121 Matching Annotations
  1. Last 7 days
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    Relationship between inner hair cell synaptopathy and outer hair cell loss in two mouse models of accelerated age-related hearing loss
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    sciencedirect.com/science/article/pii/S019745802500137X
  3. Aug 2025
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    Protocol for vibratome sectioning, immunofluorescence, and S-phase labeling of inner ear organoids
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    sciencedirect.com/science/article/pii/S2666166725004381
  5. Jul 2025
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    Microtubule networks in zebrafish hair cells facilitate presynapse transport and fusion during development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286606/
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    Fusiform Cells in the Dorsal Cochlear Nucleus Change Intrinsic Electrophysiological Properties and Morphologically Remodel Their Basal Dendrites with Age
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    biorxiv.org/content/10.1101/2025.07.16.665173v1
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    Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236841/
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    Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae
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    sciencedirect.com/science/article/pii/S2589004225011903
  10. Jun 2025
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    Cochlear gene therapy restores hearing and auditory processing in an atypical DFNB9 mouse model
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    nature.com/articles/s43856-025-00926-3
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12139522/
  13. May 2025
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    Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures
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    sciencedirect.com/science/article/pii/S2211124725005522
  15. Apr 2025
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    Deciphering enhancers of hearing loss genes for efficient and targeted gene therapy of hereditary deafness
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    sciencedirect.com/science/article/pii/S0896627325002235
  17. Feb 2025
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    Cdh23 Gene Mutation–Induced Vestibular Dysfunction in Mice: Abnormal Stereocilia Bundle and Otolith Development and Activation of p53/FoxO Signaling Pathway
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    link.springer.com/article/10.1007/s12031-025-02318-7
  19. Dec 2024
  20. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Irx3/5 Null Deletion in Mice Blocks Cochlea-Saccule Segregation and Disrupts the Auditory Tonotopic Map
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    onlinelibrary.wiley.com/doi/10.1002/cne.70008
  21. Nov 2024
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Local delivery of soluble fractalkine (CX3CL1) peptide restores ribbon synapses after noise-induced cochlear synaptopathy
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    pmc.ncbi.nlm.nih.gov/articles/PMC11557324/
  23. Oct 2024
  24. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Kif1a and intact microtubules maintain synaptic-vesicle populations at ribbon synapses in zebrafish hair cells
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP286263
  25. Sep 2024
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    Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network
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    sciencedirect.com/science/article/pii/S2211124720314200
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    Transcriptomic characterization of dying hair cells in the avian cochlea
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    sciencedirect.com/science/article/pii/S2211124721002163
  28. Aug 2024
  29. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Large basolateral processes on type II hair cells are novel processing units in mammalian vestibular organs
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    onlinelibrary.wiley.com/doi/10.1002/cne.23625/full
  30. Jul 2024
  31. www.science.org www.science.org
    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    science.org/doi/10.1126/sciadv.adk2299
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for in vivo elimination of avian auditory hair cells, multiplexed mRNA detection, immunohistochemistry, and S-phase labeling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11217775/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Age-related changes in olivocochlear efferent innervation in gerbils
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    ncbi.nlm.nih.gov/pmc/articles/PMC11180762/
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    Maturation of type I and type II rat vestibular hair cells in vivo and in vitro
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    ncbi.nlm.nih.gov/pmc/articles/PMC11183282/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    From hidden hearing loss to supranormal auditory processing by neurotrophin 3-mediated modulation of inner hair cell synapse density
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    ncbi.nlm.nih.gov/pmc/articles/PMC11210788/
  36. Jun 2024
  37. www.science.org www.science.org
    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    science.org/doi/10.1126/sciadv.adk2299
  38. May 2024
  39. www.jneurosci.org www.jneurosci.org
    Age-related deficits in binaural hearing: Contribution of peripheral and central effects
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    jneurosci.org/content/44/16/e0963222024
  40. Apr 2024
  41. www.sciencedirect.com www.sciencedirect.com
    BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing
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    sciencedirect.com/science/article/pii/S221112472400353X
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    Extrasynaptic distribution of NMDA receptors in cochlear inner hair cell afferent signaling complex
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    sciencedirect.com/science/article/pii/S0891061824000309
  43. Mar 2024
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cochlear Ribbon Synapses in Aged Gerbils
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    ncbi.nlm.nih.gov/pmc/articles/PMC10931817/
