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A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma

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1. scibot 08 May 2026
  
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  DOI: 10.1016/j.neuron.2026.03.039
  
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sciencedirect.com/science/article/pii/S0896627326002692
Mar 2026
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E2A selectively regulates TGF-β–induced apoptosis in KRAS-mutant non-small cell lung cancer

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1. scibot 31 Mar 2026
  
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  DOI: 10.1002/1878-0261.70236
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.70236
Feb 2026
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Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis

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1. scibot 24 Feb 2026
  
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  DOI: 10.1016/j.cmet.2026.01.016
  
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sciencedirect.com/science/article/pii/S1550413126000161
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TGFβ1 Activates Lnc-APUE to Promote Tumor Metastasis via the Alu Element-Driven STAU1-Mediated Decay of CDH1 mRNA

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1. scibot 06 Feb 2026
  
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  DOI: 10.1002/advs.202518731
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202518731
Jan 2026
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Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity

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1. scibot 16 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.018
  
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cell.com/cancer-cell/fulltext/S1535-6108(25)00552-5
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Fibroblast-derived alarmin promotes oral wound healing by activating regulatory T cells that relay pro-angiogenic and anti-inflammatory responses

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1. scibot 15 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116829
  
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sciencedirect.com/science/article/pii/S2211124725016018
Dec 2025
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Targeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer

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1. scibot 03 Dec 2025
  
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sciencedirect.com:5037/science/article/pii/S2666379125005476
Jul 2025
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Artificial intelligence-driven discovery of YH395A: A novel TGFβR1 inhibitor with potent anti-tumor activity against triple-negative breast cancer

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1. scibot 10 Jul 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12235933/
May 2025
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1-s2.0-S2589004225008168-main-html.html

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112555
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12145850/
Mar 2025
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ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.xcrm.2025.102038
  
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sciencedirect.com/science/article/pii/S2666379125001119
Feb 2025
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LRRC75A-AS1 drives the epithelial-mesenchymal transition in cervical cancer by binding IGF2BP1 and inhibiting SYVN1-mediated NLRP3 ubiquitination

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1. scibot 14 Feb 2025
  
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  DOI: 10.1158/1541-7786.MCR-23-0478
  
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aacrjournals.org/mcr/article/22/12/1075/750095/LRRC75A-AS1-Drives-the-Epithelial-Mesenchymal
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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-22-3009
  
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aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
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SMAD4 and KRAS Status Shape Cancer Cell-Stromal Crosstalk and Therapeutic Response in Pancreatic Cancer

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1. scibot 11 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2330
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7617379/
Jan 2025
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TWEAK-Fn14 signaling protects mice from pulmonary fibrosis by inhibiting fibroblast activation and recruiting pro-regenerative macrophages

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115220
  
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sciencedirect.com/science/article/pii/S2211124724015717
Dec 2024
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Resistance to Spindle Inhibitors in Glioblastoma Depends on STAT3 and Therapy Induced Senescence

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1. scibot 11 Dec 2024
  
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  DOI: 10.1016/j.isci.2024.111311
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11617384/
Nov 2024
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ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss

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1. scibot 17 Nov 2024
  
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  DOI: 10.1016/j.molcel.2024.10.020
  
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sciencedirect.com/science/article/pii/S1097276524008608
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

RNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential

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1. scibot 07 Jul 2024
  
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  DOI: 10.1158/1541-7786.MCR-23-0512
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10841372/
Jun 2024
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Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

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1. scibot 06 Jun 2024
  
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  DOI: 10.1101/2024.02.09.579580
  
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  DOI: 10.1101/2024.02.09.579580
  
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52.53.155.43/be49547c4f9e1293474726024249294abe2db848/2024.02.09.579580v1.full-html.html
May 2024
52.53.155.43 52.53.155.43

mcr-23-0478-html.html

2
1. scibot 23 May 2024
  
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52.53.155.43/a4d1b1195ce648b46cbdc2b7d1e41b22ba16f57e/mcr-23-0478-html.html
52.53.155.43 52.53.155.43

2024.02.09.579580v1.full-html.html

2
1. scibot 10 May 2024
  
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  DOI: 10.1038/nature05972
  
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52.53.155.43/32c668e9e171a0d93bacd7fd25061d69f59c1b8d/2024.02.09.579580v1.full-html.html
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Positive and negative feedback regulation of the TGF-β1 explains two equilibrium states in skin aging

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1. scibot 08 May 2024
  
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  DOI: 10.1016/j.isci.2024.109708
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11066433/
Apr 2024
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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

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1. scibot 30 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114149
  
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sciencedirect.com/science/article/pii/S2211124724004777
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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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1. scibot 24 Apr 2024
  
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  DOI: 10.1093/narcan/zcae018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
52.53.155.43 52.53.155.43

mcr-23-0478-html.html

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  DOI: 10.1158/1541-7786.mcr-23-0478
  
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52.53.155.43/a4d1b1195ce648b46cbdc2b7d1e41b22ba16f57e/mcr-23-0478-html.html
Feb 2024
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Stromal-derived MAOB promotes prostate cancer growth and progression

