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    Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet
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    ProSAAS is preferentially up-regulated during homeostatic scaling and reduces amyloid plaque burden in the 5xFAD mouse hippocampus
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    Interhemispheric CA1 projections support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome
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    Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport
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    Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system
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  7. Sep 2024
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    Nuclear actin is a critical regulator of Drosophila female germline stem cell maintenance
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  9. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    Reproducible Differentiation of Human Pluripotent Stem Cells into Two-Dimensional Cortical Neuron Cultures with Checkpoints for Success
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    Protofilament-specific nanopatterns of tubulin post-translational modifications regulate the mechanics of ciliary beating
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    Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
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  12. Aug 2024
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    Rapid reorganization of serotonin projections and antidepressant response to 5-HT1A-biased agonist NLX-101 in fluoxetine-resistant cF1ko mice.
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    Non-canonical function of ADAM10 in presynaptic plasticity
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    Spatial characterization and stratification of colorectal adenomas by deep visual proteomics
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    Mechanoresponsive regulation of myogenesis by the force-sensing transcriptional regulator Tono
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    Insect-transmitted plant virus balances its vertical transmission through regulating Rab1-mediated receptor localization
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    The adeno-associated virus 2 (AAV2) genome and rep 68/78 proteins interact with cellular sites of DNA damage
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    Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition
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    The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C
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    Immunogold characteristics of VGLUT3‐positive GABAergic nerve terminals suggest corelease of glutamate
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    Connexin50 couples axon terminals of mouse horizontal cells by homotypic gap junctions
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    DEP domain‐containing mTOR‐interacting protein in the rat brain: Distribution of expression and potential implication
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  25. Jul 2024
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    The Effects of Cathepsin B Inhibition in the Face of Diffuse Traumatic Brain Injury and Secondary Intracranial Pressure Elevation
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    Generation of an induced pluripotent stem cell line (BIORTCi001-A) from a healthy adult indigenous Nigerian participant
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    Sub-membrane actin rings compartmentalize the plasma membrane
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  31. www.embopress.org www.embopress.org
    TDP1 phosphorylation by CDK1 in mitosis promotes MUS81-dependent repair of trapped Top1-DNA covalent complexes
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    The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway
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    Taste quality and hunger interactions in a feeding sensorimotor circuit
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    Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons
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  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Two Brain Pathways Initiate Distinct Forward Walking Programs in Drosophila
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  36. analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com
    Label-free three-dimensional imaging and quantitative analysis of living fibroblasts and myofibroblasts by holotomographic microscopy
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibitory Interactions and Columnar Inputs to an Object Motion Detector in Drosophila
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mushroom body output neurons MBON-a1/a2 define an odor intensity channel that regulates behavioral odor discrimination learning in larval Drosophila
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  39. Jun 2024
  40. www.sciencedirect.com www.sciencedirect.com
    Spatial proteomics of skeletal muscle using thin cryosections reveals metabolic adaptation at the muscle-tendon transition zone
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  41. 52.53.155.43 52.53.155.43
    elife-90523-v1-html.html
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    Protocol for generating three-dimensional induced early ameloblasts using serum-free media and growth factors
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    Neuronal activity-driven O-GlcNAcylation promotes mitochondrial plasticity
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    Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation
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    Nuclear aggregates of NONO/SFPQ and A-to-I-edited RNA in Parkinson’s disease and dementia with Lewy bodies
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    Acute intoxication with diisopropylfluorophosphate promotes cellular senescence in the adult male rat brain
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    Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle
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    PDZD8 promotes autophagy at ER-Lysosome contact sites to regulate synaptogenesis
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    Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation
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    ProSAAS is Preferentially Secreted from Neurons During Homeostatic Scaling and Reduces Amyloid Plaque Size in the 5xFAD Mouse Hippocampus
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    hESC- and hiPSC-derived Schwann cells are Molecularly Comparable and Functionally Equivalent
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  53. Apr 2024
  54. www.sciencedirect.com www.sciencedirect.com
    Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
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    Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites
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    Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
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    Ankrd26 is a retinoic acid-responsive plasma membrane-binding and -shaping protein critical for proper cell differentiation
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    Time-series reconstruction of the molecular architecture of human centriole assembly
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    Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice
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    GCN5 mediates DNA-PKcs crotonylation for DNA double-strand break repair and determining cancer radiosensitivity
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    “Heterogeneous subpopulations of GABAAR-responding neurons coexist across neuronal networks scales and developmental stages in health and disease”
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    Ankrd26 is a retinoic acid-responsive plasma membrane-binding and -shaping protein critical for proper cell differentiation
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    Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells
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    Generation of induced pluripotent stem cells (UCLi024-A) from a patient with argininosuccinate lyase deficiency carrying a homozygous c.437G > A (p.Arg146Gln) mutation
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    Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkCre mouse line
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    Collective cell migration relies on PPP1R15-mediated regulation of the endoplasmic reticulum stress response
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    The proteomic landscape of genotoxic stress-induced micronuclei
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    Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury
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    Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons
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    Dual roles of CCDC102A in governing centrosome duplication and cohesion
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  76. Jan 2024
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    Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome
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    Examining memory linking and generalization using scFLARE2, a temporally precise neuronal activity tagging system
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    KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth
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  81. Dec 2023
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    Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation
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    Maternal separation early in life induces excessive activity of the central amygdala related to abnormal aggression
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      DOI: 10.1111/jnc.16020

