[Paper-level Aggregated] PMCID: PMC4884999

Evidence Type(s): Oncogenic, Predictive

Justification: Oncogenic: The text indicates that the majority of KRAS mutations occur in codon 12, with G12C being the most common, suggesting its role in cancer development. Predictive: The mention of KRAS mutations, including G12C, in the context of studies focused on NSCLC implies that these mutations may predict response to targeted therapies.

Gene→Variant (gene-first): KRAS(3845):G12C

Genes: KRAS(3845)

Variants: G12C

[Paragraph-level] PMCID: PMC4884999 Section: RESULTS PassageIndex: 3

Evidence Type(s): Diagnostic, Oncogenic

Justification: Diagnostic: The passage discusses the frequency of KRAS mutations, specifically mentioning that the majority occur in codon 12 with G12C being the most common, indicating its association with lung cancer subtypes. Oncogenic: The mention of KRAS mutations, including G12C, in the context of lung adenocarcinoma suggests that this somatic variant contributes to tumor development or progression.

Gene→Variant (gene-first): 3845:G12C

Genes: 3845

Variants: G12C

[Paragraph-level] PMCID: PMC4884999 Section: RESULTS PassageIndex: 3

Evidence Type(s): Diagnostic, Oncogenic

Justification: Diagnostic: The passage discusses the frequency of KRAS mutations, specifically mentioning that the majority occur in codon 12 with G12C being the most common, indicating its association with lung cancer subtypes. Oncogenic: The mention of KRAS mutations, including G12C, in the context of lung adenocarcinoma suggests that this somatic variant contributes to tumor development or progression.

Gene→Variant (gene-first): 3845:G12C

Genes: 3845

Variants: G12C