78 Matching Annotations
  1. Jul 2024
  2. www.sciencedirect.com www.sciencedirect.com
    DNA break induces rapid transcription repression mediated by proteasome-dependent RNAPII removal
    1
    1. scibot 04 Jul 2024
      RRID:AB_10003037

      DOI: 10.1016/j.celrep.2024.114420

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    sciencedirect.com/science/article/pii/S2211124724007496
  3. May 2024
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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
    1
    1. scibot 16 May 2024
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      DOI: 10.1016/j.celrep.2024.114205

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    sciencedirect.com/science/article/pii/S2211124724005333
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
    1
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      DOI: 10.1016/j.xgen.2024.100550

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    ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
  6. Apr 2024
  7. www.sciencedirect.com www.sciencedirect.com
    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
    1
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114024

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    sciencedirect.com/science/article/pii/S2211124724003528
  8. Feb 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Specialized replication mechanisms maintain genome stability at human centromeres
    2
    1. scibot 15 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.018

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    2. scibot 15 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.018

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    sciencedirect.com/science/article/pii/S1097276524000546
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
    1
    1. scibot 13 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113778

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    sciencedirect.com/science/article/pii/S2211124724001062
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.biopha.2024.116217

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    sciencedirect.com/science/article/pii/S0753332224000982
  12. Oct 2023
  13. www.sciencedirect.com www.sciencedirect.com
    TERRA R-loops connect and protect sister telomeres in mitosis
    1
    1. scibot 17 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113235

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    sciencedirect.com/science/article/pii/S2211124723012470
  14. www.sciencedirect.com www.sciencedirect.com
    Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113181

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    sciencedirect.com/science/article/pii/S2211124723011932
  15. Jul 2023
  16. www.sciencedirect.com www.sciencedirect.com
    Mechanisms of insertions at a DNA double-strand break
    1
    1. scibot 06 Jul 2023
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      DOI: 10.1016/j.molcel.2023.06.016

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    sciencedirect.com/science/article/abs/pii/S1097276523004616
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
    1
    1. scibot 06 Jul 2023
      RRID:AB_10003037

      DOI: 10.7554/eLife.87086

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    ncbi.nlm.nih.gov/pmc/articles/PMC10319438/
  18. Jun 2023
  19. www.sciencedirect.com www.sciencedirect.com
    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
    1
    1. scibot 09 Jun 2023
      RRID:AB_10003037

      DOI: 10.1016/j.isci.2023.106951

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    sciencedirect.com/science/article/pii/S2589004223010283
  20. May 2023
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination
    1
    1. scibot 05 May 2023
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      DOI: 10.1038/s41597-022-01508-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC9276747/
  22. Apr 2023
  23. www.sciencedirect.com www.sciencedirect.com
    XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors
    1
    1. scibot 07 Apr 2023
      RRID:AB_10003037

      DOI: 10.1016/j.celrep.2023.112342

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    sciencedirect.com/science/article/pii/S2211124723003534
  24. www.sciencedirect.com www.sciencedirect.com
    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
    1
    1. scibot 06 Apr 2023
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      DOI: 10.1016/j.molcel.2023.02.004

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    sciencedirect.com/science/article/pii/S1097276523000837
  25. Mar 2023
  26. www.sciencedirect.com www.sciencedirect.com
    HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression
    1
    1. scibot 23 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112284

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    sciencedirect.com/science/article/pii/S2211124723002954
  27. Feb 2023
  28. www.sciencedirect.com www.sciencedirect.com
    GEN1 promotes common fragile site expression
    1
    1. scibot 02 Feb 2023
      RRID:AB_10003037

      DOI: 10.1016/j.celrep.2023.112062

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    sciencedirect.com/science/article/pii/S2211124723000736
  29. Jan 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Loss of epigenetic information as a cause of mammalian aging
    1
    1. scibot 19 Jan 2023
      RRID:AB_10003037

      DOI: 10.1016/j.cell.2022.12.027

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    sciencedirect.com/science/article/pii/S0092867422015707
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway
    1
    1. scibot 11 Jan 2023
      RRID:AB_10003037

      DOI: 10.1016/j.isci.2022.105806

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    ncbi.nlm.nih.gov/pmc/articles/PMC9827073/
  32. Dec 2022
  33. www.sciencedirect.com www.sciencedirect.com
    The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
    1
    1. scibot 18 Dec 2022
      RRID:AB_10003037

      DOI: 10.1016/j.celrep.2022.111819

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    sciencedirect.com/science/article/pii/S2211124722017119
  34. Nov 2022
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis
    1
    1. scibot 19 Nov 2022
      RRID:AB_10003037

