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  1. Oct 2020
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent non-covalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease
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    1. zhentg 17 Oct 2020
      This furyl amide series was of particular interest due to its starting potency, modular nature, structural properties and absence of reactive functionality found within typical covalent modifiers.

      they are seeking for non-covalent inhibitors.

      reversible inhbitor
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    ncbi.nlm.nih.gov/pmc/articles/PMC3569073/