Our results show a sustained legacy effect of an intensive glucose-control strategy that appears to be longer than previously reported. These observations indicate that intensive glucose control starting at the time of diagnosis is associated with a significantly decreased risk of myocardial infarction and death from any cause, in addition to the well-established reduction in the risk of microvascular disease. On the basis of extensive trial evidence, strategies for cardiovascular risk reduction in patients with type 2 diabetes emphasize the importance of lipid-lowering therapy with statins21 and of targeted antihypertensive treatment.22-24 (A companion article in this issue of the Journal reports the 10-year, postinterventional data on blood-pressure control from the UKPDS.25) Our results highlight the added importance of glucose lowering in reducing the risk of coronary events and death from any cause. The findings strengthen the rationale for attaining optimal glycemic control and indicate emergent long-term benefits on cardiovascular risk.