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RIPK1 autophosphorylation at S161 mediates cell death and inflammation

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Jul 2025
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Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity

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MLKL activates the cGAS-STING pathway by releasing mitochondrial DNA upon necroptosis induction

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Jun 2025
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Triflumizole induces excessive reactive oxygen species, inhibits the GPR30/PI3K/AKT pathway, and triggers apoptosis and autophagy in GC-1 spermatogonia cells

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Apr 2025
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ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

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Mar 2025
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity

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Dec 2024
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1-s2.0-S2589004224028086-main-html.html

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Nov 2024
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MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions

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Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

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Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis

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Jul 2024
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An immunohistochemical atlas of necroptotic pathway expression

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ncbi.nlm.nih.gov/pmc/articles/PMC11250867/
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Extracellular vesicles from alveolar macrophages harboring phagocytosed methicillin-resistant Staphylococcus aureus induce necroptosis

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cell.com/cell-reports/fulltext/S2211-1247(24)00782-4
Jun 2024
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The interaction between RIPK1 and FADD controls perinatal lethality and inflammation

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Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress

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ncbi.nlm.nih.gov/pmc/articles/PMC11140209/
May 2024
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The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation

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Apr 2024
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Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy

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Mar 2024
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A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis

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1. scibot 27 Mar 2024
  
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Dec 2023
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The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases

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Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death

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Nov 2023
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An immunohistochemical atlas of necroptotic pathway expression

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biorxiv.org/content/10.1101/2023.10.31.565039v1
Aug 2023
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Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function

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Jun 2023
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Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

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Jan 2023
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Gasdermin D pore-forming activity is redox-sensitive

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SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

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Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells

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aacrjournals.org/mcr/article/20/12/1785/710999/Loss-of-VOPP1-Contributes-to-BET-Inhibitor
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Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome

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Dec 2022
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Gasdermins and pannexin-1 mediate pathways of chemotherapy-induced cell lysis in hematopoietic malignancies

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Nov 2022
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An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice

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science.org/doi/10.1126/scisignal.abi8713
Jul 2022
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Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

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  DOI: 10.7554/eLife.74443
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9262386/
Jun 2022
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Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

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ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
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Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors

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Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control

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academic.oup.com/endo/article/163/6/bqac048/6569208
Feb 2022
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T63 induces apoptosis in nasopharyngeal carcinoma cells through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway

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  DOI: 10.21037/tcr-20-1677
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8797319/
Nov 2021
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Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation

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  RRID:AB_10545768
  
  DOI: 10.1016/j.isci.2021.103256
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
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sciencedirect.com/science/article/pii/S2589004221012256
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma

1
1. scibot 17 Aug 2021
  
  in Public
  
  RRID:AB_10545768
  
  DOI: 10.1158/1078-0432.CCR-18-3683
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7887036/
Jun 2021
elifesciences.org elifesciences.org

Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis

1
1. scibot 17 Jun 2021
  
  in Public
  
  RRID:AB_10545768
  
  DOI: 10.7554/eLife.58342
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
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elifesciences.org/articles/58342
May 2021
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Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

1
1. scibot 12 May 2021
  
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  RRID:AB_10545768
  
  DOI: 10.1016/j.immuni.2021.04.012
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
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sciencedirect.com/science/article/pii/S1074761321001746
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A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade

1
1. scibot 07 May 2021
  
  in Public
  
  RRID:AB_10545768
  
  DOI: 10.1016/j.molcel.2020.09.004
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
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sciencedirect.com/science/article/pii/S1097276520306122
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Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

1
1. scibot 06 May 2021
  
  in Public
  
  RRID:AB_10545768
  
  DOI: 10.1016/j.immuni.2020.04.010
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
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sciencedirect.com/science/article/pii/S1074761320301680
Apr 2021
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Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells

1
1. scibot 29 Apr 2021
  
  in Public
  
  RRID:AB_10545768
  
  DOI: 10.1016/j.cmet.2020.10.017
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
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sciencedirect.com/science/article/pii/S1550413120305507
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Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

1
1. scibot 14 Apr 2021
  
  in Public
  
  RRID:AB_10545768
  
  DOI: 10.1016/j.celrep.2021.108998
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
  Curator: @Naa003
  
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sciencedirect.com/science/article/pii/S2211124721003120
Jan 2020
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Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10545768
  
  DOI: 10.1016/j.cell.2019.06.014
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S0092867419306774
onlinelibrary.wiley.com onlinelibrary.wiley.com

Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10545768
  
  DOI: 10.1111/jnc.14661
  
  Resource: (Cell Signaling Technology Cat# 4790, RRID:AB_10545768)
  
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onlinelibrary.wiley.com/doi/full/10.1111/jnc.14661
Nov 2018
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Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death

1
1. scibot 05 Nov 2018
  
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  RRID:AB_10545768
  
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sciencedirect.com/science/article/pii/S2451945618301855
Nov 2017
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Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages

1
1. scibot 08 Nov 2017
  
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  AB_10545768
  
  Curator: @Zeljana_Babic
  
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sciencedirect.com/science/article/pii/S2451945617300922