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  1. Last 7 days
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    Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors
    1
    1. scibot 16 May 2024
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      DOI: 10.1016/j.celrep.2024.114205

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    sciencedirect.com/science/article/pii/S2211124724005333
  3. May 2024
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    NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors
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    sciencedirect.com/science/article/pii/S2666979X2400106X
  5. Apr 2024
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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    sciencedirect.com/science/article/pii/S2211124724003528
  7. Feb 2024
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    Specialized replication mechanisms maintain genome stability at human centromeres
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    sciencedirect.com/science/article/pii/S1097276524000546
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
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    sciencedirect.com/science/article/pii/S2211124724001062
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    sciencedirect.com/science/article/pii/S0753332224000982
  11. Oct 2023
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    TERRA R-loops connect and protect sister telomeres in mitosis
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    sciencedirect.com/science/article/pii/S2211124723012470
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    Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection
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    1. scibot 13 Oct 2023
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    sciencedirect.com/science/article/pii/S2211124723011932
  14. Jul 2023
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    Mechanisms of insertions at a DNA double-strand break
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    1. scibot 06 Jul 2023
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      DOI: 10.1016/j.molcel.2023.06.016

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    sciencedirect.com/science/article/abs/pii/S1097276523004616
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    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
    1
    1. scibot 06 Jul 2023
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      DOI: 10.7554/eLife.87086

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    ncbi.nlm.nih.gov/pmc/articles/PMC10319438/
  17. Jun 2023
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    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
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      DOI: 10.1016/j.isci.2023.106951

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    sciencedirect.com/science/article/pii/S2589004223010283
  19. May 2023
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination
    1
    1. scibot 05 May 2023
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      DOI: 10.1038/s41597-022-01508-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC9276747/
  21. Apr 2023
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    XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors
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      DOI: 10.1016/j.celrep.2023.112342

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    sciencedirect.com/science/article/pii/S2211124723003534
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    SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology
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      DOI: 10.1016/j.molcel.2023.02.004

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    sciencedirect.com/science/article/pii/S1097276523000837
  24. Mar 2023
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    HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression
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    1. scibot 23 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112284

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    sciencedirect.com/science/article/pii/S2211124723002954
  26. Feb 2023
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    GEN1 promotes common fragile site expression
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      DOI: 10.1016/j.celrep.2023.112062

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    sciencedirect.com/science/article/pii/S2211124723000736
  28. Jan 2023
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    Loss of epigenetic information as a cause of mammalian aging
    1
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      DOI: 10.1016/j.cell.2022.12.027

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    sciencedirect.com/science/article/pii/S0092867422015707
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    Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway
    1
    1. scibot 11 Jan 2023
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      DOI: 10.1016/j.isci.2022.105806

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    ncbi.nlm.nih.gov/pmc/articles/PMC9827073/
  31. Dec 2022
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    The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
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    sciencedirect.com/science/article/pii/S2211124722017119
  33. Nov 2022
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis
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    1. scibot 19 Nov 2022
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      DOI: 10.1016/j.celrep.2022.110871

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    ncbi.nlm.nih.gov/pmc/articles/PMC9637995/
  35. Oct 2022
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    DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation
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    sciencedirect.com/science/article/pii/S2211124722013821
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    Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization
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      DOI: 10.1016/j.chembiol.2022.09.002

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    sciencedirect.com/science/article/pii/S2451945622003506
  38. Sep 2022
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS
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      DOI: 10.1158/0008-5472.CAN-21-1843

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612475/
  40. Aug 2022
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    Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
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    sciencedirect.com/science/article/pii/S1097276522007079
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    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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    sciencedirect.com/science/article/pii/S1535610822003245
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    Increasing cell size remodels the proteome and promotes senescence
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    sciencedirect.com/science/article/pii/S1097276522007134
  44. Jun 2022
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    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
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      DOI: 10.1016/j.devcel.2022.06.003

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    sciencedirect.com/science/article/pii/S1534580722004129
  46. Mar 2022
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    CENP-B-mediated DNA loops regulate activity and stability of human centromeres
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    sciencedirect.com/science/article/pii/S1097276522002064
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    Pathway-specific effects of ADSL deficiency on neurodevelopment
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      DOI: 10.7554/eLife.70518

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    elifesciences.org/articles/70518
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    RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
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    sciencedirect.com/science/article/pii/S1097276522001010
  50. Jan 2022
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    Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity
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    sciencedirect.com/science/article/pii/S2589004221015911
  52. Nov 2021
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    The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair
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      DOI: 10.1016/j.devcel.2021.10.022

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    sciencedirect.com/science/article/pii/S1534580721008534
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    Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
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    sciencedirect.com/science/article/pii/S1097276521009072
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    Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks
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      DOI: 10.1007/s10571-021-01163-7

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    link.springer.com/article/10.1007/s10571-021-01163-7
  56. Oct 2021
  57. www.sciencedirect.com www.sciencedirect.com
    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
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    sciencedirect.com/science/article/pii/S1097276521007474
  58. Sep 2021
  59. www.sciencedirect.com www.sciencedirect.com
    The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
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      DOI: 10.1016/j.celrep.2021.109694

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    sciencedirect.com/science/article/pii/S2211124721011414
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    Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons
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      DOI: 10.1016/j.celrep.2021.109666

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    sciencedirect.com/science/article/pii/S2211124721011104
  61. Aug 2021
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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      DOI: 10.1016/j.neuron.2018.09.044

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    ncbi.nlm.nih.gov/pmc/articles/PMC6277851/
  63. Jul 2021
  64. www.sciencedirect.com www.sciencedirect.com
    HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis
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      DOI: 10.1016/j.celrep.2019.05.096

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    PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells
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    Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation
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  75. Jan 2021
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    A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans
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    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
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    Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
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    PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
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    ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition
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    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition
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    METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation
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    Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication
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  89. Jan 2020
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    53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
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    Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells
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    Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation
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    TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1
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    LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
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    HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis
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    Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
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    Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
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    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
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    Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
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    Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe
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    Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts
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    RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis
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    Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1
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