120 Matching Annotations
  1. Mar 2021
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional characterization of 84 PALB2 variants of uncertain significance
    4
    1. shannon_mcnulty 18 Mar 2021
      Cells reconstituted with WT-PALB2 showed substantially less sensitivity to olaparib than cells expressing p.A1025R and p.I944N (Fig. 4a). Similar results were observed for cisplatin treatment, although the difference in sensitivity was less pronounced (Fig. 4b). p.L24S, p.L1070P, and p.L35P were also associated with greater sensitivity to olaparib (Fig. 4c) and cisplatin (Fig. 4d) than WT-PALB2.

      AssayResult: 0.01 µM: 90; 0.08 µM: 80; 0.8 µM: 75; 8 µM: 35

      AssayResultAssertion: Normal

      ControlType: Normal; wild type PALB2 cDNA

      Approximation: Exact Olaparib concentrations and assay result values not reported; values estimated from Figures 4a and 4c.

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    2. shannon_mcnulty 18 Mar 2021
      Cells reconstituted with WT-PALB2 showed substantially less sensitivity to olaparib than cells expressing p.A1025R and p.I944N (Fig. 4a). Similar results were observed for cisplatin treatment, although the difference in sensitivity was less pronounced (Fig. 4b). p.L24S, p.L1070P, and p.L35P were also associated with greater sensitivity to olaparib (Fig. 4c) and cisplatin (Fig. 4d) than WT-PALB2.

      AssayResult: 0.01 µM: 102; 0.1 µM: 85; 0.8 µM: 55; 1 µM: 25

      AssayResultAssertion: Normal

      ControlType: Normal; wild type PALB2 cDNA

      Approximation: Exact cisplatin concentrations and assay result values not reported; values estimated from Figures 4b and 4d.

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    3. shannon_mcnulty 18 Mar 2021
      WT-PALB2 was associated with robust formation of damage-induced RAD51 foci, whereas the four variants were associated with defective foci formation (Fig. 3d, e).

      AssayResult: 27

      AssayResultAssertion: Normal

      StandardDeviation: 14

      ControlType: Normal; wild type PALB2 cDNA

      Approximation: Exact assay result and standard deviation values not reported; values estimated from Figure 3e.

      CGType:FunctionalAssayResult FuncAssay:2 ValidationControl:WildType AssayControl:Normal
    4. shannon_mcnulty 18 Mar 2021
      Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 5

      AssayResultAssertion: Normal

      StandardErrorMean: 0

      ControlType: Normal; wild type PALB2 cDNA

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 ValidationControl:WildType AssayControl:Normal
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    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC7056643/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor
    3
    1. shannon_mcnulty 18 Mar 2021
      SUPPLEMENTARY DATA

      AssayResult: 100

      AssayResultAssertion: Normal

      ControlType: Normal; wild type PALB2 cDNA

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    2. shannon_mcnulty 18 Mar 2021
      SUPPLEMENTARY DATA

      AssayResult: 0

      AssayResultAssertion: Normal

      ControlType: Normal; wild type PALB2 cDNA

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:2 ValidationControl:WildType AssayControl:Normal
    3. shannon_mcnulty 18 Mar 2021
      SUPPLEMENTARY DATA

      AssayResult: 100

      AssayResultAssertion: Normal

      ControlType: Normal; wild type PALB2 cDNA

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 ValidationControl:WildType AssayControl:Normal
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    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC6847799/
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2
    4
    1. shannon_mcnulty 18 Mar 2021
      Following exposure to IR, the average number of RAD51 foci was scored in cyclin-A- and YFP-PALB2-expressing S-phase cells

      AssayResult: 24.90 foci/cell

      AssayResultAssertion: Normal

      Range: 1 - 90

      ControlType: Normal; wild type PALB2 cDNA

      Comment: Exact values reported in "Source Data" file

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    2. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 100

      AssayResultAssertion: Normal

      ReplicateCount: 6

      StandardErrorMean: 0

      ControlType: Normal; wild type PALB2 cDNA

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    3. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 100

      AssayResultAssertion: Normal

      ReplicateCount: 38

      StandardErrorMean: 0

      ControlType: Normal; wild type

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:2 ValidationControl:WildType AssayControl:Normal
    4. shannon_mcnulty 18 Mar 2021
      Source Data

      AssayResult: 100

      AssayResultAssertion: Normal

      ReplicateCount: 38

      StandardDeviation: 0

      StandardErrorMean: 0

      ControlType: Normal; wild type PALB2 cDNA

      Comment: Exact values reported in “Source Data” file.

