15 Matching Annotations
  1. Mar 2021
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional characterization of 84 PALB2 variants of uncertain significance
    1
    1. shannon_mcnulty 18 Mar 2021
      WT-PALB2 was associated with robust formation of damage-induced RAD51 foci, whereas the four variants were associated with defective foci formation (Fig. 3d, e).

      AssayResult: 1

      AssayResultAssertion: Abnormal

      ControlType: Abnormal; empty vector

      Approximation: Exact assay result value not reported; value estimated from Figure 3e.

      CGType:FunctionalAssayResult FuncAssay:2 AssayControl:Abnormal
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    ncbi.nlm.nih.gov/pmc/articles/PMC7056643/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor
    3
    1. shannon_mcnulty 18 Mar 2021
      SUPPLEMENTARY DATA

      AssayResult: 5

      AssayResultAssertion: Abnormal

      PValue: < 0.0001

      Approximation: Exact assay result value not reported; value estimated from Figure 6C.

      ControlType: Abnormal; empty vector

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:3 AssayControl:Abnormal
    2. shannon_mcnulty 18 Mar 2021
      SUPPLEMENTARY DATA

      AssayResult: -96

      AssayResultAssertion: Abnormal

      PValue: < 0.0001

      ControlType: Abnormal; empty vector

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:2 AssayControl:Abnormal
    3. shannon_mcnulty 18 Mar 2021
      SUPPLEMENTARY DATA

      AssayResult: 48

      AssayResultAssertion: Abnormal

      PValue: < 0.0001

      Approximation: Exact assay result value not reported; value estimated from Figure 1D.

      ControlType: Abnormal; empty vector

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 AssayControl:Abnormal
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    ncbi.nlm.nih.gov/pmc/articles/PMC6847799/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2
    11
    1. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 19.43

      AssayResultAssertion: Abnormal

      ReplicateCount: 5

      StandardErrorMean: 4.42

      ControlType: Abnormal; empty vector

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:3 AssayControl:Abnormal
    2. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 17.29

      AssayResultAssertion: Abnormal

      ReplicateCount: 3

      StandardErrorMean: 6.81

      ControlType: Abnormal; empty vector (set 5)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:2 AssayControl:Abnormal
    3. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 7.86

      AssayResultAssertion: Abnormal

      ReplicateCount: 3

      StandardErrorMean: 2.39

      ControlType: Abnormal; empty vector (set 4)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:2 AssayControl:Abnormal
    4. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 34.03

      AssayResultAssertion: Abnormal

      ReplicateCount: 3

      StandardErrorMean: 10.86

      ControlType: Abnormal; empty vector (set 3)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:2 AssayControl:Abnormal
    5. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 12.78

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardErrorMean: 3.65

      ControlType: Abnormal; empty vector (set 2)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:2 AssayControl:Abnormal
    6. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 10.93

      AssayResultAssertion: Abnormal

      ReplicateCount: 2

      StandardErrorMean: 0.78

      ControlType: Abnormal; empty vector (set 1)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:2 AssayControl:Abnormal
    7. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 15.58

      AssayResultAssertion: Abnormal

      ReplicateCount: 6

      StandardDeviation: 0.52

      StandardErrorMean: 0.37

      ControlType: Abnormal; empty vector (set 5)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 AssayControl:Abnormal
    8. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 7.93

      AssayResultAssertion: Abnormal

      ReplicateCount: 6

      StandardDeviation: 0.56

      StandardErrorMean: 0.39

      ControlType: Abnormal; empty vector (set 4)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 AssayControl:Abnormal
    9. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 8.71

      AssayResultAssertion: Abnormal

      ReplicateCount: 6

      StandardDeviation: 1.75

      StandardErrorMean: 1.24

      ControlType: Abnormal; empty vector (set 3)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 AssayControl:Abnormal
    10. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 7.11

      AssayResultAssertion: Abnormal

      ReplicateCount: 6

      StandardDeviation: 2.37

      StandardErrorMean: 1.68

      ControlType: Abnormal; empty vector (set 2)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 AssayControl:Abnormal
    11. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 7.83

      AssayResultAssertion: Abnormal

      ReplicateCount: 6

      StandardDeviation: 1.13

      StandardErrorMean: 0.8

      ControlType: Abnormal; empty vector (set 1)

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 AssayControl:Abnormal
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    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC6876638/