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The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis

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  DOI: 10.1016/j.celrep.2025.116654
  
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sciencedirect.com:5037/science/article/pii/S2211124725014263
Dec 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Exploring STEAP1 Expression in Prostate Cancer Cells in Response to Androgen Deprivation and in Small Extracellular Vesicles

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  DOI: 10.1158/1541-7786.MCR-24-0903
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12133427/
Nov 2025
54.241.53.176 54.241.53.176

2025.11.15.688645v1.full-html.html

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  DOI: 10.1101/2025.11.15.688645
  
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54.241.53.176/cdba0437d888cfd69c6cc9c318e9bbcd22b9769b/2025.11.15.688645v1.full-html.html
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Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3

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Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality

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pmc.ncbi.nlm.nih.gov/articles/PMC12616019/
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DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors

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  DOI: 10.1016/j.isci.2025.113686
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12616096/
Oct 2025
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Productive mRNA chromatin escape is promoted by PRMT5 activity

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Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI

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1. scibot 02 Oct 2025
  
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  DOI: 10.7554/eLife.90375
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12483517/
Sep 2025
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Mutant RIT1 cooperates with YAP to drive an EMT-like lung cancer state

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  DOI: 10.1016/j.celrep.2025.116185
  
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sciencedirect.com/science/article/pii/S2211124725009568
Jul 2025
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Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

1
1. scibot 25 Jul 2025
  
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  DOI: 10.1126/science.adm9805
  
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science.org/doi/10.1126/science.adm9805
Jun 2025
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A first-in-class EGFR-directed KRAS G12V selective inhibitor

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1. scibot 21 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.05.016
  
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sciencedirect.com/science/article/pii/S1535610825002259
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ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair

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  DOI: 10.1016/j.devcel.2025.05.007
  
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sciencedirect.com/science/article/pii/S1534580725003181
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Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS

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  DOI: 10.1016/j.cell.2025.05.008
  
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sciencedirect.com/science/article/pii/S0092867425005562
May 2025
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Direct Arp2/3-vinculin binding is required for pseudopod extension, but only on compliant substrates and in 3D

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.isci.2025.112623
  
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sciencedirect.com/science/article/pii/S2589004225008843
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Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis

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  DOI: 10.1016/j.ccell.2025.04.013
  
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sciencedirect.com/science/article/pii/S1535610825001722
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Functional characterization of the ATOH1 molecular subtype indicates a pro-metastatic role in small cell lung cancer

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  DOI: 10.1016/j.celrep.2025.115603
  
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sciencedirect.com/science/article/pii/S2211124725003742
Apr 2025
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A new nano-encapsulated TSPO ligand reduces neuroinflammation and improves cognitive functions in Alzheimer's disease model

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1. scibot 19 Apr 2025
  
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  DOI: 10.7150/thno.106083
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11984405/
Jan 2025
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

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1. scibot 18 Jan 2025
  
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  DOI: 10.1038/s41556-024-01565-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11735390/
Sep 2024
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A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib

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  DOI: 10.1016/j.xcrm.2024.101703
  
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sciencedirect.com/science/article/pii/S2666379124004245
Aug 2024
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The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

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Sestrin2 drives ER-phagy in response to protein misfolding

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  DOI: 10.1016/j.devcel.2024.07.004
  
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Jul 2024
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Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord

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1. scibot 26 Jul 2024
  
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  DOI: 10.3390/ijms25137168
  
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mdpi.com/1422-0067/25/13/7168
Jun 2024
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Short-term cold exposure induces persistent epigenomic memory in brown fat

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  DOI: 10.1016/j.cmet.2024.05.011
  
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Apr 2024
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Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization

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  DOI: 10.1083/jcb.202307026
  
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rupress.org/jcb/article/223/4/e202307026/276570/Tunable-DNMT1-degradation-reveals-DNMT1-DNMT3B
Feb 2024
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Pim kinase inhibitors increase gilteritinib cytotoxicity in FLT3-ITD acute myeloid leukemia through GSK-3β activation and c-Myc and Mcl-1 proteasomal degradation

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  DOI: 10.1158/2767-9764.CRC-23-0379
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10870818/
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Specialized replication mechanisms maintain genome stability at human centromeres

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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability

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CRISPR/Cas9 mediated Y-chromosome elimination affects human cells transcriptome

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  DOI: 10.1186/s13578-024-01198-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10829266/
Nov 2023
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K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.molcel.2023.10.011
  
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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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  DOI: 10.1016/j.molcel.2021.03.010
  
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Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function

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  DOI: 10.1016/j.isci.2023.108151
  
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sciencedirect.com/science/article/pii/S2589004223022289
Oct 2023
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GLUT-1 changes in paediatric Huntington disease brain cortex and fibroblasts: an observational case-control study

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.ebiom.2023.104849
  
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sciencedirect.com/science/article/pii/S2352396423004152
Aug 2023
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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Jul 2023
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FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns

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Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

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PIMT regulates Hepatic Gluconeogenesis in Mice

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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops

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BPS Publications

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Architecture of the outbred brown fat proteome defines regulators of metabolic physiology

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Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

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Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice

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CENP-B-mediated DNA loops regulate activity and stability of human centromeres

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Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation

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Glutamine deprivation triggers NAGK-dependent hexosamine salvage

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Myopalladin knockout mice develop cardiac dilation and show a maladaptive response to mechanical pressure overload

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Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub

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Inhibition of HIV infection by structural proteins of the inner nuclear membrane is associated with reduced chromatin dynamics

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Establishment and genetic characterization of cell lines derived from proliferating nasal polyps and sinonasal inverted papillomas

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Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome

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Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy

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Untitled document

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Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity

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NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma

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Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion

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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells

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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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mTORC1 promotes cell growth via m6A-dependent mRNA degradation

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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity

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Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

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Androgen Receptor signaling promotes the neural progenitor cell pool in the developing cortex

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A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV

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Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma

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Assembly of Peripheral Actomyosin Bundles in Epithelial Cells Is Dependent on the CaMKK2/AMPK Pathway

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Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration

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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability

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Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization

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  RRID:AB_10603627
  
  DOI: 10.1016/j.ccell.2019.08.006
  
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Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cub.2019.07.052
  
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cell.2019.09.008
  
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.01.106
  
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Untitled document

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  DOI: 10.1016/j.celrep.2019.01.105
  
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Nov 2018
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NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

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1. scibot 05 Nov 2018
  
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mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation

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Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity

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1. scibot 05 Nov 2018
  
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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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1. scibot 08 Nov 2017
  
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Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy

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1. scibot 08 Nov 2017
  
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Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

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1. scibot 08 Nov 2017
  
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