5 Matching Annotations
  1. Mar 2026
    1. A comparison of ARMS and direct sequencing for EGFR mutation analysis and Tyrosine Kinase Inhibitors treatment prediction in body fluid samples of Non-Small-Cell Lung Cancer patients

      [Paper-level Aggregated] PMCID: PMC3287118

      Evidence Type(s): Oncogenic

      Summary: Mutation: L858R | Summary: The L858R mutation is associated with tumor development or progression as it is mentioned in the context of samples with other mutations indicative of cancer.

      Evidence Type: Oncogenic Mutation: T790M | Summary: The T790M mutation is associated with tumor development or progression as it is mentioned in the context of samples with other mutations indicative of cancer.

      Evidence Type: Oncogenic Mutation: L861Q | Summary: The L861Q mutation is associated with tumor development or progression as it is mentioned in the context of samples with other mutations indicative of cancer.

      Evidence Type: Oncogenic Mutation: S768I | Summary: The S768I mutation is associated with tumor development or progression as it is mentioned in the context of samples with other mutations indicative of cancer.

      Gene→Variant (gene-first): EGFR(1956):L858R EGFR(1956):T790M EGFR(1956):L861Q EGFR(1956):S768I

      Genes: EGFR(1956)

      Variants: L858R T790M L861Q S768I

    2. In addition, the ADx-ARMS identified 2 samples with both 19 del and L858R mutation, 4 with both 19 del and T790M mutation, and 1 with both L858R and L861Q or S768I (The two spots were designed in one tube, we could not d

      [Paragraph-level] PMCID: PMC3287118 Section: RESULTS PassageIndex: 7

      Evidence Type(s): Oncogenic

      Summary: Evidence Type: Oncogenic | Mutation: L858R | Summary: The L858R mutation is associated with tumor development or progression as it is mentioned in the context of samples with other mutations indicative of cancer. Evidence Type: Oncogenic | Mutation: T790M | Summary: The T790M mutation is associated with tumor development or progression as it is mentioned in the context of samples with other mutations indicative of cancer. Evidence Type: Oncogenic | Mutation: L861Q | Summary: The L861Q mutation is associated with tumor development or progression as it is mentioned in the context of samples with other mutations indicative of cancer. Evidence Type: Oncogenic | Mutation: S768I | Summary: The S768I mutation is associated with tumor development or progression as it is mentioned in the context of samples with other mutations indicative of cancer.

      Gene→Variant (gene-first): 1956:L858R 1956:L861Q 1956:S768I 1956:T790M

      Genes: 1956

      Variants: L858R L861Q S768I T790M

  2. Feb 2026
    1. In addition, the ADx-ARMS identified 2 samples with both 19 del and L858R mutation, 4 with both 19 del and T790M mutation, and 1 with both L858R and L861Q or S768I (The two spots were designed in one tube, we could not d

      [Paragraph-level] PMCID: PMC3287118 Section: RESULTS PassageIndex: 7

      Evidence Type(s): None

      Justification: Not enough information in this passage.

      Gene→Variant (gene-first): 1956:L858R 1956:L861Q 1956:S768I 1956:T790M

      Genes: 1956

      Variants: L858R L861Q S768I T790M

    2. In addition, the ADx-ARMS identified 2 samples with both 19 del and L858R mutation, 4 with both 19 del and T790M mutation, and 1 with both L858R and L861Q or S768I (The two spots were designed in one tube, we could not d

      [Paragraph-level] PMCID: PMC3287118 Section: RESULTS PassageIndex: 7

      Evidence Type(s): None

      Justification: Not enough information in this passage.

      Gene→Variant (gene-first): 1956:L858R 1956:L861Q 1956:S768I 1956:T790M

      Genes: 1956

      Variants: L858R L861Q S768I T790M