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Feb 2026
www.biorxiv.org www.biorxiv.org

Mechanistic Language Modeling and Oxygenated 3D Screening Reveal Berberine and Enzalutamide Synergy in Resistant Prostate Cancer

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  AB_10622186
  
  DOI: 10.64898/2026.01.24.701539
  
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biorxiv.org/content/10.64898/2026.01.24.701539v1
Jan 2026
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DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

1
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  DOI: 10.1016/j.cmet.2025.12.009
  
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sciencedirect.com/science/article/pii/S1550413125005406
Dec 2025
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Metformin hijacks AMPK-ERK1/2 signaling to trigger a pathogenic “selection trap” and thymic atrophy

1
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  DOI: 10.1016/j.celrep.2025.116762
  
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sciencedirect.com/science/article/pii/S2211124725015347
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Metabolic reprogramming in the spinal cord drives the transition to pain chronicity

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116261
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12717780/
Sep 2025
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Disrupting mitochondrial dynamics attenuates ferroptosis and chemotoxicity via upregulating NRF2-mediated FSP1 expression

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  DOI: 10.1016/j.celrep.2025.116234
  
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sciencedirect.com/science/article/pii/S2211124725010058
Aug 2025
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High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116207
  
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sciencedirect.com/science/article/pii/S2211124725009787
52.53.155.43 52.53.155.43

dhar-et-al-programmed-cell-revival-from-imminent-cell-death-enhances-tissue-repair-and-regeneration-html.html

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1. scibot 27 Aug 2025
  
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  RRID:AB_10622186
  
  DOI: 10.1038/s44318-025-00540-y
  
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52.53.155.43/6e1a51ae3d978e6c74ed455dd826dbf65caf9c68/dhar-et-al-programmed-cell-revival-from-imminent-cell-death-enhances-tissue-repair-and-regeneration-html.html
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Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism

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1. scibot 21 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.041
  
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sciencedirect.com/science/article/pii/S0092867425008633
Jul 2025
52.53.155.43 52.53.155.43

Postabsorptive and postprandial myofibrillar protein synthesis rates at rest and after resistance exercise in women with post-menopause

1
1. scibot 23 Jul 2025
  
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  i
  
  DOI: 10.1152/japplphysiol.00886.2023
  
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52.53.155.43/c621f6fdd0b0ae98562b5c2c70d20e1e6e100deb/mckenna-et-al-2024-postabsorptive-and-postprandial-myofibrillar-protein-synthesis-rates-at-rest-and-after-resistance-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Cinnabarinic acid protects against metabolic dysfunction-associated steatohepatitis by activating Aryl hydrocarbon Receptor-dependent AMPK signaling

1
1. scibot 16 Jul 2025
  
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  AB_10622186
  
  DOI: 10.1152/ajpgi.00337.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12258133/
Jun 2025
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ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA

1
1. scibot 14 Jun 2025
  
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  RRID:AB_10622186
  
  DOI: 10.1016/j.celrep.2025.115851
  
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sciencedirect.com/science/article/pii/S2211124725006229
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Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer

1
1. scibot 11 Jun 2025
  
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  RRID:AB_10622186
  
  DOI: 10.1016/j.celrep.2025.115792
  
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sciencedirect.com/science/article/pii/S2211124725005637
Mar 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans

1
1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.xgen.2025.100782
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11960549/
Jan 2025
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Mitochondrial uncouplers inhibit oncogenic E2F1 activity and prostate cancer growth

1
1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101890
  
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sciencedirect.com/science/article/pii/S266637912400661X
Nov 2024
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Imbalance in glucose metabolism regulates the transition of microglia from homeostasis to Disease Associated Microglia stage 1

1
1. scibot 23 Nov 2024
  
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  RRID:AB_10622186
  
  DOI: 10.1523/JNEUROSCI.1563-23.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11097271/
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Clopidogrel ameliorates high-fat diet-induced hepatic steatosis in mice through activation of the AMPK signaling pathway and beyond

1
1. scibot 10 Nov 2024
  
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  RRID:AB_10622186
  
  DOI: 10.3389/fphar.2024.1496639
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11537861/
Sep 2024
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Crosstalk between butyrate oxidation in colonocyte and butyrate-producing bacteria

