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Compartmentalized branched-chain amino acid metabolism orchestrates colorectal cancer dissemination via an UMP-vimentin axis

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sciencedirect.com/science/article/pii/S1550413126000070
Jan 2026
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2026.01.21.700886v1.full-html.html

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54.241.53.176/bdd50a9018c213744bdf3c237d3ef5763deb458b/2026.01.21.700886v1.full-html.html
Dec 2025
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Serotonin-licensed macrophages potentiate chemoresistance via inositol metabolic crosstalk in ovarian cancer

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sciencedirect.com:5037/science/article/pii/S1550413125004954
Nov 2025
54.241.53.176 54.241.53.176

1-s2.0-S2589004225024940-main-html.html

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1. scibot 29 Nov 2025
  
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54.241.53.176/13313ba76aa728306d91fd68baab10e4c6cdec0c/1-s2.0-S2589004225024940-main-html.html
Oct 2025
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Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism

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sciencedirect.com/science/article/pii/S1550413125004334
Aug 2025
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Ridaifen derivatives function as potent lysosomotropic agents, depending on their basic side chains.

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1. scibot 21 Aug 2025
  
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  DOI: 10.1016/j.ejphar.2025.178082
  
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sciencedirect.com/science/article/pii/S0014299925008362
Jul 2025
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Complete loss of PAX4 causes transient neonatal diabetes in humans

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1. scibot 22 Jul 2025
  
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Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia

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Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling

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1. scibot 16 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12258133/
Jun 2025
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Hyperacute response proteins synthesized on γ-tubulin-FTO-MARK4 translation microdomains regulate cancer’s acute stress response

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May 2025
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Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.chom.2025.05.004
  
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sciencedirect.com/science/article/pii/S1931312825001830
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Complete Loss of PAX4 causes Transient Neonatal Diabetes in Humans

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1. scibot 20 May 2025
  
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  DOI: 10.1101/2025.04.01.25324926
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11998800/
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TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicing factors

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115616
  
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sciencedirect.com/science/article/pii/S2211124725003870
Apr 2025
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Activity-dependent synthesis of Emerin gates neuronal plasticity by regulating proteostasis

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  DOI: 10.1016/j.celrep.2025.115439
  
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sciencedirect.com/science/article/pii/S2211124725002104
Mar 2025
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Antagonistic roles for MITF and TFE3 in melanoma plasticity

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  DOI: 10.1016/j.celrep.2025.115474
  
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sciencedirect.com/science/article/pii/S2211124725002451
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Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation

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1. scibot 24 Mar 2025
  
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  DOI: 10.1016/j.stem.2025.02.017
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00088-8
Jan 2025
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The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway

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1. scibot 24 Jan 2025
  
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  DOI: 10.1016/j.celrep.2025.115231
  
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Claudin-4 stabilizes the genome via nuclear and cell cycle remodeling to support ovarian cancer cell survival

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1. scibot 15 Jan 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0558
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11705808/
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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control

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  DOI: 10.1016/j.devcel.2024.12.024
  
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sciencedirect.com/science/article/pii/S1534580724007639
Dec 2024
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Adipocyte-derived ferroptotic signaling mitigates obesity

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cell.com/cell-metabolism/abstract/S1550-4131(24)00456-X
52.53.155.43 52.53.155.43

crc-24-0558-html.html

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52.53.155.43/84b181f6e67618dcb22aba5ea65de17db9b57a38/crc-24-0558-html.html
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The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses

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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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Sep 2024
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Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents

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1. scibot 14 Sep 2024
  
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  DOI: 10.1101/2024.09.04.611120
  
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biorxiv.org/content/10.1101/2024.09.04.611120v1
Aug 2024
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Confinement controls the directional cell responses to fluid forces

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  DOI: 10.1016/j.celrep.2024.114692
  
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A single-cell transcriptomic census of mammalian olfactory epithelium aging

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Jul 2024
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N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma

