2 Matching Annotations
- Feb 2018
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Different sets of ESR1 polymorphisms were associated with cognitive decline from CDR 0 to 0.5 and CDR 0.5 to 1. ESR1 polymorphisms (rs3853248, rs22334693 [ESR1+397], rs9340799 [ESR1+351], rs9397456, rs1801132 [ESR1+975], rs2179922, rs932477, and rs9341016) were associated with the deterioration of episodic memory among subjects with baseline CDR 0, indicating these polymorphisms might be markers for episodic memory decline at an earlier stage
p(HGNC:ESR1) hasVariant g(dbSNP:rs3853248) p(HGNC:ESR1) hasVariant g(dbSNP:rs22334693) p(HGNC:ESR1) hasVariant g(dbSNP:rs9340799) p(HGNC:ESR1) hasVariant g(dbSNP:rs9397456) p(HGNC:ESR1) hasVariant g(dbSNP:rs1801132) p(HGNC:ESR1) hasVariant g(dbSNP:rs2179922) p(HGNC:ESR1) hasVariant g(dbSNP:rs932477) p(HGNC:ESR1) hasVariant g(dbSNP:rs9341016) a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs3853248) a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs22334693) a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9340799) a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9397456) a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs1801132) a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs2179922) a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs932477) a(NIFT:"Clinical dementia rating") pos g(dbSNP:rs9341016)
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Although we observed no association between rs3785883 or rs1868402 alone and change in CDR-sb (P > .10), there was a significant association between a combined genotype model and change in CDR-sb: carriers of the high-risk genotypes at both loci progressed >2.9 times faster than noncarriers (P = .015)
g(dbSNP:rs1868402) cnc a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes") g(dbSNP:rs3785883) cnc a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes") composite(g(dbSNP:rs1868402),g(dbSNP:rs3785883)) pos a(CTO:"Clinical_Dementia_Rating_Scale-sum_of_boxes")
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