Gene set enrichment analysis is a leading computational method for placing newly acquired high content data in the context of prior biological knowledge (1). Gene set enrichment analysis tools such as DAVID (2), GenePattern (3), WebGestalt (4), AmiGO (5), Babelomics (6), GeneVestigator (7), GOEAST (8), Panther (9) and Enrichr (10,11) have been widely used, demonstrating the utility and relevance of this approach for many diverse studies.