1
1. scibot 13 Sep 2024
  
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  AB_10622186
  
  DOI: 10.1016/j.isci.2024.110853
  
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sciencedirect.com/science/article/pii/S2589004224020789
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Beyond mitochondrial transfer, cell fusion rescues metabolic dysfunction and boosts malignancy in adenoid cystic carcinoma

1
1. scibot 04 Sep 2024
  
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  RRID:AB_10622186
  
  DOI: 10.1016/j.celrep.2024.114652
  
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sciencedirect.com/science/article/pii/S2211124724010039
Aug 2024
www.cell.com www.cell.com

RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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1. scibot 02 Aug 2024
  
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  AMPK
  
  DOI: 10.1016/j.molcel.2020.11.008
  
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cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
Jul 2024
52.53.155.43 52.53.155.43

1-s2.0-S2589004224017851-main-html.html

1
1. scibot 25 Jul 2024
  
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  RRID:AB_10622186
  
  DOI: 10.1016/j.isci.2024.110560
  
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52.53.155.43/28f1f0cd51770599356cfb72d036c0e468b38b34/1-s2.0-S2589004224017851-main-html.html
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Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers

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1. scibot 25 Jul 2024
  
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  AB_10622186
  
  DOI: 10.1016/j.celrep.2024.114496
  
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sciencedirect.com/science/article/pii/S2211124724008258
May 2024
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 03 May 2024
  
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  RRID:AB_10622186
  
  DOI: 10.1111/bph.16391
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16391
Apr 2024
52.53.155.43 52.53.155.43

JNEUROSCI.1563-23.2024.full (1)-html.html

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1. scibot 26 Apr 2024
  
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  RRID:AB_10622186
  
  DOI: 10.1523/jneurosci.1563-23.2024
  
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52.53.155.43/3d13c66ed91f2e0714f85e7c6a7de97c0df74a89/JNEUROSCI.1563-23.2024.full (1)-html.html
www.embopress.org www.embopress.org

PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

2
1. scibot 25 Apr 2024
  
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  Cell signalingCat#5831;RRID:AB_10622186
  
  DOI: 10.1038/s44319-024-00110-z
  
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  RRID:AB_10622186
  
  DOI: 10.1038/s44319-024-00110-z
  
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embopress.org/doi/full/10.1038/s44319-024-00110-z
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PRODH safeguards human naive pluripotency by limiting mitochondrial oxidative phosphorylation and reactive oxygen species production

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  RRID:AB_10622186
  
  DOI: 10.1038/s44319-024-00110-z
  
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embopress.org/doi/10.1038/s44319-024-00110-z
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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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  DOI: 10.1016/j.immuni.2024.03.021
  
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sciencedirect.com/science/article/pii/S1074761324001420
Mar 2024
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PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

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  DOI: 10.1016/j.celrep.2024.113868
  
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sciencedirect.com/science/article/pii/S2211124724001967
Jan 2024
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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

1
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  RRID:AB_10622186
  
  DOI: 10.1016/j.cmet.2023.12.016
  
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sciencedirect.com/science/article/pii/S1550413123004679
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD

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1. scibot 13 Dec 2023
  
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  RRID:AB_10622186
  
  DOI: 10.1016/j.isci.2023.108560
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10711470/
Nov 2023
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CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

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  RRID:AB_10622186
  
  DOI: 10.1016/j.celrep.2023.113306
  
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sciencedirect.com/science/article/pii/S2211124723013189
Oct 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes

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1. scibot 20 Oct 2023
  
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  RRID:AB_10622186
  
  DOI: 10.1016/j.isci.2023.108091
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10583057/
Aug 2023
52.53.155.43 52.53.155.43

Supplemental_Material.doc-html.html

1
1. scibot 10 Aug 2023
  
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  RRID:AB_10622186
  
  DOI: 10.2337/db22-0745
  
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52.53.155.43/f40c8204621797818d872b387b2c0141763e87fb/Supplemental_Material.doc-html.html
Jul 2023
52.53.155.43 52.53.155.43

