61 Matching Annotations
  1. Nov 2024
  2. www.sciencedirect.com www.sciencedirect.com
    A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells
    1
    1. scibot 14 Nov 2024
      RRID:AB_1030947

      DOI: 10.1016/j.chembiol.2024.10.008

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    sciencedirect.com/science/article/pii/S2451945624004434
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
    1
    1. scibot 08 Nov 2024
      RRID:AB_1030947

      DOI: 10.1158/0008-5472.CAN-23-3574

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532783/
  4. Oct 2024
  5. aacrjournals.org aacrjournals.org
    YAP-Mediated Repression of HRK Regulates Tumor Growth, Therapy Response, and Survival Under Tumor Environmental Stress in Neuroblastoma
    1
    1. scibot 02 Oct 2024
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      DOI: 10.1158/0008-5472.CAN-20-0025

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    aacrjournals.org/cancerres/article/80/21/4741/645935/YAP-Mediated-Repression-of-HRK-Regulates-Tumor
  6. Sep 2024
  7. www.sciencedirect.com www.sciencedirect.com
    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
    1
    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2666379124004245
  8. Aug 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells
    1
    1. scibot 23 Aug 2024
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      DOI: 10.7554/eLife.76940

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    ncbi.nlm.nih.gov/pmc/articles/PMC11333044/
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    LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
    1
    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.cell.2024.07.018

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    sciencedirect.com/science/article/pii/S0092867424007785
  11. Jul 2024
  12. www.sciencedirect.com www.sciencedirect.com
    IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma
    1
    1. scibot 24 Jul 2024
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      DOI: 10.1016/j.ccell.2024.05.026

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    sciencedirect.com/science/article/pii/S1535610824002174
  13. Apr 2024
  14. www.sciencedirect.com www.sciencedirect.com
    Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy
    1
    1. scibot 09 Apr 2024
      2933

      DOI: 10.1016/j.bcp.2024.116198

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    sciencedirect.com/science/article/pii/S0006295224001813
  15. Mar 2024
  16. www.sciencedirect.com www.sciencedirect.com
    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
    2
    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.035

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      DOI: 10.1016/j.molcel.2024.02.035

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    sciencedirect.com/science/article/pii/S109727652400176X
  17. Dec 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
    1
    1. scibot 17 Dec 2023
      AB_1030947

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    sciencedirect.com/science/article/pii/S2666379123005037
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Statin-induced mitochondrial priming sensitizes multiple myeloma cells to BCL2 and MCL1 inhibitors
    1
    1. scibot 13 Dec 2023
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      DOI: 10.1158/2767-9764.CRC-23-0350

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    ncbi.nlm.nih.gov/pmc/articles/PMC10704957/
  20. www.sciencedirect.com www.sciencedirect.com
    Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113513

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    sciencedirect.com/science/article/pii/S2211124723015255
  21. Nov 2023
  22. www.sciencedirect.com www.sciencedirect.com
    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
    1
    1. scibot 22 Nov 2023
      RRID:AB_1030947

      DOI: 10.1016/j.xcrm.2023.101290

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    sciencedirect.com/science/article/pii/S2666379123004846
  23. Oct 2023
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
    1
    1. scibot 20 Oct 2023
      RRID:AB_1030947

      DOI: 10.1158/0008-5472.CAN-22-1337

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    ncbi.nlm.nih.gov/pmc/articles/PMC10570680/
  25. Sep 2023
  26. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Yin-html.html
    2
    1. scibot 16 Sep 2023
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      DOI: 10.1111/bph.16245

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      DOI: 10.1111/bph.16245

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    52.53.155.43/3f4c3b7a8c80fd686d3f27ef9d97ee6662a4385e/British J Pharmacology - 2023 - Yin-html.html
  27. Aug 2023
  28. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
    2
    1. scibot 18 Aug 2023
      RRID:AB_1030947

      DOI: 10.1016/j.xcrm.2023.101142

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    2. scibot 10 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101142

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    52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
  29. Jun 2023
  30. www.sciencedirect.com www.sciencedirect.com
    The potential therapeutic regimen for overcoming resistance to osimertinib due to rare mutations in NSCLC
    1
    1. scibot 24 Jun 2023
      RRID:AB_1030947

      DOI: 10.1016/j.isci.2023.107105

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    sciencedirect.com/science/article/pii/S2589004223011823
  31. Feb 2023
  32. www.sciencedirect.com www.sciencedirect.com
    IFNγ signaling sensitizes melanoma cells to BH3 Mimetics
    1
    1. scibot 04 Feb 2023
      RRID:AB_1030947

      DOI: 10.1016/j.jid.2023.01.017

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    sciencedirect.com/science/article/pii/S0022202X23000726
  33. Nov 2022
  34. aacrjournals.org aacrjournals.org
    p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness
    1
    1. scibot 22 Nov 2022
      RRID:AB_1030947

      DOI: 10.1158/1078-0432.CCR-22-1357

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    aacrjournals.org/clincancerres/article/28/21/4757/709842/p53-Inhibits-Bmi-1-driven-Self-Renewal-and-Defines
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
    1
    1. scibot 18 Nov 2022
      RRID:AB_1030947

      DOI: 10.1016/j.isci.2022.105458

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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  36. Oct 2022
  37. 52.53.155.43 52.53.155.43
    ccr-22-1357-html.html
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    1. scibot 27 Oct 2022
      RRID:AB_1030947

