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  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    1. karim2001khoury 19 Feb 2026
      KAT6A amplifications are associated with shorter progression-free survival and overall survival in patients with endometrial serous carcinoma

      [Paper-level Aggregated] PMCID: PMC7467277

      Evidence Type(s): Oncogenic, Functional

      Justification: Oncogenic: The text indicates that the genomic segment on chr8:208343-27992852 is associated with somatic copy number alterations (CNA), specifically deletions, which can contribute to tumorigenesis, suggesting an oncogenic role. Functional: The mention of somatic CNAs implies that the alterations may affect gene function, indicating a potential functional impact on the genes located within the specified genomic segment.

      Gene→Variant (gene-first): NA:chr8:208343-27992852

      Genes: NA

      Variants: chr8:208343-27992852

      CIViC paper-level aggregated PMC7467277
    2. karim2001khoury 19 Feb 2026
      1,449 genes with somatic CNA were observed in at least 10% of tumors (S1 Table) and were located on 26 genomic segments on chromosomes 1, 2, 3, 5, 8, 10, 11, 17, 18, 19 and 20. The size of these genomic loci ranged from

      [Paragraph-level] PMCID: PMC7467277 Section: RESULTS PassageIndex: 5

      Evidence Type(s): Oncogenic

      Justification: Oncogenic: The passage discusses somatic copy number alterations (CNAs) and specifically mentions a segment on chromosome 8 that exhibits deletion, indicating a potential role in tumor development or progression.

      Gene→Variant (gene-first): NA:chr8:208343-27992852

      Genes: NA

      Variants: chr8:208343-27992852

      CIViC paragraph-level PMC7467277 Oncogenic
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    pmc.ncbi.nlm.nih.gov/articles/PMC7467277/pdf/pone.0238477.pdf