62 Matching Annotations
  1. Sep 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early-Stage Moderate Alcohol Feeding Dysregulates Insulin-Related Metabolic Hormone Expression in the Brain: Potential Links to Neurodegeneration Including Alzheimer’s Disease
    1
    1. scibot 12 Sep 2024
      AB_10013724

      DOI: 10.3233/ADR-240026

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    ncbi.nlm.nih.gov/pmc/articles/PMC11380283/
  3. www.sciencedirect.com www.sciencedirect.com
    Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation
    1
    1. scibot 10 Sep 2024
      RRID:AB_10013724

      DOI: 10.1016/j.crmeth.2024.100858

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    sciencedirect.com/science/article/pii/S2667237524002364
  4. Aug 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy
    1
    1. scibot 30 Aug 2024
      RRID:AB_10013724

      DOI: 10.1002/alz.14074

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    ncbi.nlm.nih.gov/pmc/articles/PMC11350046/
  6. May 2024
  7. www.jneurosci.org www.jneurosci.org
    Human iPSC-derived neurons with reliable synapses and large presynaptic action potentials
    1
    1. scibot 25 May 2024
      AB_10013724

      DOI: 10.1523/JNEUROSCI.0971-23.2024

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    jneurosci.org/content/jneuro/early/2024/05/07/JNEUROSCI.0971-23.2024.full.pdf
  8. Apr 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
    1
    1. scibot 16 Apr 2024
      RRID:AB_10013724

      DOI: 10.1016/j.stem.2024.03.013

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    sciencedirect.com/science/article/pii/S1934590924000948
  10. Feb 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioural, metabolic and lipidomic characterisation of the 5xFADxTg30 mouse model of Alzheimer’s Disease.
    1
    1. scibot 01 Feb 2024
      RRID:AB_10013724

      DOI: 10.1016/j.isci.2024.108800

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    ncbi.nlm.nih.gov/pmc/articles/PMC10826307/
  12. Oct 2023
  13. www.sciencedirect.com www.sciencedirect.com
    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
    1
    1. scibot 06 Oct 2023
      RRID:AB_10013724

      DOI: 10.1016/j.neuron.2023.08.012

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    sciencedirect.com/science/article/pii/S0896627323006232
  14. Sep 2023
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Agent Orange Causes Metabolic Dysfunction and Molecular Pathology Reminiscent of Alzheimer’s Disease
    1
    1. scibot 07 Sep 2023
      AB_10013724

      DOI: 10.3233/ADR-230046

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    ncbi.nlm.nih.gov/pmc/articles/PMC10473158/
  16. Aug 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
    1
    1. scibot 23 Aug 2023
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2023.112994

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    sciencedirect.com/science/article/pii/S2211124723010057
  18. Jul 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
    1
    1. scibot 05 Jul 2023
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2023.112725

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    sciencedirect.com/science/article/pii/S2211124723007362
  20. Jun 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
    1
    1. scibot 07 Jun 2023
      RRID:AB_10013724

      DOI: 10.1016/j.isci.2023.106905

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    sciencedirect.com/science/article/pii/S2589004223009823
  22. May 2023
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
    1
    1. scibot 23 May 2023
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.2102-22.2023

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    ncbi.nlm.nih.gov/pmc/articles/PMC10198456/
  24. Nov 2022
  25. academic.oup.com academic.oup.com
    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
    1
    1. scibot 15 Nov 2022
      RRID:AB_10013724

      DOI: 10.1093/brain/awac325

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    academic.oup.com/brain/advance-article/doi/10.1093/brain/awac325/6694190
  26. Sep 2022
  27. www.sciencedirect.com www.sciencedirect.com
    TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy
    1
    1. scibot 11 Sep 2022
      AB_10013724

      DOI: 10.1016/j.crmeth.2022.100292

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    sciencedirect.com/science/article/pii/S2667237522001746
  28. www.sciencedirect.com www.sciencedirect.com
    A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer
    1
    1. scibot 11 Sep 2022
      RRID:AB_10013724

      DOI: 10.1016/j.crmeth.2022.100289

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    sciencedirect.com/science/article/pii/S2667237522001710
  29. Aug 2022
  30. www.sciencedirect.com www.sciencedirect.com
    Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
    1
    1. scibot 26 Aug 2022
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2022.111249

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    sciencedirect.com/science/article/pii/S2211124722010671
  31. Jul 2022
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1-month following repetitive mild traumatic brain injury
    1
    1. scibot 27 Jul 2022
      AB_10013724