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  84. www.sciencedirect.com www.sciencedirect.com
    YAP targetome reveals activation of SPEM in gastric pre-neoplastic progression and regeneration
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      DOI: 10.1016/j.celrep.2023.113497

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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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      DOI: 10.1016/j.cell.2023.09.027

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  86. www.biorxiv.org www.biorxiv.org
    Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkCre mouse line
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      DOI: 10.1101/2023.11.20.567945

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  87. Nov 2023
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disruptions in cell fate decisions and transformed enteroendocrine cells drive intestinal tumorigenesis in Drosophila
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  89. www.cell.com www.cell.com
    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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  90. www.sciencedirect.com www.sciencedirect.com
    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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      DOI: 10.1016/j.celrep.2023.113460

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    Impact of Heat and Cold Shock on Epigenetics and Chromatin Structure
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    Generation of induced pluripotent stem cell line (TMOi001-A-11) carrying a homozygous deletion in the synemin gene using CRISPR/Cas9
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    Stress-induced β cell early senescence confers protection against type 1 diabetes
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  94. Oct 2023
  95. www.sciencedirect.com www.sciencedirect.com
    Transgenic mouse models support a protective role of type I IFN response in SARS-CoV-2 infection-related lung immunopathology and neuroinvasion
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      DOI: 10.1016/j.celrep.2023.113275

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  96. elifesciences.org elifesciences.org
    Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement
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      DOI: 10.7554/eLife.85756

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  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification
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      DOI: 10.1126/scisignal.add5750

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  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome
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    Generation and characterization of induced pluripotent stem cells from a Parkinson’s disease patient carrying the digenic LRRK2 p.G2019S and GBA1 p.N409S mutations
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    DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C
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    Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells
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    Neuronal activity drives IGF2 expression from pericytes to form long-term memory
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      DOI: 10.1016/j.neuron.2023.08.030

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  104. 52.53.155.43 52.53.155.43
    PIIS0092867423009650-html.html
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      DOI: 10.1016/j.cell.2023.08.032

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  105. www.embopress.org www.embopress.org
    Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth
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      DOI: 10.15252/embj.2023114032

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  106. Sep 2023
  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion
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  108. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Salt-inducible kinases are required for glucose uptake and insulin signaling in human adipocytes
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      DOI: 10.1002/oby.23858

