Molecular and clinicopathologic features of gliomas harboring NTRK fusions
[Paper-level Aggregated] PMCID: PMC7362646
Evidence Type(s): Oncogenic
Summary: Mutation: p.R132H | Summary: The IDH1 p.R132H mutation is associated with glioma development and progression, indicating its role as a somatic variant contributing to tumorigenesis.
Gene→Variant (gene-first): IDH1(3417):p.R132H
Genes: IDH1(3417)
Variants: p.R132H
NTRK-fused gliomas in our cohort demonstrated concurrent aberrations involving CDKN2A/2B, TERT promoter, TP53, PTEN, EGFR, ATRX, RB1, IDH1, polysomy 7, ROS1, PIK3CA, NF1, and MDM4. The frequency of these genetic aberrati
[Paragraph-level] PMCID: PMC7362646 Section: RESULTS PassageIndex: 11
Evidence Type(s): Oncogenic
Summary: Evidence Type: Oncogenic | Mutation: p.R132H | Summary: The IDH1 p.R132H mutation is associated with glioma development and progression, indicating its role as a somatic variant contributing to tumorigenesis.
Gene→Variant (gene-first): 3417:p.R132H
Genes: 3417
Variants: p.R132H
Molecular and clinicopathologic features of gliomas harboring NTRK fusions
[Paper-level Aggregated] PMCID: PMC7362646
Evidence Type(s): Oncogenic, Prognostic
Justification: Oncogenic: The IDH1 p.R132H mutation is mentioned as a significant alteration in adult gliomas, indicating its role in tumorigenesis. Prognostic: The presence of the IDH1 p.R132H mutation correlates with specific histological grades and patient age cohorts, suggesting it may have implications for patient outcomes.
Gene→Variant (gene-first): IDH1(3417):p.R132H
Genes: IDH1(3417)
Variants: p.R132H
NTRK-fused gliomas in our cohort demonstrated concurrent aberrations involving CDKN2A/2B, TERT promoter, TP53, PTEN, EGFR, ATRX, RB1, IDH1, polysomy 7, ROS1, PIK3CA, NF1, and MDM4. The frequency of these genetic aberrati
[Paragraph-level] PMCID: PMC7362646 Section: RESULTS PassageIndex: 11
Evidence Type(s): Oncogenic
Justification: Oncogenic: The passage discusses the IDH1 p.R132H mutation as part of the genetic aberrations detected in gliomas, indicating its contribution to tumor development or progression in the context of high-grade gliomas.
Gene→Variant (gene-first): 3417:p.R132H
Genes: 3417
Variants: p.R132H
NTRK-fused gliomas in our cohort demonstrated concurrent aberrations involving CDKN2A/2B, TERT promoter, TP53, PTEN, EGFR, ATRX, RB1, IDH1, polysomy 7, ROS1, PIK3CA, NF1, and MDM4. The frequency of these genetic aberrati
[Paragraph-level] PMCID: PMC7362646 Section: RESULTS PassageIndex: 11
Evidence Type(s): Oncogenic
Justification: Oncogenic: The passage discusses the IDH1 p.R132H mutation as part of the genetic aberrations detected in gliomas, indicating its contribution to tumor development or progression in the context of high-grade gliomas.
Gene→Variant (gene-first): 3417:p.R132H
Genes: 3417
Variants: p.R132H