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1. scibot 14 Feb 2024
  
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  DOI: 10.1126/sciadv.adi4935
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10857382/
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EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis

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1. scibot 09 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113714
  
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sciencedirect.com/science/article/pii/S2211124724000421
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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

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1. scibot 09 Feb 2024
  
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  DOI: 10.1101/2023.12.05.570182
  
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  DOI: 10.1101/2023.12.05.570182
  
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biorxiv.org/content/10.1101/2023.12.05.570182v1
Dec 2023
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EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.ccell.2023.12.002
  
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sciencedirect.com/science/article/pii/S1535610823004300
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FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression

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1. scibot 21 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108580
  
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Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.devcel.2023.11.020
  
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sciencedirect.com/science/article/pii/S1534580723006184
Sep 2023
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Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.xcrm.2023.101200
  
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sciencedirect.com/science/article/pii/S2666379123003671
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ESRRB inhibits the TGF-β signaling pathway to drive cell proliferation in cervical cancer

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1. scibot 20 Sep 2023
  
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CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis

1
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can-23-0067-html.html

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Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer

1
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Acetate controls endothelial-to-mesenchymal transition

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Increased fibrosis in white adipose tissue of male and female bGH transgenic mice appears independent of TGF-β action

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5-Azacytidine- and retinoic-acid-induced reprogramming of DCCs into dormancy suppresses metastasis via restored TGF-β-SMAD4 signaling

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BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage

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Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51

1
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Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity

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Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer

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Recombinant production of growth factors for application in cell culture

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HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs

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Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

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Mar 2022
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Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

1
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Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway

1
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Dec 2021
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Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease

1
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Inhibition of TGF-β signaling attenuates disuse-induced trabecular bone loss after spinal cord injury in male mice

1
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Effect of miR-183-5p on Cholestatic Liver Fibrosis by Regulating Fork Head Box Protein O1 Expression

1
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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

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TGF-β-mediated epithelial–mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma

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Oct 2021
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Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice

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Loss of Growth Differentiation Factor 11 Shortens Telomere Length by Downregulating Telomerase Activity

1
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Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-β-Smads signaling and myofibroblast differentiation

1
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Untitled document

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Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia

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Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation

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TNAP is a novel regulator of cardiac fibrosis after myocardial infarction by mediating TGF-β/Smads and ERK1/2 signaling pathways

1
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  e
  
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May 2021
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Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection

1
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LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis

1
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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

1
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  rabbit anti-Smad2
  
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Cell intercalation driven by SMAD3 underlies secondary neural tube formation

1
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Mar 2021
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Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling

1
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The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation

1
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Oct 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

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Sep 2020
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Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

2
1. scibot 26 Sep 2020
  
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  RRID:AB_10626777
  
  DOI: 10.1016/j.stem.2020.02.007
  
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2. scibot 03 Sep 2020
  
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  RRID: AB_10626777
  
  DOI: 10.1016/j.stem.2020.02.007
  
  Resource: (Cell Signaling Technology Cat# 5339, RRID:AB_10626777)
  
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sciencedirect.com/science/article/pii/S1934590920300606
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BPS Publications

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1. scibot 11 Sep 2020
  
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  RRID:AB_10626777
  
  DOI: 10.1111/bph.15010
  
  Resource: (Cell Signaling Technology Cat# 5339, RRID:AB_10626777)
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15010
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PRMT1-p53 Pathway Controls Epicardial EMT and Invasion

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1. scibot 05 Sep 2020
  
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  RRID:AB_10626777
  
  DOI: 10.1016/j.celrep.2020.107739
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7425665/
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Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis

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1. scibot 03 Sep 2020
  
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  DOI: 10.1016/j.phrs.2020.104751
  
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sciencedirect.com/science/article/pii/S1043661820303479
Jan 2020
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Protective effects of GHK-Cu in bleomycin-induced pulmonary fibrosis via anti-oxidative stress and anti-inflammation pathways

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1. scibot 13 Jan 2020
  
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  RRID:AB_10626777
  
  DOI: 10.1016/j.lfs.2019.117139
  
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sciencedirect.com/science/article/pii/S0024320519310677
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Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10626777
  
  DOI: 10.1016/j.celrep.2019.10.109
  
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sciencedirect.com/science/article/pii/S2211124719314421
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Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10626777
  
  DOI: 10.7554/eLife.45418
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6663295/
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_10626777
  
  DOI: 10.1016/j.devcel.2019.04.015
  
  Resource: (Cell Signaling Technology Cat# 5339, RRID:AB_10626777)
  
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sciencedirect.com/science/article/pii/S1534580719302850
Nov 2018
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A Metabolic Basis for Endothelial-to-Mesenchymal Transition

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1. scibot 05 Nov 2018
  
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  RRID:AB_10626777
  
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sciencedirect.com/science/article/pii/S109727651830039X
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Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages

1
1. scibot 05 Nov 2018
  
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  RRID:AB_10626777
  
  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S1534580717309826
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Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression

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1. scibot 05 Nov 2018
  
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  RRID:AB_10626777
  
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sciencedirect.com/science/article/pii/S2405471217305380

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