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 ValidationControl:WildType AssayControl:Normal
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    URL

    ncbi.nlm.nih.gov/pmc/articles/PMC6876638/
  5. www.cell.com www.cell.com
    High-Throughput Reclassification of SCN5A Variants
    1
    1. shannon_mcnulty 18 Mar 2021
      Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 100

      AssayResultAssertion: Normal

      ReplicateCount: 471

      StandardErrorMean: 3.7

      ControlType: Normal; wild type

      Comment: This variant (wildtype) had normal function. All other variant parameters were normalized to the values of wildtype. (Personal communication: A. Glazer)

      CGType:FunctionalAssayResult CG:BulkAnnotation FuncAssay:1 ValidationControl:WildType AssayControl:Normal
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    cell.com/ajhg/fulltext/S0002-9297(20)30162-2
  6. Feb 2021
  7. jmg.bmj.com jmg.bmj.com
    Blood functional assay for rapid clinical interpretation of germline TP53 variants
    108
    1. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 111

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    2. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 102

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    3. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 105

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    4. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 85

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    5. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 88

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    6. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 95

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    7. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 99

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    8. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 125

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    9. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 115

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    10. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 84

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    11. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 75

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    12. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 88

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    13. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 79

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    14. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 84

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    15. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 91

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    16. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 86

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    17. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 102

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    18. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 80

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    19. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 90

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    20. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 85

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    21. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 90

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    22. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 116

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    23. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 103

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    24. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 89

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    25. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 8.3

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    26. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 12

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    27. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 96

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    28. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 100

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    29. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 122

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    30. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 84

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    31. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 97

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    32. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 78

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    33. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 79

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    34. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 94

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    35. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 98

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    36. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 86

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    37. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 78

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    38. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 95

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    39. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 89

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    40. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 92

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    41. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 95

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    42. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 74

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    43. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 83

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    44. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 84

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    45. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 95

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    46. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 82

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    47. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 100

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    48. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 117

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    49. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 86

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    50. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 112

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    51. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 87

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    52. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 92

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    53. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 84

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:4 ValidationControl:WildType AssayControl:Normal
    54. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 14.7

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    55. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 16

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    56. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 12.3

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    57. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 11.8

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    58. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 16.3

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    59. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 15.4

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    60. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 19.3

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    61. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 9.8

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    62. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 9.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    63. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 8.7

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    64. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 15.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    65. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 10.4

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    66. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 11.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    67. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 17.2

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    68. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 19.7

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    69. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 11.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    70. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 17.4

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    71. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 11.7

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    72. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 14.2

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    73. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 8

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    74. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 18.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    75. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 15.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    76. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 14.7

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    77. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 10

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    78. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 11.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    79. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 11.7

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    80. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 9.4

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    81. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 12.9

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    82. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 10.8

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    83. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 13

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    84. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 8.4

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    85. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 15.4

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    86. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 13

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    87. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 22.8

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    88. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 14.6

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    89. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 16.5

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    90. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 14.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    91. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 10.3

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    92. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 7.5

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    93. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 12.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    94. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 10

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    95. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 7.8

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    96. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 12.8

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    97. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 14.6

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    98. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 10.6

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    99. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 8.9

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    100. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 12.1

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    101. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 10.6

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    102. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 12.5

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53

      Comment: See Table S3 for details

      CGType:FunctionalAssayResult FuncAssay:3 ValidationControl:WildType AssayControl:Normal
    103. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 88

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53 from control 3

      Comment: See Table S2 for details

      CGType:FunctionalAssayResult FuncAssay:2 ValidationControl:WildType AssayControl:Normal
    104. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 95

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53 from control 2

      Comment: See Table S2 for details

      CGType:FunctionalAssayResult FuncAssay:2 ValidationControl:WildType AssayControl:Normal
    105. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 100

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53 from control 1

      Comment: See Table S2 for details

      CGType:FunctionalAssayResult FuncAssay:2 ValidationControl:WildType AssayControl:Normal
    106. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 11.5

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53 from control 3

      Comment: See Table S2 for details

      CGType:FunctionalAssayResult FuncAssay:1 ValidationControl:WildType AssayControl:Normal
    107. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 10.8

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53 from control 2

      Comment: See Table S2 for details

      CGType:FunctionalAssayResult FuncAssay:1 ValidationControl:WildType AssayControl:Normal
    108. shannon_mcnulty 24 Feb 2021
      Supplemental material

      AssayResult: 13.6

      AssayResultAssertion: Normal

      ControlType: Normal, wild type TP53 from control 1

      Comment: See Table S2 for details

      CGType:FunctionalAssayResult FuncAssay:1 ValidationControl:WildType AssayControl:Normal
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    jmg.bmj.com/content/early/2020/10/13/jmedgenet-2020-107059