  45. Feb 2024
  46. 52.53.155.43 52.53.155.43
    JNEUROSCI.0963-22.2024.full-html.html
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    Local Delivery of Soluble Fractalkine (CX3CL1) Peptide Restore Ribbon Synapses After Noise-Induced Cochlear Synaptopathy
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    biorxiv.org/content/10.1101/2024.02.20.581182v1
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    Hair cell regeneration, reinnervation, and restoration of hearing thresholds in the avian hearing organ
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    sciencedirect.com/science/article/pii/S2211124724001505
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mapping the developmental potential of mouse inner ear organoids at single-cell resolution
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    ncbi.nlm.nih.gov/pmc/articles/PMC10875570/
  50. www.jneurosci.org www.jneurosci.org
    EBF1 limits the numbers of cochlear hair and supporting cells and forms the scala tympani and spiral limbus during inner ear development
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    jneurosci.org/content/44/7/e1060232023
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    Cell-type identity of the avian cochlea
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    sciencedirect.com/science/article/pii/S221112472100214X
  52. Jan 2024
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    Nestin-Expressing Cells are Mitotically Active in the Mammalian Inner Ear
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    sciencedirect.com/science/article/pii/S0378595524000157
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    Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti
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    jneurosci.org/content/43/29/5305
  56. Dec 2023
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    An essential signaling cascade for avian auditory hair cell regeneration
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    sciencedirect.com/science/article/pii/S1534580723006494
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    RNA-seq analysis highlights DNA replication and DNA repair associated with early-onset hearing loss in the cochlea of DBA/2J mice
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    sciencedirect.com/science/article/pii/S0024320523009852
  59. Nov 2023
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    Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells
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  61. Oct 2023
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Absence of Embigin accelerates hearing loss and causes sub-viability, brain and cardiac defects in C57BL/6N mice due to interaction with Cdh23ahl
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    pmc.ncbi.nlm.nih.gov/articles/PMC10579432/
  63. Sep 2023
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cross-species analysis and comparison of the inner ear between chickens and mice
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    onlinelibrary.wiley.com/doi/10.1002/cne.25524
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    Generating high-fidelity cochlear organoids from human pluripotent stem cells
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    sciencedirect.com/science/article/pii/S1934590923002175
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    Loss of synaptic ribbons is an early cause in ROS-induced acquired sensorineural hearing loss
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    sciencedirect.com/science/article/pii/S0969996123002954
  67. www.embopress.org www.embopress.org
    Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease
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    embopress.org/doi/10.15252/emmm.202317393
  68. Jun 2023
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    A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs
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    sciencedirect.com/science/article/pii/S2211124723006344
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    Macrophages Promote Repair of Inner Hair Cell Ribbon Synapses Following Noise-Induced Cochlear Synaptopathy
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    jneurosci.org/content/43/12/2075
  71. May 2023
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Round-window delivery of lithium chloride regenerates cochlear synapses damaged by noise-induced excitotoxic trauma via inhibition of the NMDA receptor in the rat
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    ncbi.nlm.nih.gov/pmc/articles/PMC10202264/
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    The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans
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    link.springer.com/article/10.1007/s00204-023-03518-z
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    Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development
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    sciencedirect.com/science/article/pii/S2211124723005156
  75. Apr 2023
  76. www.sciencedirect.com www.sciencedirect.com
    Asymmetric mechanotransduction by hair cells of the zebrafish lateral line
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    sciencedirect.com/science/article/pii/S0960982223001732
  77. Feb 2023
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    Runx1 controls auditory sensory neuron diversity in mice
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    sciencedirect.com/science/article/pii/S1534580723000394
  79. Dec 2022
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses
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    ncbi.nlm.nih.gov/pmc/articles/PMC9722480/
  81. elifesciences.org elifesciences.org
    Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals
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    elifesciences.org/articles/79712
  82. Nov 2022
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    Developmental spontaneous activity promotes formation of sensory domains, frequency tuning and proper gain in central auditory circuits
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    sciencedirect.com/science/article/pii/S2211124722015200
  84. Oct 2022
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC9549866/
  86. Sep 2022
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    Cell-type identity of the avian utricle
