3 Matching Annotations
- Jul 2024
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propofol,have also been demonstrated to act at extrasynaptic receptors and enhance tonicinhibition in hippocampus
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this form of GABAergic cellular communi-cation is more similar to the type of volume transmission observed with monoamineneurotransmitters like serotonin, dopamine and histamine
I'm going to hang onto the wording of volume transmission.
It makes me think about an alternative hypothesis to the functions behind Cannabis causing HPPD, as the psychedelics typically responsible for that symptom are serotonergic.
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that very low (nM) concentrations of GABA,which typically occur in the cerebrospinal fluid (CSF) of the extracellular space,can persistently activate a population of non-synaptic GABA A receptors resultingin a ‘tonic’ increase in membrane conductance
GABA typically occurs in the CSF, and very small levels of GABA can activate extrasynaptic receptors.
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