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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial network adaptations of microglia reveal sex-specific stress response after injury and UCP2 knockout
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  110. www.embopress.org www.embopress.org
    Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease
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      DOI: 10.15252/emmm.202317393

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  111. Aug 2023
  112. www.sciencedirect.com www.sciencedirect.com
    Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal
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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer
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  114. Jul 2023
  115. www.sciencedirect.com www.sciencedirect.com
    Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation
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  116. 52.53.155.43 52.53.155.43
    A dual hit of α-synuclein internalization and immune challenge leads to formation and maintenance of Lewy body-like inclusions in human dopaminergic neurons
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  117. 52.53.155.43 52.53.155.43
    Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
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    Vamorolone improves Becker muscular dystrophy and increases dystrophin protein in bmx model mice
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  119. Jun 2023
  120. www.sciencedirect.com www.sciencedirect.com
    Protocol to analyze endogenous translesion DNA synthesis in single mammalian cells
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3
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      DOI: 10.1126/sciadv.adh1281

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    Ccdc85c-Par3 condensates couple cell polarity with Notch to control neural progenitor proliferation
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    Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body
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    Detection of endogenous translesion DNA synthesis in single mammalian cells
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    Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.815G>A (p.R272Q) or c.1348C>T (p.R450C) in the RHOT1 gene encoding Miro1
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway
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      DOI: 10.1083/jcb.202208108

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  128. www.science.org www.science.org
    Oct1 cooperates with the Smad family of transcription factors to promote mesodermal lineage specification
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  129. May 2023
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    Compartmentalization of soluble endocytic proteins in synaptic vesicle clusters by phase separation
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  131. academic.oup.com academic.oup.com
    FriendlyClearMap: an optimized toolkit for mouse brain mapping and analysis
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Drosophila Tachykininergic Neurons Modulate the Activity of Two Groups of Receptor-Expressing Neurons to Regulate Aggressive Tone
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  133. Apr 2023
  134. www.sciencedirect.com www.sciencedirect.com
    Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
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    Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathways
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    A tubule-sheet continuum model for the mechanism of nuclear envelope assembly
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    Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication
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    Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners
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    Optineurin provides a mitophagy contact site for TBK1 activation
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    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Visual and Circadian Regulation of Drosophila BDBT and BDBT Effects on DBT and PER Localization
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    Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen
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    Extracellular matrix protein anosmin-1 overexpression alters dopaminergic phenotype in the CNS and the PNS with no pathogenic consequences in a MPTP model of Parkinson’s disease
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  144. Mar 2023
  145. www.sciencedirect.com www.sciencedirect.com
    Examining the engram encoding specificity hypothesis in mice
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    Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity
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    Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS
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    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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    Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.1290A>G (p.T351A) or c.2067A>G (p.T610A) in the RHOT1 gene encoding Miro1
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  150. Feb 2023
  151. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prostaglandins limit nuclear actin to control nucleolar function during oogenesis
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    Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits
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    Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression
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    Novel image analysis tool for rapid screening of cell morphology in preclinical animal models of disease
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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes
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    D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase
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  158. Jan 2023
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    CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human metastatic cholangiocarcinoma patient-derived xenografts and tumoroids for preclinical drug evaluation
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  161. www.jneurosci.org www.jneurosci.org
    Multisession Anodal Transcranial Direct Current Stimulation Enhances Adult Hippocampal Neurogenesis and Context Discrimination in Mice
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    Generation of glutamatergic/GABAergic neuronal co-cultures derived from human induced pluripotent stem cells for characterizing E/I balance in vitro
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    Selective integration of diverse taste inputs within a single taste modality
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    Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis
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    Loss of epigenetic information as a cause of mammalian aging
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  166. www.embopress.org www.embopress.org
    Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease
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    ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen
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  168. Dec 2022
  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit
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    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Notch-dependent Abl signaling regulates cell motility during ommatidial rotation in Drosophila
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    Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum
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    Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
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    POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells
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    Neuroprotective effects of insulin-like growth factor-2 in... : Neural Regeneration Research
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    A high-throughput electron tomography workflow reveals over-elongated centrioles in relapsed/refractory multiple myeloma
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  181. Sep 2022
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    Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in mice with temporal lobe epilepsy
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    A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration
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    The NHE3 Inhibitor Tenapanor Prevents Intestinal Obstructions in CFTR-Deleted Mice
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    Tonotopic differentiation of presynaptic neurotransmitter-releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice
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    Molecular dissection of condensin II-mediated chromosome assembly using in vitro assays
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  188. Aug 2022
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    RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
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    A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice
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    Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
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    Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
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    A regulatory network of Sox and Six transcription factors initiate a cell fate transformation during hearing regeneration in adult zebrafish
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    Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
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    Improved Fluorescent Signal in Expansion Microscopy Using Fluorescent Fab Fragment Secondary Antibodies
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    Melanopsin retinal ganglion cells mediate light-promoted brain development
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    Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
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    Flattening of circadian glucocorticoid oscillations drives acute hyperinsulinemia and adipocyte hypertrophy
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    Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts
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    Attenuating Adaptive VEGF-A and IL8 Signaling Restores Durable Tumor Control in AR Antagonist–Treated Prostate Cancers
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    Drosophila gustatory projections are segregated by taste modality and connectivity
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    Glutamate released by Cajal-Retzius cells impacts specific hippocampal circuits and behaviors
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    Generation of isogenic control DJ-1-delP GC13 for the genetic Parkinson‘s disease-patient derived iPSC line DJ-1-delP (LCSBi008-A-1)
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    Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
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    Vocal changes in a zebra finch model of Parkinson’s disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway
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    Cocaine Modulates the Neuronal Endosomal System and Extracellular Vesicles in a Sex-Dependent Manner
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      RRID:AB_10563566

