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Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation

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1. scibot 01 Nov 2025
  
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  DOI: 10.1016/j.immuni.2025.10.007
  
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sciencedirect.com/science/article/pii/S1074761325004613
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Autonomous STING signaling in Purkinje cells drives neurodegeneration independent of type I interferon

1
1. scibot 30 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116480
  
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sciencedirect.com/science/article/pii/S2211124725012513
Jun 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A guide to selecting high-performing antibodies for STING1 (Uniprot ID: Q86WV6) for use in western blot, immunoprecipitation, and immunofluorescence

1
1. scibot 25 Jun 2025
  
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  DOI: 10.12688/f1000research.155929.2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12175898/
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ILC3s sense gut microbiota through STING to initiate immune tolerance

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.016
  
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sciencedirect.com/science/article/pii/S1074761325002377
May 2025
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Diffuse traumatic brain injury induced stimulator of interferons (STING) signaling in microglia drives cortical neuroinflammation, neuronal dysfunction, and impaired cognition

1
1. scibot 21 May 2025
  
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  DOI: 10.1186/s12974-025-03451-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12044788/
Apr 2025
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1-s2.0-S2589004225006522-main-html.html

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1. scibot 10 Apr 2025
  
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  DOI: 10.1016/j.isci.2025.112391
  
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52.53.155.43/65da5ba6fe747fbc09139b682088b351a925dfd8/1-s2.0-S2589004225006522-main-html.html
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STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.008
  
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sciencedirect.com/science/article/pii/S1097276525002011
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Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115510
  
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sciencedirect.com/science/article/pii/S2211124725002815
Mar 2025
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Diffuse Traumatic Brain Injury Induced Stimulator of Interferons (STING) Signaling in Microglia Drives Cortical Neuroinflammation, Neuronal Dysfunction, and Impaired Cognition

1
1. scibot 13 Mar 2025
  
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  DOI: 10.21203/rs.3.rs-5960640/v1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11875282/
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Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

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1. scibot 04 Mar 2025
  
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  DOI: 10.1002/advs.202414260
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12021055/
Feb 2025
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Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling

1
1. scibot 04 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115251
  
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sciencedirect.com/science/article/pii/S2211124725000221
Jan 2025
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Mechanical Force-Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis

1
1. scibot 11 Jan 2025
  
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  DOI: 10.1002/advs.202401127
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202401127
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AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice

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1. scibot 03 Jan 2025
  
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  DOI: 10.1038/s41598-024-83027-w
  
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nature.com/articles/s41598-024-83027-w
Dec 2024
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MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling

1
1. scibot 18 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.026
  
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sciencedirect.com/science/article/pii/S1097276524009511
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The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance

1
1. scibot 17 Dec 2024
  
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  DOI: 10.1016/j.immuni.2024.11.017
  
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sciencedirect.com/science/article/pii/S1074761324005326
Sep 2024
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Click-chemistry-based protocol for detecting 4-octyl-itaconate-alkylated proteins in primary mouse macrophages

1
1. scibot 26 Sep 2024
  
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  DOI: 10.1016/j.xpro.2024.103314
  
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sciencedirect.com/science/article/pii/S2666166724004799
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A TBK1-independent primordial function of STING in lysosomal biogenesis

1
1. scibot 25 Sep 2024
  
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  AB_10665370
  
  DOI: 10.1016/j.molcel.2024.08.026
  
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sciencedirect.com/science/article/pii/S1097276524007032
Jul 2024
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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
May 2024
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RGD Targeted Magnetic Ferrite Nanoparticles Enhance Antitumor Immunotherapeutic Efficacy by Activating STING Signaling Pathway

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1. scibot 01 May 2024
  
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  DOI: 10.1016/j.isci.2024.109062
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11039334/
Apr 2024
52.53.155.43 52.53.155.43

1-s2.0-S2589004224002839-main-html.html

1
1. scibot 11 Apr 2024
  
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  DOI: 10.3892/ijo.2023.5518
  
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52.53.155.43/e4b4251b496f91f14f0400600f97646c0efe1fb3/1-s2.0-S2589004224002839-main-html.html
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

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1. scibot 23 Mar 2024
  
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  DOI: 10.7554/eLife.88122
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10945704/
52.53.155.43 52.53.155.43

1-s2.0-S2589004224002839-main-html.html

2
1. scibot 06 Mar 2024
  
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  DOI: 10.3892/ijo.2023.5518
  
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52.53.155.43/e4b4251b496f91f14f0400600f97646c0efe1fb3/1-s2.0-S2589004224002839-main-html.html
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Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses

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1. scibot 05 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113886
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11019558/
Feb 2024
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RNA methyltransferase FTSJ3 regulates the type I interferon pathway to promote hepatocellular carcinoma immune evasion

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1. scibot 23 Feb 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-2049
  
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  RRID:AB_10665370
  
  DOI: 10.1158/0008-5472.CAN-23-2049
  
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aacrjournals.org/cancerres/article/84/3/405/733849/RNA-Methyltransferase-FTSJ3-Regulates-the-Type-I
Nov 2023
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Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses

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1. scibot 17 Nov 2023
  
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  DOI: 10.1002/glia.24475
  
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onlinelibrary.wiley.com/doi/10.1002/glia.24475
Oct 2023
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Itaconate inhibits SYK through alkylation and suppresses inflammation against hvKP induced intestinal dysbiosis