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1. scibot 27 Jul 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0428
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11270646/
Jun 2024
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Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement

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  DOI: 10.1371/journal.pgen.1011326
  
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Altered nucleocytoplasmic export of adenosine-rich circRNAs by PABPC1 contributes to neuronal function

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sciencedirect.com/science/article/pii/S1097276524004349
May 2024
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Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression

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Mar 2024
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Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice

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  DOI: 10.1016/j.celrep.2024.113875
  
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sciencedirect.com/science/article/pii/S2211124724002031
Feb 2024
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The proteomic landscape of genotoxic stress-induced micronuclei

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  DOI: 10.1016/j.molcel.2024.02.001
  
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ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation

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1. scibot 09 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113720
  
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sciencedirect.com/science/article/pii/S2211124724000482
Dec 2023
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Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines

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1. scibot 02 Dec 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-2316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10658995/
Nov 2023
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Endonucleosis mediates internalization of cytoplasm into the nucleus in senescent cells

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Mechanical overloading leads to chondrocyte degeneration and senescence via Zmpste24 mediated nuclear membrane instability

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TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal

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Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts

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Liver-specific overexpression of HKDC1 increases hepatocyte size and proliferative capacity

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Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

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Complementary gene regulation by NRF1 and NRF2 protects against hepatic cholesterol overload

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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination

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Downregulation of iNOS/NO Promotes Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer

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Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response

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Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins

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Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks

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Na/K-ATPase Suppresses LPS-Induced Pro-Inflammatory Signaling Through Lyn

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Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia

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Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

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Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing

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Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism

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Aberrant nuclear translocation of E2F1 and its association in Cushing’s disease

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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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Norepinephrine activates β1-adrenergic receptors at the inner nuclear membrane in astrocytes

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Nde1 is required for heterochromatin compaction and stability in neocortical neurons

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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition

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Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

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Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis

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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

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Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate

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A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

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MAP3K7 loss drives enhanced androgen signaling and independently confers risk of recurrence in prostate cancer with joint loss of CHD1

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The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

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Interplay between protein acetylation and ubiquitination controls MCL1 protein stability

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Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase

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The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation

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SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages

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Generation of a laminopathies-specific iPSC line EHTJUi005-A-3 with homozygous knockout of the LMNA gene by CRISPR/Cas9 technology

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SubCellBarCode: Proteome-wide Mapping of Protein Localization and Relocalization

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ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

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p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

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Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function

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A tri-functional amino acid enables mapping of binding sites for posttranslational-modification-mediated protein-protein interactions

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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs

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Mulberroside A repairs high fructose diet‐induced damage of intestinal epithelial and blood–brain barriers in mice: A potential for preventing hippocampal neuroinflammatory injury

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Apoptosis, the only cell death pathway that can be measured in human diploid dermal fibroblasts following lethal UVB irradiation

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Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

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A marine fungus‐derived nitrobenzoyl sesquiterpenoid suppresses RANKL‐induced osteoclastogenesis and attenuates inflammatory bone destruction

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NF-κB Dynamics Discriminate between TNF Doses in Single Cells

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

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Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion

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Lamin B2 Levels Regulate Polyploidization of Cardiomyocyte Nuclei and Myocardial Regeneration

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Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway

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Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

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Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain

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Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase

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Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

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Untitled document

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Nov 2018
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A bidirectional crosstalk between glioblastoma and brain endothelial cells potentiates the angiogenic and proliferative signaling of sphingosine-1-phosphate in the glioblastoma microenvironment

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Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation

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Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms

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Untitled document

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sciencedirect.com/science/article/pii/S2405471217304489
Nov 2017
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Protein kinase D exerts neuroprotective functions during oxidative stress via Nuclear Factor kappaB‐independent signaling pathways

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onlinelibrary.wiley.com/doi/10.1111/jnc.14131/full
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An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

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  Mouse monoclonal anti-Lamin A/C (4C11)
  
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sciencedirect.com/science/article/pii/S0092867416316671

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