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The class A repeats of Lrp5 are required for normal development of bone, retinal vasculature, and mammary gland in vivo

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1. scibot 21 May 2026
  
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  DOI: 10.1242/dmm.052280
  
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Combined Inhibition of HRAS and MEK Induces Tumor Regression and Restores Myogenic Differentiation in HRAS-Mutant Rhabdomyosarcoma

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May 2026
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Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion

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1-s2.0-S2589004226013337-main-html.html

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Feb 2026
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The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12900249/
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Investigation into ligand selectivity and bias at the formyl peptide receptor family

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  DOI: 10.1016/j.jpet.2025.103764
  
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1-s2.0-S2589004225024654-main-html.html

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Jan 2026
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2026.01.11.698831v1.full-html.html

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54.241.53.176/c7c91e8cb5f2ef627fac130ae2db15d41b2c023d/2026.01.11.698831v1.full-html.html
Dec 2025
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PSMD8 cooperates with USP14 to promote bladder cancer progression by inhibiting ferroptosis

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A BRN2:MYC transcriptional axis regulates interconversion between therapy-resistant and tumorigenic phenotypes in melanoma

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Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer

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TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence

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  DOI: 10.1038/s44318-025-00608-9
  
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Nov 2025
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Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality

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1. scibot 19 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.113770
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12616019/
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FGD3 mediates lytic cell death, enhancing efficacy and immunogenicity of chemotherapy agents in breast cancer

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1. scibot 15 Nov 2025
  
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  DOI: 10.1186/s13046-025-03559-5
  
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54.241.53.176 54.241.53.176

1-s2.0-S2589004225021996-main-html.html

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Oct 2025
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Modeling response to the KRAS-G12C inhibitor AZD4625 in KRASG12C NSCLC patient-derived xenografts reveals insights into primary resistance mechanisms

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1. scibot 23 Oct 2025
  
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  DOI: 10.1038/s41416-025-03216-w
  
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nature.com/articles/s41416-025-03216-w
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TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis

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1. scibot 23 Oct 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4224
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618269/
Sep 2025
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RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity

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1. scibot 19 Sep 2025
  
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Aug 2025
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ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis

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  DOI: 10.1016/j.devcel.2025.07.016
  
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Jul 2025
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1-s2.0-S2589004225013288-main-html.html

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Jun 2025
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Systematic identification and characterization of eukaryotic and viral 2A peptide-bond-skipping sequences

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VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells

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Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation

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Mar 2025
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The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1α/ERRα axis

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Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis

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Feb 2025
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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway

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Integration of metabolomic and transcriptomic analyses reveals regulatory functions of the ChREBP transcription factor in energy metabolism

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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

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Dec 2024
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Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma

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IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages

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Reactive oxygen species control protein degradation at the mitochondrial import gate

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Aug 2024
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
May 2024
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Comprehensive proteogenomic characterization of rare kidney tumors

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

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  DOI: 10.1016/j.celrep.2024.114174
  
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Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma

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Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

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FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy

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Recruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B

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Synonymous codon usage regulates translation initiation

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Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

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Orphan quality control shapes network dynamics and gene expression

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DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer

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Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals

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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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Reversal of mitochondrial malate dehydrogenase 2 enables anaplerosis via redox rescue in respiration-deficient cells

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OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy

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Gut microbe-derived metabolite trimethylamine N-oxide activates PERK to drive fibrogenic mesenchymal differentiation

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer

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Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex

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Co-adaptor driven assembly of a CUL3 E3 ligase complex

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Triple targeting of breast tumors driven by hormonal receptors and HER2

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Macrophages are metabolically heterogeneous within the tumor microenvironment

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Enteric glial cell heterogeneity regulates intestinal stem cell niches

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Reprogramming of glucocorticoid receptor function by hypoxia

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Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis

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RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal

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Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification

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FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer

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In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

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KDM5A mutations identified in autism spectrum disorder using forward genetics

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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

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Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities

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STAT3‐dependent regulation of the electrogenic Na+/HCO3− cotransporter 1 (NBCe1) functional expression in cortical astrocytes

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Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors

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Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts

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Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity

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A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers

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Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

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Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

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Generation of human iPS cell line IBCHi001-A from dentatorubral–pallidoluysian atrophy patient's fibroblasts

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Passive heat therapy protects against endothelial cell hypoxia‐reoxygenation via effects of elevations in temperature and circulating factors

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Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

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Untitled document

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Untitled document

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The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells

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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

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Three-Dimensional Adipose Tissue Imaging Reveals Regional Variation in Beige Fat Biogenesis and PRDM16-Dependent Sympathetic Neurite Density

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Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

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