85 Matching Annotations
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    Striatal neuron dysfunction in C9ORF72-FTD/ALS is driven by AIS and potassium channel dysregulation
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    sciencedirect.com/science/article/pii/S2211124726007503
  3. May 2026
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    NaV1.7 mRNA and Protein Expression in Resident Neurons of the Human Spinal Dorsal Horn
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    onlinelibrary.wiley.com/doi/10.1002/cne.70168
  5. Dec 2025
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    Endoplasmic Reticulum Stress Mediates Axon Initial Segment Shortening: Implications for Diabetic Brain Complications
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    link.springer.com/article/10.1007/s12031-025-02448-y
  7. Sep 2025
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    Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration
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    sciencedirect.com/science/article/pii/S1074761325003796
  9. Jun 2025
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    Long-term muscarinic inhibition increases intrinsic excitability through the upregulation of A-type potassium currents in cortical neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12149742/
  11. Aug 2024
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    An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels
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    rupress.org/jcb/article/223/10/e202401140/276880/An-evolutionarily-conserved-AnkyrinG-dependent
  13. May 2024
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    Postsynaptic β1 spectrin maintains Na+ channels at the neuromuscular junction
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    physoc.onlinelibrary.wiley.com/doi/10.1113/JP285894
  15. Dec 2023
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    Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons
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    sciencedirect.com/science/article/pii/S2211124723015218
  17. Oct 2023
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    Antibody-directed extracellular proximity biotinylation reveals that Contactin-1 regulates axo-axonic innervation of axon initial segments
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    nature.com/articles/s41467-023-42273-8
  19. Jul 2023
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    Early developmental deletion of forebrain Ank2 causes seizure-related phenotypes by reshaping the synaptic proteome
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  21. May 2023
  22. 52.53.155.43 52.53.155.43
    Spatially Resolved Proteomic Profiling Uncovers Structural and Functional Regulators of the Axon Initial Segment
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    52.53.155.43/1b0cedf04512903e90b9ef1858ffefd94df1235f/2023.03.06.531334v1.full-html.html
  23. Apr 2023
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    Contextual fear response is modulated by M-type K+ channels and is associated with subtle structural changes of the axon initial segment in hippocampal GABAergic neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC10106335/
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    Antibody-directed extracellular proximity biotinylation reveals Contactin-1 regulates axo-axonic innervation of axon initial segments
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    ncbi.nlm.nih.gov/pmc/articles/PMC10028829/
  26. Mar 2023
  27. 52.53.155.43 52.53.155.43
    NaV1.7 mRNA and protein expression in putative projection neurons of the human spinal dorsal horn
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    52.53.155.43/b5caca5e6aa2d35c58d7fbbd4b834fa3352e749d/2023.02.04.527110v1.full-html.html
  28. Aug 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sensitivity to extracellular potassium underlies type-intrinsic differences in retinal ganglion cell excitability
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    ncbi.nlm.nih.gov/pmc/articles/PMC9390602/
  30. Jul 2022
  31. www.jneurosci.org www.jneurosci.org
    Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels
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    jneurosci.org/content/42/28/5482
  32. May 2022
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    Differences in spike generation instead of synaptic inputs determine the feature selectivity of two retinal cell types
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    sciencedirect.com/science/article/pii/S0896627322003579
  34. Nov 2021
  35. journals.plos.org journals.plos.org
    Axon initial segment geometry in relation to motoneuron excitability
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  36. Oct 2021
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    Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony
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    sciencedirect.com/science/article/pii/S221112472101322X
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    The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and alters neuronal function at the cellular and network levels
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    eneuro.org/content/8/5/ENEURO.0201-21.2021
  39. Sep 2021
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    Utilizing mouse optic nerve crush to examine CNS remyelination
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    sciencedirect.com/science/article/pii/S2666166721005025
  41. Aug 2021
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    Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells
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    sciencedirect.com/science/article/pii/S2211124721009104
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    frontiersin.org/article/10.3389/fncel.2014.00272/full
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    Remodeling neuronal ER–PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels
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    molbiolcell.org/doi/abs/10.1091/mbc.E18-05-0337
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  48. Jul 2021
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    Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity
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    Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC4990423/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of AKT Signaling Alters βIV Spectrin Distribution at the AIS and Increases Neuronal Excitability
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    ncbi.nlm.nih.gov/pmc/articles/PMC8278006/
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    WDR47 protects neuronal microtubule minus ends from katanin-mediated severing
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  54. May 2021
