SUPPLEMENTARY DATA
AssayResult: 85
AssayResultAssertion: Not reported
PValue: Not reported
Approximation: Exact assay result value not reported; value estimated from Figure 6C.
8 Matching Annotations
- Mar 2021
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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SUPPLEMENTARY DATA
AssayResult: 3
AssayResultAssertion: Indeterminate
PValue: Not reported
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SUPPLEMENTARY DATA
AssayResult: 82.06
AssayResultAssertion: Indeterminate
PValue: 0.0058
Comment: Exact values reported in Table S3.
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To this end, 44 missense variants found in breast cancer patients were identified in the ClinVar database (https://www.ncbi.nlm.nih.gov/clinvar) and/or selected by literature curation based on their frequency of description or amino acid substitution position in the protein (Supplemental Table S1).
HGVS: NM_024675.3:c.53A>G p.(Lys18Arg)
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www.nature.com www.nature.com
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Source Data
AssayResult: 84.05
AssayResultAssertion: Not reported
ReplicateCount: 2
StandardErrorMean: 16.48
Comment: Exact values reported in “Source Data” file.
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Source Data
AssayResult: 94.47
AssayResultAssertion: Not reported
ReplicateCount: 2
StandardErrorMean: 0.99
Comment: Exact values reported in “Source Data” file.
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Source Data
AssayResult: 100.19
AssayResultAssertion: Not reported
ReplicateCount: 2
StandardDeviation: 5.64
StandardErrorMean: 3.99
Comment: Exact values reported in “Source Data” file.
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We, therefore, analyzed the effect of 48 PALB2 VUS (Fig. 2a, blue) and one synthetic missense variant (p.A1025R) (Fig. 2a, purple)29 on PALB2 function in HR.
HGVS: NM_024675.3:c.53A>G p.(K18R)
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