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1. scibot 31 Oct 2023
  
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  DOI: 10.1007/s00018-023-04971-w
  
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link.springer.com/article/10.1007/s00018-023-04971-w
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Regulation of STING activity in DNA sensing by ISG15 modification

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1. scibot 27 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113277
  
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sciencedirect.com/science/article/pii/S2211124723012895
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Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.108082
  
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cell.com/iscience/abstract/S2589-0042(23)02159-4
Aug 2023
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4-Octyl itaconate restricts STING activation by blocking its palmitoylation

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1. scibot 25 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.113040
  
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sciencedirect.com/science/article/pii/S2211124723010513
Jul 2023
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STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages

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1. scibot 29 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107376
  
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sciencedirect.com/science/article/pii/S2589004223014530
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Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112852
  
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sciencedirect.com/science/article/pii/S221112472300863X
Apr 2023
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C9ORF72 suppresses JAK-STAT mediated inflammation

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1. scibot 26 Apr 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.isci.2023.106579
  
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sciencedirect.com/science/article/pii/S2589004223006569
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The mechanism of STING autoinhibition and activation

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1. scibot 22 Apr 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.molcel.2023.03.029
  
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sciencedirect.com/science/article/pii/S1097276523002435
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ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer

1
1. scibot 13 Apr 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.devcel.2023.03.015
  
  Resource: (Proteintech Cat# 19851-1-AP, RRID:AB_10665370)
  
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sciencedirect.com/science/article/pii/S1534580723001314
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Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis

1
1. scibot 06 Apr 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.celrep.2023.112327
  
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sciencedirect.com/science/article/pii/S2211124723003388
Mar 2023
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STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion

1
1. scibot 30 Mar 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.immuni.2023.02.015
  
  Resource: (Proteintech Cat# 19851-1-AP, RRID:AB_10665370)
  
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sciencedirect.com/science/article/pii/S1074761323000894
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Protocol for the identification and expression analysis of a cytoplasmic membrane-localized protein STING

1
1. scibot 23 Mar 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.xpro.2023.102172
  
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sciencedirect.com/science/article/pii/S2666166723001302
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ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING

1
1. scibot 16 Mar 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.immuni.2023.02.004
  
  Resource: (Proteintech Cat# 19851-1-AP, RRID:AB_10665370)
  
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sciencedirect.com/science/article/pii/S107476132300078X
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4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

1
1. scibot 02 Mar 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.celrep.2023.112145
  
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sciencedirect.com/science/article/pii/S2211124723001560
onlinelibrary.wiley.com onlinelibrary.wiley.com

Stimulator of interferon genes (STING) expression in the enteric nervous system and contributions of glial STING in disease

1
1. scibot 01 Mar 2023
  
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  AB_10665370
  
  DOI: 10.1111/nmo.14553
  
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onlinelibrary.wiley.com/doi/10.1111/nmo.14553
Jan 2023
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Protocol using lentivirus to establish THP-1 suspension cell lines for immunostaining and confocal microscopy

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1. scibot 24 Jan 2023
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.xpro.2022.102032
  
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sciencedirect.com/science/article/pii/S2666166722009121
Dec 2022
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Mitochondrial cristae architecture protects against mtDNA release and inflammation

1
1. scibot 08 Dec 2022
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.celrep.2022.111774
  
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sciencedirect.com/science/article/pii/S2211124722016576
Sep 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

cGAS-STING Activation by Cytosolic Mitochondrial DNA Contributes to Podocyte Injury in Diabetic Kidney Disease

1
1. scibot 30 Sep 2022
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.isci.2022.105145
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9513272/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy

1
1. scibot 09 Sep 2022
  
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  RRID:AB_10665370
  
  DOI: 10.1002/jcla.24631
  
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onlinelibrary.wiley.com/doi/10.1002/jcla.24631
Jul 2022
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Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING mediated T cell activation

1
1. scibot 13 Jul 2022
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.isci.2022.104690
  
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sciencedirect.com/science/article/pii/S2589004222009622
Jul 2021
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Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

1
1. scibot 31 Jul 2021
  
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  19851-1-AP
  
  DOI: 10.1038/s41586-021-03762-2
  
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nature.com/articles/s41586-021-03762-2
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FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

1
1. scibot 10 Jul 2021
  
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  19851-1-AP
  
  DOI: 10.1038/s41598-021-92408-4
  
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nature.com/articles/s41598-021-92408-4
Apr 2021
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Mutant p53 suppresses innate immune signaling to promote tumorigenesis

1
1. scibot 22 Apr 2021
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.ccell.2021.01.003
  
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sciencedirect.com/science/article/pii/S1535610821000416
Feb 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reactive oxygen species oxidize STING and suppress interferon production

1
1. scibot 26 Feb 2021
  
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  RRID:AB_10665370
  
  DOI: 10.7554/eLife.57837
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7473769/
Jan 2021
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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

1
1. scibot 08 Jan 2021
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.celrep.2020.108586
  
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sciencedirect.com/science/article/pii/S2211124720315758
Sep 2020
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SPHK2-Generated S1P in CD11b+ Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages

1
1. scibot 09 Sep 2020
  
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  RRID:AB_10665370
  
  DOI: 10.1016/j.celrep.2020.02.112
  
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  RRID:AB_10665370 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S221112472030293X