82 Matching Annotations
  1. Sep 2026
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting TTLL1 Alleviates Aβ-Induced Microtubule Disruption and TAU Pathology in Human iPSC-Derived Cortical Neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC13516559/
  3. Jul 2026
  4. www.sciencedirect.com www.sciencedirect.com
    NAT10 inhibition corrects nuclear defects in tau mutant human neurons and extends lifespan in a Drosophila tauopathy model
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    sciencedirect.com/science/article/pii/S258900422602239X
  5. Jun 2026
  6. 54.241.53.176 54.241.53.176
    table 2-html.html
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    54.241.53.176/7020dca9788500a2a3a21b57d11329053909eb77/table 2-html.html
  7. May 2026
  8. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro-Inflammatory Responses via Modulation of JNK and NFkB Signaling
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    onlinelibrary.wiley.com/doi/10.1002/glia.70165
  9. Mar 2026
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Alzheimer’s disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits
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    pmc.ncbi.nlm.nih.gov/articles/PMC13045655/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12973372/
  12. Dec 2025
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proteomic analysis links truncated tau to lysosome motility, autophagy, and endo‐lysosomal dysfunction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12706120/
  14. Jul 2025
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12268982/
  16. Jun 2025
  17. 52.53.155.43 52.53.155.43
    JNEUROSCI.2331-24.2025.full-html.html
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    52.53.155.43/dfcafbf6016452035fb509063d975ec0368221ae/JNEUROSCI.2331-24.2025.full-html.html
  18. 52.53.155.43 52.53.155.43
    PDF-html.html
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    52.53.155.43/919062f2a268aa52112faee2995da7ba1fbb82bd/PDF-html.html
  19. May 2025
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12087151/
  21. www.cell.com www.cell.com
    Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
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    cell.com/cell/fulltext/S0092-8674(25)00408-8
  22. Mar 2025
  23. www.biorxiv.org www.biorxiv.org
    Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction
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    biorxiv.org/content/10.1101/2025.03.18.643906v1
  24. Dec 2024
  25. www.sciencedirect.com www.sciencedirect.com
    Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
    1
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    sciencedirect.com/science/article/pii/S0896627324008006
  26. Nov 2024
  27. 52.53.155.43 52.53.155.43
    effects_of_p301l_tau_on_post_translational.25-html.html
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    52.53.155.43/6f5189698d9c1b8a18d3fb9b9f3d0cf87ff075d6/effects_of_p301l_tau_on_post_translational.25-html.html
  28. Oct 2024
  29. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mass spectrometry identifies tau C-terminal phosphorylation cluster during neuronal hyperexcitation
    1
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16221
  30. Sep 2024
  31. www.biorxiv.org www.biorxiv.org
    Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration
    1
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    biorxiv.org/content/10.1101/2024.09.19.613736v1
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early-Stage Moderate Alcohol Feeding Dysregulates Insulin-Related Metabolic Hormone Expression in the Brain: Potential Links to Neurodegeneration Including Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC11380283/
  33. www.sciencedirect.com www.sciencedirect.com
    Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation
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    sciencedirect.com/science/article/pii/S2667237524002364
  34. Aug 2024
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11350046/
  36. May 2024
  37. www.jneurosci.org www.jneurosci.org
    Human iPSC-derived neurons with reliable synapses and large presynaptic action potentials
    1
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    jneurosci.org/content/jneuro/early/2024/05/07/JNEUROSCI.0971-23.2024.full.pdf
  38. Apr 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
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    sciencedirect.com/science/article/pii/S1934590924000948
  40. Feb 2024
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioural, metabolic and lipidomic characterisation of the 5xFADxTg30 mouse model of Alzheimer’s Disease.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10826307/
  42. Oct 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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    sciencedirect.com/science/article/pii/S0896627323006232
  44. Sep 2023
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Agent Orange Causes Metabolic Dysfunction and Molecular Pathology Reminiscent of Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10473158/
  46. Aug 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
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    sciencedirect.com/science/article/pii/S2211124723010057
  48. Jul 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
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    sciencedirect.com/science/article/pii/S2211124723007362
  50. Jun 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
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    sciencedirect.com/science/article/pii/S2589004223009823
  52. May 2023
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
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    ncbi.nlm.nih.gov/pmc/articles/PMC10198456/
  54. Nov 2022
  55. academic.oup.com academic.oup.com
    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
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    academic.oup.com/brain/advance-article/doi/10.1093/brain/awac325/6694190
  56. Sep 2022
  57. www.sciencedirect.com www.sciencedirect.com
    TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy
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    sciencedirect.com/science/article/pii/S2667237522001746
  58. www.sciencedirect.com www.sciencedirect.com
    A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer
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    sciencedirect.com/science/article/pii/S2667237522001710
  59. Aug 2022
  60. www.sciencedirect.com www.sciencedirect.com
    Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
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    sciencedirect.com/science/article/pii/S2211124722010671
  61. Jul 2022
  62. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1-month following repetitive mild traumatic brain injury
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    onlinelibrary.wiley.com/doi/10.1111/ejn.15752
  63. Jun 2022
  64. www.sciencedirect.com www.sciencedirect.com
    Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons
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    sciencedirect.com/science/article/pii/S1934590922002004
  65. May 2022
  66. www.sciencedirect.com www.sciencedirect.com
