needing more instruction than merely menial or praedial1 labor; and the same advantages to youths whose education may have been neglected untill too late to lay a foundation in the learned languages.
The first part of this clause outlines that UVA is not going to be a place of meritocracy; it is for those that wish to become distinguished in their future as a scholar. It follows with a suggestion, that these people may also come from backgrounds not traditionally fit for academia. In this age, there was no public school and only the wealthy children were put into schools. But here, Jefferson and the other founders are suggesting that these kids may also be the future scholars and they should make specific accommodations in their curriculum for these children. I think this is realized to this day with programs such as "Access UVA" which give financial aid to all those that need it to come to UVA.