2 Matching Annotations
- Nov 2021
-
www.nature.com www.nature.com
-
The study demonstrated the capacity of a third dose to broaden antibody-based immunity and boost protection against circulating variants of concern. However, it is interesting that neutralizing responses against the Beta variant, known to markedly escape vaccine-elicited antibody responses4, were only fractionally better in those receiving a Beta-specific booster immunization.
Choi et al. showed that a Beta-targeted booster shot broadened antibody-based immunity and boosted protection against circulating variants, the neutralizing response against the Beta variant was only slightly better.
@gerdosi thinks this points to Original Antigenic Sin.
-
-
www.medrxiv.org www.medrxiv.org
-
Interestingly, all four vaccine breakthrough infection subjects who had previous COVID-19 were seropositive for anti-membrane IgG during acute infection, while no breakthrough subjects without prior COVID-19 had detectable anti-membrane antibodies in the acute infection period (Figure 1I).
Vaccinated individuals that experience a breakthrough infection do not develop antibodies to the parts of the virus that is not encoded by the vaccine.
-