      DOI: 10.1158/1078-0432.ccr-22-1357

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    52.53.155.43/b06e31323fa05ae99a3ee4406ee4cfeac8533d8b/ccr-22-1357-html.html
  38. Sep 2022
  39. www.sciencedirect.com www.sciencedirect.com
    Error-prone protein synthesis recapitulates early symptoms of Alzheimer disease in aging mice
    1
    1. scibot 28 Sep 2022
      RRID:AB_1030947

      DOI: 10.1016/j.celrep.2022.111433

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    sciencedirect.com/science/article/pii/S2211124722012748
  40. www.sciencedirect.com www.sciencedirect.com
    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
    1
    1. scibot 27 Sep 2022
      RRID:AB_1030947

      DOI: 10.1016/j.jbc.2022.102532

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    sciencedirect.com/science/article/pii/S0021925822009759
  41. Aug 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
    1
    1. scibot 23 Aug 2022
      RRID:AB_1030947

      DOI: 10.1016/j.crmeth.2022.100271

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    sciencedirect.com/science/article/pii/S2667237522001485
  43. Jul 2022
  44. www.embopress.org www.embopress.org
    LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance
    1
    1. scibot 09 Jul 2022
      RRID:AB_1030947

      DOI: 10.15252/embr.202154195

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    embopress.org/doi/10.15252/embr.202154195
  45. Jun 2022
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
    1
    1. scibot 25 Jun 2022
      RRID:AB_1030947

      DOI: 10.1016/j.isci.2022.104518

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    ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
  47. www.sciencedirect.com www.sciencedirect.com
    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
    1
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      RRID:AB_1030947

      DOI: 10.1016/j.isci.2022.104517

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    sciencedirect.com/science/article/pii/S258900422200788X
  48. May 2022
  49. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
    1
    1. scibot 13 May 2022
      RRID:AB_1030947

      DOI: 10.1158/2159-8290.CD-21-1168

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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  50. Mar 2022
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR/Cas9 Screens Reveal Epstein-Barr Virus Transformed B-Cell Host Dependency Factors
    1
    1. scibot 26 Mar 2022
      RRID:AB_1030947

      DOI: 10.1016/j.chom.2017.04.005

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    ncbi.nlm.nih.gov/pmc/articles/PMC8938989/
  52. Jan 2022
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
    1
    1. scibot 15 Jan 2022
      RRID:AB_1030947

      DOI: 10.1038/s41408-021-00603-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC8752621/
  54. Oct 2021
  55. www.sciencedirect.com www.sciencedirect.com
    Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
    1
    1. scibot 08 Oct 2021
      2933T

      DOI: 10.1016/j.stem.2021.09.009

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    sciencedirect.com/science/article/pii/S1934590921003854
  56. Aug 2021
  57. www.nature.com www.nature.com
    Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
    1
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      RRID:AB_1030947

      DOI: 10.1038/s41467-021-24821-2

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    nature.com/articles/s41467-021-24821-2
  58. www.sciencedirect.com www.sciencedirect.com
    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
    1
    1. scibot 06 Aug 2021
      RRID:AB_1030947

      DOI: 10.1016/j.cmet.2019.01.011

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    sciencedirect.com/science/article/pii/S1550413119300117
  59. Jul 2021
  60. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
    1
    1. scibot 31 Jul 2021
      rabbit anti‐BIM

      DOI: 10.1002/ijc.32709

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    onlinelibrary.wiley.com/doi/full/10.1002/ijc.32709
  61. www.sciencedirect.com www.sciencedirect.com
    Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
    1
    1. scibot 28 Jul 2021
      RRID:AB_1030947

      DOI: 10.1016/j.cmet.2019.01.011

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    sciencedirect.com/science/article/pii/S1550413119300117
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
    1
    1. scibot 28 Jul 2021
      RRID:AB_1030947

      DOI: 10.1038/s41408-018-0165-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC6333829/
  63. www.sciencedirect.com www.sciencedirect.com
    Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells
    1
    1. scibot 27 Jul 2021
      RRID:AB_103947

      DOI: 10.1016/j.celrep.2019.05.020

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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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  65. Apr 2021
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    Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells
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    Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia
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    MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
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    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
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  71. Sep 2020
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    Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
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      DOI: 10.1016/j.ccell.2019.12.006

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  73. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.
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      DOI: 10.1158/1078-0432.CCR-19-1900

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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    Kinetic Heterogeneity of Cancer Cell Fractional Killing
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  76. Jan 2020
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    TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision
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      DOI: 10.1016/j.immuni.2019.09.013

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  78. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  79. mbio.asm.org mbio.asm.org
    TREM-1 Protects HIV-1-Infected Macrophages from Apoptosis through Maintenance of Mitochondrial Function
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      DOI: 10.1128/mBio.02638-19

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    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
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      DOI: 10.1016/j.celrep.2019.05.043

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      RRID:AB_1030947

      DOI: 10.1016/j.celrep.2019.02.108

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    BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
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      DOI: 10.1016/j.ccell.2019.04.005

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  83. www.sciencedirect.com www.sciencedirect.com
    Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R−STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity
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      RRID:AB_1030947

      DOI: 10.1016/j.immuni.2018.10.010

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  84. Nov 2018
  85. www.sciencedirect.com www.sciencedirect.com
    MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation
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    sciencedirect.com/science/article/pii/S1535610818302691
  86. Nov 2017
  87. www.jneurosci.org www.jneurosci.org
    Long Noncoding RNA Malat1 Regulates Cerebrovascular Pathologies in Ischemic Stroke
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      Curator: @Zeljana_Babic

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    jneurosci.org/content/37/7/1797
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    CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors
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      Curator: @chewbeccax

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    sciencedirect.com/science/article/pii/S1931312817301518
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    Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
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      AB_1030947

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    sciencedirect.com/science/article/pii/S0092867417302465