.com www.sciencedirect.com
    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
    1
    1. scibot 31 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2022.111278

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    sciencedirect.com/science/article/pii/S2211124722010981
  27. 52.53.155.43 52.53.155.43
    can-21-2908-html.html
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    1. scibot 27 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1158/0008-5472.can-21-2908

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    52.53.155.43/e58395037b6fc963ccf3afdad25ef582040a5a24/can-21-2908-html.html
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Decoding Functional High-Density Lipoprotein Particle Surfaceome Interactions
    1
    1. scibot 27 Aug 2022
      RRID:Addgene_12259

      DOI: 10.3390/ijms23169506

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    ncbi.nlm.nih.gov/pmc/articles/PMC9409371/
  29. www.sciencedirect.com www.sciencedirect.com
    A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
    2
    1. scibot 22 Aug 2022
      RRID: Addgene_12259

      DOI: 10.1016/j.ccell.2022.07.012

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    2. scibot 22 Aug 2022
      plasmid_12259

      DOI: 10.1016/j.ccell.2022.07.012

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    sciencedirect.com/science/article/pii/S1535610822003257
  30. www.sciencedirect.com www.sciencedirect.com
    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
    1
    1. scibot 22 Aug 2022
      Addgene, Cat# 12259

      DOI: 10.1016/j.ccell.2022.07.011

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    sciencedirect.com/science/article/pii/S1535610822003245
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPRi-mediated knock-down of PRDM1/BLIMP1 programs central memory differentiation in ex vivo-expanded human T cells
    1
    1. scibot 22 Aug 2022
      RRID:Addgene_12259

      DOI: 10.34172/bi.2021.23522

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    ncbi.nlm.nih.gov/pmc/articles/PMC9376159/
  32. www.sciencedirect.com www.sciencedirect.com
    Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation
    1
    1. scibot 17 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.celrep.2022.111205

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    sciencedirect.com/science/article/pii/S2211124722010221
  33. www.sciencedirect.com www.sciencedirect.com
    Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways
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    1. scibot 17 Aug 2022
      addgene_12259

      DOI: 10.1016/j.celrep.2022.111181

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    sciencedirect.com/science/article/pii/S2211124722009949
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains
    1
    1. scibot 13 Aug 2022
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      DOI: 10.1371/journal.pbio.3001738

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    ncbi.nlm.nih.gov/pmc/articles/PMC9359572/
  35. www.nature.com www.nature.com
    Identifying cell receptors for the nanoparticle protein corona using genome screens
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    1. scibot 13 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1038/s41589-022-01093-5

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    nature.com/articles/s41589-022-01093-5
  36. www.sciencedirect.com www.sciencedirect.com
    Protocol for the generation of HIV-1 genomic RNA with altered levels of N6-methyladenosine
    1
    1. scibot 12 Aug 2022
      plasmid_12259

      DOI: 10.1016/j.xpro.2022.101616

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    sciencedirect.com/science/article/pii/S2666166722004968
  37. www.nature.com www.nature.com
    Spatial multi-omic map of human myocardial infarction
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    1. scibot 11 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1038/s41586-022-05060-x

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    nature.com/articles/s41586-022-05060-x
  38. link.springer.com link.springer.com
    CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer
    1
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      RRID:Addgene_12259

      DOI: 10.1186/s13046-022-02443-w

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    link.springer.com/article/10.1186/s13046-022-02443-w
  39. www.sciencedirect.com www.sciencedirect.com
    Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype
    1
    1. scibot 10 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.neo.2022.100830

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    sciencedirect.com/science/article/pii/S1476558622000574
  40. rupress.org rupress.org
    Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity
    1
    1. scibot 10 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1083/jcb.202111066

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    rupress.org/jcb/article/221/8/e202111066/213352/Dissecting-protein-tyrosine-phosphatase-signaling
  41. www.sciencedirect.com www.sciencedirect.com
    METTL14-dependent m6A modification controls iNKT cell development and function
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      Addgene: 12259

      DOI: 10.1016/j.celrep.2022.111156

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    sciencedirect.com/science/article/pii/S2211124722009652
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope
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      RRID:Addgene_12259

      DOI: 10.1016/j.cell.2022.07.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC9279490/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CRISPR-Cas12a-based diagnostic method for multiple genotypes of severe fever with thrombocytopenia syndrome virus
    1
    1. scibot 06 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1371/journal.pntd.0010666

