3 Matching Annotations
  1. Dec 2017
    1. By mapping these sites onto a predicted secondary structure of ZIKV 3′UTR, we found all three sites to be present on stem-loop structures, which are considered optimal for MSI binding

      Uren et al., (2015) investigated the mechanism of action of the RNA-binding protein MSI1 to help identify target genes. Using individual-nucleotide resolution cross-linking and immunoprecipitation, researchers found that MSI1 prefers UAG sequences with a specific structure, especially in the 3’ untranslated region. MSI1 target RNAs encode proteins involved in cell proliferation and adhesion, known to underlie the spread of glioblastomas.

    2. analysis of the genomic RNA of the Brazilian ZIKV strain, PE243

      Donald and colleagues (2016) researched the genomic sequences of the zika virus to understand the host and viral interactions along with the process of replication. One response, interferon, to the zika virus is suppressed to allow the virus to replicate. siRNA causes the suppression of the interferon response.

  2. Sep 2016
    1. Conversely, other authors argue that the similarities in molecular signaling observed among all skin appendages suffice to support their homology (9). Note that such placodal signaling centers have been recently evidenced as underlying the development of Chelonia shell scutes

      Other works have contradicted models where there is independent evolution of these traits.

      They suggest that due to the similarity of the molecules in the processes, they are closely related and come from a common ancestor.

      It is also suggested that this is true for turtles as well which have been shown to need the placode for the development of their shell.