      DOI: 10.1016/j.celrep.2022.110871

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    ncbi.nlm.nih.gov/pmc/articles/PMC9637995/
  36. Oct 2022
  37. www.sciencedirect.com www.sciencedirect.com
    DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation
    1
    1. scibot 26 Oct 2022
      RRID:AB_10003037

      DOI: 10.1016/j.celrep.2022.111526

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    sciencedirect.com/science/article/pii/S2211124722013821
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    Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
    1
    1. scibot 07 Oct 2022
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      DOI: 10.1016/j.chembiol.2022.09.002

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    sciencedirect.com/science/article/pii/S2451945622003506
  39. Sep 2022
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
    1
    1. scibot 02 Sep 2022
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      DOI: 10.1158/0008-5472.CAN-21-1843

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612475/
  41. Aug 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
    1
    1. scibot 26 Aug 2022
      RRID:AB_10003037

      DOI: 10.1016/j.molcel.2022.07.011

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    sciencedirect.com/science/article/pii/S1097276522007079
  43. www.sciencedirect.com www.sciencedirect.com
    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
    1
    1. scibot 22 Aug 2022
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      DOI: 10.1016/j.ccell.2022.07.011

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    sciencedirect.com/science/article/pii/S1535610822003245
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    Increasing cell size remodels the proteome and promotes senescence
    1
    1. scibot 22 Aug 2022
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      DOI: 10.1016/j.molcel.2022.07.017

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    sciencedirect.com/science/article/pii/S1097276522007134
  45. Jun 2022
  46. www.sciencedirect.com www.sciencedirect.com
    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
    1
    1. scibot 30 Jun 2022
      RRID:AB_10003037

      DOI: 10.1016/j.devcel.2022.06.003

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    sciencedirect.com/science/article/pii/S1534580722004129
  47. Mar 2022
  48. www.sciencedirect.com www.sciencedirect.com
    CENP-B-mediated DNA loops regulate activity and stability of human centromeres
    1
    1. scibot 26 Mar 2022
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      DOI: 10.1016/j.molcel.2022.02.032

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    sciencedirect.com/science/article/pii/S1097276522002064
  49. elifesciences.org elifesciences.org
    Pathway-specific effects of ADSL deficiency on neurodevelopment
    1
    1. scibot 04 Mar 2022
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      DOI: 10.7554/eLife.70518

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    elifesciences.org/articles/70518
  50. www.sciencedirect.com www.sciencedirect.com
    RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
    1
    1. scibot 04 Mar 2022
      RRID:AB_1000303

      DOI: 10.1016/j.molcel.2022.01.025

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    sciencedirect.com/science/article/pii/S1097276522001010
  51. Jan 2022
  52. www.sciencedirect.com www.sciencedirect.com
    Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity
    1
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      DOI: 10.1016/j.isci.2021.103621

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    sciencedirect.com/science/article/pii/S2589004221015911
  53. Nov 2021
  54. www.sciencedirect.com www.sciencedirect.com
    The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair
    1
    1. scibot 24 Nov 2021
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      DOI: 10.1016/j.devcel.2021.10.022

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    sciencedirect.com/science/article/pii/S1534580721008534
  55. www.sciencedirect.com www.sciencedirect.com
    Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
    1
    1. scibot 12 Nov 2021
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      DOI: 10.1016/j.molcel.2021.10.015

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    sciencedirect.com/science/article/pii/S1097276521009072
  56. link.springer.com link.springer.com
    Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks
    1
    1. scibot 09 Nov 2021
      NB100304

      DOI: 10.1007/s10571-021-01163-7

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    link.springer.com/article/10.1007/s10571-021-01163-7
  57. Oct 2021
  58. www.sciencedirect.com www.sciencedirect.com
    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
    1
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      DOI: 10.1016/j.molcel.2021.09.013

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    sciencedirect.com/science/article/pii/S1097276521007474
  59. Sep 2021
  60. www.sciencedirect.com www.sciencedirect.com
    The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
    1
    1. scibot 16 Sep 2021
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      DOI: 10.1016/j.celrep.2021.109694

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    sciencedirect.com/science/article/pii/S2211124721011414
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    Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons
    1
    1. scibot 08 Sep 2021
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      DOI: 10.1016/j.celrep.2021.109666

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    sciencedirect.com/science/article/pii/S2211124721011104
  62. Aug 2021
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 05 Aug 2021
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      DOI: 10.1016/j.neuron.2018.09.044

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  64. Jul 2021
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    HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis
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    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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    The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair
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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation
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  76. Jan 2021
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    A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans
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  79. Dec 2020
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    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
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    PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
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    ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
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    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
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    METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation
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    Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication
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  90. Jan 2020
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    53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
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    Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells
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    Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
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    TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1
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    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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    HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis
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    Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
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    Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
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    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
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    Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
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    Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe
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    Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
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    RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
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    Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
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