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BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116461
  
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sciencedirect.com/science/article/pii/S221112472501232X
Sep 2025
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Reproducibility of PD patient-specific midbrain organoid data for in vitro disease modeling

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  DOI: 10.1016/j.isci.2025.113541
  
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sciencedirect.com/science/article/pii/S2589004225018024
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RAD51 is chromatin enriched and targetable in BRCA1-deficient cells

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  DOI: 10.1016/j.molcel.2025.08.017
  
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sciencedirect.com/science/article/pii/S1097276525007026
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Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer

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  DOI: 10.1016/j.immuni.2025.08.008
  
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sciencedirect.com/science/article/pii/S1074761325003711
Aug 2025
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres

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  DOI: 10.1016/j.celrep.2025.116178
  
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sciencedirect.com/science/article/pii/S2211124725009490
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Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS

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  DOI: 10.1016/j.celrep.2025.116113
  
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sciencedirect.com/science/article/pii/S2211124725008848
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Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress

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1. scibot 14 Aug 2025
  
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sciencedirect.com/science/article/pii/S1097276525006148
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Conserved and unique features of terminal telomeric sequences in ALT-positive cancer cells

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1. scibot 06 Aug 2025
  
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  DOI: 10.7554/eLife.106657
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12316455/
Jul 2025
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Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116090
  
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sciencedirect.com/science/article/pii/S2211124725008617
Feb 2025
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Viral oncogene EBNALP regulates YY1 DNA binding and alters host 3D genome organization

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  DOI: 10.1038/s44319-024-00357-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11811279/
Jan 2025
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1-s2.0-S2589004225001130-main-html.html

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52.53.155.43/278e6cc24708021aeceb3c07dbca9cf273e76266/1-s2.0-S2589004225001130-main-html.html
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

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1. scibot 18 Jan 2025
  
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  DOI: 10.1038/s41556-024-01565-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735390/
Dec 2024
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Control of cell proliferation by memories of mitosis

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1. scibot 11 Dec 2024
  
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  DOI: 10.1126/science.add9528
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11621110/
Jul 2024
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DNA break induces rapid transcription repression mediated by proteasome-dependent RNAPII removal

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1. scibot 04 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114420
  
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sciencedirect.com/science/article/pii/S2211124724007496
May 2024
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Loss of POLE3-POLE4 unleashes replicative gap accumulation upon treatment with PARP inhibitors

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1. scibot 16 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114205
  
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sciencedirect.com/science/article/pii/S2211124724005333
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NRDE2 deficiency impairs homologous recombination repair and sensitizes hepatocellular carcinoma to PARP inhibitors

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1. scibot 02 May 2024
  
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  DOI: 10.1016/j.xgen.2024.100550
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11099347/
Apr 2024
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A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation

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1. scibot 09 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114024
  
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sciencedirect.com/science/article/pii/S2211124724003528
Feb 2024
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Specialized replication mechanisms maintain genome stability at human centromeres

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1. scibot 15 Feb 2024
  
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  DOI: 10.1016/j.molcel.2024.01.018
  
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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability

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  DOI: 10.1016/j.celrep.2024.113778
  
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sciencedirect.com/science/article/pii/S2211124724001062
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β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models

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  DOI: 10.1016/j.biopha.2024.116217
  
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sciencedirect.com/science/article/pii/S0753332224000982
Oct 2023
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TERRA R-loops connect and protect sister telomeres in mitosis

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  DOI: 10.1016/j.celrep.2023.113235
  
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sciencedirect.com/science/article/pii/S2211124723012470
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Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection

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  DOI: 10.1016/j.celrep.2023.113181
  
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sciencedirect.com/science/article/pii/S2211124723011932
Jul 2023
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Mechanisms of insertions at a DNA double-strand break

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.016
  
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sciencedirect.com/science/article/abs/pii/S1097276523004616
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Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

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1. scibot 06 Jul 2023
  
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  DOI: 10.7554/eLife.87086
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10319438/
Jun 2023
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PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors

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1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.106951
  
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sciencedirect.com/science/article/pii/S2589004223010283
May 2023
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An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination

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  DOI: 10.1038/s41597-022-01508-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9276747/
Apr 2023
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XLF/Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors

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  DOI: 10.1016/j.celrep.2023.112342
  
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sciencedirect.com/science/article/pii/S2211124723003534
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SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology

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  DOI: 10.1016/j.molcel.2023.02.004
  
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sciencedirect.com/science/article/pii/S1097276523000837
Mar 2023
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HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

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1. scibot 23 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112284
  
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sciencedirect.com/science/article/pii/S2211124723002954
Feb 2023
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GEN1 promotes common fragile site expression

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  DOI: 10.1016/j.celrep.2023.112062
  
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sciencedirect.com/science/article/pii/S2211124723000736
Jan 2023
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Loss of epigenetic information as a cause of mammalian aging

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  DOI: 10.1016/j.cell.2022.12.027
  
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sciencedirect.com/science/article/pii/S0092867422015707
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Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

1
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  DOI: 10.1016/j.isci.2022.105806
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9827073/
Dec 2022
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The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response

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1. scibot 18 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111819
  
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sciencedirect.com/science/article/pii/S2211124722017119
Nov 2022
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Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

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1. scibot 19 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.110871
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9637995/
Oct 2022
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DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation

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  DOI: 10.1016/j.celrep.2022.111526
  
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Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization

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CANCER-ASSOCIATED SF3B1 MUTATIONS CONFER A BRCA-LIKE CELLULAR PHENOTYPE AND SYNTHETIC LETHALITY TO PARP INHIBITORS

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Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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Increasing cell size remodels the proteome and promotes senescence

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Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD

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CENP-B-mediated DNA loops regulate activity and stability of human centromeres

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Pathway-specific effects of ADSL deficiency on neurodevelopment

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RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1

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Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity

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The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

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Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1

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Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks

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Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells

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The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress

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Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons

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Untitled document

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HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis

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  DOI: 10.1016/j.celrep.2019.05.096
  
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Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

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The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair

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Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening

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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

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Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation

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Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity

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A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

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A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans

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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

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CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma

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Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining

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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

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PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

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ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition

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cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

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  53BP1
  
  DOI: 10.1158/2159-8290.CD-19-1228
  
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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

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  DOI: 10.1016/j.molcel.2020.06.017
  
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Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication

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  DOI: 10.1016/j.celrep.2020.107675
  
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53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function

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Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells

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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

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  DOI: 10.1016/j.stem.2019.06.011
  
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TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1

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LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL

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HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis

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  DOI: 10.1016/j.celrep.2019.05.096
  
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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

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Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

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  DOI: 10.1016/j.cmet.2018.12.008
  
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Untitled document

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Untitled document

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Untitled document

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Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

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Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

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Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe

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Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts

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RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis

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Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1

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Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

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