96 Matching Annotations
  1. Sep 2024
  2. dx.doi.org dx.doi.org
    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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    1. scibot 27 Sep 2024
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      DOI: 10.1093/hmg/ddae135

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    dx.doi.org/10.1093/hmg/ddae135
  3. Aug 2024
  4. www.cell.com www.cell.com
    Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.cmet.2024.07.014

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    cell.com/cell-metabolism/fulltext/S1550-4131(24)00285-7
  5. academic.oup.com academic.oup.com
    Exploring visceral and subcutaneous adipose tissue secretomes in human obesity: implications for metabolic disease
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1210/endocr/bqac140

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    academic.oup.com/endo/article-abstract/163/11/bqac140/6678177
  6. www.sciencedirect.com www.sciencedirect.com
    Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors
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    1. scibot 01 Aug 2024
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    sciencedirect.com/science/article/pii/S1534580724004428
  7. May 2024
  8. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
    1
    1. scibot 24 May 2024
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      DOI: 10.1126/scisignal.adh4475

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    science.org/doi/10.1126/scisignal.adh4475
  9. www.sciencedirect.com www.sciencedirect.com
    Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy
    1
    1. scibot 17 May 2024
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      DOI: 10.1016/j.ajpath.2024.04.006

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    sciencedirect.com/science/article/pii/S0002944024001743
  10. www.sciencedirect.com www.sciencedirect.com
    Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus
    1
    1. scibot 14 May 2024
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      DOI: 10.1016/j.celrep.2024.114226

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    sciencedirect.com/science/article/pii/S2211124724005540
  11. Apr 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.isci.2024.109540

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    ncbi.nlm.nih.gov/pmc/articles/PMC10993184/
  13. dx.doi.org dx.doi.org
    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
    1
    1. scibot 10 Apr 2024
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      DOI: 10.1210/endocr/bqae044

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    dx.doi.org/10.1210/endocr/bqae044
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Creatine and low-dose lithium supplementation separately alter energy expenditure, body mass and adipose metabolism for the promotion of thermogenesis
    2
    1. scibot 03 Apr 2024
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      DOI: 10.1016/j.isci.2024.109468

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    ncbi.nlm.nih.gov/pmc/articles/PMC10973579/
  15. Mar 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
    1
    1. scibot 09 Mar 2024
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      DOI: 10.14814/phy2.15969

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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113927

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    ncbi.nlm.nih.gov/pmc/articles/PMC11101011/
  18. Feb 2024
  19. actaneurocomms.biomedcentral.com actaneurocomms.biomedcentral.com
    Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1186/s40478-024-01742-x

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    actaneurocomms.biomedcentral.com/articles/10.1186/s40478-024-01742-x
  20. Jan 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Disruption of lysosomal nutrient sensing scaffold hyperactivates mTORC1 contributing to pathogenesis of a fatal neurodegenerative disease
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.jbc.2024.105641

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    sciencedirect.com/science/article/pii/S0021925824000176
  22. Dec 2023
  23. www.sciencedirect.com www.sciencedirect.com
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
    1
    1. scibot 20 Dec 2023
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      DOI: 10.1016/j.isci.2023.108596

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    sciencedirect.com/science/article/pii/S2589004223026731
  24. www.sciencedirect.com www.sciencedirect.com
    An oncogenic phenoscape of colonic stem cell polarization
    2
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.004

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      DOI: 10.1016/j.cell.2023.11.004

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    sciencedirect.com/science/article/pii/S0092867423012217
  25. www.sciencedirect.com www.sciencedirect.com
    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
    2
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.cell.2023.11.005

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      DOI: 10.1016/j.cell.2023.11.005

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    sciencedirect.com/science/article/pii/S0092867423012205
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain
    1
    1. scibot 07 Dec 2023
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      DOI: 10.1016/j.isci.2023.108409

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    ncbi.nlm.nih.gov/pmc/articles/PMC10696114/
  27. Nov 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
    1
    1. scibot 30 Nov 2023
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      DOI: 10.1186/s40779-023-00494-4

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    ncbi.nlm.nih.gov/pmc/articles/PMC10675918/
  29. Oct 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.xcrm.2023.101238