British J Pharmacology - 2023 - Chen - Anthelmintics nitazoxanide protects against experimental pulmonary fibrosis-html.html

2
1. scibot 21 Jul 2023
  
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  RRID:AB_10622186
  
  DOI: 10.1111/bph.16190
  
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  RRID:AB_10622186
  
  DOI: 10.1111/bph.16190
  
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Jun 2023
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Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling

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TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy

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Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats

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Correction: Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

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Skeletal muscle contraction kinetics and AMPK responses are modulated by the adenine nucleotide degrading enzyme AMPD1

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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity

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Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha

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Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

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Hyperuricemia contributes to glucose intolerance of hepatic inflammatory macrophages and impairs the insulin signaling pathway via IRS2-proteasome degradation

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Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction

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The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations

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HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

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Manipulating bovine granulosa cell energy metabolism limits inflammation

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1

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The lactate receptor GPR81 mediates hepatic lipid metabolism and the therapeutic effect of metformin on experimental NAFLDs

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Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease

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Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes

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GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure

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Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells

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β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME

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Rosiglitazone requires hepatocyte PPARγ expression to promote steatosis in male mice with diet-induced obesity

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DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation

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Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

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Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice

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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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  DOI: 10.1016/j.molcel.2021.03.037
  
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A Cellular Mechanism to Detect and Alleviate Reductive Stress

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  RRID:AB_1062218
  
  DOI: 10.1016/j.cell.2020.08.034
  
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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

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The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity

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  DOI: 10.1016/j.cmet.2021.02.007
  
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Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy

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1. scibot 26 Feb 2021
  
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  anti-AMPK
  
  DOI: 10.1038/s42255-020-0256-z
  
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Myeloid-derived Growth Factor Promotes Intestinal Glucagon-like Peptide-1 Production in Male Mice with Type 2 Diabetes

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academic.oup.com/endo/article/161/2/bqaa003/5698328
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SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

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  RRID:AB_10622186
  
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AMPK promotes SPOP-mediated NANOG degradation to regulate prostate cancer cell stemness

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  DOI: 10.1016/j.devcel.2018.11.033
  
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FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

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A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

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AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

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14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation

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  AMPKα
  
  DOI: 10.1074/jbc.RA119.011089
  
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Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels

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  RRID:AB_10622186
  
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Immobilization leads to alterations in intracellular phosphagen and creatine transporter content in human skeletal muscle | American Journal of Physiology-Cell Physiology

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1. scibot 03 Sep 2020
  
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  total AMPK
  
  DOI: 10.1152/ajpcell.00072.2020
  
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journals.physiology.org/doi/full/10.1152/ajpcell.00072.2020
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 03 Sep 2020
  
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  anti‐rabbit AMPKα
  
  DOI: 10.1111/bph.15149
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15149
Jan 2020
elifesciences.org elifesciences.org

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

1
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  RRID:AB_10622186
  
  DOI: 10.7554/eLife.50416
  
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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

1
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  RRID:AB_10622186
  
  DOI: 10.1016/j.celrep.2019.11.067
  
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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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1. scibot 13 Jan 2020
  
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  RRID:AB_10622186
  
  DOI: 10.1016/j.immuni.2019.06.007
  
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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10622186
  
  DOI: 10.1016/j.ccell.2019.08.005
  
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Untitled document

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  RRID:AB_10622186
  
  DOI: 10.1155/2019/6254269
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6409035/
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Untitled document

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  RRID:AB_10622186
  
  DOI: 10.1016/j.celrep.2019.01.087
  
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Untitled document

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  DOI: 10.7554/eLife.41351
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6351101/
Nov 2018
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Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

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Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence

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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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academic.oup.com academic.oup.com

Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells

1
1. scibot 05 Nov 2018
  
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  AB_10622186
  
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academic.oup.com/endo/article/159/5/1950/4935101
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The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer

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Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

1
1. scibot 08 Nov 2017
  
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Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice

1
1. scibot 08 Nov 2017
  
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  AB_10622186
  
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Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

1
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  AB_10622186
  
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Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection

1
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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging

1
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Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy

1
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  AB_10622186
  
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sciencedirect.com/science/article/pii/S1097276517300539

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