[Paper-level Aggregated] PMCID: PMC3997489

Evidence Type(s): Oncogenic, Prognostic

Justification: Oncogenic: The text indicates that nearly 80% of DIPGs harbor a K27M mutation, suggesting that this variant is associated with the disease and contributes to its oncogenic properties. Prognostic: The identification of distinct molecular subgroups, including those with the K27M mutation, implies that this variant may have implications for disease progression and patient outcomes in DIPG.

Gene→Variant (gene-first): H3-3B(3021):K27M

Genes: H3-3B(3021)

Variants: K27M

[Paragraph-level] PMCID: PMC3997489 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Diagnostic, Oncogenic

Justification: Diagnostic: The passage discusses the prevalence of the K27M mutation in DIPG, indicating its association with this specific disease, which supports its use as a biomarker for classification. Oncogenic: The K27M mutation is described as part of the unique genetic make-up of DIPG, suggesting its contribution to tumor development or progression in this specific cancer type.

Gene→Variant (gene-first): 3021:K27M

Genes: 3021

Variants: K27M