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    sciencedirect.com/science/article/pii/S2211124722012736
  88. Jul 2022
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    Template-independent genome editing in the Pcdh15av−3j mouse, a model of human DFNB23 nonsyndromic deafness
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    sciencedirect.com/science/article/pii/S2211124722008592
  91. Apr 2022
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    Molecular and cytological profiling of biological aging of mouse cochlear inner and outer hair cells
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  93. Mar 2022
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    Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages
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    Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme
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    link.springer.com/article/10.1186/s12915-022-01257-8
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    Neural Contributions to the Cochlear Summating Potential: Spiking and Dendritic Components
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    link.springer.com/article/10.1007/s10162-022-00842-6
  97. Jan 2022
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    An Efficient Method to Detect Messenger RNA (mRNA) in the Inner Ear by RNAscope In Situ Hybridization
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    link.springer.com/protocol/10.1007/978-1-0716-2022-9_6
  99. Dec 2021
  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cy3-ATP labeling of unfixed, permeabilized mouse hair cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8668996/
  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea
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    ncbi.nlm.nih.gov/pmc/articles/PMC8616558/
  102. Oct 2021
  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Noise Exposure Potentiates Exocytosis From Cochlear Inner Hair Cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8511412/
  104. www.jneurosci.org www.jneurosci.org
    The differentiation status of hair cells that regenerate naturally in the vestibular inner ear of the adult mouse
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    jneurosci.org/content/41/37/7779
  105. Sep 2021
  106. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC8439656/
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    Takeda2017_Article_EffectsOfAgingAndNoiseExposure-html.html
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    Age-related decline in cochlear ribbon synapses and its relation to different metrics of auditory-nerve activity
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    sciencedirect.com/science/article/pii/S0197458021002736
  109. Aug 2021
  110. www.sciencedirect.com www.sciencedirect.com
    Fluorescent in situ mRNA detection in the adult mouse cochlea
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    sciencedirect.com/science/article/pii/S2666166721004184
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.23625
  112. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Using Extracochlear Multichannel Electrical Stimulation to Relieve Tinnitus and Reverse Tinnitus-Related Auditory-Somatosensory Plasticity in the Cochlear Nucleus
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    onlinelibrary.wiley.com/doi/10.1111/ner.13506
  113. Jul 2021
  114. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Development of hair cell phenotype and calyx nerve terminals in the neonatal mouse utricle
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24658
  115. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/abs/10.1002/cne.24658
  116. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea
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    physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP277997
  117. www.jneurosci.org www.jneurosci.org
    Global Analysis of Protein Expression of Inner Ear Hair Cells
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    jneurosci.org/content/37/5/1320.long
  118. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Efferent innervation of turtle semicircular canal cristae: Comparisons with bird and mouse
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    onlinelibrary.wiley.com/doi/10.1002/cne.23738/full
  119. www.sciencedirect.com www.sciencedirect.com
    Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics
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    sciencedirect.com/science/article/pii/S2211124721007567
  120. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    The role of oxidative stress in the susceptibility of noise-impaired cochleae to synaptic loss induced by intracochlear electrical stimulation
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    pubmed.ncbi.nlm.nih.gov/34246683/
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    Murine cochlear cell sorting and cell-type-specific organoid culture
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  122. Jun 2021
  123. www.jneurosci.org www.jneurosci.org
    Nox3-derived superoxide in cochleae induces sensorineural hearing loss Mechanisms of Nox3-dependent hearing loss
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    jneurosci.org/content/41/21/4716
  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris
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    ncbi.nlm.nih.gov/pmc/articles/PMC8189719/
  125. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Phenotypic differences in the inner ears of CBA/CaJ and C57BL/6J mice carrying missense and single base pair deletion mutations in the Cdh23 gene
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24905
  126. May 2021
  127. www.sciencedirect.com www.sciencedirect.com
    Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing
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    sciencedirect.com/science/article/pii/S1534580721003555
  128. Apr 2021
  129. www.sciencedirect.com www.sciencedirect.com
    Sex difference in the efferent inner hair cell synapses of the aging murine cochlea
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    sciencedirect.com/science/article/pii/S0378595521000496
  130. Mar 2021
  131. www.sciencedirect.com www.sciencedirect.com
    Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise
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    sciencedirect.com/science/article/pii/S0896627321000374