      DOI: 10.1007/s11064-022-03612-1

      Resource: (Thermo Fisher Scientific Cat# A-11036, RRID:AB_10563566)

      Curator: @scibot

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    link.springer.com/article/10.1007/s11064-022-03612-1
  219. Apr 2022
  220. www.sciencedirect.com www.sciencedirect.com
    Generation and characterization of a genetic Parkinson‘s disease-patient derived iPSC line DJ-1-delP (LCSBi008-A)
    1
    1. scibot 27 Apr 2022
      RRID:AB_143011

      DOI: 10.1016/j.scr.2022.102792

      Resource: (Thermo Fisher Scientific Cat# A-11036, RRID:AB_10563566)

      Curator: @scibot

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    sciencedirect.com/science/article/pii/S1873506122001416
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    Analyses of transplanted human retinal ganglion cell morphology and localization in murine organotypic retinal explant culture
    1
    1. scibot 21 Apr 2022
      Thermo Fisher ScientificCat#A11036

      DOI: 10.1016/j.xpro.2022.101328

      Resource: (Thermo Fisher Scientific Cat# A-11036, RRID:AB_10563566)

      Curator: @sophiastull

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    sciencedirect.com/science/article/pii/S2666166722002088
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    Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements
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    1. scibot 21 Apr 2022
      RRID:AB_10563566

      DOI: 10.1016/j.devcel.2022.03.014

      Resource: (Thermo Fisher Scientific Cat# A-11036, RRID:AB_10563566)

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    sciencedirect.com/science/article/pii/S1534580722002088
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    Inhibitory co-transmission from midbrain dopamine neurons relies on presynaptic GABA uptake
    1
    1. scibot 21 Apr 2022
      RRID:AB_10563566

      DOI: 10.1016/j.celrep.2022.110716

      Resource: (Thermo Fisher Scientific Cat# A-11036, RRID:AB_10563566)

      Curator: @scibot

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    sciencedirect.com/science/article/pii/S2211124722004776