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    ncbi.nlm.nih.gov/pmc/articles/PMC9345333/
  44. www.sciencedirect.com www.sciencedirect.com
    EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity
    1
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      Addgene_12259

      DOI: 10.1016/j.stem.2022.06.014

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    sciencedirect.com/science/article/pii/S1934590922002958
  45. academic.oup.com academic.oup.com
    FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations
    1
    1. scibot 04 Aug 2022
      RRID:Addgene_12259

      DOI: 10.1093/nar/gkac673

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  46. www.sciencedirect.com www.sciencedirect.com
    Protocol for genome-wide CRISPR knockout screens of bacterial cytotoxins in HeLa cells
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    The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors
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  48. Jul 2022
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance
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    Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
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    Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID
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    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Self-assembly of pericentriolar material in interphase cells lacking centrioles
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  54. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
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    Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery
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    Mislocalization of protein kinase A drives pathology in Cushing’s syndrome
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    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
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    Targeting the transcriptional activity of STAT3 by a novel fusion protein
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    EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks
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  62. Jun 2022
  63. 52.53.155.43 52.53.155.43
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  64. 52.53.155.43 52.53.155.43
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transcriptional reprogramming differentiates active from inactive ESR1 fusions in endocrine therapy-refractory metastatic breast cancer
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi
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    Targeting EP2 receptor with multifaceted mechanisms for high-risk neuroblastoma
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    Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached
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    Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria
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    RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells
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    Granger-causal inference of the lamellipodial actin regulator hierarchy by live cell imaging without perturbation
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    Itaconate is a lysosomal inducer that promotes antibacterial innate immunity
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineering of human mesenchymal stem cells resistant to multiple natural killer subtypes
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  77. www.sciencedirect.com www.sciencedirect.com
    Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs
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    YAP1 activation is associated with the progression and response to immunotherapy of non-muscle invasive bladder cancer
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    A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs
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  80. May 2022
  81. link.springer.com link.springer.com
    Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation
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    DDX41 is required for cGAS-STING activation against DNA virus infection
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    HIV-1 exploits the Fanconi anemia pathway for viral DNA integration
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    Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging
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    Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2
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  90. www.sciencedirect.com www.sciencedirect.com
    Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway
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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme
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  92. aacrjournals.org aacrjournals.org
    Concurrent Inhibition of ERK and Farnesyltransferase Suppresses the Growth of HRAS Mutant Head and Neck Squamous Cell Carcinoma
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  93. www.sciencedirect.com www.sciencedirect.com
    MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
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  95. www.sciencedirect.com www.sciencedirect.com
    Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
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  96. www.nature.com www.nature.com
    Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection
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  97. www.sciencedirect.com www.sciencedirect.com
    Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy
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    SETD4-mediated KU70 methylation suppresses apoptosis
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    The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
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    The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
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    Synthetic Carbohydrate Binding Agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2.
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  102. www.nature.com www.nature.com
    The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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  104. www.sciencedirect.com www.sciencedirect.com
    Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
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  105. Apr 2022
  106. www.nature.com www.nature.com
    TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer
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  107. www.nature.com www.nature.com
    Identifying a confused cell identity for esophageal squamous cell carcinoma
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  108. www.sciencedirect.com www.sciencedirect.com
    Establishing transgenic murine esophageal organoids
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  109. aacrjournals.org aacrjournals.org
    CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses
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    aacrjournals.org/cancerimmunolres/article/10/4/525/689540/CDK2-Inhibition-Enhances-Antitumor-Immunity-by
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRAF Inhibitor Resistance Confers Increased Sensitivity to Mitotic Inhibitors
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  111. www.sciencedirect.com www.sciencedirect.com
    In vitro and in vivo assay of the ER lipid scramblase TMEM41B
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  112. www.sciencedirect.com www.sciencedirect.com
    Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity
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    sciencedirect.com/science/article/pii/S1550413122001267
  113. www.sciencedirect.com www.sciencedirect.com
    CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair
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    Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis
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  115. www.sciencedirect.com www.sciencedirect.com
    A presynaptic phosphosignaling hub for lasting homeostatic plasticity
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  116. www.sciencedirect.com www.sciencedirect.com
    Mitotic Spindle Positioning (MISP) is an actin bundler that selectively stabilizes the rootlets of epithelial microvilli
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  117. www.sciencedirect.com www.sciencedirect.com
    Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
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    Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling
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    Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
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    Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells
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    Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex
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    Rapid establishment of human colonic organoid knockout lines
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    Brown adipose tissue involution associated with progressive restriction in progenitor competence
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  124. www.sciencedirect.com www.sciencedirect.com
    Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function
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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Single Transcript Knockdown-Replacement Strategy Employing 5’ UTR Secondary Structures to Precisely Titrate Rescue Protein Translation
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  126. www.sciencedirect.com www.sciencedirect.com
    Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma
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    Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma
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    Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis
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    Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation
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  131. Mar 2022
  132. elifesciences.org elifesciences.org
    Persistent cell migration emerges from a coupling between protrusion dynamics and polarized trafficking
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  133. academic.oup.com academic.oup.com
    Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor
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  134. www.sciencedirect.com www.sciencedirect.com
    Genome-wide CRISPR-Cas9 screening identifies the CYTH2 host gene as a potential therapeutic target of influenza viral infection
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    Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases
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    Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine
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    A multiplexed epitope barcoding strategy that enables dynamic cellular phenotypic screens
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Potential Metabolite Markers for Pancreatic Cancer Identified by Metabolomic Analysis of Induced Cancer-Associated Fibroblasts
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  139. 52.53.155.43 52.53.155.43
    Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy
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    The mTOR chromatin-bound interactome in prostate cancer
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    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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    CTNNBL1 restricts HIV-1 replication by suppressing viral DNA integration into the cell genome
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  143. www.nature.com www.nature.com
    Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell analyses reveal diverse mechanisms of resistance to EGFR tyrosine kinase inhibitors in lung cancer
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  145. www.sciencedirect.com www.sciencedirect.com
    A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors
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    Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations
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  148. www.sciencedirect.com www.sciencedirect.com
    Generation of highly pure motor neurons from human induced pluripotent stem cells
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    Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrin Beta 4E Promotes Endothelial Phenotypic Changes and Attenuates Lung Endothelial Cell Inflammatory Responses
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  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells
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  152. www.sciencedirect.com www.sciencedirect.com
    Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms
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    Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication
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  154. www.sciencedirect.com www.sciencedirect.com
    Local hyperthermia therapy induces browning of white fat and treats obesity
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  155. aacrjournals.org aacrjournals.org
    MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
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  156. www.nature.com www.nature.com
    Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors
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  157. www.nature.com www.nature.com
    Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning
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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin
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  159. elifesciences.org elifesciences.org
    Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity
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  160. www.sciencedirect.com www.sciencedirect.com
    Full-length and split-NanoLuc reporters identify pathogenic COL4A5 nonsense mutations susceptible to premature termination codon readthrough
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  161. www.sciencedirect.com www.sciencedirect.com
    An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function
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    Recruitment of DNA to tumor-derived microvesicles
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  163. Feb 2022
  164. www.sciencedirect.com www.sciencedirect.com
    High-throughput identification of autoantibodies that target the human exoproteome
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    HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
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    Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing
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    Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination
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  168. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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  169. www.sciencedirect.com www.sciencedirect.com
    Enzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cell migration
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A zebrafish embryo screen utilizing gastrulation identifies the HTR2C inhibitor pizotifen as a suppressor of EMT-mediated metastasis
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  171. www.sciencedirect.com www.sciencedirect.com
    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
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  172. www.sciencedirect.com www.sciencedirect.com
    TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells
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  173. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway
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  174. www.sciencedirect.com www.sciencedirect.com
    Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells
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    2. scibot 09 Feb 2022
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    sciencedirect.com/science/article/pii/S2211124722000596
  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of NKX2.5GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts
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    1. scibot 08 Feb 2022
      RRID:Addgene_12259

      DOI: 10.3389/fcell.2021.797927

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    ncbi.nlm.nih.gov/pmc/articles/PMC8815860/
  176. www.sciencedirect.com www.sciencedirect.com
    Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
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    1. scibot 04 Feb 2022
      RRID:Addgene_12259

      DOI: 10.1016/j.ccell.2022.01.003

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    sciencedirect.com/science/article/pii/S1535610822000058
  177. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12
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    1. scibot 03 Feb 2022
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33929
  178. www.sciencedirect.com www.sciencedirect.com
    Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface
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    1. scibot 02 Feb 2022
      Addgene; Cat#12259

