338 Matching Annotations
  1. Last 7 days
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    EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission
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    sciencedirect.com/science/article/pii/S2211124721001972
  3. Apr 2024
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    Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
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  5. Mar 2024
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    FEAR antiviral response pathway is independent of interferons and countered by poxvirus proteins
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  7. rupress.org rupress.org
    Rab32 family proteins regulate autophagosomal components recycling
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    rupress.org/jcb/article/223/3/e202306040/276549/Rab32-family-proteins-regulate-autophagosomal
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
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  10. Feb 2024
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    UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
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    PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
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    Nuclear Translocation of Cleaved PCDH9 Impairs Gastric Cancer Metastasis by Downregulating CDH2 Expression
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    Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes
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  15. Jan 2024
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    Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival
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    ULK phosphorylation of STX17 controls autophagosome maturation via FLNA
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  18. Dec 2023
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    An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling
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    OsHLP1 is an endoplasmic-reticulum-phagy receptor in rice plants
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  21. Nov 2023
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    Reversible phosphorylation of a lectin-receptor-like kinase controls xylem immunity
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    Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis
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    Membrane remodeling properties of the Parkinson’s disease protein LRRK2
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  25. Oct 2023
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    JNK mediates cell death by promoting the ubiquitination of the apurinic/apyrimidinic endonuclease APE1
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    The heat shock protein Hsp27 controls mitochondrial function by modulating ceramide generation
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    cell.com/cell-reports/abstract/S2211-1247(23)01092-6
  28. Aug 2023
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of Selective ATP-Competitive CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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      DOI: 10.21203/rs.3.rs-3182731/v1

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  30. 52.53.155.43 52.53.155.43
    PIIS2211124723009774-html.html
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    Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3
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    G-quadruplexes associated with R-loops promote CTCF binding
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    Small molecule targeting of transcription-replication conflict for selective chemotherapy
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  34. Jul 2023
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    Mechanism of orphan subunit recognition during assembly quality control
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    Transcription factors interact with RNA to regulate genes
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  37. Jun 2023
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    Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity
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    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
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  41. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers
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    Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation
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    WeiTsing, a pericycle-expressed ion channel, safeguards the stele to confer clubroot resistance
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    sciencedirect.com/science/article/pii/S0092867423005421
  45. May 2023
  46. www.sciencedirect.com www.sciencedirect.com
    EWSR1 maintains centromere identity
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  47. www.nature.com www.nature.com
    ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
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      DOI: 10.1038/s41467-023-38605-3

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    A phospho-switch constrains BTL2-mediated phytocytokine signaling in plant immunity
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    sciencedirect.com/science/article/pii/S0092867423004233
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    CKB regulates BCAR1 phosphorylation to facilitate DNA damage repair
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    sciencedirect.com/science/article/pii/S2589004223007617
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    Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases
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    Remodeling of the Ribosomal Quality Control and Protein Translation by a Viral Ubiquitin Deconjugase
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    Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
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  106. Mar 2022
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    Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly
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    Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells
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    Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons
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    Transmembrane topology and oligomeric nature of an astrocytic membrane protein, MLC1
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    Suppression of MYC transcription activators by the immune cofactor NPR1 fine-tunes plant immune responses
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    Cryo-Electron Microscopy Structures of VCP/p97 Reveal a New Mechanism of Oligomerization Regulation
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    Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
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    Molecular mapping of transmembrane mechanotransduction through the β1 integrin–CD98hc–TRPV4 axis
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    Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    P5A ATPase controls ER translocation of Wnt in neuronal migration
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    Spt4 facilitates the movement of RNA polymerase II through the +2 nucleosomal barrier
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    A hydride transfer complex reprograms NAD metabolism and bypasses senescence
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    DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
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    The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter
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    Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome
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    Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    Molecular insights into the biased signaling mechanism of the μ-opioid receptor
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    Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function
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    The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking
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    BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
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    Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2
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    Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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  160. Jul 2021
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    A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation
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    STCH4/REIL2 Confers Cold Stress Tolerance in Arabidopsis by Promoting rRNA Processing and CBF Protein Translation
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  164. wellcomeopenresearch.org wellcomeopenresearch.org
    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
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  165. www.embopress.org www.embopress.org
    Cyclin F‐dependent degradation of E2F7 is critical for DNA repair and G2‐phase progression
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  167. elifesciences.org elifesciences.org
    USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication
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      ANTI-FLAG M2 Affinity Gel

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  168. elifesciences.org elifesciences.org
    A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits
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  169. elifesciences.org elifesciences.org
    Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM
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  170. onlinelibrary.wiley.com onlinelibrary.wiley.com
    DFCP1 associates with lipid droplets
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  173. www.sciencedirect.com www.sciencedirect.com
    Intrinsically Disordered Protein TEX264 Mediates ER-phagy
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    Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site
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    Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy
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  180. Jun 2021
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    BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation
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    RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis
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    ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability
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  186. May 2021
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    Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors
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    A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression
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    Membraneless condensates by Rapsn phase separation as a platform for neuromuscular junction formation
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    The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin
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    Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion
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      ANTI-FLAG® M2 Affinity Agarose Gel slurry

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    The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination
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    Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP
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    Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity
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    The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors
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    RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins
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  197. Apr 2021
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    TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation
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    GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme
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      ANTI-FLAG M2 affinity gel

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    Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production
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    Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
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    SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
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    SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms
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  204. Mar 2021
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    EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission
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    Activity- and sleep-dependent regulation of tonic inhibition by Shisa7
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    DSB repair pathway choice is regulated by recruitment of 53BP1 through cell cycle-dependent regulation of Sp1
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    Functional proteomics protocol for the identification of interaction partners in Tetrahymena thermophila
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      Packed M2-agarose

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    PTEN dephosphorylates Abi1 to promote epithelial morphogenesis
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  210. Feb 2021
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    Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma
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    The deubiquitinase TRABID stabilises the K29/K48-specific E3 ubiquitin ligase HECTD1
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      anti-FLAG M2 mouse monoclonal

      DOI: 10.1074/jbc.RA120.015162

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    Uncoupling the hydrolysis of lipid-linked oligosaccharide from the oligosaccharyl transfer reaction by point mutations in yeast oligosaccharyltransferase
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      anti-FLAG M2–agarose

      DOI: 10.1074/jbc.RA120.015013

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    CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation
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      DOI: 10.1073/pnas.2003228117

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    Ribosome Collision Is Critical for Quality Control during No-Go Decay
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    The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans
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    Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells
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  218. Jan 2021
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    VELCRO-IP RNA-seq reveals ribosome expansion segment function in translation genome-wide
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    Impact of WIN site inhibitor on the WDR5 interactome
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    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
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    A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA
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    The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin
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  224. Oct 2020
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    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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  226. Sep 2020
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    Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms
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    Signaling from Plastid Genome Stability Modulates Endoreplication and Cell Cycle during Plant Development
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    An ER translocon for multi-pass membrane protein biogenesis
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  230. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Phosphorylation‐dependent osterix degradation negatively regulates osteoblast differentiation
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      anti‐Flag M2 affinity gel

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    The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs
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    MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells
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    CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching
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    Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death
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    APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin
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