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TRPM4 Expression During Postnatal Developmental of Mouse CA1 Pyramidal Neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC8113704/
  56. www.eneuro.org www.eneuro.org
    Essential Role of Somatic Kv2 Channels in High-Frequency Firing in Cartwheel Cells of the Dorsal Cochlear Nucleus
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    eneuro.org/content/8/3/ENEURO.0515-20.2021
  57. Apr 2021
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structural Refinement of the Auditory Brainstem Neurons in Baboons During Perinatal Development
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    ncbi.nlm.nih.gov/pmc/articles/PMC8062779/
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    Fragment-linking peptide design yields a high-affinity ligand for microtubule-based transport
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  60. Feb 2021
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    Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells
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  62. Dec 2020
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment
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    ncbi.nlm.nih.gov/pmc/articles/PMC7685708/
  64. Sep 2020
  65. elifesciences.org elifesciences.org
    The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression
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    elifesciences.org/articles/44252
  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC7380941/
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    Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome
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    Accumulation of Neurofascin at nodes of Ranvier is regulated by a Paranodal Switch
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    jneurosci.org/content/40/30/5709
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    Nodal β spectrins are required to maintain Na+ channel clustering and axon integrity
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    elifesciences.org/articles/52378
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    TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance
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    β spectrin-dependent and domain specific mechanisms for Na+ channel clustering
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  72. www.molbiolcell.org www.molbiolcell.org
    Remodeling neuronal ER–PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels | Molecular Biology of the Cell
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  73. Jan 2020
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    Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis
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    sciencedirect.com/science/article/pii/S0896627319306920
  75. currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com
    Imaging of the Axon Initial Segment
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    currentprotocols.onlinelibrary.wiley.com/doi/full/10.1002/cpns.78
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    Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development
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    Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK
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    Impact of Auditory Experience on the Structural Plasticity of the AIS in the Mouse Brainstem Throughout the Lifespan
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    In Vivo Single-Cell Genotyping of Mouse Cortical Neurons Transfected with CRISPR/Cas9
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    Feedback-Driven Assembly of the Axon Initial Segment
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    Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity
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    Glial βII spectrin contributes to paranode formation and maintenance
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    An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons
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    Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM
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    Maturation Dynamics of the Axon Initial Segment (AIS) of Newborn Dentate Granule Cells in Young Adult C57BL/6J Mice
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  91. Nov 2018
  92. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice
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    europepmc.org/articles/PMC6002488/
  95. www.frontiersin.org www.frontiersin.org
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    Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation
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    Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron
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    elifesciences.org/articles/32373
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    KCa2 channel localization and regulation in the axon initial segment | The FASEB Journal
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    fasebj.org/doi/full/10.1096/fj.201700605R
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy
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    Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3
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    Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome
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    ncbi.nlm.nih.gov/pmc/articles/PMC5758499/
  103. Nov 2017
  104. link.springer.com link.springer.com
    Immunohistochemical Procedures for Characterizing the Retinal Expression Patterns of Cre Driver Mouse Lines
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    LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels
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    Bassoon Controls Presynaptic Autophagy through Atg5
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  107. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC4990423/
  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier
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    Multiscale Analysis of Neurite Orientation and Spatial Organization in Neuronal Images
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    link.springer.com/article/10.1007/s12021-016-9306-9
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    Developing high-quality mouse monoclonal antibodies for neuroscience research – approaches, perspectives and opportunities
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    JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size, and influences fine motor coordination
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    ncbi.nlm.nih.gov/pmc/articles/PMC4162472/
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    Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain
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    onlinelibrary.wiley.com/doi/10.1002/cne.23715/full