75 Matching Annotations
  1. Last 7 days
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    Proteomic analysis links truncated tau to lysosome motility, autophagy, and endo‐lysosomal dysfunction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12706120/
  3. Jul 2025
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer’s Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration.
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    pmc.ncbi.nlm.nih.gov/articles/PMC12268982/
  5. Jun 2025
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    JNEUROSCI.2331-24.2025.full-html.html
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    PDF-html.html
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  8. May 2025
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12087151/
  10. www.cell.com www.cell.com
    Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons
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    cell.com/cell/fulltext/S0092-8674(25)00408-8
  11. Mar 2025
  12. www.biorxiv.org www.biorxiv.org
    Proteomic Analysis Links Truncated Tau to Lysosome Motility, Autophagy and Endo-lysosomal Dysfunction
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    biorxiv.org/content/10.1101/2025.03.18.643906v1
  13. Dec 2024
  14. www.sciencedirect.com www.sciencedirect.com
    Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease
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    sciencedirect.com/science/article/pii/S0896627324008006
  15. Nov 2024
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    effects_of_p301l_tau_on_post_translational.25-html.html
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  17. Oct 2024
  18. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mass spectrometry identifies tau C-terminal phosphorylation cluster during neuronal hyperexcitation
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16221
  19. Sep 2024
  20. www.biorxiv.org www.biorxiv.org
    Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration
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    biorxiv.org/content/10.1101/2024.09.19.613736v1
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Early-Stage Moderate Alcohol Feeding Dysregulates Insulin-Related Metabolic Hormone Expression in the Brain: Potential Links to Neurodegeneration Including Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC11380283/
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    Fully defined NGN2 neuron protocol reveals diverse signatures of neuronal maturation
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    sciencedirect.com/science/article/pii/S2667237524002364
  23. Aug 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11350046/
  25. May 2024
  26. www.jneurosci.org www.jneurosci.org
    Human iPSC-derived neurons with reliable synapses and large presynaptic action potentials
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    jneurosci.org/content/jneuro/early/2024/05/07/JNEUROSCI.0971-23.2024.full.pdf
  27. Apr 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
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    sciencedirect.com/science/article/pii/S1934590924000948
  29. Feb 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Behavioural, metabolic and lipidomic characterisation of the 5xFADxTg30 mouse model of Alzheimer’s Disease.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10826307/
  31. Oct 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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    sciencedirect.com/science/article/pii/S0896627323006232
  33. Sep 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Agent Orange Causes Metabolic Dysfunction and Molecular Pathology Reminiscent of Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10473158/
  35. Aug 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
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    sciencedirect.com/science/article/pii/S2211124723010057
  37. Jul 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
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    sciencedirect.com/science/article/pii/S2211124723007362
  39. Jun 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
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    sciencedirect.com/science/article/pii/S2589004223009823
  41. May 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
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    ncbi.nlm.nih.gov/pmc/articles/PMC10198456/
  43. Nov 2022
  44. academic.oup.com academic.oup.com
    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
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    academic.oup.com/brain/advance-article/doi/10.1093/brain/awac325/6694190
  45. Sep 2022
  46. www.sciencedirect.com www.sciencedirect.com
    TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy
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    sciencedirect.com/science/article/pii/S2667237522001746
  47. www.sciencedirect.com www.sciencedirect.com
    A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer
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    sciencedirect.com/science/article/pii/S2667237522001710
  48. Aug 2022
  49. www.sciencedirect.com www.sciencedirect.com
    Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
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    sciencedirect.com/science/article/pii/S2211124722010671
  50. Jul 2022
  51. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Altered amyloid precursor protein, tau-regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1-month following repetitive mild traumatic brain injury
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    onlinelibrary.wiley.com/doi/10.1111/ejn.15752
  52. Jun 2022
  53. www.sciencedirect.com www.sciencedirect.com
    Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons
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    sciencedirect.com/science/article/pii/S1934590922002004
  54. May 2022
  55. www.sciencedirect.com www.sciencedirect.com
    Cholesterol determines the cytosolic entry and seeded aggregation of tau
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    sciencedirect.com/science/article/pii/S221112472200540X
  56. link.springer.com link.springer.com
    Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
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    link.springer.com/article/10.1186/s13024-022-00526-y
  57. Apr 2022
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model
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    ncbi.nlm.nih.gov/pmc/articles/PMC9027016/
  59. www.sciencedirect.com www.sciencedirect.com
    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
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    sciencedirect.com/science/article/pii/S1074761322001418
  60. Jan 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies
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    ncbi.nlm.nih.gov/pmc/articles/PMC8764631/
  62. www.sciencedirect.com www.sciencedirect.com
    Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
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    sciencedirect.com/science/article/pii/S0092867421015634
  63. www.sciencedirect.com www.sciencedirect.com
    Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model
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    sciencedirect.com/science/article/pii/S258900422101628X
  64. Nov 2021
  65. europepmc.org europepmc.org
    Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog
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    europepmc.org/article/MED/34805331
  66. Sep 2021
  67. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Surface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization
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    ncbi.nlm.nih.gov/pmc/articles/PMC8452691/
  68. www.sciencedirect.com www.sciencedirect.com
    Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
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    sciencedirect.com/science/article/pii/S089662732100578X
  69. Aug 2021
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6335264/
  71. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
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    jneurosci.org/content/37/47/11485
  72. Jul 2021
  73. www.sciencedirect.com www.sciencedirect.com
    ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
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    sciencedirect.com/science/article/pii/S0092867421008291
  74. www.nature.com www.nature.com
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    nature.com/articles/s41598-018-33474-z
  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  76. www.jneurosci.org www.jneurosci.org
    GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils
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    jneurosci.org/content/37/47/11485
  77. www.nature.com www.nature.com
    Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures
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    nature.com/cddis/journal/v8/n3/full/cddis201797a.html
  78. www.sciencedirect.com www.sciencedirect.com
    Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy
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    sciencedirect.com/science/article/pii/S2352396419301732
  79. Jun 2021
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Templated α-synuclein inclusion formation is independent of endogenous tau
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    ncbi.nlm.nih.gov/pmc/articles/PMC8213444/
  81. May 2021
  82. www.sciencedirect.com www.sciencedirect.com
    Axonal generation of amyloid-β from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes
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    sciencedirect.com/science/article/pii/S2211124721004733
  83. Apr 2021
  84. www.sciencedirect.com www.sciencedirect.com
    Tau seeds are subject to aberrant modifications resulting in distinct signatures
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    sciencedirect.com/science/article/pii/S2211124721003533
  85. Mar 2021
  86. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Suppression of tau‐induced phenotypes by vitamin E demonstrates the dissociation of oxidative stress and phosphorylation in mechanisms of tau toxicity
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15253
  87. Feb 2021
  88. www.frontiersin.org www.frontiersin.org
    A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila
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    frontiersin.org/article/10.3389/fnins.2020.00068/full
  89. Jan 2021
  90. www.sciencedirect.com www.sciencedirect.com
    Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation
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    sciencedirect.com/science/article/pii/S0896627320309983
  91. Dec 2020
  92. www.sciencedirect.com www.sciencedirect.com
    Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S2211124720314091
  93. Sep 2020
  94. link.springer.com link.springer.com
    Tau reduction in aged mice does not impact Microangiopathy
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    link.springer.com/article/10.1186/s40478-020-01014-4
  95. link.springer.com link.springer.com
    The unfolded protein response is activated in the olfactory system in Alzheimer’s disease
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    link.springer.com/article/10.1186/s40478-020-00986-7
  96. www.jneurosci.org www.jneurosci.org
    Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity
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    jneurosci.org/content/40/2/459
  97. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Aggrecan modulates the expression and phosphorylation of tau in a novel bigenic TauP301L ‐ acan mouse model
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    onlinelibrary.wiley.com/doi/10.1111/ejn.14923
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease risk gene BIN1 induces Tau-dependent network hyperexcitability
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    ncbi.nlm.nih.gov/pmc/articles/PMC7392604/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axon-like protrusions promote small cell lung cancer migration and metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC6940020/
  100. Aug 2020
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Axon-like protrusions promote small cell lung cancer migration and metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC6940020/
  102. Jan 2020
  103. www.frontiersin.org www.frontiersin.org
    Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson’s Disease
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    frontiersin.org/articles/10.3389/fimmu.2019.02253/full
  104. www.sciencedirect.com www.sciencedirect.com
    Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
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    sciencedirect.com/science/article/pii/S0896627319308839
  105. www.sciencedirect.com www.sciencedirect.com
    Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S2211124719311660
  106. www.sciencedirect.com www.sciencedirect.com
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    sciencedirect.com/science/article/pii/S221112471832045X
  107. www.sciencedirect.com www.sciencedirect.com
    Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S0896627318309395
  108. Nov 2018
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
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    ncbi.nlm.nih.gov/pmc/articles/PMC6185981/
  110. www.sciencedirect.com www.sciencedirect.com
    Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease
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    sciencedirect.com/science/article/pii/S0896627318306378
  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC5761430/
  112. Nov 2017
  113. www.sciencedirect.com www.sciencedirect.com
    Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain
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    sciencedirect.com/science/article/pii/S0896627317300582