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    sciencedirect.com/science/article/pii/S2211124722000456
  179. www.sciencedirect.com www.sciencedirect.com
    Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML
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      DOI: 10.1016/j.tranon.2022.101354

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    sciencedirect.com/science/article/pii/S193652332200016X
  180. www.sciencedirect.com www.sciencedirect.com
    Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death
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    sciencedirect.com/science/article/pii/S245194562200006X
  181. www.sciencedirect.com www.sciencedirect.com
    Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death
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    1. scibot 02 Feb 2022
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    sciencedirect.com/science/article/pii/S2211124722000274
  182. journals.biologists.com journals.biologists.com
    Contribution of protein-protein interactions to the endothelial barrier-stabilizing function of KRIT1
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    1. scibot 01 Feb 2022
      RRID:Addgene_12259

      DOI: 10.1242/jcs.258816

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    journals.biologists.com/jcs/article/135/2/jcs258816/274104/Contribution-of-protein-protein-interactions-to
  183. Jan 2022
  184. www.sciencedirect.com www.sciencedirect.com
    scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells
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    1. scibot 29 Jan 2022
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    sciencedirect.com/science/article/pii/S1097276521011436
  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Comprehensive Analysis of CD4+ T Cell Response Cross-Reactive to SARS-CoV-2 Antigens at the Single Allele Level of HLA Class II
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      RRID: Addgene_12259

      DOI: 10.3389/fimmu.2021.774491

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    ncbi.nlm.nih.gov/pmc/articles/PMC8770530/
  186. www.sciencedirect.com www.sciencedirect.com
    The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression
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    sciencedirect.com/science/article/pii/S0091674921025811
  187. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors
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      DOI: 10.1002/advs.202104344

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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
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    1. scibot 22 Jan 2022
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      DOI: 10.3390/cancers14020326

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    ncbi.nlm.nih.gov/pmc/articles/PMC8773906/
  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death
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    1. scibot 22 Jan 2022
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      DOI: 10.3390/cancers14020339

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  190. www.sciencedirect.com www.sciencedirect.com
    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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    1. scibot 16 Jan 2022
      AddgeneCat#12259

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    sciencedirect.com/science/article/pii/S2211124721017459
  191. www.sciencedirect.com www.sciencedirect.com
    Autologous humanized mouse models of iPSC-derived tumors enable characterization and modulation of cancer-immune cell interactions
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      DOI: 10.1016/j.crmeth.2021.100153

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    sciencedirect.com/science/article/pii/S2667237521002307
  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
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      RRID:Addgene_12259

      DOI: 10.1016/j.cell.2021.12.026

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    ncbi.nlm.nih.gov/pmc/articles/PMC8695127/
  193. www.sciencedirect.com www.sciencedirect.com
    Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity
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      RRID:Addgene_12259

      DOI: 10.1016/j.isci.2021.103621

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    sciencedirect.com/science/article/pii/S2589004221015911
  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation
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    1. scibot 12 Jan 2022
      RRID:Addgene_12259

      DOI: 10.1242/jcs.251645

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    ncbi.nlm.nih.gov/pmc/articles/PMC7823158/
  195. link.springer.com link.springer.com
    p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function
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    1. scibot 11 Jan 2022
      RRID:Addgene_12259

      DOI: 10.1007/s12035-021-02715-0

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    link.springer.com/article/10.1007/s12035-021-02715-0
  196. www.sciencedirect.com www.sciencedirect.com
    Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
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      12259

      DOI: 10.1016/j.ebiom.2021.103803

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    sciencedirect.com/science/article/pii/S2352396421005971
  197. Dec 2021
  198. www.sciencedirect.com www.sciencedirect.com
    Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells
    1
    1. scibot 29 Dec 2021
      plasmid_12259

      DOI: 10.1016/j.isci.2021.103605

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    sciencedirect.com/science/article/pii/S2589004221015753
  199. www.sciencedirect.com www.sciencedirect.com
    Substratum stiffness regulates Erk signaling dynamics through receptor-level control
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    1. scibot 29 Dec 2021
      Addgene_12259

      DOI: 10.1016/j.celrep.2021.110181

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    sciencedirect.com/science/article/pii/S2211124721016818