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Mar 2022
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Toxicities of amyloid-beta and tau protein are reciprocally ... : Neural Regeneration Research

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ADARs act as potent regulators of circular transcriptome in cancer

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  DOI: 10.1038/s41467-022-29138-2
  
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CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors

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Interleukin-18mediated inflammatory brain injury after intracerebral hemorrhage in male mice

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  DOI: 10.1002/jnr.25044
  
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  DOI: 10.1002/jnr.25044
  
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Comprehensive proteomic profiling of plasma and serum phosphatidylserine-positive extracellular vesicles reveals tissue-specific proteins

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Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy

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Protocol for RNA fluorescence in situ hybridization in mouse meningeal whole mounts

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Profiling of diverse tumor types establishes the broad utility of VHL-based ProTaCs and triages candidate ubiquitin ligases

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  DOI: 10.1016/j.isci.2022.103985
  
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AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells

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A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer

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Urolithin A alleviates blood-brain barrier disruption and... : Neural Regeneration Research

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Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

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Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments

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  DOI: 10.1016/j.celrep.2022.110411
  
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Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response

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Canonical thyroid hormone receptor β action stimulates hepatocyte proliferation in male mice

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  DOI: 10.1210/endocr/bqac003
  
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academic.oup.com/endo/article/163/3/bqac003/6509895
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Aberrant induction of a mesenchymal/stem-cell program engages senescence in normal mammary epithelial cells.

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  DOI: 10.1158/1541-7786.MCR-19-1181
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8867383/
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A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair

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1. scibot 04 Mar 2022
  
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  DOI: 10.7554/eLife.72917
  
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Engineering of thick human functional myocardium via static stretching and electrical stimulation

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  DOI: 10.1016/j.isci.2022.103824
  
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Tofacitinib Suppresses Natural Killer Cells In Vitro and In Vivo: Implications for Amyotrophic Lateral Sclerosis

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Maelstrom functions in the production of Siwi-piRISC capable of regulating transposons in Bombyx germ cells

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ajpgi.00290.2021-html.html

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  DOI: 10.6084/m9.figshare.16613464.v1
  
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DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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  DOI: 10.1111/febs.16365
  
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Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus

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  DOI: 10.1016/j.ebiom.2022.103903
  
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Generation of a MSX1 knockout human embryonic stem cell line using CRISPR/Cas9 technology

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Sebocytes contribute to melasma onset

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Isoform- and cell-state-specific lipidation of ApoE in astrocytes

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Creatine transport and creatine kinase activity is required for CD8+ T cell immunity

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Systematic illumination of druggable genes in cancer genomes

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  DOI: 10.1016/j.celrep.2022.110400
  
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How BamA recruits OMP substrates via poly-POTRAs domain

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  DOI: 10.1096/fj.201900681RR
  
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HBD-2 binds SARS-CoV-2 RBD and blocks viral entry: Strategy to combat COVID-19

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  DOI: 10.1016/j.isci.2022.103856
  
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Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

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Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

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Oxysterols Protect Epithelial Cells Against Pore-Forming Toxins

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  DOI: 10.3389/fimmu.2022.815775
  
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Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapy

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  DOI: 10.1016/j.xgen.2022.100095
  
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Hypermethylation of miR-145 promoter-mediated SOX9-CLDN8 pathway regulates intestinal mucosal barrier in Crohn's disease

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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells

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Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex

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Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer

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Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions

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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers

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Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection

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Identification of a dihydropyridine scaffold that blocks ryanodine receptors

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CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer

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Global RNA interactome of Salmonella discovers a 5′ UTR sponge for the MicF small RNA that connects membrane permeability to transport capacity

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Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism

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Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

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Clusterin is involved in mediating the metabolic function of adipose SIRT1

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Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

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C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis

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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

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Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

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Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation

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Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses

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Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries

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4-Phenylbutyrate restores localization and membrane repair to human dysferlin mutations

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A purine metabolic checkpoint that prevents autoimmunity and autoinflammation

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AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

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Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

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<p>Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells</p>

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Translational and post-translational control of human naïve versus primed pluripotency

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Transcription Factor ChREBP Mediates High Glucose-Evoked Increase in HIF-1α Content in Epithelial Cells of Renal Proximal Tubules

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Macrophages are metabolically heterogeneous within the tumor microenvironment

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SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes

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Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H3 receptor antagonist/inverse agonist

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Hypothalamic miR-1983 targets insulin receptor beta and the insulin-mediated miR-1983 increase is blocked by metformin

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Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty-acid metabolism genes in the fetal sheep heart

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Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer

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3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis

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Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation

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PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective

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Low-intensity pulsed ultrasound-generated singlet oxygen induces telomere damage leading to glioma stem cell awakening from quiescence

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β-catenin links cell seeding density to global gene expression during mouse embryonic stem cell differentiation

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Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

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Generation of an induced pluripotent stem cell line (SYSUi005-A)from a patient with hypertrophic cardiomyopathy

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Pleiotropic vascular effects of ivabradine in streptozotocin-induced diabetes

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Olfactory receptor 5B21 drives breast cancer metastasis

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Role of extracellular microRNA-146a-5p in host innate immunity and bacterial sepsis

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Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

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Nasal obstruction during the growth period modulates the Wnt/β-Catenin pathway and brain-derived neurotrophic factor production in association with tyrosine kinase receptor B mRNA reduction in mouse hippocampus

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Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis

