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Oct 2026
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EZH2-dependent phenotypic plasticity reveals TTP-associated and mTORC1 therapeutic vulnerabilities in lethal prostate cancer

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  DOI: 10.1016/j.xcrm.2026.103083
  
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sciencedirect.com/science/article/pii/S2666379126005008
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth

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  DOI: 10.1016/j.devcel.2025.05.008
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12258181/
Apr 2026
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Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes

1
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  DOI: 10.1016/j.celrep.2026.117228
  
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sciencedirect.com/science/article/pii/S2211124726003062
Feb 2026
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p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program

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  DOI: 10.1158/2159-8290.CD-25-0525
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12877752/
Jan 2026
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Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma

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1. scibot 29 Jan 2026
  
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  DOI: 10.7150/thno.35458
  
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thno.org/v09p4946.htm
Oct 2025
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HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis

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  DOI: 10.1016/j.celrep.2025.116382
  
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sciencedirect.com/science/article/pii/S2211124725011532
Jul 2025
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FMRP drives mRNP targets into translationally silenced complexes

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sciencedirect.com/science/article/pii/S109727652500512X
May 2025
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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  DOI: 10.1016/j.molcel.2025.05.003
  
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sciencedirect.com/science/article/pii/S1097276525004083
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TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

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1. scibot 20 May 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12052438/
Mar 2025
journals.lww.com journals.lww.com

Exosomes originating from neural stem cells undergoing... : Neural Regeneration Research

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  DOI: 10.4103/NRR.NRR-D-24-00068
  
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journals.lww.com/nrronline/fulltext/2025/11000/exosomes_originating_from_neural_stem_cells.30.aspx
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A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans

1
1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.xgen.2025.100782
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11960549/
Dec 2024
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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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  DOI: 10.1016/j.celrep.2024.115026
  
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sciencedirect.com/science/article/pii/S2211124724013779
Nov 2024
52.53.155.43 52.53.155.43

exosomes_originating_from_neural_stem_cells.435-html.html

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1. scibot 07 Nov 2024
  
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52.53.155.43/06cd22edc3669129f399a285179ef8ca5454e381/exosomes_originating_from_neural_stem_cells.435-html.html
Aug 2024
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Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells

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  AB_10547134
  
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sciencedirect.com/science/article/pii/S1097276524006191
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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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1. scibot 02 Aug 2024
  
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  TSC2
  
  DOI: 10.1016/j.molcel.2020.11.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
Jul 2024
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Multiparameter quantitative analyses of diagnostic cells in brain tissues from tuberous sclerosis complex

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1. scibot 30 Jul 2024
  
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  DOI: 10.1002/cyto.b.22194
  
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onlinelibrary.wiley.com/doi/10.1002/cyto.b.22194
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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.devcel.2020.07.005
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7606764/
Jun 2024
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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

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1. scibot 21 Jun 2024
  
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  RRID:AB_10547134
  
  DOI: 10.1016/j.cmet.2024.05.015
  
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sciencedirect.com/science/article/pii/S1550413124001918
May 2024
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Leucyl-tRNA synthetase contributes to muscle weakness through mTORC1 activation and autophagy suppression in a mouse model of Duchenne Muscular Dystrophy

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1. scibot 17 May 2024
  
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  DOI: 10.1016/j.ajpath.2024.04.006
  
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sciencedirect.com/science/article/pii/S0002944024001743
Apr 2024
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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1. scibot 24 Apr 2024
  
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  RRID:AB_10547134
  
  DOI: 10.1093/narcan/zcae018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
Mar 2024
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MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors

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  RRID:AB_10547134
  
  DOI: 10.1016/j.isci.2024.109188
  
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  RRID:AB_10547134
  
  DOI: 10.1016/j.isci.2024.109188
  
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sciencedirect.com/science/article/pii/S2589004224004097
Feb 2024
www.biorxiv.org www.biorxiv.org

HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

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  RRID:AB_10547134
  
  DOI: 10.1101/2023.12.05.570182
  
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  RRID:AB_10547134
  
  DOI: 10.1101/2023.12.05.570182
  
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  DOI: 10.1101/2023.12.05.570182
  
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biorxiv.org/content/10.1101/2023.12.05.570182v1
Nov 2023
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Tsc2 coordinates neuroprogenitor differentiation

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  DOI: 10.1016/j.isci.2023.108442
  
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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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  RRID:AB_10547134
  
  DOI: 10.1016/j.molcel.2021.03.010
  
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sciencedirect.com/science/article/pii/S1097276521001787
Oct 2023
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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  DOI: 10.1016/j.molcel.2021.03.009
  
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Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex

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  DOI: 10.1016/j.celrep.2023.112838
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10529098/
Apr 2023
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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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  DOI: 10.1016/j.neuron.2023.04.006
  
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sciencedirect.com/science/article/pii/S0896627323002684
Mar 2023
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Neurovascular development in Pten and Tsc2 mouse mutants

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  DOI: 10.1523/ENEURO.0340-22.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9953070/
Jan 2023
academic.oup.com academic.oup.com

Neuropeptide Y Promotes mTORC1 to Regulate Chondrocyte Proliferation and Hypertrophy

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  RRID:AB_10547134
  
  DOI: 10.1210/endocr/bqac213
  
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academic.oup.com/endo/article/164/3/bqac213/6967060
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HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease

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  DOI: 10.1016/j.celrep.2022.111976
  
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sciencedirect.com/science/article/pii/S2211124722018800
Dec 2022
www.science.org www.science.org

Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension

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  RRID:AB_10547134
  
  DOI: 10.1126/scisignal.abn2743
  
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science.org/doi/10.1126/scisignal.abn2743
Aug 2022
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Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing

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  DOI: 10.1016/j.celrep.2022.111192
  
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sciencedirect.com/science/article/pii/S2211124722010099
Jul 2022
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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

1
1. scibot 02 Jul 2022
  
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  DOI: 10.1016/j.molcel.2022.06.008
  
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sciencedirect.com/science/article/pii/S1097276522005445
May 2022
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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

1
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Rheb regulates nuclear mTORC1 activity independent of farnesylation

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

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Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling

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Genomic alterations in PIK3CA-mutated breast cancer result in mTORC1 activation and limit the sensitivity to PI3Kα inhibitors

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Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex

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KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis

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Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin

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Untitled document

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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

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  TSC2
  
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Untitled document

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Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

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The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

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A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle

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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

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MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer

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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

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Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

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The mTORC1/S6K/PDCD4/eIF4A Axis Determines Outcome of Mitotic Arrest

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Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations

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Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons

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Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia

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Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

1
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  DOI: 10.15252/embr.201949898
  
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BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

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Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1

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academic.oup.com/jb/article/doi/10.1093/jb/mvaa076/5870373
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Nociceptor deletion of Tsc2 enhances axon regeneration by inducing a conditioning injury response in dorsal root ganglia

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Cartilage ablation of Sirt1 causes inhibition of growth plate chondrogenesis by hyperactivation of mTORC1 signaling

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  DOI: 10.1210/en.2019-00427
  
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TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency

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Lysosome Positioning Influences mTORC2 and AKT Signaling

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  DOI: 10.1016/j.molcel.2019.05.009
  
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

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Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice

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1. scibot 05 Nov 2018
  
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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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1. scibot 09 Nov 2017
  
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PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes

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