    Cholesterol determines the cytosolic entry and seeded aggregation of tau
    1
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    sciencedirect.com/science/article/pii/S221112472200540X
  67. link.springer.com link.springer.com
    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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    link.springer.com/article/10.1186/s13024-022-00526-y
  68. Apr 2022
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9027016/
  70. www.sciencedirect.com www.sciencedirect.com
    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
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    sciencedirect.com/science/article/pii/S1074761322001418
  71. Jan 2022
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies
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    ncbi.nlm.nih.gov/pmc/articles/PMC8764631/
  73. www.sciencedirect.com www.sciencedirect.com
    Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
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    sciencedirect.com/science/article/pii/S0092867421015634
  74. www.sciencedirect.com www.sciencedirect.com
    Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
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    sciencedirect.com/science/article/pii/S258900422101628X
  75. Nov 2021
  76. europepmc.org europepmc.org
    Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog
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    europepmc.org/article/MED/34805331
  77. Sep 2021
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC8452691/
  79. www.sciencedirect.com www.sciencedirect.com
    Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
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    sciencedirect.com/science/article/pii/S089662732100578X
  80. Aug 2021
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6335264/
  82. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
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    jneurosci.org/content/37/47/11485
  83. Jul 2021
  84. www.sciencedirect.com www.sciencedirect.com
    ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
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    sciencedirect.com/science/article/pii/S0092867421008291
  85. www.nature.com www.nature.com
    Untitled document
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    nature.com/articles/s41598-018-33474-z
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  87. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
    2
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    jneurosci.org/content/37/47/11485
  88. www.nature.com www.nature.com
    Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures
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    nature.com/cddis/journal/v8/n3/full/cddis201797a.html
  89. www.sciencedirect.com www.sciencedirect.com
    Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy
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    sciencedirect.com/science/article/pii/S2352396419301732
  90. Jun 2021
  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Templated α-synuclein inclusion formation is independent of endogenous tau
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    ncbi.nlm.nih.gov/pmc/articles/PMC8213444/
  92. May 2021
  93. www.sciencedirect.com www.sciencedirect.com
    Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes
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    sciencedirect.com/science/article/pii/S2211124721004733
  94. Apr 2021
  95. www.sciencedirect.com www.sciencedirect.com
    Tau seeds are subject to aberrant modifications resulting in distinct signatures
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    sciencedirect.com/science/article/pii/S2211124721003533
  96. Mar 2021
  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Suppression of tau‐induced phenotypes by vitamin E demonstrates the dissociation of oxidative stress and phosphorylation in mechanisms of tau toxicity
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15253
  98. Feb 2021
  99. www.frontiersin.org www.frontiersin.org
    A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila
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    frontiersin.org/article/10.3389/fnins.2020.00068/full
  100. Jan 2021
  101. www.sciencedirect.com www.sciencedirect.com
    Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
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    sciencedirect.com/science/article/pii/S0896627320309983
  102. Dec 2020
  103. www.sciencedirect.com www.sciencedirect.com
    Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S2211124720314091
  104. Sep 2020
  105. link.springer.com link.springer.com
    Tau reduction in aged mice does not impact Microangiopathy
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    link.springer.com/article/10.1186/s40478-020-01014-4
  106. link.springer.com link.springer.com
    The unfolded protein response is activated in the olfactory system in Alzheimer’s disease
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    link.springer.com/article/10.1186/s40478-020-00986-7
  107. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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    jneurosci.org/content/40/2/459
  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L ‐ acan mouse model
    1
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    onlinelibrary.wiley.com/doi/10.1111/ejn.14923
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC7392604/
  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axon-like protrusions promote small cell lung cancer migration and metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC6940020/
  111. Aug 2020
  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axon-like protrusions promote small cell lung cancer migration and metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC6940020/
  113. Jan 2020
  114. www.frontiersin.org www.frontiersin.org
    Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson’s Disease
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    frontiersin.org/articles/10.3389/fimmu.2019.02253/full
  115. www.sciencedirect.com www.sciencedirect.com
    Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
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    sciencedirect.com/science/article/pii/S0896627319308839
  116. www.sciencedirect.com www.sciencedirect.com
    Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S2211124719311660
  117. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S221112471832045X
  118. www.sciencedirect.com www.sciencedirect.com
    Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S0896627318309395
  119. Nov 2018
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
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    ncbi.nlm.nih.gov/pmc/articles/PMC6185981/
  121. www.sciencedirect.com www.sciencedirect.com
    Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S0896627318306378
  122. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  123. Nov 2017
  124. www.sciencedirect.com www.sciencedirect.com
    Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
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    sciencedirect.com/science/article/pii/S0896627317300582