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Effect of miR-183-5p on Cholestatic Liver Fibrosis by Regulating Fork Head Box Protein O1 Expression

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NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

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Genomic and experimental evidence that ALKATI does not predict single agent sensitivity to ALK inhibitors

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Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdown

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In vivo efficacy of tesevatinib in patient-derived xenograft glioblastoma models may be limited by tissue binding and compensatory signaling

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Oligodendrocyte progenitor proliferation is disinhibited following traumatic brain injury in leukemia inhibitory factor heterozygous mice

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Force-dependent activation of actin elongation factor mDia1 protects the cytoskeleton from mechanical damage and promotes stress fiber repair

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A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

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Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine

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The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

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Differential ER Stress as a Driver of Cell Fate following Ricin Toxin Exposure

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PD-L1 expression on circulating tumor cells and platelets in patients with metastatic breast cancer

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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue

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RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association

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The multicellular signalling network of ovarian cancer metastases

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Integrated genomic and proteomic analyses identify stimulus-dependent molecular changes associated with distinct modes of skeletal muscle atrophy

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A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors

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GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

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Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

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SLC1A5 provides glutamine and asparagine necessary for bone development in mice

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AKAP79 enables calcineurin to directly suppress protein kinase A activity

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TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer

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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

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Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage

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Analysis of Il36a induction by C/EBPβ via a half-CRE•C/EBP element in murine macrophages in dependence of its CpG methylation level

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Melatonin Analogues Potently Inhibit MAO-B and Protect PC12 Cells against Oxidative Stress

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Hsa_circ_0023990 promotes tumor growth and glycolysis in dedifferentiated TC via targeting miR-485-5p/FOXM1 axis

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GCN2 adapts protein synthesis to scavenging-dependent growth

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Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome

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Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

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Thioredoxin interacting protein drives astrocytic glucose hypometabolism in corticosterone-induced depressive state

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BPS Publications

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L-cell Arntl is required for rhythmic glucagon-like peptide-1 secretion and maintenance of intestinal homeostasis

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St. John’s Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism

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Monocarboxylate Transporter-2 Expression Restricts Tumor Growth in a Murine Model of Lung Cancer: A Multi-Omic Analysis

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Differences in Glycolysis and Mitochondrial Respiration between Cytotrophoblast and Syncytiotrophoblast In-Vitro: Evidence for Sexual Dimorphism

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Site-specific N-glycosylation of integrin α2 mediates collagen-dependent cell survival

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Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

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Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension

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Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation

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Generation of a heterozygous SOX10 knockout human embryonic stem cell line using CRISPR/Cas9 technology

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Differential DNA Methylation and Expression of MicroRNAs in Adipose Tissue from Twin Pairs Discordant for Type 2 Diabetes

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LH induces de novo cholesterol biosynthesis via SREBP activation in granulosa cells during ovulation in female mice

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Inhibition of HIV infection by structural proteins of the inner nuclear membrane is associated with reduced chromatin dynamics

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Activity and mechanism of acquired resistance to tarloxotinib in HER2 mutant lung cancer: an in vitro study

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Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity

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Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

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Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity

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Oxysterols protect bovine endometrial cells against pore-forming toxins from pathogenic bacteria

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Low folate induces abnormal neuronal maturation and DNA hypomethylation of neuronal differentiation-related genes in cultured mouse neural stem and progenitor cells

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CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models

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Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine

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The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9

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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

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Preparation of monovalent follistatin-like 3-Fc-fusion protein and evaluation of its effects on muscle mass in mice

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Metabolic endotoxemia is dictated by the type of lipopolysaccharide

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Increased fidelity of protein synthesis extends lifespan

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Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

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Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite

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Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages

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Light regulates alternative splicing outcomes via the TOR kinase pathway

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Doxazosin and erlotinib have anticancer effects in the endometrial cancer cell and important roles in ERα and Wnt/β-catenin signaling pathways

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Chromatin-mediated alternative splicing regulates cocaine-reward behavior

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Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy

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A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells

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Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice

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Effect of handling on ATP utilization of cerebral Na,K-ATPase in rats with trimethyltin-induced neurodegeneration

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Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration

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Cytidine acetylation yields a hypoinflammatory synthetic messenger RNA

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Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria

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BPS Publications

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Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication

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Cdc42 is required for male germline niche development in mice

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The histone chaperone Anp32e regulates memory formation, transcription, and dendritic morphology by regulating steady-state H2A.Z binding in neurons

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NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells

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A light-switching pyrene probe to detect phase separated biomolecules

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Tonotopic distribution and inferior colliculus projection pattern of inhibitory and excitatory cell types in the lateral superior olive of Mongolian gerbils

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Hormonally regulated myogenic miR-486 influences sex-specific differences in cancer-induced skeletal muscle defects

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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

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MicroRNA 223 Targeting ATG16L1 Affects Microglial Autophagy in the Kainic Acid Model of Temporal Lobe Epilepsy

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Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2

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Instability in NAD+ metabolism leads to impaired cardiac mitochondrial function and communication

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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

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The BET bromodomain inhibitor ZEN-3365 targets the Hedgehog signaling pathway in acute myeloid leukemia

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Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells

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Oestrogen signalling drives ciliogenesis in human endometrial organoids

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Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability

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Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity

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Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice

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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

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Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

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Molecular analysis of cell survival and death pathways in the proteasome inhibitor bortezomib-resistant PC3 prostate cancer cell line

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Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation

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FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection

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