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    sciencedirect.com/science/article/pii/S2666379123004159
  31. www.cell.com www.cell.com
    Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.isci.2023.107940

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    cell.com/iscience/abstract/S2589-0042(23)02017-5
  32. www.sciencedirect.com www.sciencedirect.com
    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
    1
    1. scibot 06 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113202

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    sciencedirect.com/science/article/pii/S2211124723012147
  33. Aug 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
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    1. scibot 26 Aug 2023
      RRID:AB_10013750

      DOI: 10.1158/2767-9764.CRC-22-0293

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      DOI: 10.1158/2767-9764.CRC-22-0293

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      DOI: 10.1158/2767-9764.CRC-22-0293

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    ncbi.nlm.nih.gov/pmc/articles/PMC10430783/
  35. 52.53.155.43 52.53.155.43
    crc-22-0293-html.html
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    1. scibot 11 Aug 2023
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      DOI: 10.1158/2767-9764.crc-22-0293

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  36. Jun 2023
  37. www.sciencedirect.com www.sciencedirect.com
    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112647

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    sciencedirect.com/science/article/pii/S2211124723006587
  38. www.cell.com www.cell.com
    Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
    1
    1. scibot 03 Jun 2023
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      DOI: 10.1016/j.chom.2023.05.007

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    cell.com/cell-host-microbe/fulltext/S1931-3128(23)00200-7
  39. academic.oup.com academic.oup.com
    Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing
    1
    1. scibot 02 Jun 2023
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      DOI: 10.1210/endocr/bqad045

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    academic.oup.com/endo/article/164/6/bqad045/7079002
  40. May 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice
    1
    1. scibot 27 May 2023
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      DOI: 10.3389/fimmu.2023.1182278

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    ncbi.nlm.nih.gov/pmc/articles/PMC10208528/
  42. Apr 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
    1
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      DOI: 10.7554/eLife.78629

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    ncbi.nlm.nih.gov/pmc/articles/PMC10069870/
  44. Mar 2023
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats
    1
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      DOI: 10.1152/ajpendo.00240.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8897003/
  46. Feb 2023
  47. www.sciencedirect.com www.sciencedirect.com
    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
    1
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      DOI: 10.1016/j.isci.2023.106070

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    sciencedirect.com/science/article/pii/S2589004223001475
  48. Dec 2022
  49. 52.53.155.43 52.53.155.43
    Prenatal stress induces changes in PAR2- and M3-dependent regulation of colon primitive cells
    1
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      DOI: 10.1152/ajpgi.00061.2022

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    52.53.155.43/70ada42d2ce6dee75a90bb8da12329ef248af60d/ajpgi.00061.2022-html.html
  50. journals.physiology.org journals.physiology.org
    Prenatal stress induces changes in PAR2- and M3-dependent regulation of colon primitive cells
    1
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      DOI: 10.1152/ajpgi.00061.2022

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    journals.physiology.org/doi/10.1152/ajpgi.00061.2022
  51. Nov 2022
  52. www.sciencedirect.com www.sciencedirect.com
    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
    1
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      DOI: 10.1016/j.isci.2022.105184

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    sciencedirect.com/science/article/pii/S2589004222014560
  53. Sep 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development
    1
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      DOI: 10.1016/j.celrep.2022.111350

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    sciencedirect.com/science/article/pii/S2211124722011780
  55. Jun 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Active APPL1 sequestration by Plasmodium favors liver-stage development
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      DOI: 10.1016/j.celrep.2022.110886

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    Translational and post-translational control of human naïve versus primed pluripotency
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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  64. Oct 2021
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
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    Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets
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    Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway
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    Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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    A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes
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    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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    The day‐night differences in ERK1/2, GSK3β activity and c‐Fos levels in the brain, and the responsiveness of various brain structures to morphine
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    Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders
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  92. Dec 2020
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    Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer’s Disease
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  94. Sep 2020
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    microRNA‐9‐5p alleviates blood‐brain barrier damage and neuroinflammation after traumatic brain injury
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    CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus
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    Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain
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    The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling
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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism
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  115. Nov 2018
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    Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration
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    Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles
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    AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
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  121. Nov 2017
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    CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc
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    Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a
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    Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis
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