      DOI: 10.1111/ejn.15752

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    onlinelibrary.wiley.com/doi/10.1111/ejn.15752
  33. Jun 2022
  34. www.sciencedirect.com www.sciencedirect.com
    Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons
    1
    1. scibot 03 Jun 2022
      RRID:AB_10013724

      DOI: 10.1016/j.stem.2022.04.018

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    sciencedirect.com/science/article/pii/S1934590922002004
  35. May 2022
  36. www.sciencedirect.com www.sciencedirect.com
    Cholesterol determines the cytosolic entry and seeded aggregation of tau
    1
    1. scibot 13 May 2022
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2022.110776

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    sciencedirect.com/science/article/pii/S221112472200540X
  37. link.springer.com link.springer.com
    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
    1
    1. scibot 05 May 2022
      RRID:AB_10013724

      DOI: 10.1186/s13024-022-00526-y

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    link.springer.com/article/10.1186/s13024-022-00526-y
  38. Apr 2022
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model
    1
    1. scibot 27 Apr 2022
      RRID:AB_10013724

      DOI: 10.3390/biom12040505

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    ncbi.nlm.nih.gov/pmc/articles/PMC9027016/
  40. www.sciencedirect.com www.sciencedirect.com
    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
    1
    1. scibot 20 Apr 2022
      RRID:AB_10013724

      DOI: 10.1016/j.immuni.2022.03.018

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    sciencedirect.com/science/article/pii/S1074761322001418
  41. Jan 2022
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies
    1
    1. scibot 28 Jan 2022
      RRID:AB_10013724

      DOI: 10.3233/ADR-210050

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    ncbi.nlm.nih.gov/pmc/articles/PMC8764631/
  43. www.sciencedirect.com www.sciencedirect.com
    Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
    1
    1. scibot 21 Jan 2022
      RRID:AB_10013724

      DOI: 10.1016/j.cell.2021.12.041

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    sciencedirect.com/science/article/pii/S0092867421015634
  44. www.sciencedirect.com www.sciencedirect.com
    Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
    1
    1. scibot 14 Jan 2022
      RRID:AB_10013724

      DOI: 10.1016/j.isci.2021.103658

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    sciencedirect.com/science/article/pii/S258900422101628X
  45. Nov 2021
  46. europepmc.org europepmc.org
    Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog
    1
    1. scibot 29 Nov 2021
      AB_10013724

      DOI: 10.3389/fvets.2021.725386

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    europepmc.org/article/MED/34805331
  47. Sep 2021
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization
    1
    1. scibot 25 Sep 2021
      AB_10013724

      DOI: 10.1038/s41598-021-98142-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC8452691/
  49. www.sciencedirect.com www.sciencedirect.com
    Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
    1
    1. scibot 03 Sep 2021
      RRID:AB_10013724

      DOI: 10.1016/j.neuron.2021.08.003

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    sciencedirect.com/science/article/pii/S089662732100578X
  50. Aug 2021
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
    1
    1. scibot 07 Aug 2021
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2018.12.085

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    ncbi.nlm.nih.gov/pmc/articles/PMC6335264/
  52. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
    1
    1. scibot 03 Aug 2021
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.2393-17.2017

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    jneurosci.org/content/37/47/11485
  53. Jul 2021
  54. www.sciencedirect.com www.sciencedirect.com
    ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
    1
    1. scibot 31 Jul 2021
      RRID:AB_10013724

      DOI: 10.1016/j.cell.2021.07.003

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    sciencedirect.com/science/article/pii/S0092867421008291
  55. www.nature.com www.nature.com
    Untitled document
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    1. scibot 31 Jul 2021
      RRID:AB_10013724

      DOI: 10.1038/s41598-018-33474-z

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    nature.com/articles/s41598-018-33474-z
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
    1
    1. scibot 30 Jul 2021
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.1550-17.2017

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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  57. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
    2
    1. scibot 27 Jul 2021
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.2393-17.2017

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    2. scibot 27 Jul 2021
      RRID:AB_10013724

      DOI: 10.1523/JNEUROSCI.2393-17.2017

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    jneurosci.org/content/37/47/11485
  58. www.nature.com www.nature.com
    Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures
    2
    1. scibot 27 Jul 2021
      AB_10013724

      DOI: 10.1038/cddis.2017.97

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      RRIDCUR:Validated RRIDCUR:Duplicate RRID:AB_10013724
    2. scibot 27 Jul 2021
      AB_10013724