  132. www.sciencedirect.com www.sciencedirect.com
    Cell-type identity of the avian cochlea
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  133. www.sciencedirect.com www.sciencedirect.com
    Transcriptomic characterization of dying hair cells in the avian cochlea
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    sciencedirect.com/science/article/pii/S2211124721002163
  134. Feb 2021
  135. bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com
    Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor
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    bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-00953-1
  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse
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    ncbi.nlm.nih.gov/pmc/articles/PMC7652395/
  137. elifesciences.org elifesciences.org
    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
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    elifesciences.org/articles/39159
  138. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Light Sheet Microscopy of the Gerbil Cochlea
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    onlinelibrary.wiley.com/doi/10.1002/cne.24977
  139. Jan 2021
  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models
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  141. www.sciencedirect.com www.sciencedirect.com
    Greater epithelial ridge cells are the principal organoid-forming progenitors of the mouse cochlea
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    sciencedirect.com/science/article/pii/S2211124720316351
  142. Dec 2020
  143. www.jneurosci.org www.jneurosci.org
    The Notch Ligand Jagged1 is Required for the Formation, Maintenance, and Survival of Hensen’s Cells in the Mouse Cochlea
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    jneurosci.org/content/40/49/9401
  144. www.sciencedirect.com www.sciencedirect.com
    Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network
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  145. Nov 2020
  146. link.springer.com link.springer.com
    Acoustic Trauma Increases Ribbon Number and Size in Outer Hair Cells of the Mouse Cochlea
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    link.springer.com/article/10.1007/s10162-020-00777-w
  147. Sep 2020
  148. elifesciences.org elifesciences.org
    Synaptic mitochondria regulate hair-cell synapse size and function
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    elifesciences.org/articles/48914
  149. www.nature.com www.nature.com
    The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia
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  150. www.nature.com www.nature.com
    The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice
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  151. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Comparison of ethylenediaminetetraacetic acid and rapid decalcificier solution for studying human temporal bones by immunofluorescence
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  152. www.sciencedirect.com www.sciencedirect.com
    The Cation Channel TMEM63B Is an Osmosensor Required for Hearing
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  153. www.nature.com www.nature.com
    Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss
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  154. elifesciences.org elifesciences.org
    Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space
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    elifesciences.org/articles/52160
  155. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea
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    physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP279012
  156. dev.biologists.org dev.biologists.org
    Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis
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    dev.biologists.org/content/147/15/dev192070
  157. Jan 2020
  158. www.sciencedirect.com www.sciencedirect.com
    Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids
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    sciencedirect.com/science/article/pii/S0960982219307845
  159. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea
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    ncbi.nlm.nih.gov/pmc/articles/PMC6561706/
  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vesicular Glutamatergic Transmission in Noise-Induced Loss and Repair of Cochlear Ribbon Synapses
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    ncbi.nlm.nih.gov/pmc/articles/PMC6554621/
  161. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Development of hair cell phenotype and calyx nerve terminals in the neonatal mouse utricle
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24658
  162. Nov 2018
  163. www.sciencedirect.com www.sciencedirect.com
    Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness
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  164. www.sciencedirect.com www.sciencedirect.com
    Concurrent gradients of ribbon volume and AMPA-receptor patch volume in cochlear afferent synapses on gerbil inner hair cells
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    sciencedirect.com/science/article/pii/S0378595517306068
  165. Nov 2017
  166. dev.biologists.org dev.biologists.org
    Cell migration, intercalation and growth regulate mammalian cochlear extension
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    dev.biologists.org/content/144/20/3766
  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC5462538/
  168. elifesciences.org elifesciences.org
    PDZD7-MYO7A complex identified in enriched stereocilia membranes
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    elifesciences.org/articles/18312
  169. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Large basolateral processes on type II hair cells are novel processing units in mammalian vestibular organs
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    onlinelibrary.wiley.com/doi/10.1002/cne.23625/full
  170. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin‐CreERT2/tdTomato‐reporter mice
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    onlinelibrary.wiley.com/doi/10.1002/cne.23747/full
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Postnatal Expression of Neurotrophic Factors Accessible to Spiral Ganglion Neurons in the Auditory System of Adult Hearing and Deafened Rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC4172804/