      DOI: 10.1038/cddis.2017.97

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      RRIDCUR:Validated RRID:AB_10013724
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    nature.com/cddis/journal/v8/n3/full/cddis201797a.html
  59. www.sciencedirect.com www.sciencedirect.com
    Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy
    1
    1. scibot 19 Jul 2021
      RRID: AB_10013724

      DOI: 10.1016/j.ebiom.2019.03.033

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      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S2352396419301732
  60. Jun 2021
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Templated α-synuclein inclusion formation is independent of endogenous tau
    2
    1. scibot 24 Jun 2021
      AB_10013724

      DOI: 10.1523/ENEURO.0458-20.2021

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    2. scibot 24 Jun 2021
      AB_10013724

      DOI: 10.1523/ENEURO.0458-20.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8213444/
  62. May 2021
  63. www.sciencedirect.com www.sciencedirect.com
    Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes
    1
    1. scibot 19 May 2021
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2021.109134

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    sciencedirect.com/science/article/pii/S2211124721004733
  64. Apr 2021
  65. www.sciencedirect.com www.sciencedirect.com
    Tau seeds are subject to aberrant modifications resulting in distinct signatures
    1
    1. scibot 28 Apr 2021
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2021.109037

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  66. Mar 2021
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Suppression of tau‐induced phenotypes by vitamin E demonstrates the dissociation of oxidative stress and phosphorylation in mechanisms of tau toxicity
    1
    1. scibot 04 Mar 2021
      RRID:AB_10013724

      DOI: 10.1111/jnc.15253

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  68. Feb 2021
  69. www.frontiersin.org www.frontiersin.org
    A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila
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    1. scibot 24 Feb 2021
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      DOI: 10.3389/fnins.2020.00068

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  70. Jan 2021
  71. www.sciencedirect.com www.sciencedirect.com
    Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
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    1. scibot 20 Jan 2021
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      DOI: 10.1016/j.neuron.2020.12.016

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    sciencedirect.com/science/article/pii/S0896627320309983
  72. Dec 2020
  73. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease
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    1. scibot 07 Dec 2020
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      DOI: 10.1016/j.celrep.2020.108420

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  74. Sep 2020
  75. link.springer.com link.springer.com
    Tau reduction in aged mice does not impact Microangiopathy
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    1. scibot 25 Sep 2020
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      DOI: 10.1186/s40478-020-01014-4

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  76. link.springer.com link.springer.com
    The unfolded protein response is activated in the olfactory system in Alzheimer’s disease
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      DOI: 10.1186/s40478-020-00986-7

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  77. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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      DOI: 10.1523/JNEUROSCI.1076-19.2019

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  78. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L ‐ acan mouse model
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    1. scibot 13 Sep 2020
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      DOI: 10.1111/ejn.14923

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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability
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    1. scibot 08 Sep 2020
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      DOI: 10.7554/eLife.57354

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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axon-like protrusions promote small cell lung cancer migration and metastasis
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    1. scibot 04 Sep 2020
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      DOI: 10.7554/eLife.50616

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    ncbi.nlm.nih.gov/pmc/articles/PMC6940020/
  81. Aug 2020
  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axon-like protrusions promote small cell lung cancer migration and metastasis
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      DOI: 10.7554/eLife.50616

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  83. Jan 2020
  84. www.frontiersin.org www.frontiersin.org
    Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson’s Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_10013724

      DOI: 10.3389/fimmu.2019.02253

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  85. www.sciencedirect.com www.sciencedirect.com
    Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.neuron.2019.10.010

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    sciencedirect.com/science/article/pii/S0896627319308839
  86. www.sciencedirect.com www.sciencedirect.com
    Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2019.08.104

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    sciencedirect.com/science/article/pii/S2211124719311660
  87. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      RRID:AB_10013724

      DOI: 10.1016/j.celrep.2018.12.085

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    sciencedirect.com/science/article/pii/S221112471832045X
  88. www.sciencedirect.com www.sciencedirect.com
    Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
    1
    1. scibot 13 Jan 2020
      RRID:AB_10013724

      DOI: 10.1016/j.neuron.2018.10.031

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    sciencedirect.com/science/article/pii/S0896627318309395
  89. Nov 2018
  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
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    1. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC6185981/
  91. www.sciencedirect.com www.sciencedirect.com
    Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease
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    1. scibot 05 Nov 2018
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0896627318306378
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
    1
    1. scibot 05 Nov 2018
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      Curator: @Zeljana_Babic

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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  93. Nov 2017
  94. www.sciencedirect.com www.sciencedirect.com
    Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
    1
    1. scibot 08 Nov 2017
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      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S0896627317300582